olea25®hydroxytyrosol- health benefits from olive leaf

HEALTH BENEFITS

OLEA25®HYDROXYTYROSOL

25%ORGANICOLIVE LEAF EXTRACT

BAUERHEALTHACTION.COM WWW.EUSS.EDU

Olea25® Hydroxytyrosol

Bioactive Polyphenol ofOlive Leaf &Mediterranean Diet

PurificationTechnology

BiotransformationProcess

BAUERHEALTHACTION.COM

Hydroxytyrosol(3,4-dihydroxyphenylethanol;

DOPET)


Olea25®25% Hydroxytyrosol

Heart Disease & DiabetesCellular Function & Protection Skin Health and UV Protection

Joint & Bone HealthNeuroprotective


ANTIOXIDANT

ANTI-INFLAMMATORY

CELLULAR LIFESPAN

MITOCHONDRIAL BIOGENESIS

H E A L T H C A R E

P R O F E S S I O N A L

W H O L E S A L E I N T E R E S T

R E T A I L I N Q U I R I E S .BAUERHEALTHACTION.COM

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Scientific-based nutraceutical for your clients.

Olive Leaf extract utilizing botanicalextraction technology.

Olea25® is manufactured under GMP andISO Certifications and the quality controlsystem guarantees each item on thecertificate of analysis and the traceabilityfrom raw material to final extract.

Olea25Hydroxytyrosol 25%


Anti-InflammatoryRoles

Reduces Acute and Chronic Inflammatory Biomarkers

Heart Disease

Hyperglycemia and

Metabolic Syndrome

Osteoarthritis and

Rheumatoid Arthritis

Cancer

Hydroxytyrosol prevents metabolic impairment reducing hepatic inflammation and restoring duodenal integrity in a rat modelof NAFLD.Pirozzi, Claudio et al. Journal of Nutritional Biochemistry , Volume 30 , 108 - 115



Anti-InflammatoryRoles

BAUERHEALTHACTION.COMBiol Pharm Bull (2009) 32:578–82.10.1248/bpb.32.578

Decreased Cytokines

Decreased Chemokines

Reduced expression of Cyclooxygenase-2(COX-2)

and inducible Nitric Oxide Synthase (iNOS) more

60%


Anti-Inflammatory

Roles

Reduces Inflammatory Biomarkers

Hydroxytyrosol ability to reduce NF-κBactivation(NF-κB is a regulator of inflammation,activating genes): Pro-inflammatory cytokines Immunoregulatory



Anti-Inflammatory

Roles

Inhibits the production of Pro-Inflammatory Cytokines

in an in vitro model of Neuroinflammation.

Impacts Neuroinflammation in Parkinson’s and other

Neurodegenerative diseases.



Cellular AgingChronological Lifespan

Quiescent cells exhibit age-dependent loss in

regenerative capacity.

Manganese Superoxide Dismutase(MnSOD) extends

Chronological Lifespan(CLS)

Presence of Telomere-Independent pathways

influence CLSBAUERHEALTHACTION.COM


Cellular AgingChronological Lifespan

HydroxytyrosolIncreases MnSOD

Inhibits Age-Associated increase in

Mitochondrial Reaction Oxygen Species(ROS)

Extends CLS of normal Human Skin Fibroblasts



Metabolic Syndrome & Diabetes

Olive leaf extract may represent an effective adjunct

therapy that normalizes glucose homeostasis in

individuals with diabetes.

Julio Wainstein, Tali Ganz, Mona Boaz, Yosefa Bar Dayan, Eran Dolev, Zohar Kerem, and Zecharia Madar. Journal of MedicinalFood. June 2012, 15(7): 605-610. doi:10.1089/jmf.2011.0243.

Olive Leaf Extract as a Hypoglycemic Agent in Both Human Diabetic Subjects and in Rats


HydroxytyrosolImproves glucosehomestasis(HbA1c)Improves plasma insulinlevelsImproves insulinsensitivity Improves pancreatic β-cellsecretion


M e c h a n i s m b y

w h i c h O A ( O l e i c

A c i d ) a n d H T

p r e v e n t T N F -α -

i n d u c e d

i m p a i r m e n t i n

a d i p o n e c t i n

e x p r e s s i o n

Scoditti, Egeria et al. “Additive Regulation ofAdiponectin Expression by theMediterranean Diet Olive Oil ComponentsOleic Acid and Hydroxytyrosol in HumanAdipocytes.” Ed. Salvatore Papa. PLoS ONE10.6 (2015): e0128218. PMC. Web. 17 July 2016.


http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0128218


Joint & Bone Health

Hydroxytyrosol Prevents Increase of Osteoarthritis(OA) Marker inHuman Chondrocytes Treated with Hydrogen Peroxide or Growth-

Related Oncogene

Facchini A, Cetrullo S, D’Adamo S, Guidotti S, Minguzzi M, et al. (2014) Hydroxytyrosol Prevents Increase of OsteoarthritisMarkers in Human Chondrocytes Treated with Hydrogen Peroxide or Growth-Related Oncogene a. PLoS ONE 9(10):

e109724. doi:10.1371/journal.pone.0109724



Joint & Bone Health

Hydroxytyrosol Prevents or Reduces Increases In OA

Pathogenic Stimuli(Facchini, et al)

Cell deathActivation of ExecutiveCaspasesDNA Damage

Expression of Pro-Inflammatory Genes(COX-2, iNOS)Expression of Genes DrivingCondrocyte Terminal Differentiation


HT potential as a chondroprotective nutraceutical compound againstOA, not merely for its antioxidant ability, but as an autophagy and

SIRT-1 inducer as well.

Cetrullo, Silvia, et al. "Hydroxytyrosol prevents chondrocyte death under oxidative stress by inducing autophagy through sirtuin1-dependent and-independent mechanisms." Biochimica et Biophysica Acta (BBA)-General Subjects 1860.6 (2016): 1181-1191.


Hydroxytyrosol

Acts directly on DNA to reduceexpression of inflammatory mediators orinhibit their biosynthesis pathwaysthrough a similar mechanism ofglucocorticoids and/or NSAIDs.


Hydroxytyrosol

Results obtained after 2 months ofsupplementation demonstrate for the firsttime the potential therapeutic effect ofolive tree extract with high polyphenolscontent against inflammation andassociated pain in RA.Effect of rich polyphenols olive tree extract on inflammation and pain in patientswith rheumatoid arthritis: a 8-week randomized, double-blind, placebo-controlledclinical trial. Ghanam J. et al


http://mcmed.us/downloads/1425555318.pdf


Potent Anti-Cancer Properties

Cell death/AutophagyAnti-InflammatoryDown Regulates TERT(subunit of Telomerase)

RadioprotectiveUpregulates numerous anti-oxidantproteins and enzymesAlters transcription factors

Rafehi, Haloom et al. “Investigation into the Biological Properties of the Olive Polyphenol,Hydroxytyrosol: Mechanistic Insights by Genome-Wide mRNA-Seq Analysis.” Genes & Nutrition 7.2(2012): 343–355. PMC. Web. 19 July 2016.


Kathrin Pallauf, Katrin Giller, Patricia Huebbe, and Gerald Rimbach, “Nutrition and Healthy Ageing: CalorieRestriction or Polyphenol-Rich “MediterrAsian” Diet?,” Oxidative Medicine and Cellular Longevity, vol. 2013,

Article ID 707421, 14 pages, 2013. doi:10.1155/2013/707421

Polyphenols and Caloric Restriction



Regulation of Sirtuins activities are, together withAMPK activity and PGC-1α-dependent pathways,

at the centre of the response to CR.

López-Lluch, G. and Navas, P. (2016), Calorierestriction as an intervention in ageing. J Physiol,

594: 2043–2060.

Sirtuins and CaloricRestriction

Sirtuins play a pivotal role in theresponse to Caloric Restriction.

Sirtuins are shown to be involved in theregulation of lifespan and metabolism indifferent organisms.

Sirt-1

Guardian against Cellular Oxidative Stress andDNA damage

metabolismstress resistancecellular survival cellular senescence/aging

Regulates

inflammation-immune function endothelial functions circadian rhythms


HydroxytyrosolSirt-Food

Polyphenol Hydroxytyrosol Sirt-1 Food

Contributes to the Health Benefitsof the Mediterranean Diet



Olea25®Hydroxytyrosol

25%

Scientific-basednutraceutical for your clients.Olive Leaf extract utilizingbotanical extractiontechnologyOLEA25® is manufacturedunder GMP and ISOCertifications and the qualitycontrol system guaranteeseach item on the certificateof analysis and thetraceability from rawmaterial to final extract.

http://bauerhealthaction.com/olea25-page/



Olea25®Hydroxytyrosol

25%

Contact Information

Randall [email protected]

Questions Call:949-872-2488

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olea25®hydroxytyrosol- health benefits from olive leaf

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