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Information Sheet

Reconstitution Procedure

Materials

Opadry II film coating system.

Water, deionized or distilled preferred, ambient

temperature (maximum 30 C)

Equipment Variable-speed mixer capable of producing and

maintaining a vortex.

Propeller stirrer. For optimum mixing, utilize a propeller

with a diameter equivalent to 1/4 - 1/3 of the diameter

of the mixing vessel. (see Figure 1.)

Mixing vessel large enough to contain a liquid volume

15% to 25% greater than the total suspension being

prepared. The liquid height and vessel diameter should

be equal.

*Mixing Procedure1. Weigh necessary quantity of Opadry II film coating

system.

2. Weigh necessary quantity of water into the mixing vessel.

3. With the propeller in the center and as close to the bottom

of the vessel as possible, stir the water to form a vortex

without drawing air into the liquid.

4. Steadily add the Opadry II system powder to the vortex,

avoiding powder flotation on the liquid surface. If

required, increase the stirrer speed in order to maintain

the vortex .

5. After all the Opadry II system has been added, reducethe mixer speed to nearly eliminate the vortex. Mix for

45 minutes.

OPADRY II film coating systems are quick and easy to prepare. Simply add OPADRY II film coating

system powder to water and mix for 45 minutes with a propeller stirrer.*

The coating suspension can be made with up to 20% solids. Your Area Technical Manager can recommend

the ideal solids for your specific Opadry II system and your equipment.

Suspension Handling

The prepared Opadry II dispersion can be

pumped directly from the preparation vessel if

desired.

We recommend that the Opadry II dispersion be

gently agitated during the coating process.

Figure 1.

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Opadry II is a trademark of BPSI Holding, Inc.

FC/OPADRYIIRECON/06/99 REV.2_0703

World Headquarters

Colorcon

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Tel: 215-699-7733 Fax: 215-661-2605 Web Site @http://www.colorcon.com

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Locations Telephone Facsimile

United States

Santa Ana, California 714-549-0631 714-549-4921

Indianapolis,lndiana 317-545-6211 317-545-6218

Humacao, Puerto Rico 787-852-3815 787-852-0030

Europe

Dartford, Kent, England 44-1322-293000 44-1322-627200

Bougival, France 33-1-3082-1582 33-1-3082-7879

Idstein, Germany 49-6126-9961-0 49-6126-9961-11

Gallarate, Italy 39-0331-776932 39-0331-776831

Budapest, Hungary 36-1-200-8000 36-1-200-8010

Istanbul, Turkey 90-216-465-0360 90-216-465-0361

Barcelona, Spain 34-9-3589-3756 34-9-3589-3792

The information contained herein, to the best of our knowledge is true and accurate. Any recommendations or suggestions are made without warranty or guarantee, since the

conditions of use are beyond our control. Any information contained herein is intended as a recommendation for use of our products so as not to infringe on any patent.

2003 Colorcon. The information contained in this document is proprietary to Colorcon and may not be used or disseminated inappropriately.