29© Springer Nature Switzerland AG 2019 Y. Tshomba et al. (eds.), Visceral Vessels and Aortic Repair, https://doi.org/10.1007/978-3-319-94761-7_3

Open Repair of Pararenal Aneurysms: Renal Vessel Surgical Management

Daniele Mascia, Alessandro Grandi, Luca Porcellato, Luca Bertoglio, Andrea Kahlberg, Domenico Baccellieri, Germano Melissano, and Roberto Chiesa

3.1 Proximal Abdominal Aortic Aneurysms (P-AAA)

The proximal abdominal aorta constitutes a par-ticular location for the dilative process of the aneurysms because the splanchnic vessels or the renal artery ostium may be involved. As a result, we can make a more specific classification of this type of aneurysms:

• Juxtarenal infrarenal abdominal aortic aneu-rysms (JR-AAA): The proximal extension of the aneurysms starts adjacent or at the lower margin of the renal artery origins, without involving them in the dilative process.

• Pararenal infrarenal abdominal aortic aneu-rysms (PR-AAA): One or both renal arteries are involved in the dilative process.

• Suprarenal abdominal aortic aneurysms (SR-AAA): The splanchnic arteries and the renal artery origins are involved in the dilative process.

3.2 Epidemiology

3.2.1 Incidence

The involvement of the proximal abdominal aorta takes place in 5–15% of all AAAs [1, 2]. AAAs mostly affect the population above 50 years of age; they are two to six times more frequent in men than women and two to three times more common in people of Caucasian descent than in other populations [3–5]. Screening studies have provided us with impor-tant information on the incidence and prevalence of this disease: for men above 50 years of age, an incidence of 3.5 for 1000 people/year [6] was shown, while new- onset AAAs were discovered in only 2% of patients at a second examination performed after a mean time of 5.5 years, after a negative result upon first examination. Overall, the incidence by age of ruptured and symptom-atic P-AAAs, and the mortality rate of P-AAAs, is six times greater in men than in women. A sig-nificant increase in the incidence of asymptom-atic AAAs has been observed over the last two decades [7, 8], which may be due to increased diagnostic detection. However, there is emerging proof of a plateau reached by hospitalization numbers for aortic aneurysm repair, perhaps owing to health policies which are finalized to reduce the morbidity and mortality of cardiovas-cular diseases.

D. Mascia (*) · A. Grandi · L. Porcellato L. Bertoglio · A. Kahlberg · G. Melissano Vascular Surgery Unit, IRCCS San Raffaele Scientific Institute, Milan, Italye-mail: mascia.daniele@hsr.it

D. BaccellieriUnit of Vascular Surgery, San Raffaele Scientific Institute, Milan, Italy

R. Chiesa Unit of Vascular Surgery, San Raffaele Scientific Institute, Vita-Salute University, Milan, Italy

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3.2.2 Prevalence

The asymptomatic prevalence estimate of TAAA (probability of being an AAA carrier) is more accurate compared to the incidence estimate (probability of developing AAA), now that duplex ultrasound screenings are performed on numerous populations. The duplex ultrasound screening studies on the population offer the most accurate information for the prevalence of AAA (>3 cm). Those studies have been conducted both as epidemiologic screening studies (Tromso and Rotterdam) and as randomized studies to evaluate the benefits of the screening itself [Multicentric Aneurysm Screening Study (MASS), Chichester, Viborg, Western Australia]. In Veteran Affairs, a screening study of more than 73,000 patients between 50 and 79 years of age was carried out. The AAA ≥3 cm prevalence was 4.6%, and the AAA ≥4 cm prevalence was 1.4% [9]. The reported prevalence varies according to age and gender. The highest AAA ≥3  cm prevalence was 5.9% that was found in a subpopulation of white males with smoking habits between 50 and 79 years of age [10].

3.3 Preoperative Analysis

3.3.1 Clinical Presentation and Indication for Surgery

AAA is generally a pathology found by chance, as the majority of cases are found to be asymptomatic. Any symptoms related to a locoregional compression by the aneurysm are rare, as there are no structures and organs that suffer the aneurysmal dilation.  Ischemic symptoms related to embolization for the crushing of the thrombus near the walls of the aneurysm are even rarer. A typical clinical sign is the appreciation of a pulsating mass in the epi- mesogastrium synchronous with the cardiac cycle, particularly in aneurysms of a certain size and in people of slim build. From a semiotic perspective, the suspicion of a pararenal aneurysm must be present when, during the physical examination, the upper pole of the aneurysmal

dilation is not palpable at the arch rib (DeBakey maneuver). In the case of AAAs, the indication for elective surgery arises for aneurysms with a diameter >55 mm, even if intervention must be taken into account for smaller diameters in case of rapid growth and morphological aspects indicating a high risk of ruptures, such as highly eccentric thrombotic material, protrusions (blisters), or even parietal fissures. Currently, the diameter of the aorta is the best criteria for predicting the risk of aortic rupture [11]. According to a study by Juvonen et  al., each increase of 1  cm in the diameter of abdominal aortic aneurysms is related to a 1.9-fold increase of the relative risk of rupture [12]. Lo et  al. showed that the risk of aortic rupture is precisely calculated, by taking the area of the patient’s body surface area (BSA) [13] into account.

3.3.2 Diagnostic Imaging

The use of imaging techniques is crucial in the assessment of AAAs, both to confirm the clinical diagnostic suspicion and to precisely define the critical morphological characteristics indicating surgery.

3.3.2.1 Duplex UltrasoundThe transabdominal ultrasonography is the least invasive examination and more frequently applied, in particular for screening and follow-up. Vessel diameter is measured by ultrasonography, allow-ing for an inter-operator variability of around 5 mm in 84% of studies, and is more accurate in assessing the anteroposterior than the transverse [14] diameter. The display of the suprarenal aorta and the iliac arteries may be impeded by anatomi-cal characteristics, particularly in obese patients. In such cases, the ultrasound cannot accurately determine the presence of rupture [15] and is often not able to precisely determine the proximal exten-sion of AAA [16]. Ultrasound typically underesti-mates the anteroposterior diameter of an AAA by 2–4 mm [17–20]. In general, ultrasound is used to diagnose and monitor the AAA until the aneurysm nears a typically operable diameter size. At this point, secondary examinations are required.

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3.3.2.2 CT AngiographyThe abdominal aorta CT angiography must be performed with an acquisition thickness of 1.25 mm or less, depending on the available CT technology (Fig. 3.1). The overlap (in particular sections, the interval is half of the actual thickness) is recommended to increase the quality of multiplanar images (MPR) and 3D visualization. This phase, without contrast medium, allows for the evaluation of potential wall calcification or the presence of prosthetic aortic grafts in already operated patients. Aneurysms of 3–4.5  cm in diameter require 12-month follow-up with CT scan. This intervention is highly recommended when the diameter increases by 5  mm or more within 6  months or in cases of diameters larger than 55  mm. The CT angiography has become essential for surgical planning [21]. The executive protocol of a CT with contrast enhancement at our center involves the intravenous injection of a high concentration of iodized agent (370–400  mg/mL) at a high flow rate (4–5  mL/s) to obtain a prolonged opacification of the vessels [22]. The interpretation of the CT findings is based on the analysis of a combination of axial images and reformatted images. For some years now, several software applications are available

(freeware, OsiriX MD, Pixmeo; paid, TeraRecon, TeraRecon, Inc.) to view and analyze DICOM (Digital Imaging and Communications in Medicine) files, which is the most common format used in medical imaging. This software allows you to automatically download files from any DICOM CD-ROM, regardless of the hospital or the country of origin and rescale. If the acquired images are of sufficient quality, these studies allow a proper assessment, avoiding replication of the CT. The vascular surgeon, who will perform the endovascular or surgical procedure, is personally involved in the assessment of the aortic images and in planning/sizing the case. For the pre-procedural assessment, in addition to morphological information, such as diameter and extension of the aneurysm, angiography provides other fundamental anatomical information such as:

• The quality of the aortic wall• The involvement of visceral vessels and iliac

arteries• Clamping locations• Left renal vein (anterior, posterior, or double)• Visceral vessel-associated diseases (stenosis,

occlusion, anatomical abnormalities, such as the “double cluster,” hypoplasia)

• Extravascular-associated diseases (pelvic kid-ney and horseshoe kidney)

The images acquired from CT angiography are equally essential for a thorough follow-up, to recognize quickly and subsequently treat potential complications.

3.3.2.3 MRIThe absence of exposure to ionizing radiation makes the use of magnetic resonance imaging (MRI) for diagnosis and subsequent controls of P-AAAs an apparently advantageous choice compared to CT. Magnetic resonance angiography is comparable to the CT angiography in many aspects but has some shortcomings: the lack of visualization of calcified plaques—it typically owns half of the spatial resolution; it has longer acquisition times and creates more problems for claustrophobic patients, but it can be useful in

Fig. 3.1 3D reconstruction of a juxtarenal infrarenal abdominal aortic aneurysm

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cases of allergy to iodinated contrast. However, its high cost and limited diffusion do not make it the first choice.

3.3.3 Preoperative Risk Stratification and Patient Optimization

Surgical repair of a proximal abdominal aortic aneurysm is considered a high-risk intervention. Clamping the aorta carries significant hemodynamic stress, which is the reason careful assessment of cardiac, lung, and kidney function is required to determine the eligibility of patients for intervention. Often patients with abdominal aortic aneurysm have comorbidities, such as ischemic heart disease (16–30%), respiratory problems, and kidney failure [23].

3.3.3.1 Heart FunctionThe European Society of Cardiology (ESC) has recently developed guidelines aimed at helping the choice for a more efficient approach to preoperative evaluation [24]. Vascular interventions are of particular interest because they will involve a significant risk of cardiac complications. These guidelines propose an algorithm to identify patients with a significant risk of cardiac complications during elective surgery. The gradual approach advocated by the ESC has more than one step. The first one is the identification of active heart disease: unstable angina pectoris, recent myocardial infarction (within 30 days), residual myocardial ischemia, acute heart failure, symptomatic valvular disease, and significant cardiac arrhythmias. The second step is the evaluation of functional capacity, which is measured in metabolic equivalents (MET). The third step is the evaluation of the specific risk for surgical procedures. Aortic sur-gery is considered at high risk (rate of cardiac events at 30 days >5) [25]. It is also important to assess the risk factors in patients with low functional capacity. If there are up to two risk factors, patients can proceed to the intervention, providing a treatment with statins and beta- blockers (including ACE inhibitors in the

presence of left ventricular systolic dysfunction are needed). The fourth step is the execution of a noninvasive stress test in patients with a low functional capacity and more than two risk factors, which are scheduled for surgery.

The transthoracic echocardiography is an important noninvasive screening test that assesses the valve function. Coronary CT angiography is becoming the alternative less-invasive method for the visualization of the anatomy of the coronary arteries. The new multi-detector of CT angiography, built to reduce radiation, uses the acquisition of related ECG images allowing us to obtain images of specific phases of the cardiac cycle. In patients with asymptomatic disease, a severe occlusive disease of the coronary arteries can be treated with percutaneous transluminal angioplasty before proceeding to repair the aneurysm.

3.3.3.2 Renal FunctionThe renal function is traditionally calculated by measuring levels of creatinine, serum electrolytes, and blood urea nitrogen (BUN). These indices are quite sensitive, especially in patients with intermediate and moderate degrees of renal dysfunction. The National Kidney Foundation recommends the use of estimated glomerular filtration rate (GFR) to evaluate kidney function and avoid misclassification based on only one level of serum creatinine [26]. Based on the assessment of GFR, chronic kidney disease has proven to be a strong predictor factor of death after the surgical treatment of abdominal aortic aneurysms, even in patients without clinical evidence of preoperative renal disease. CT angiography, MRI, and ultrasound determine the kidneys’ size and renal anatomy. The classification KDOQI has identified five levels of kidney function, based on GFR values. There is also evidence that low levels of GFR and high levels of albuminuria independently correlated with mortality, cardiovascular events, and the probability of progression to kidney failure. This is the reason the latest guidelines suggest the integration of the GFR and albuminuria study for a more accurate assessment of renal function. Of great interest are the data in a meta-analysis

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conducted by the Chronic Kidney Disease Prognosis Consortium, in which the independent and combined association of the GFR and albuminuria on cardiovascular mortality and on all-cause of death in the general population were evaluated. Compared with a GFR of 95 mL/min, the relative risk of death from all causes was increased by 18% for GFR of 60  mL/min and 57% for GFR of 45 mL/min and was more than tripled for GFR of 15  mL/min. Similarly, the risk-related albuminuria followed linear growth, no threshold effect, and it was already significant at low values of albuminuria or in the presence of traces of proteinuria. Similar results were also found for mortality from all causes. In conclusion, GFR and albuminuria are independent predictors and risk multipliers of mortality in the general population, with no evidence of interactions [27].

3.3.3.3 Respiratory FunctionPotential risk factors for respiratory failure are age, gender, aneurysm size, preoperative lung function calculated through the forced expiratory volume in 1  s (FEV1), forced vital capacity (FVC), the relationship between these two units (FEV1/FVC), comorbidities and operative parameters (such as when an extended incision is requested, when there is a left hemi-diaphragm paralysis, or when there is the necessity for a high number of transfusions), timing of aortic clamping operators, and postoperative complications (in addition to the lung, even kidney, failure, bleeding, and infection of surgical wounds). Pre-, intra-, and postoperative blood tests (creatinine, BUN, lactic dehydrogenase, pH) are also important. A standard chest X-ray reveals unexpected abnormalities in approximately 5% of patients between 40 and 60 years and in 6–30% of patients over 60 years. The abnormalities include tracheal deviation, deviation of the left main bronchus, lung or mediastinal masses, lung bubbles, pulmonary edema, pneumonia, atelectasis, fractures of the vertebrae or ribs, cardiomegaly, and dextrocardia. The evaluation of lung function with spirometry and arterial blood gas test is used in all patients who undergo open surgery. The reduction in FEV1 or other spirometric indicators of

pulmonary function not within the limits, in addition to arterial blood gas analysis abnormalities, such as hypoxemia or hypercapnia, suggests that the patient is at high risk for the development of postoperative pulmonary complications.

3.4 Surgical Technique

Open surgery for P-AAA is a major vascular pro-cedure with significant mortality and morbidity rates, mostly with regard to renal function. A radial arterial pressure line is always inserted in order to guarantee continuous intraoperative arte-rial blood pressure monitoring. A central venous catheter (jugular or subclavian) is inserted to rap-idly administer medications and fluids and to monitor central venous pressure.

Temperature is monitored by means of a blad-der or nasopharyngeal sensor and is used to guide hypothermia when the hypothermic perfusion of renal arteries is required or where long-lasting procedural time or large bleeding may be expected.

Intraoperative transesophageal echocardiogra-phy (TEE) enables the dynamic monitoring of hemodynamic status assessing the systolic and diastolic function, ejection fraction, wall motion, dyssynchrony, and valvular function in patients with increased cardiac risk or who develop unex-pected nonreversible intraoperative hypotension.

3.4.1 Transperitoneal Access

The patient is usually in a supine position. A median laparotomy from the xiphoid to the symphysis pubis is routinely performed; in patients with specific concerns such as previous median laparotomies, severe obesity, or other technical issues, bilateral subcostal laparotomy may be the alternative (Fig. 3.2). With this access, however, the distal control of iliac arteries is more challenging, and it should be avoided in cases of associated iliac aneurysms. In cases of very large aneurysms, transperitoneal medial

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visceral rotation is helpful to obtain adequate exposure and proximal aortic control.

3.4.2 Retroperitoneal Access

The patient is positioned in partial right lateral decubitus. The left shoulder is fixed vertically, the pelvis is rotated toward the horizontal plane, and the table broken. The incision usually extends from the lateral border of the left rectus muscle anteriorly to the erector spinae in the eighth intercostal space to the area of the umbilicus. The level and the extent of the incision depend on the patient’s anatomy and required exposure. In extensive pathology, a thoraco-phreno- laparotomy may be performed.

3.4.3 Aortic Clamping and Reconstruction

In the preparation of the pararenal aorta, cor-rect management of the left renal vein is man-datory. Usually collocated anteriorly to the aorta, the left renal vein can be mobilized to obtain a greater proximal exposition of the aorta, dividing the gonadic, surrenali, and lum-bar ramifications (Fig.  3.3). Alternatively, the left renal vein can be sectioned close to the inferior vena cava; unfortunately, this type of approach increases the postoperative renal insufficiency (Fig. 3.4).

The proximal aortic cross-clamping site is, along with aortic reconstruction technique, the most important issue in the surgical treatment of P-AAA.  Suprarenal and supra-celiac clamping (Fig.  3.5) are possibilities. The correct choice depends on the proximal extension of the aneurysm, its morphology, and on the ease of exposing the suprarenal aorta. Sometimes, supra- celiac clamping, especially in inflammatory aneurysm, re-treatment, and emergency treatment can be technically manageable compared to suprarenal one. The need for supra-celiac clamp-ing must be brought forward as much as possible, based on the preoperative imaging, and the pres-ence of extensive calcifications or thrombotic material in pararenal aorta highlighted.

Systemic heparinization is administered before aortic cross-clamping in order to achieve activated clotting time (ACT) of >200  s. Thromboembolism from pararenal aorta to renal arteries is a well-known complication and can be prevented by renal artery cross-clamping before aortic manipulation and clamping. Common iliac arteries and aorta are then cross-clamped. The aneurysm is entered, thrombus is removed, and back-bleeding from lumbar arteries is quickly controlled by the ligation of the ostia (2/0 polypropylene suture reinforced by Teflon pledgets). If the inferior mesenteric artery is patent, it is temporarily clamped with a bulldog clamp, as previously described.

a b c d

Fig. 3.2 (a) Xipho-pubic laparotomic access, (b) pararectal laparotomy, (c) bilateral subcostal laparotomy access, and (d) thoraco-phreno-laparotomy access

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a

c

b

Fig. 3.3 Intraoperative photographs showing the correct steps to mobilize the left renal vein without damaging it

a b

Fig. 3.4 Intraoperative photographs showing the correct steps to section the left renal vein

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In the case of renal artery involvement with no option of infrarenal aortic reconstruction, we put various strategies in place:

• Aorto-aortic repair with proximal end-to-end anastomosis and direct renal reattachment to the aortic graft (Fig. 3.6)

Fig. 3.5 Different clamping sites. From left to right: infrarenal, suprarenal, supra-celiac

a b

Fig. 3.6 Intraoperative pictures showing (a) the right renal artery being perfused while the anastomosis to the aortic graft is completed and (b) the final result of a direct renal artery reattachment to the aortic graft

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• Aorto-aortic repair with proximal end-to-end anastomosis and uni- or bilateral aorto-renal bypass grafting (Fig. 3.7)

• Aorto-aortic repair with proximal end-to-end anastomosis and uni- or bilateral aorto-renal bypass grafting using a Gore Hybrid graft, inserting the stent in the side into the renal artery, deploying it, and then reinforcing it with four single sutures (Figs. 3.8 and 3.9)

• A proximal beveled anastomosis that includes renal arteries

• Carrel’s patch including visceral vessels (celiac trunk, superior mesenteric, and renal arteries) that may be performed by means of a thoraco-phreno-laparotomy or through bilateral subcos-tal laparotomy with medial visceral rotation

3.5 Complications

The perioperative complications are not rare events in the surgical repair of the P-AAAs. It is clear that the perioperative management is crucial

a b

Fig. 3.7 Intraoperative pictures showing aorto-aortic repair with proximal end-to-end anastomosis and (a) uni- or (b) bilateral aorto-renal bypass grafting

Fig. 3.8 Aorto-aortic repair with proximal end-to-end anastomosis and aorto-renal bypass grafting using a Gore Hybrid graft, inserting the stent in the side into the renal artery, deploying it, and then reinforcing it with four single sutures

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in reducing postoperative complications. A team of professionals is needed with experience in this type of work, not only from a strictly surgical point of view but also anesthetic and nursing [28, 29].

3.5.1 Bleeding

Because of the type of aneurysmectomy P-AAAs, patients are subject to increased risk of bleeding in the perioperative period. Meticulous attention to hemostasis is essential to minimize the risk of postoperative bleeding, and the surgeon must pay close attention to the fact that there is no active bleeding before closing the retroperitoneum or abdomen. All anastomoses must be checked and all surfaces thoroughly examined. The therapy with blood components should be used to correct

the coagulopathy that inevitably occurs. Similarly, topical hemostatic agents can be of great value in treating bleeding of the anastomosis. Despite all, postoperative bleeding can still occur.

The causes of bleeding can be:

• Bleeding from the anastomosis• Dripping from the wall• Bleeding from retrograde lumbar branches

inadequately controlled• Insult spleen, often secondary to the use of

retractors

3.5.2 Cardiac ischemia

As described above, aortic clamping causes sig-nificant hemodynamic disturbances and creates an

a

d e

b c

Fig. 3.9 (a) Preoperative CT scan showing thrombus close to the ostium of the renal arteries and a dissection of the right renal artery, (b) intraoperative picture showing the juxtarenal aortic aneurysm, (c) intraoperative picture showing the end-to-end proximal anastomosis and the two

renal arteries being selectively perfused, (d) intraoperative picture showing renal artery reconstruction with a Gore Hybrid bypass graft, (e) postoperative CT scan showing the renal arteries reimplanted on the graft using the Gore Hybrid bypass graft

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increase in cardiac workload. Preoperative screen-ing, risk stratification, and appropriate patient selection may help to reduce this. The use of beta-blockers, in the perioperative period, in patients undergoing non-high-risk cardiac surgery, has been shown to reduce cardiovascular events and mortality at 30 days [30–32]. The administration of beta-blockers is associated with a significant reduction in peri- and postoperative mortality [33].

3.5.3 Kidney Failure

Patients undergoing surgical repair of P-AAA have a significant risk of developing kidney com-plications (Figs. 3.10 and 3.11). The percentage of postoperative renal failure in Medicare rises to 10% study, although with only 0.5% needing

renal replacement therapy [34]. A meta-analysis of patients undergoing elective surgery for aortic pararenal aneurysmectomy showed the presence of postoperative renal failure in 15–20% of patients, of which only 3.5% require dialysis [35]. The acute tubular necrosis secondary to renal hypoperfusion is the leading cause of acute renal failure in these patients and occurs because of the important hemodynamic changes that the aortic clamping causes to the renal blood flow, as well as hypovolemia and perioperative hypotension. Particular attention should be paid to blood vol-ume and to the use of crystalloid and colloid dur-ing the perioperative period as they are essential in the prevention of recurrent episodes of renal ischemia and for tackling the negative effects of aortic clamping. Despite the evidence that few patients need continuous renal replacement

Fig. 3.10 Preoperative CT scan showing parietal thrombus close to the origin of the renal arteries

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therapy, it has been shown that even subtle changes in the glomerular filtration rate can have profound long-term effects. The postoperative renal failure, in fact, has been shown to adversely affect the short- and long- term survival after this kind of surgery [36, 37].

3.5.3.1 Classification and Staging of Acute Kidney Injury (AKI)

The KDIGO (Kidney Disease Improving Global Outcomes) guidelines were released in 2012;

they associated with the RIFLE (Risk, Injury, Failure, Loss, End-Stage Kidney Disease) and AKIN (Acute Kidney Injury Network) criteria. The KDIGO guidelines introduced a new defini-tion of AKI and a new kidney injury staging sys-tem: AKI was defined as an increase in serum creatinine of 0.3 mg/dL or more within 48 h of surgery, or an increase of at least 1.5 times com-pared to the preoperative value in the last 7 days, or a lower hourly diuresis of 0.5 mL/kg for more than 6 h [38].

a

c

b

d

Fig. 3.11 Intraoperative angiography showing (a) com-plete occlusion of both right and left renal arteries, (b) catheterization of the right renal artery with a BERN

catheter, (c) ballooning of the vessels, and (d) complete angiography which shows restoration of the blood flow to the right kidney

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3.5.4 Intestinal Ischemia

Intestinal ischemia is a feared complication in the surgical repair of abdominal aortic aneurysm. Binding of the AMI, failure of the hypogastric artery revascularization, iliofemoral occlusive disease, stenosis of the SMA, athero-embolism, injuries from retractor, and previous resection of the colon may contribute to intestinal ischemia, which has a clinical incidence from 0.2% to 6% following surgical repair of AAA [17, 39, 40]. Upon diagnosis, intestinal ischemia requires early and aggressive treatment because it has a generally unfavorable outcome. In some large series, the intestinal ischemia is associated with mortality rates ranging from 25% to 50% [40, 41]. Consequently, all patients should be treated aggressively with intravenously broad-spectrum antibiotics, targeting the bacteria of the intestinal flora. Patients with full-thickness ischemia require emergency treatment with exploratory laparotomy and bowel resection [42].

3.5.5 Long-Term Complications

There is clear evidence from many sources that the proximal aorta continues to reshape over time, regardless of the type of repair [18]. Although the anastomosis with continuous suture allows a robust surgical fixation of the aortic graft, a possible long-term complication is represented by anastomotic pseudoaneurysms. Large cohorts with a significant follow-up pose the incidence of anastomotic pseudoaneurysms to <1% in 6 years, from 1% to 10% at 10 years, and 20% at 15 years, depending on the study [19, 20, 43, 44]. One of these studies, the Mayo Clinic, is significant because it followed 307 patients undergoing AAA repair surgery for an average of 5.8 cases by years [20]. The anasto-motic pseudoaneurysm is the most common late complication, with a median of 6 years of onset period; other complications are occlusion (2%), aorto-enteric fistula (1.6%), and the prosthesis infection (1.3%). Taken together, these data show that the result of a correct surgical repair of abdominal aortic aneurysm is excellent, but not

perfect. Although the surgery definitively repairs the aneurysmal segment, the underlying aortic disease remains, and this leads to dilation of the proximal and distal portion. This can cause the formation of metachronous aneurysms and pseu-doaneurysms, as well as increase the likelihood of rupture of the anastomosis. For these reasons, all patients who underwent surgical repair of abdominal aortic aneurysm require at least a per-manent ultrasound monitoring.

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3 Open Repair of Pararenal Aneurysms: Renal Vessel Surgical Management