opening i lab novio tech campus floris rutjes 17042014

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Visie op Valorisatie in de Topsector Chemie Floris Rutjes Radboud University, Institute for Molecules and Materials Opening Innovation Lab NTC Nijmegen April 17, 2014

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Page 1: Opening i lab novio tech campus   floris rutjes 17042014

Visie op Valorisatie in de Topsector Chemie

Floris Rutjes

Radboud University, Institute for Molecules and Materials

Opening Innovation Lab NTC

NijmegenApril 17, 2014

Page 2: Opening i lab novio tech campus   floris rutjes 17042014

Business opportunities: rowing

The Macon blade became popular in the 1960s and was the most widely used blade type for thirty years.

Introduced in 1991, its asymmetric design and increased surface area create a bigger "shovel".

The latest design offers the greatest potential for increasing boat speed.

Page 3: Opening i lab novio tech campus   floris rutjes 17042014

Organic synthesis over the years

The Lavoisier lab (1770)

2-deoxy-D-ribose

KC Nicolaou, FPJT Rutjes, EA Theodorakis, J Tiebes, M Sato, E Untersteller J Am Chem Soc 1995, 117, 1173.

Microreactor flow synthesis

Page 4: Opening i lab novio tech campus   floris rutjes 17042014

Our design: Microreactor setup

GC / HPLC Offline analysis

NMR / MS / Raman / IROnline analysis

Collaboration with Prof. van Hest (Radboud University) and Fraunhofer IMS (Duisburg, Germany)

Page 5: Opening i lab novio tech campus   floris rutjes 17042014

Conventional batch versus flow process

Conventional batch process

Continuous flowmicroreactors

Continuous flow process Translation

Intrinsic benefits– Safer reactions– Faster reactions– Cleaner products and process– Easy scale‐upPractical benefits– Reproducible results– Quick optimization– Inline analysis possible– On site (local) production

Page 6: Opening i lab novio tech campus   floris rutjes 17042014

6

Research prototypes

Patent application PCT/EP/2006/010299

Page 7: Opening i lab novio tech campus   floris rutjes 17042014

From micro to production scale

Step 1: design of new flow process

Step 2: automated optimization

Step 3: synthesis(multigram)

Step 4: Scale out

• Step 1: Design of a new flow process• Step 2: Automated optimization and modeling of reaction data• Step 3: Scale up to larger microreactor• Step 4: Further scale out through numbering up microreactors

Page 8: Opening i lab novio tech campus   floris rutjes 17042014

FutureChemistry

• New spin-off FutureChemistry was founded in 2008• Investments by FhG and PPM Oost• Former PhD-students – Kaspar Koch

and Pieter Nieuwland – became CEO and CTO• First commercial equipment launched March 2009 gelanceerd• Joint projects with academic groups were setup to develop new

technology

• www.futurechemistry.com

Page 9: Opening i lab novio tech campus   floris rutjes 17042014

From research to commercial equipment

PCT/2006/010299/EP2086684

Page 10: Opening i lab novio tech campus   floris rutjes 17042014

New opportunities: Quantum dot applications

QD Sector examples

Biomedical Electronics Optoelectronics

In Vivo imaging Transistors QDLED displays

Optics Energy Security

Laser Solar panels Tracing methods

Page 11: Opening i lab novio tech campus   floris rutjes 17042014

New opportunities: PET tracer synthesis

DCF

F11:00

15:00

17:00

13:00

DC

FDC

Cyclotron

FlowSafeInjection

PET‐scanner

PET‐image

1

23

4

5 15

23

4

Page 12: Opening i lab novio tech campus   floris rutjes 17042014

Chemistry-related companies in Nijmegen

IMMInstitute for Molecules

and Materials

NCMLSNijmegen Centre for

Molecular Life Sciences

DI-BCB Donders

Institute for Brain,

Cognition and Behavior

Nijmegen Centre for Clinical &

Translational Medical

Research Radboud Translational Medicine

tf2 devices

Page 13: Opening i lab novio tech campus   floris rutjes 17042014

Key success factors

• Basis of high quality, challenging – curiosity-driven – science• Awareness of the societal and commercial potential of scientific

research and inventions• Entrepreneurial researchers to develop these scientific inventions

into commercial products (the actual innovation)• Attention to entrepreneurship in academic degree programs and

PhD-programs– Create awareness among students in Bachelor- and Master-programs– MSc- and PhD-students realize that it is a viable possibility to start their own

company– Strong stimulus provided by peers - ‘zien ondernemen is doen ondernemen’

13

Page 14: Opening i lab novio tech campus   floris rutjes 17042014

KplusV organisatieadvies, verschil zien verschil maken

De visie van het Topteam Chemie

werkgroep ‘Ondernemerschap en de Regio’

Page 15: Opening i lab novio tech campus   floris rutjes 17042014

KplusV organisatieadvies, verschil zien verschil maken

De visie op nieuwe bedrijvigheid

?

+ =

faciliteitenondernemer(schap)

financieringbedrijfsvoering

Page 16: Opening i lab novio tech campus   floris rutjes 17042014

KplusV organisatieadvies, verschil zien verschil maken

Team Bert-Jan Lommerts & Arie Brouwer

// Makelen en schakelen netwerk topsector

// Ontsluiten financieringsmogelijkheden

// Ondersteuning bij bedrijfsvoering

Aandachtsvelden stuurgroep ‘O&R’Team Floris Rutjes & Nelo Emerencia

// Thematisch ingestoken, fysieke locaties

voor jonge, innovatieve bedrijven

// Coördinatiefunctie: netwerk van locaties

www.topchemie.nl www.topsectorchemie.nl

Page 17: Opening i lab novio tech campus   floris rutjes 17042014

KplusV organisatieadvies, verschil zien verschil maken

KIEM

START

ONTWIKKEL

GROEICONSOLIDATIE

innovatie proces

1

Positionering in het innovatie proces

100

Page 18: Opening i lab novio tech campus   floris rutjes 17042014

KplusV organisatieadvies, verschil zien verschil maken

Onderscheid tussen iLAB en COCi-locatie

schrijven v/h business plan

subsidieoverzicht

zuurkastiLAB

advies over de groeistrategie

training van het ondernemerschap

contact met financiers

PilotschaalCOCi

inrichting van personeelsbestand

Page 20: Opening i lab novio tech campus   floris rutjes 17042014

iLAB

COCi

iLAB (i.o.)

COCi (i.o.)

tandem

LEGENDA LOCATIES

iLABs-Nijmegen-Eindhoven-Amsterdam-Delft (ond. Biotech Campus)-Zwolle (ond. Green PAC)-Wageningen (per 10-4)-Utrecht (i.o.)-Groningen (i.o)-Leiden (i.o)-Enschede (i.o)

COCi-locaties-Chemelot-Plant One-Green Chemistry Campus-Delft (ond. Biotech Campus)-Emmen (ond. Green PAC)

Page 21: Opening i lab novio tech campus   floris rutjes 17042014

KplusV organisatieadvies, verschil zien verschil maken

Toekomst van iLABS en COCi locaties

• Sterk interactief netwerk van iLABS en COCi locaties, nauw verbonden met TopchemieΔ• Regelmatige bijeenkomsten, uitwisseling ervaringen• Nauwe samenwerking tussen specifieke iLABs en COCi’s• Sterkere link naar HBO• Aansluiting bij gevestigde industrieën

• Monitoren van activiteiten en voortgang op elke locatie om kwaliteit van het label te waarborgen

• Sterkere links naar andere topsectoren, met name LSH, Agri/Food, HTSM en Energie• Verduurzamen van iLAB/COCi netwerk als zelfstandig opererende valorisatiemotor