osteoporosis and osteoarthritis 2011 conference
TRANSCRIPT
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OSTEOARTHRITIS AND MALE OSTEOPOROSIS: ARE THEY
INVERSELY RELATED?
By
Samia Zaki, Mamdouh Mahfouz, Ahmed Mortagy, Hanan K Abdallah and Hala El
Badawy
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Osteoporosis and osteoarthritis are two common age-related skeletal disorders responsible for major health expenses in the elderly.
Lane and Nevett , Arthritis Rheum; 2002
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Osteoarthritis
Degeneration of articular cartilage
Osteophytes
Bone wideningSubchondral plate sclerosis
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Osteoporosis
Microarchitectural deterioration of bony
tissue
Low bone mass
Bone fragility
Susceptibility to fractures
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There is a growing awareness that osteoporosis in men is not a rare problem. Men loose bone mineral density at a rate of about 1% per year with advance in age.
Their morbidity and mortality rates from this disease are higher than in other patients.
Hannan et al., J Bone Miner Res, 2000
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The current lifetime risk for a fragility fracture is approximately 27% in men aged 50 years or more, and will increase further over the next 20 years.
A twofold to threefold increased risk for death was demonstrated in men with a history of a major osteoporotic fracture versus men without a history of fractures
Ebeling; Treat Endocrinol, 2004
Ebeling; N Engl J Med, 2008
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Osteoporosis is undetectable until the onset of fractures, just as hypertension may remain undetected until a serious consequence of untreated hypertension occurs.
Both hypertension and osteoporosis are asymptomatic, but, if left untreated and undetected may lead to their perspective clinical consequences.
Therefore detection of the disease is paramount before the manifestations manifest clinically.
Rochira et al., Eur J Endocrinol, 2006
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Secondary causes for osteoporosis are more common in men than women, and require rigorous exclusion and treatment.
Undiagnosed clinical hypogonadism is a common cause of osteoporosis in men, and is readily treatable.
Ebeling; Treat Endocrinol, 2004
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Osteoarthritis and osteoporosis are both common conditions in the elderly.
It would be anticipated that the conditions frequently coexist due to their high prevalence, but some studies have suggested that there is an inverse association between the occurrence of OA and osteoporosis.
Lane and Nevett; Arthritis Rheum, 2002
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Several epidemiological studies have shown a lower prevalence of osteoporotic hip fractures in patients with osteoarthritis.
Other studies have demonstrated elevated bone mineral density in patients with osteoarthritis.
The prevailing view is that there may be an inverse relationship between osteoarthritis and osteoporosis
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The purpose of the present study was to examine the hypothesis that OA and osteoporosis are inversely related in male patients and to assess the testosterone level in all subjects and its relation to osteoporosis in males.
Objective
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The study included 40 knee OA male patients and 40 age matched healthy male controls.
Patients with risk factors for secondary osteoporosis were excluded.
All patients and controls had a full history taking and physical examination.
Patients and Methods
Hyperparathyroidism, thyroid disease, intestinal disorders, malignancies, glucocorticoids therapy, immobilization, chronic diseases, drug therapy, or adverse lifestyle practices that increase bone loss
Hyperparathyroidism, thyroid disease, intestinal disorders, malignancies, glucocorticoids therapy, immobilization, chronic diseases, drug therapy, or adverse lifestyle practices that increase bone loss
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Bilateral knee examination of all subjects for tenderness, swelling, hard bony tissue enlargement and deformity using the ACR clinical criteria for classification of OA of the knee.
Patients and Methods
Altman et al., Arthritis Rheum, 1986
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AP weight bearing knee radiographs, that were scored for: global severity of OA (K&L, range 0-4) presence of osteophytes (range 0-3) joint space narrowing (range 0-3).
Patients and Methods
Spector and Hart; Ann Rheum Dis, 1992
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Bone Mineral Density (g/cm2) was measured at the hip, anteroposterior and lateral lumbar spine (L1-L4 spinal region) using DXA.
Osteoporosis was defined by BMD levels, according to the WHO criteria, as 2.5 standard deviations below young adult mean; according to the T-score, and severe osteoporosis when osteoporotic fractures were present.
Patients and Methods
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Serum testosterone measurement was done for all patients using an Enzyme Immunoassay, which used a sensitive and specific rabbit anti-human testosterone antibody.
Patients and Methods
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In this case-control study the mean age of OA patients was 49.5 ± 13.6 (range: 39-60 yrs) and of the 40 healthy male controls 48.3 ± 9.8 (range: 40-60), they were age matched p>0.05.
OA was bilateral in 16 cases (40%) and unilateral in 24 cases (60%).
Results
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Distribution of OA cases and Controls by Body Mass Index
BMIOA Cases, n=40 Controls, n=40
No % No %
Normal 16 43.2 24 66.7
Overweight 16 43.2 8 22.2
Obese 5 13.5 4 11.1
Total 37 100.0 36 100.0
The BMI was not significantly different between the osteoarthritis cases and the control group; p>0.05.
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There was no significant difference between OA cases and controls as regards smoking (p>0.05) and life style level of activity (p>0.05).
There was no significant difference between the osteoarthritis cases and the control group as regards incidence of hypertension (p>0.05), or diabetes (p>0.05).
Results
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Distribution of Hypertension, diabetes and Thyroid disease among OA cases and Controls
OA Cases Controls Total pHypertension No % No % No %
Present 10 25.6 8 20.0 18 22.8>0.05
Absent 29 74.4 32 80.0 61 77.2
Total 39 100.0 40 100.0 79 100 NS
DiabetesPresent 8 20.0 9 22.5 17 78.8
>0.05Absent 32 80.0 31 77.5 63 21.3
Total 40 100.0 40 100.0 80 100 NS
Thyroid diseasePresent 4 10.0 4 10.0 8 10
>0.05Absent 36 90.0 36 90.0 72 90
Total 40 100.0 40 100.0 80 100 NS
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Spine T Score among OA cases and Controls
The difference was non significant; p=<0.05
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Hip T Score among OA cases and Controls
The difference was non significant; p=<0.05
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Results
Mean BMD ± SDPOA Cases;
n=40Controls;
n=40Spine 0.926 ± 0.164 0.968 ± 0.160 0.251Hip 1.002 ± 0.117 1.00 ± 0.136 0.292
Bone Mineral Density among OA Cases and Controls
The mean bone mineral density in the spine and the femur was not significantly different between the osteoarthritis group and the controls
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To ensure that none of the men had undiagnosed clinical hypogonadism, serum testosterone was assessed for all patients and control group.
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ResultsMean level of testosterone in OA Cases and Controls
Type Mean ± SD (Mean ± SD) t-test POA
casesn=40
14.35 ± 10.4 1.07 ± 0.232.68 0.007
Controlsn=40
19.65 ± 10.4 1.23 ± 0.25
The mean testosterone level in the osteoarthritis patients was statistically lower than among the control cases (p=0.007)
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ResultsMean level of testosterone in Cases with Osteoporosis and Without
Type Mean ± SD POsteoporosis Spine (n=30) 17.11 ± 10.04
>0.05NS
Hip (n=6) 15.76 ± 7.81No
OsteoporosiSpine (n=50) 16.95 ± 10.99
Hip (n=74) 17.09 ± 10.89
The mean testosterone level was not statistically different between cases with osteoporosis and those without osteoporosis
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There was no significant difference between OA cases and controls in the frequency of osteoporosis of the spine or hip.
The mean BMD was not statistically different among both groups.
We did not find an association between BMD as measured by DXA and clinical or radiographic features of OA in the knee.
There was no correlation between level of testosterone and osteoporosis.
Results
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With multiple logistic regression analysis, knee osteoarthritis was a risk factor for spine osteoporosis; patients with radiological findings diagnostic of osteoarthritis could be 3.5 times at risk of developing spinal osteoporosis.
Smoking and presence of knee OA were risk factors for occurrence of hip osteoporosis.
Results
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Almost 40 years have passed since Foss and Byers published their report confirming observations made by orthopedic surgeons on the relative absence of osteoarthritic changes in excised femoral heads from patients who had had hip fracture.
Association between these conditions is still controversial
Foss MVL, Byers PD. Bone density, osteoarthrosis of the hip and fracture of the upper end of the femur. Ann Rheum Dis 1972;31:259-64.
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Many studies have been conducted examining the effect of OA on bone density at different sites and with different techniques.
Most of them showed a significant increase in bone mass or bone mineral density in OA cases compared to age-sex matched controls .
Lane and Nevett, Arthritis Rheum, 2002
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The Framingham Study (1993)
Examined the BMD of the proximal femur and radius in 932 men and women over 63 yrs of age in relation to knee OA.
The mean femoral BMD, was 5-9% higher in grade 1 and 2 knee OA compared with no knee OA.
The higher BMD was associated with osteophytes, but not joint space narrowing
Hannan MT, Anderson JJ, Zhang Y, Levy D, Felson DT: BMD and knee OA in elderly men and women. The Framingham Study. Arthritis Rheum; 1993
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Speculation has been that weight-bearing activities, which are beneficial to the attainment and preservation of peak bone mass, also increase the risk of damage to articular cartilage leading to OA in lower extremity joints.
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Another explanation has been that high BMI, which is associated with higher BMD, confers a detrimental biomechanical load to weight-bearing joints, thus leading to OA
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The subchondral bone may play an important role in the pathogenesis of OA.
The sclerotic subchondral bone is considered to weaken the articular cartilage by impairing its ability to absorb mechanical shock, thereby influencing the progression of OA.
Li B, Aspden RM: Composition and mechanical properties of cancellous bone from the femoral head of patients with osteoporosis or osteoarthritis. J Bone Mine Res 1997
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The Rancho Bernardo Study in 2002
Examined the relation between hand OA and BMD levels (as measured by DXA) among 1779 community-dwelling, ambulatory white adults aged 50-96 years.
OA was not associated with increased BMD levels in men or women. The only significant difference was that women with hand OA had lower hip BMD
Schneider et al. BMD and clinical hand osteoarthritis in elderly men and women: The Rancho Bernardo study. J Rheumatol;, 2002.
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In some others, however, no increase was found and in others, bone mass was reduced.
Much of this controversy can be attributed to differences in subject selection, different anatomical sites measured and different methods used in evaluation and expression of the results.
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We could not find a relation between osteoarthritis and osteoporosis, but owing to the small number of patients we cautiously conclude that osteoarthritis and osteoporosis are not inversely related.
Conclusion
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Conclusion Even though many have shown an
inverse relation between OA and osteoporosis, it does not mean that the 2 conditions are mutually exclusive.
The presence of OA in a joint should not exclude the diagnosis of osteoporosis in a patient.
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Thank You
Thank You