outbreak investigation operational aspects 12 th epiet introductory course lazareto, spain marta...
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Outbreak Investigation
Operational Aspects
12th EPIET Introductory CourseLazareto, Spain
Marta Valenciano, Susan Hahné, Jet de Valk, Mike Ryan,
Intervention epidemiology
Definition:
• The timely use of epidemiology to solve urgent public health problems
Objective:• To maximise the scientific quality
of the investigation in a complex environment
What is an outbreak ?• Occurrence of more cases of disease than
expected
– over a particular period of time
– in a given area
– among a specific group of people
Why investigate outbreaks?
• Stop the outbreak
• Understand what happened and why
• Prevent future outbreaks
• Improve our knowledge
• Improve surveillance and outbreak detection
• Training
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DAY
CASES
LabConfirmation
Outbreak Detection and Response
Response
Opportunity for control
Detection/Reporting
First Case
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1 4 7 10 13 16 19 22 25 28 31 34 37 40
DAY
CASES
Outbreak Detection and Response
First CaseDetection/
ReportingConfirmationInvestigation
Opportunity for control
Response
Objectives for this sessionYesterday:
• Methodological aspects
Today
• Scenarios for your involvement
• Challenges in getting organised during outbreak investigation
• Preparing and organising yourself for field work
• Systematic approach to operational aspects
Scenarios
Local Outbreak - Local authorities coordinate
- Your are asked to assist / help
National Outbreak - Your institute coordinates-You are asked to lead
International / European outbreak involving your country
- ECDC coordinates
- Your institute collaborates
- You participate
Outbreak in another country
-The authorities in that country coordinate- You are asked to assist
e.g. EPIET fellow involvement
Local - Local authorities
Hepatitis A in Bretagne
National - Your institute S. Typhi
International / European outbreak involving your country
- ECDC coordinates
Meningococal infections in pilgrims returning from Haj
Another country - The authorities in that country coordinate
Leptospirosis in Nicaragua (French Ministry mission)
Rift Valley Fever, Kenya (WHO mission)
Operational challenges
• Unexpected event
• Need to investigate quickly
• Pressure for answers
• Multiple agencies
• Work carried out at many levels
• You are in the media spotlight
• Legal implications
Operational challenges
• You may arrive late– rumours?
• Local sensitivities• Foreign country• Need to feedback to various people• Stress, long working hours,
finding time to rest and relax
Systematic approach
Unexplained illness in a high school in
Normandie, 2001• 5/03 : 15 ill; headache, nausea, abdominal pain• 8/03 : 35 ill– school closed– investigation for toxic products–medical examination of all ill students
• 15/03 : 45 ill• 16/03 : one student found dead
InVS to investigate
On call epidemiologist + « volunteers »
Co-ordination
Epidemiology
Environmental health
Clinicians
Laboratory : clinicalenvironmental
Media AuthoritiesDiagnostic
Clinical
Specimen transfer
Dead Sick
Exposed
SurveillanceInvestigation
Prediction
ParentsStudents
PrincipalTeachers
Generalpopulation
DecisionsSchool closureMedical examinations
Toxic products
Psychological support unit
Police, legal authorities
Autopsy
Systematic approach• Reasons for inviting you
– ´Terms of reference´ ?
• Preparing to leave for the field
• When you arrive
• In the field
– Outbreak Control Team
– Information management
– Leaving the field
• Back home
Reasons for inviting you
• Expertise• More resources• Share responsibility• Political or mass media pressure• Mandatory or in guidelines• Need to confirm local findings• Specialised investigations
Reasons for inviting youNormandie, 2001
• Expertise• More resources• Share responsibility• Political or mass media pressure
Terms of referenceClarify before accepting
• What are their expectations
– Expertise, tasks, time?
– What local resources are available?
• What has already been done?
• What resources do you need to bring?
• What is your role ?
• Who is in charge?
Clarify before accepting,Normandie, 2001
• Expectations
– Epidemiological expertise
– Experience with mass sociogenic illness (MSI)
– Human ressources: 5 persons
• Environmental investigation already started
• Computers, phones, car ...
• DMO in charge
You are going to the field !
Preparing to leave
• Consult colleagues (microbiologist, vet, entomologist….)
• Review pertinent litterature• Decide who will lead the team• Identify who provides support
in the head office• One page report before leaving– objectives
• Arrange initial meeting for your arrival
Preparing to leave, Normandie 2001
• Consult infectious disease experts, pathologist, toxicologist
• Review litterature causes of sudden death
• Support in head office: 3 departments..
• One page report before leaving
• Arrange initial meeting for your arrival
Bring your ”epi-pack”• Computer, calculator, mobile phone• Software • USB, CDs • Notebook• File templates• Standard questionnaires• Handbooks, relevant articles• Camera• (Laboratory equipment)• Telephone, address list:
– reference centers &persons• Maps, GPS• Others... (money, ”health kit”,)
When you arrive
• Provide help - don’t take charge• Meet with key people• Review and update status of problem• Assess sensitivities • Identify local resources and skills• Discuss liaison• Set up communications with base
Arrival to Normandie
• Meeting with:– College principal– Parents
• Visiting the school• Understand rumours– second world war
Tristesse et inquiétude à Port-en-Bessin Le collège reste fermé après le décès inexpliqué d'un adolescent de 15 ans. La préfecture recommande aux 275 élèves d'aller à l'hôpital.
Les portes du collège Ernest-Hemingway de Port-en-Bessin (Calvados), où plus d'une cinquantaine d'élèves ont été intoxiqués en 15 jours, resteront fermées jusqu'à nouvel ordre, après le décès d'un adolescent de 15 ans pour des raisons indéterminées. Cet élève de troisième ne faisait cependant pas partie des enfants incommodés lors de l'intoxication suspecte. Inquiets, les parents d'élèves se sont succédés vendredi après-midi dans une des salles communales, où avait été installée une cellule de soutien psychologique. La préfecture a également conseillé
Organising the Outbreak Control
Team
• Membership
• Leadership
• Responsibilities
• Lines of communication
• Communication
• Decision making process
The Outbreak Control Team Tasks• Agree plan of Action
• Commit resources
• Co-ordinate further investigation and response
• Report to and advise higher authorities
• ECDC and WHO alerts ?
• Maintain communication with
– other investigators
– stakeholders
– general public
– the media
The Outbreak Control Team
MSI NormandieDistrict medical officer
- coordination - communication with authorities, parents
InVS epidemiologists
- Epi investigation - communication with media
Hospital paediatrician
- clinical investigation
District health engineer
- environmental investigation
Mayor - facilities and resources
Psychiatrist - psychological support unit
The Outbreak Control Team
MSI NormandiePlan of action: • Describe events and exposures
• Retrospective cohort study
• Environmental investigation and sampling
• Systematic review of clinical findings
• Autopsy deceased student
• Psychological support
• Communication and information
The Outbreak Control Centre - I
Headquarters of the investigation• Where
• How big
• Accessibility/Security
• Separation from normal work
• Catering
The Outbreak Control Centre - II
Equipment• Computers with Internet connection
• Telephones, telefax
• Copy machine
• Reference materials
• Office furniture and stationery
Information \ Data• Types of information
– epidemiological
– operational
• Managing information (databases)
• Briefing, feed-back
• Communicating with the media
– one person !
• Writing reports: ongoing process
Epidemiological data• Line listing is vital
– cases/contacts
– lab results, questionnaires available
– in excel
Operational information• Contacts: name, position, contact details
• Types of files
– epidemiological (questionnaires, data, protocols)
– interviews, meetings, press
– source and date
– emails
• Meetings
– minutes
– actions and those responsible
• Decisions and rationale (information available at the time of decision making)
• All steps taken in the investigation
Managing data \ data bases• Software
• Database design
• Data– entry and validation
– multiple data bases : how linked?
– analysis
– programmes
• Backups / confidentiality / access
• Overall responsibility for data management
• Sometimes professional data manager
Operational informationStorage and organisation
• Computer, laptop, web?
• Inventory of files
• Log book!
– every day
Information Management –
The Media• Appoint one (professional) spokesperson– prepare briefings for him / her
• Coordinate with other agencies• Inform early and often– interviews– press statements– press briefings - regularly
• Be clear about what is– fact– speculation– not known
Normandie, 2001The media and the general
public
Different spoke persons
• DMO decision maker– parents– school authorities
• Epi investigator (experts..)– media
Conflicting information from other investigators
Leaving the field
• Debriefing meeting
• Preliminary report
• Commit to produce final report
• Archive data
Back home
• Inform your supervisor and colleagues– debriefing
• Follow up– lab, clinical other studies results
• Finalise the report ASAP• Beware of confidentiality– anonymise database– anonymise questionnaires
Normandie, 2001
• Deceased student: congenital heart malformation
• Mass sociogenic illness
• Triggering factors:
poor ventilation, high temperature
• Environmental contamination below toxic levels
• Children dispatched to other schools:
malaises reported
• School reopened after renovation
Normandie: lessons learned
• Involve other (competing) investigators• Consult all partners and other investigators
before communicating important results• Stick to basic principals:
- test your questionnaire• Back up from headquarters• Distinguish investigators / decision makers• Follow up after return
Summary
• Outbreak investigations are challenging• Preparation and good operational skills help• Offer help, do not take charge• Stay organised• Don´t come back until the job ids done• Write your report all the time• Take time to have a rest !!!
Laboratory confirmation
Source
Outbreak control team
meeting - urgent!
TV inter view
Control measures ?
Meet minister