Overview of the Harvard Catalyst Imaging program

ClareTempany, MD; Ron Kikinis, MD;

Valerie Humblet, PhD

http://catalyst.harvard.edu April 9, 2009

Agenda

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• Harvard Catalyst

• Imaging Consortium

• Technology and Expertise

• IT Structure

• Why be a consultant ?

• Educational Opportunities

• Contact

Harvard Catalyst: The History and the Basics

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• GCRC program (20+ yr NCRR/NIH funded clinical trials program) discontinued– BWH/MGH imaging cores (CT/AVD/GS)

• CTSA 2007(Roadmap initiative-EAZ)• HU- Response-Harvard Catalyst

– (PI Lee Nadler/Co-Director: Steve Freedman)– GCRC replaced by PCIR

• We are a pan-Harvard enterprise dedicated to improving human health by:– Creating Connections– Enabling research At the Cutting Edge of discovery– Nurturing clinical and translational researchers

National Effort in C/T Research

38 AHC/23 states

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• Member of the NCRR Clinical and Translational Science Award (CTSA) Consortium-14 new in 08

Source: http://www.ctsaweb.org/

Duke

Mayo Clinic

Cornell

J.Hopkins

UC Davis

Wash. U.

Northwestern

Emory U.

• Imaging programs-(Dan Sullivan/RSNA)

Institutions participating in Harvard CTSC

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 Academic Healthcare Centers• Beth Israel-Deaconess Medical

Center• Brigham and Women’s Hospital• Massachusetts General Hospital• Children’s Hospital Boston

Specialty Hospitals and Institutes• Dana-Farber Cancer Institute• Forsyth Dental Institute• Joslin Diabetes Center• Massachusetts Eye and Ear

Infirmary• McLean Hospital• Schepens Eye Research Institute

Massachusetts Institutes of Technology

Harvard University• Faculty of Arts and Sciences• Harvard Business School• Harvard School of Dental Medicine• Harvard Divinity School• Graduate School of Design• Graduate School of Education• Kennedy School of Government• Harvard Law School• Harvard Medical School• Harvard School of Public Health• Harvard School of Engineering

Community Healthcare Institutions• Cambridge Health Alliance• HMS Department of Ambulatory

Care and Prevention at Harvard Pilgrim Healthcare

Red –Imaging Consortium

Year 01 total budget: $22,148,106

Harvard catalyst

• Programs (Selected list)

– Biomedical Informatics-Kohane– Community engagement– Design and Biostats– Dev of Novel CT methodologies-Vikas– Diversity/Health Disparities research– Ethics– Linkages-HL, HBS, Kennedy School etc– Pilot studies– Regulatory-BB– Research Education

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Harvard catalyst

• Programs– Translational Technologies and Resources

(TTR)-Gordon Williams (Imaging)– increases investigator awareness and utilization of

established translational technologies, educates the research community in the underlying principles and application of relevant translational technologies and fosters collaborations to improve these technologies.

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Pilot funds

• Eligibility:All Harvard faculty are eligible to apply, regardless of degree or institutional affiliation.

• Funds:Pilot Grants will be awarded in the amount of $50,000, with an award period of one year.

• Deadlines:Letter of intent: May 13, 2009

Full application: June 12, 2009

• Contact:Harvard Catalyst Research Navigators617 432-7800

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Bruce Rosen, DirectorRandy Gollub, Co-DirectorGordon J. Harris, Site Co-Director

Robert Lenkinski, Site Co-DirectorNeil Rofsky, Site Co-Director

Clare Tempany, Site Co-DirectorRon Kikinis, Site Co-DirectorGordon Williams, PI for CTSC Translational Technologies

Stephan Voss, Site Co-DirectorSimon Warfield, Site Co-Director

Annick D. Van den Abbeele, Site Co-DirectorJeff Yap, Site Co-Director

Gordon J. Harris, Site Co-DirectorAnnick D. Van den Abbeele, Site Co-DirectorWilliam Hanlon, Core Manager

Valerie Humblet, Imaging LiaisonYong Gao, XNAT Engineer

Imaging Consortium Team

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Mission of the Imaging Consortium

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• Expand imaging in clincial research– To build infrastructure

• Provide expert consultation and guidance to CTSC participants in the use of imaging as part of clinical translational research

• IT framework

• Educate and advise Harvard and the Affiliated Academic Health Centers about available imaging, techniques, capabilities and image processing capabilities in the Harvard environment.

Harvard Catalyst website

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• Access to resources and profiles

http://catalyst.harvard.edu/home.html

Image Consortium Consultation Service

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• Access to the consultation service:

http://catalyst.harvard.edu/home.html

Technologies and Expertise

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• Cancer imaging, MRI, PET, CT, fMRI, pediatric imaging, neuroimaging.

• Focused on assisting with planning and design of research proposals and/or methods for image analysis.

• Consultation is available for the preparation of a grant or IRB submission.

• We do not provide ongoing support for the implementation of new studies or the analysis of data from existing studies.

Imaging Consultation Service

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• Investigator fill webform on Catalyst website– Name, institution, nature research, reason for consult

• Medical Imaging Liaison – dispatches request to the imaging consortium– Follow-up with investigator

• Consultations discussed weekly• Designated consultant contacts investigator

Becoming an Imaging Consultant

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• Potential benefits of being an active collaborator:– Good framework for research– Research opportunities through collaborations– Meeting experts out of radiology– Networking with imaging cores outside of Boston

• Examples: – Standardization of physiologic monitoring system for fMRI– Development lingual nerve imaging (MGH-BIDMC)– Study of brain-development in premature infants (CHB-BWH-

MGH)– Liver inflammation– Cardiac conductivity study

Educational Opportunities proposal

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• Nanocourse: – Imaging 101 to increase knowledge about imaging

• More advanced classes for radiologists:– Tumor metrics– Radiation safety issues for IRB submission– Hands-on classes on data analysis– Imaging perfusion– Example: www.na-mic.org/Wiki/images/8/8b/Slicer3Training_ChangeTracker.ppt

XNAT-PACS-i2b2 Integration

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• IT Catalyst infrastructure:– i2b2: scalable computational framework to help

translation of genomic findings. – BIRN: XNAT imaging informatics platform: large

collections of images and study-specific metadata to be managed by image-driven clinical translational research groups.

– NA-MIC:robust, open source solutions for medical image analysis, visualization and management software tools by the creation of a “desktop” version of XNAT. Key image analysis software tools: slicer. Freesurfer.

XNATEnterprise

DataRepository

(CRC)

FileRepository

IdentityManagement

OntologyManagement

CorrelationAnalysis

De -Identification

Of dataNatural

LanguageProcessing

AnnotatingGenomicData #1

ProjectManagement

WorkflowFramework

AnnotatingGenomicData #2PACS PACS

i2b2 HIVE

Dr X Desktop Pediatric

rare disease

Dr YDesktop

Alzheimer

Dr ZDesktop

Chronic pain management Dr W

Desktop Quantitative

cancer biomarkers

XNAT-PACS-i2b2 Integration

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Slicer:Data

visualization analysis

Invitation

• Please consider getting involved– Info- Google Harvard catalyst– Pls sign up as a potential consultant today!– Pilot grants (est x2 application dates per year)– Watch your email- attend meetings

symposiums to meet new research colleagues

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http://catalyst.harvard.eduImage_Consult@catalyst.harvard.edu

www.na-mic.org/Wiki/index.php/Collaboration:Harvard_CTSC