tants are added sequentially, followed bythe regeneration of the antigen. The pres-ence or absence of binding is detected inseconds and an epitope map is rapidly built.Fisons. Circle 142.

Paraffin Embedding StationThe Zeiss AP-250 Embedding Center iscomposed of three modular units that can beused separately or put together to form a totalembedding processor. The Cryo Console is alarge plate for cooling embedded tissue speci-

mens. It has a capacity of 50 tissue or biopsycassettes, an integrated refrigerated drawerfor storing extra cassettes, and a workingtemperature of-5C. The Dispensing Con-sole can store 2.5 liters of paraffin. The flowcan be started with a foot pedal or switch.An illuminated magnifying glass allows

close observation of the sample. The consoleincludes a heating plate with four forcep-warming holes. Temperature range is + 20° to+70° C. The Thermal Console includes aprocessor chamber for storing cassettes andspecimen infiltration. All surfaces are eithernylon or Teflon. Curtin Matheson Scien-tific. Circle 143.

Growth MediumTB Dry is a high nutrient medium designedto maximize yields of vector recombinantplasmid and cosmid DNA. All componentsare included in a single dry powder. There isno need to autoclave separate solutions toproduce it. Mo Bio Laboratories. Circle 144.

m

LiteratureBiotechnology Brochure offers a comprehen-sive review of J.T. Baker's capabilities to as-sist biotechnology companies in the manu-facture of therapeutic products. Productscovered include pyrogen-tested salts, ultra-pure bioreagents, biochromatography me-dia, and high purity solvents. J.T. Baker.Circle 145.

BioSolutions is a publication with articles onapplications of membrane filtration prod-ucts. The latest issue features a lead article onrapid protein recovery from polyacrylamidegels using a centrifugal device and amicroporous separator. Amicon. Circle 146.

Lab Catalog 1995 is a 38-page introduction toa line of balances, moisture analysers, auto-matic titrators, density meters, thermal ana-lyzers, and other instruments. Mettler To-ledo. Circle 147.

Purifier Class II Safety Cabinets and CleanBenches describes a line of these products.Labconco. Circle 148.

FluorImager SI: Quantitative Fluorescent Im-aging for Gels, Blots, TLC, and Microplatespresents information on fluorescent samplepreparation, FluorImager SI system opera-tion and performance, reagent kits, andquantitative fluorescent image analysis. Mo-lecular Dynamics. Circle 149.

Drug Development and Formulations CD-ROM contains data updated monthly frompatents from seven major countries and frommore than 1200 international conferencesand journals. Derwent. Circle 150.

SCIENCE * VOL. 268 * 9 JUNE 1995

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1 520

SCIENCE

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SCIENCE JOBNET: Unless otherwise instructed,every classified advertisement submitted forpublication in Science is automatically posted onScience's on-line classified advertising service,SCiENCE JOBNET, at no additional charge.SCIENCE JOBNETaddress: gopher.aaas.org

POSITIONS OPEN

ASSISTANT PROFESSORDepartment of Biosystems and

Agricultural EngineeringUniversity of Minnesota

Applications are being accepted for an ASSISTANTPROFESSOR (12-nmonth appointment, tenure-track)to teach courses in biosystems engineering and to des elopa strong research program emphasizing improved titiliza-tion of agricultural and biological materials. Applicantsmust hase a Ph.D. by date ofappointment in agricultural,biological, chemical, or related engineering field and ed-ucation or experience in biology, biosvstems, or biopro-cessing. Send letter of application, including curriculumvitae; a one-page summars of career goals in the contextof the position; college transcripts; and names, addresses,and telephone numbers of three professional referencesby August 15, 1995, to: Dr. Kevin Janni, Search Com-mittee Chair, Department of Biosystems and Agricul-tural Engineering, University of Minnesota, 1390Eckles Avenue, St. Paul, MN 55108. Telephone: 612-625-3108; FAX: 612-624-3005.

Diu' o nhicrity f .XIititistta is an) Equal O1portunity E(dnwatorand Eiplo,),'i.

ASSISTANT PROFESSORGERIATRICS AND GERONTOLOGY

UNIVERSITY OF MICHIGAN

The Dis ision of Geriatric Medicine is seeking applica-tions for a TENURE-TRACK FACULTY positionfrom researchers sith interests in the genctics, cell biolo-gv, or molecular biology of aging and geriatric disease.The successfiil candidate sill be expected to set tip anindependent, extramurally funded research program andto interact sith other faculty researchers on projects ofmutual interest. Opportunities for participation in theclinical programs ofthe Division ofGeriatric Medicine areavailable for physician scientists. Minimum qualificationsinclude an M.D. or Ph.D. degree and ceidence of highlysuccessful postdoctoral research in a relevant discipline.Fxcellent nes space and start-tp package. Send letter ofapplication, curriculum xsitae, publication list, summary ofresearch plans, and names of three or more referees to:Faculty Search, University of Michigan GeriatricsCenter, 300 North Ingalls Building, Box 0405, AnnArbor, MI 48109-0405. An Equal Oppornniity AffiriiActitin Eiplyei}'r.

MICROBIOLOGYAssistant Professor (Tenure-Track)

The Medical College of Ohio insiites applications for aTENURE-TRACK POSITION in the Department ofMicrobiology. Candidates must has a doctoral degreeand postdoctoral research experience. Primary researchinterests should involxe molecular aspects of pathogene-sis, ssith emphasis on host-pathogen interactions. Teach-ing respoinsibilities include participation in a microbiolo-gv course for medical stridents and development of agraduate level course in molecular pathogenesis. The suc-cessful candidate is expected to develop an independentresearch program based on extramural support. Start-upfunds and a state-supported salary are available. A curric-ulum xitae, future research plans, and three letters ofrecommendation should be sent to: Chairman, Depart-ment of Microbiology, Medical College of Ohio,3000 Arlington Avenue, Toledo, OH 43699. .IdicdalCo(llit, of Oliio is anl Afi/fiatinen ActiitiiEqual OpportinityEnSiplayir.

FACULTY POSITIONNEUROSURGERY

The Department ofNeurosurgery at Hennepin CountyMedical Center invites applications for a faculty position,svith a joint appointment (ASSISTANT PROFESSOR,non-tenure) in the Department of Neurosurgery at theUneivrsity of Minnesota. Position requires postdoctoralneuroscience training and potential to establish an iode-pendent, externally funded research program focused onncurotrauma. Research interests should include neuro-transmitter alterations (microdialysis), mechanisms ofsecondary damage, and/or development of pharmaco-therapies fcillossing traumatic brain injury. Send letter ofinterest, curriculum vitac, and three letters of recommen-dation to: Neurosurgery Search Committee, Minneap-olis Medical Research Foundation, 914 South 8thStreet, Minneapolis, MN 55404. An Equial OpportlitylAffinrativ Acti(,n Emiplyir.

POSITIONS OPEN

UNIVERSITY OF VIRGINIADEPARTMENT OF MICROBIOLOGY

Viral Pathogenesis/Gene Regulation

The Department of Microbiology, University of Vir-ginia is seeking an outstanding scientist for the tenure-track position of ASSISTANT or ASSOCIATE PRO-FESSOR. The successful candidate is expected to devel-op a high quality research program in siral pathogeniesis,the molecular analysis of siral and/or eukaryotic gelleexpression, or related areas. Of particular interest to theDepartment are candidates whose research areas focus olnthe regulation of gene expression by latent and/or onco-genlic viruses, expressioin of cell cycle regulated genes andmitogen/hormone regulated gene expression. The De-partment of Microbiology ofters an outtstanding ens iron-mnenrt for research on molecular genetics, immunology,virology and cellular signaling as ssell as outstanding op-portunities for graduate and postgraduate training. Appli-cants should submit a curriculum sitae, a concise state-ment ofresearch interests and selected reprints. These andthree letters of reference should be sent to: Chair, Mi-crobiology Search Committee, Box 441, Health Sci-ences Center, University of Virginia, Charlottesville,VA 22908. Applications should be received by Septem-ber 1, 1995. I/ic I nii'cruy oft I prgipiii is an Equal O)1)ortuin-

ty/.4t~~irlll~~tilan .4-ie~l1y~ lf '1(1nloura' applicatit}1is firwiim'.- iriiiamn' it ritson iLntiisti.a

FACULTY POSITIONExperimental Gravitational Physics

The Department of Physics at MIT is seeking candi-dates for a facultv position in experimental grasitationalphs sics. MIT is collaborating svith Cal Tech in developingthe Laser Interferometer Gravitational Wave Obsers ator,(LIGO). This ssill be a national facility dedicated to thedetection of gras itational ,ssaves from astrophysical sourc-es and s ill provide unique research opportunities in phvs-ics and astrophysics. The successful candidate will engagein undergraduate and graduate education and svill estab-lish an independent research program in experimentalgravitatioinal physics. He/she may also participate in thedevelopment of LIGO. Appointment at the ASSIST-ANT PROFESSOR level or, for an exceptionally quali-fied candidate, at the senior level ssill be considered. Gis-en the developing nature of this field, candidates svithvaried experimental backgrounds svill be considered. Ap-plications are requested before October 1, 1995. Appli-cants should send a curriculum sitac, a brief description ofcurrent research, and three letters of recommendationi to:Professor Saul Rappaport, Center for Space Research,Room 37-551, MIT, Cambridge, MA 02139-4307..A17 is inl Equal I .lr firiii .4.i.n Eniplioiyr .MIT

ai ioZ -spiiikiic iiiiironnunu

FACULTY POSITIONS: The Department of Bio-chemistr and Molecular Biology in the College of Med-icine solicits applications for tsso ASSISTANT PRO-FESSORS (one on a tenture-track/12 month appoint-ment and one on a research track/12 month appoint-ment). Candidates should hase an M.1). or Ph.D. degreeand be engaged in productive research in any area ofBiochemistry or Molecular Biology. The successfiul can-didate s ill join a rapidly expanding and active departmentand svill occupy laboratories in the ness Biomedical Re-search Building. The ness facult---y member ssill be expect-ed to develop an extramurally funded research programand nmay participate in the departmental medical or grad-uiate teaching programs. Applicants should send a curric-ulum sitae, a brief description of proposed research, andthe names of three references to: Search Committee,Department of Biochemistry & Molecular Biology,Slot 516, University ofArkansas for Medical Sciences,4301 West Markham, Little Rock, AR 72205, by Au-gust 1, 1995. University if Arkanisasf(r Muediual Sciences is anEqual p)p)ortuiit)i1,4Afirutiatiiie Action EIiployer.

RADIATION ONCOLOGY PHYSICIST. Respon -

sible for calibrating and monitoring radiation therapyequipment. Verifies proper calculations and sveekly chartchecks. Orders, prepares and handles radioactive isotopesfor brachrtlherapy/HDR procedures and therapeutic dos-es of liquid radionuiclides. Plans, directs and supervisesactivities of physics staff. Required: Ph.D. in Physics andthree years of experience in job offered or as medicalphysicist; California license as Radiation Physicist; ABRcertification. $110,240 per year. Intervicw/job site: Fres-no, California. Send ad and resume to: Job No.JA36245, P.O. Box 269065, Sacramento, CA 95826-9065.

SCIENCE * VOL. 268 * 9 JUNE 1995

CONDITIONS: The AAAS encouragesemployers to actively recruit andemploy underrepresented minoritygroups. Science reserves the right, atits discretion, to edit or decline topublish advertisements submitted to it.

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POSITIONS OPEN

ASSISTANT/ASSOCIATE PROFESSORDepartment of Physiology and Biophysics

Dalhousie University

The Department of Physiology and Biophysics is seek-ing a neurophysiologist with interests in the field of elec-trophysiology. Applicants should have a strong back-ground in cellular neurophysiology and membrane bio-physics.

This is a tenure-track appointment but the successfulapplicant will be required to apply for salary support fromappropriate granting agencies, including the Medical Re-search Council of Canada. The level of appointment andsalary will depend on previous experience.Send a curriculum vitae, statement ofresearch interests,

and the names of three referees to: Dr. A. S. French,Head, Department of Physiology and Biophysics,Dalhousie University, Sir Charles Tupper MedicalBuilding, Halifax, Nova Scotia B3H 4H7 Canada.FAX: 902-494-1685. Closing date for applications: July31, 1995. Dall/ousie University is apt Employment EquiitylAffirtmative Action Emtiployer. 17ie University etncouirages applica-tions from qualified stvomen, aboryitnal peoples, racial minorities andpersons wit/i disabilities. In accordance tith Canadian imingrationrequiretietits, pnronrty usill be given to Canadian citizens and per-nianent residents of Canada.

ASSISTANT PROFESSORECOLOGY

The Biology Department ofGonzaga University invitesapplications for a TENURE-TRACK POSITION inecology to begin January 1996. Gonzaga is a competitive,comprehensive Jesuit University in the inland Northwest.Applicants should have a Ph.D. in biology and postdoc-toral experience. They should be broadly trained andcommitted to teaching in a traditional liberal arts setting.Development of a research program suitable for under-graduate involvement is required and the successful can-didate will be expected to compete for extramural fund-ing. Primary teaching responsibility will be in the area ofecology and participation in introductory courses for bothmajors and non-majors is expected. Familiarity with com-puter applications in teaching labs would be an asset.Review ofapplications begins 30 June 1995. Send curric-ulum vitae, statement of research and teaching interests,recent reprints, and three letters of recommendation to:Dr. Peter G. Pauw, Biology Department, GonzagaUniversity, Spokane, WA 99258. For additional infor-mation, Email: pauw~gonzaga.edu.

(Cotizaga I Iniversity is an Equial OpportutnitylAffirtative Ac-tion Eittployer.

HEAD, ANATOMY & CELL BIOLOGYQUEEN'S UNIVERSITY

KINGSTON, ONTARIO, CANADA

Applications and nominations are invited for the posi-tion ofHEAD, Department ofAnatomy and Cell Biolo-gy at Queen's University. Applicants will have achievedinternational recognition in research and scholarship,have proven skills in academic leadership and manage-ment, and a commitment to graduate and medical edu-cation and to the development of students, faculty andstaff.

Applicants should forward a curriculum vitac, descrip-tion of research interests and the names of three refereesto: Dr. R. F. Maudsley, Vice-Dean, Faculty of Medi-cine, Queen's University, Kingston, Ontario K7L3N6 Canada.

In accordatue vit/i Canadian Ittintigration requiirenients, thisadvoertisenient is directed to Canadian citizens and pemianent resi-dents. Queen s Utnitsersity has an employmient equity prograni,iyel/cones diversity it the isorkplace and etncouirages applications fromnall qualified candidates, including tuoinen, aboriginal peoples, peopleiiitli disabilities and visible nitnorities.

GUEST PROFESSORSHIP-NANOOPTICSThe Technical University Chemnitz-Zwickau

(TUChZ), Germany, offers a two-year FACULTY PO-SITION at the Institute of Physics. This position is partofthe innovation college "Methods and Material Systemsfor the Nanometer-Size Range" (supported by DeutscheForschungsgemeinschaft). Individuals with significantexperience and interest in establishing the field ofnanooptics at TUChZ are encouraged to apply. For moreinformation see http<.\\www.tu-chemnitz.de/ falke/nanoopt.html. or contact: Prof. Michael Hietschold,telephone: +49 371 531 3203; FAX: +49 371 5313077.

POSITIONS OPEN

FACULTY POSITIONSVASCULAR BIOLOGY

The Department of Medical Physiology and Microcir-culation Research Institute of the Texas A&M UniversityHealth Science Center invites applications for tenure-track ASSISTANT PROFESSOR positions. Individualswith backgrounds in molecular and cell biology ofcardio-vascular tissue are encouraged to apply. Preference will begiven to candidates with demonstrated expertise in themolecular basis of vascular function. The successful can-didate is expected to develop a nationally recognized lab-oratorv in his/her field of research, and to contribute tothe medical and graduate education missions of the de-partment. An intercollegiate group of cardiovascular sci-entists offers substantial opportunities for collaboration atmolecular, cellular, organ and system levels of integration.The department is located on the main campus of one ofthe leading research universities in the South and South-west. Molecular and cell biology is a major university-wide emphasis area. Applicants should send a curriculumvitae, names of three references and a statement of careergoals to: Dr. Harris J. Granger, Professor and Head,Department ofMedical Physiology, Texas A&M Uni-versity Health Science Center, College Station, TX77843-1114. Texas A&M University is ant Affinnative Action/Equal Opportuntity Entployer committed tot diversity.

RESEARCH FACULTYMAYO CLINIC SCOTTSDALE

A faculty position is available starting in 1996 at theASSOCIATE PROFESSOR or higher level. Researchprograms will address the molecular basis of human dis-ease. The new 75,000 square foot S.C. Johnson MedicalResearch Building houses laboratories and core facilities,including an 8,000 square foot animal facility devotedprimarily to transgenic and gene inactivation operations.Mayo Scottsdale is fully integrated with and electronicallycoupled to Mayo campuses in Rochester, Minnesota andJacksonville, Florida. Appointments are available in theappropriate department of the Mayo Graduate School ofMedicine. Scottsdale faculty have active research pro-grams in extracellular matrix, mucin molecular biology,mycloid cell differentiation, cosinophil-mediated inflam-mation, homeobox genes in nervous system developmentand the molecular pathophysiology of cystic fibrosis. Gen-erous start-up and space allotments are provided. A strongrecord of extramural support is required. Please forwardcurriculum vitae, statement of research interest and namesof three references to: Faculty Search, S.C. JohnsonMedical Research Center, Mayo Clinic Scottsdale,13400 East Shea Boulevard, Scottsdale, AZ 85259.MIayo Clinic Scottsdale is an Affirmnative Action Employer andEduicator. It promoisstes cultural diversity inl its tvorkfitrce.

RESEARCH ASSOCIATE position available imme-diately to study molecular aspects of cell cycle regulationin apicomplexan parasites. Ph.D. in Cell/Molecular Biol-ogy. Background in molecular parasitology is desirable.Research experience in recombinant DNA techniques es-sential. Attractive research environment and benefitspackage. Salary is commensurate with experience. Sendcurriculum vitae, statement of professional/researchgoals, and names, titles, addresses, and telephone numbersof three referees to: Ms. Tyra Burman, Position GV-2,The Center of Marine Biotechnology, University ofMaryland Biotechnology Institute, 701 East PrattStreet, Baltimore, MD 21202. Application deadline:July 15, 1995. Equal OpportuinitylAffintiative Action Empluoyer.

RESEARCH ASSOCIATE position available imme-

diately to study molecular and biochemical aspects ofprotein-carbohydrate interactions. Ph.D. in Biochemis-try/Molecular Biology. Background in molecular recog-nition is desirable. Research experience in recombinantDNA techniques essential. Attractive research environ-ment and benefits package. Salary is commensurate withexperience. Send curriculum vitae, statement of profes-sional/research goals, and names, titles, addresses, andtelephone numbers of three referees to: Ms. Tyra Bur-man, Position GV-1, The Center of Marine Biotech-nology, University of Maryland Biotechnology Insti-tute, 701 East Pratt Street, Baltimore, MD 21202.Application deadline: July 15, 1995. Equial Opp(rtuntity!Affirnative Actissi Emtployer.

POSITIONS OPEN

DUNBAR SCHOLAR IN PSYCHIATRYNorthwestern University Medical School

The Department of Psychiatry at Northwestern Uni-versity Medical School is recruiting for a full-time tenure-eligible endowed faculty position (Dunbar Scholar) at theASSISTANT or ASSOCIATE PROFESSOR levelwhose interests are in basic research related to the neuro-biological mechanisms of Depressive Disorders. This po-sition is affiliated with the Neuroscience Institute atNorthwestern. A joint appointment in the appropriatebasic science department is anticipated. The specific con-tent of the research interests considered appropriate forthis position can vary but must be basic in nature andrelated to Depressive Disorders. Applications will be ac-cepted from Ph.D.'s or M.D.'s. Starting date is flexible.Salary will be determined based on rank and experience.Send curriculum vitae and letter of intent describing pre-vious work and its relevance to Depressive Disorders bySeptember 1, 1995, to: William T. McKinney, M.D.,Director, Asher Center for the Study & Treatment ofDepressive Disorders, Northwestern University Med-ical School, 303 East Chicago Avenue, Ward 9-176,Chicago, IL 60611. Telephone: 312-908-9380; FAX:312-503-0466. Affirmative Actioul'Equal Opportuonity Emi-ployer. Wontet anid minorities are etncouaraged to apply.

POSTDOCTORAL FELLOWSHIP

Available immediately, NIH-funded POSTDOC-TORAL POSITION to study gene regulation in thedeveloping intestine. Some experience in molecular biol-ogy required. Applicants must have doctoral degree andU.S. citizenship or permanent resident status.

Please send a curriculum vitae and names of three ref-erences to: Dr. Richard J. Grand, Chief, Division ofPediatric Gastroenterology and Nutrition, New En-gland Medical Center and Tufts University School ofMedicine, 750 Washington Street, Boston, MA02111. FAX: 617-636-8388; Email: richard.grand@as.nemc.org. We art ant Equal Opportuniity Employer. Wesupport diversity itl the ussorkplaci.POSTDOCTORAL FELLOW/RESEARCH AS-

SOCIATE-Department of Pharmacology. Applicationsare invited for a position available immediately to studythe catalytic components and function of the multicata-lytic proteinase complex (Proteasocme). Candidates with aPh.D. degree in Enzymology or Bioorganic Chemistryare preferred. Previous experience is desirable. Please sub-mit a curriculum vitae and references to: Dr. M. Or-lowski, Department ofPharmacology, Box 1215, TheMount Sinai Medical Center, One Gustave L. LevyPlace, New York, NY 10029-6574. An Equal Opportu-tity Empl/oyer.

POSTDOCTORAL FELLOWSHIPS

One or two positions immediately available for moti-sated individuals for studies of the molecular biology ofAlzheimer's disease (see] Biol Client, 269:24000, 1994,and 269:24009, 1994). Experience in molecular biologynecessary; protein biochemistry or neurobiology a plus.Send curriculum vitae, references and research statementto: Dr. James Malter, A4/204-CSC, Department ofPathology, University of Wisconsin Hospital, 600Highland Avenue, Madison, WI 53792. FAX: 608-263-1568; Email: JS.Malter~hosp.wisc.edu.A POSTDOCTORAL POSITION is available to

work at Clemson University in Socith Carolina, USA onthe magnesium chelatase step of chlorophyll synthesis(Bioc/t-etti. J., 299:277-284, 1994). Experience in mlc0lec-ular biology and biochemistry is essential. The positionstarts in October 1995, and a second position may beavailable in February 1996. Send curriculum vitae, letterdescribing research experience, names and FAX numbersof three references to: Jon Weinstein (on sabbatical leaveat), Carlsberg Laboratory, Department ofPhysiology,Gamle Carlsberg vej 10, DK-2500 CopenhagenValby, Denmark. FAX: (+45)33274766; Email:ewalker~biobase.dk Clemnson University is ati AffinrativeActiouiEqual Opportuntity Employer.

POSTDOCTORAL POSITION-Cortical Nct-works and Learning. Position avrailable immediately to

examnine the plasticity of motor cortical circuits using slicepreparations. Send curriculum vitae with names of threereferences to: John P. Donoghue, Ph.D., Departmentof Neuroscience, Box 1953, Brown University, Prov-idence, RI 02912. Telephone: 401-863-2701; Email:JohnDonoghue@Brown.edu. Blrotust I Jntiversity is anlEquial OpporttunitylAffirntiative Actiotn Enmpltyer.

SCIENCE * VOL. 268 * 9 JUNE 19951522

Tenure-TrackAnd Jbstdoctoral

Listed below are some of the outstanding research training oppor-tunities that are currently available at the National Institutes of Health.

Tenure-TrackPositionAssistantProfessorEquivalent

Molecular EndocrinologyCarolyn Bondy,MD

Position available to develop an independent research programfocused on the role ofgrowth factors in gestation, growth or metabo-lism. Applicants should have expertise in molecular endocrinology anda commitment to training clinical associates in endocrinology fellow-ship program. Applicants must be US citizens or permanent residents.A two-page statement ofresearch interests and goals should be submit-ted in addition to three letters of recommendation. DevelopmentalEndocrinology Branch (OE-84), NICHD, Building 10 Room 10N262,10 CENTERDRMSC 1862, BETHESDAMD 20892-1862.

Postdoctoral PositionsCell Cycle Checkpoints and Cancer Chemotherapy

Patrick M. O'Connor, PhDTwo positions to study cell cycle checkpoints and their role in

cancer therapy. Projects are focused on investigations ofGI/S and G2/M checkpoints in cancer and normal cells and pharmacological strata-gems to exploit checkpoints for cancer treatment. Experience in cellcycle regulation and/or molecular pharmacology is an advantage.Applicants should have less than five years of postdoctoral experience.Laboratory of Molecular Pharmacology (OE-84), NCI, Building 37,Room 5C-19, 37 CONVENT DRMSC 4255, BETHESDAMD20892-4255.

Developmental Genetics ofthe ammalian OvaryJurien Dean,MD

Research focuses on molecular biology of gonadogenesis, geneexpression during oogenesis, and mechanisms of species-specific fertili-zation. These studies are carried out in mice and involve a wide range ofmolecular, cellular, and genetic experimental approaches. Ideal candi-dates will be trained in current DNAIRNA methodologies and have lessthan five years ofpostdoctoral experience. Laboratory of Cellular andDevelopmental Biology (OE-84), NIDDK, Building 6, Room B 1-26, 6CENTERDRMSC 2715, BETHESDAMD 20892-2715.

Molecular and Cell Biology ofVitamin CMark E. Levine,MD

Molecular mechanisms ofvitamin C transport and dehydro-ascorbic acid reduction, vitamin C function in immune cells, vitaminC-mediated collagen biosynthesis, and vitamin C pharmacokinetics inhealthy humans are being investigated. The goals are to understandvitamin C action at the genomic and cellular levels and to apply thisknowledge to determine human requirements. Applicants should havea background in molecular biology, although individuals with experi-ence in cell biology, protein chemistry, or enzymology may be consid-

ered. Candidates must have less than five years of postdoctoral experi-ence. Laboratory of Cell Biology and Genetics (OE-84), NIDDK,Building 8, Room 403, 8 CENTERDRMSC 0850, BETHESDAMD20892-0850.

Molecular Biology ofCardiac DiseasesNeal Epstein,MD and LamehFanpazr, MD

Studies ofthe molecular biology and pathophysiology ofhyper-trophic cardiomyopathy are being integrated with the clinical evalua-tion and management of patients with the disease. Areas of investiga-tion include mapping of other loci, expression of cloned mutant genes,and the study of the molecular correlates of therapeutic interventionsand ofvariable disease expression. A strong background in molecularbiology and less than five years of postdoctoral experience are required.Cardiology Branch (OE-84), NHLBI, Building 10, Room 7B15, 10CENTERDRMSC 1650, BETHESDA MD 20892-1650.

Papillomavirus Replication and Gene RegulationAlison A. McBride, PhD

The mechanisms by which the papillomavirus El and E2proteins regulate viral DNA replication and transcription are beinginvestigated. Candidates should have experience in molecular biology,biochemistry or cell biology and have less than five years of postdoctoralexperience. Laboratory of Viral Diseases (OE-84), NIAID, Building 4,Room 137,4 CENTERDRMSC 0455, BETHESDAMD 20892-0455.

Additional Postdoctoral Fellowship OpportunitiesFor an on-line listing of additional postdoctoral openings, you

may access the NIH EDNET Bulletin Board POSTDOC conference viaInternet (wylbur.cu.nih.gov) or modem (1,301402-2221 or 1,800-358-2221) with parameters set at "7,Even,1". When connected toNIH, type in ",vtlOO" for terminal emulation, "F5E" for initials, and"AIL1" for account number.

The Postdoctoral Research Fellowship Opportunities catalog,which describes intramural laboratories at the NIH, is also available byrequest. An electronic version of the catalog may be accessed via theInternet using either the Gopher Information System(gopher.nih.gov) or the World Wide Web (http:lhnww.nih.gov/).When connected, select Research Opportunities at the NIH. Ifyou wouldlike to request a catalog or have further questions, please contact theNIH Office of Education, Building 10, Room 1C129, 10 CENTERDRMSC 1158, BETHESDAMD 20892-1158, 301402-1603, Fax 301-402-0483.

To ApplyIfyou hold a doctoral degree (e.g., PhD, MD/PhD, MD, DO,

DDS, DMD or DVM) accompanied by previous laboratory researchexperience, and would like to be considered for one ofthese posi-tions, please send a cover letter, curriculum vitae, bibliogra-phy, and statement of research interests to the address Olisted with each position. In addition, please arrange to J:5 ihave letters ofrecommendation sent from three scientistswho can provide an evaluation ofyour qualifications. OX.Air_

*Wnuraimm lUit rsiiOfficeofEducation

The NIH is an Equal Opportunity Employer

POSITIONS OPEN

POSTDOCTORAL RESEARCH ASSOCIATESignal Transduction and Genetic Regulation of

ApoptosisPOSTDOCTORAL POSITION is available at the

MasseyCancer Center to participate in studies examiningmolecular, cell cycle, and signal transduction events reg-ulating drug-induced apoptosis in human leukemia cells.Prior experienice/intcrcst in molecular and cell biology isnecessary. This position is supported bya Cancer BiologyTraining Grant from the NIH; the starting date is flexible.U.S. citizenship or permanent residence status is required.Send letter describing research interests and experience,curriculum vitae, and the names of three references to:Dr. Steven Grant, Departments of Medicine andPharmacology, Medical College of Virginia, MCVStation Box 230, Richmond, VA 23298. Mlcdical Colli e

if Virnia Viririii Coitjiinnnonivaltli Uniiirsity is aii Equal Op-portunlity Eniployer. ll'Vsinpi and ninoiintiesfir( encoiiuraiZed toi apply.

POSTDOCTORAL SCIENTISTRESEARCH ASSOCIATE

lIT Research Institute, an independent research anddevelopment organization, has an immediate opening fora Ph.D. with zero to five years of experience to investigatethe influence of chemical and physical agents on geneexpression in human mammary epithelial cells. Hands-onexperience in mammalian cell culture and molecularbiology techniques is essential. Interest or experience incarciniogcnesis and/or molecular toxicology desirable.Development of an independent research program is

encouraged.Please forward resume with salary history to: Susan L.

Pigott, IT Research Institute, i0 West 35th Street,Chicago, IL 60616. An Equal OpprriirtitylAtfirniatiti( Ac-tion Eniploly(er lliniirity Fcni ali' Disabled 1etertsii.

UNIVERSITY OF TEXAS MEDICAL BRANCHGALVESTON

A POSTDOCTORAL POSITION available imme-diately in Experimental Pathology Division swill investi-gate the biochemical and molecular mechanisms of sas-cular injury by toxic substances; established NIH-fundedlaboratoryvwithin strong, collaborative University Toxi-cology Program. Send curriculum vitae with names andtelephone numbers of three references to: Paul J. Boor,M.D., University of Texas Medical Branch, 301 Uni-versity Boulevard, Department of Pathology, Galves-ton, TX 77555-0605. T1e Unliieirsity iif Texas .Xti'dicalBrandli (t TUIB) is an Eqiuil OpportinityiAfliniaiitiie AitionEnpipliy(er. .XliniiritylFfnale /DiSabledl Veteriran. UTA1B iiris onlyiindividuilus atlioiirizd ts iiirk in the bnited Statis.

A POSTDOCTORAL POSITION is immediatelyavailable to study ion channel gene expression and itsregulation in peripheral sensory neurons after nerve inju-rv. The candidate should have an excellent background in

molecular biology, and experience or interest in systemsneurobiology. Please send curriculum vitae, and names ofthree references to: Dr. Gudarz Davar, Molecular Neu-robiology of Pain Lab, Anesthesia Research, Brighamand Women's Hospital, 75 Francis Street, Boston,MA 02115. FAX: 617-730-2801; Email: gdavar@zeus.bwh.harvard.edu. Brigiiijisila Hd omnii 's Hospital is anAtfiri1iati~t's Actioii Equal Opportuiiity Eniplsyer. I'st s'ncoutrsWeapplisatiuiis1 frontv1iinei a(styd ininirity catndidates.

RESEARCH SPECIALIST II

This position, located in Slater, lossa involves workingin the area of Molecular Genetics for ICI Seeds. Prefer-ences svill be given to applicants with a strong backgroundin Molecular Genetics, Biology, or Biochemistry witlh ex-perience in techniques associated svith restriction frag-menit length polymorphism or polymerase chain reaction.The successful candidate ssill be expected to ssork bothindividually and as part of a team. B.S./M.S. degree inBiology, Genctics, or Agronomy is preferred. This is a

full-timne salaried position wvith complete benefits. Com-pensation wsill be commensurate with experience andqualifications. Send cover letter and resume to: Rene Mc-Cargar, Employee Relations Specialist, ICI Seeds,6945 Vista Drive, West Des Moines, IA 50266. E~qualOppoirtunity Eiplioyer .Xiiity Feiiiali Etisali'd I eti'ran

POSITIONS OPEN

POSTDOCTORAL POSITION, NIH-funded, isavailable immediately to stud!cellular and molecular reg-uilation of neuronal generation and differentiation, usingprenatal, adult and transgcnic rodent cultures that allowboth neurogenesis and maturation of olfactory sensoryneurons. Contact: Dr. S. Pixley, Department of CellBiology, University of Cincinnati, P.O. Box 670521,Cincinnati, OH 45267-0521. Telephone: 513-558-6086; FAX: 513-558-4454. AnlEqual Opportinity.Aftir-miatiive Actismt Employer.

POSTDOCTORAL POSITION available immedi-ately to work on an NIH-funded project insolving geneexpression in gastrointestinal inflammation. Molecular bi-ological experience required; immunology backgrounddesirable. Please send curriculum vitae and names of threereferences to: Dr. Keith Wilson, Department of Medi-cine, University of Maryland Medical System,N3W62, 22 South Greene Street, Baltimore, MD21201. FAX: 410-605-7914; Email: kwilson.umabnet.ab.umd.edu.

MOLECULAR TUMOR BIOLOGY

A POSTDOCTORAL POSITION is assailable to

studs the signal transduction mechanisms in cancer cells.Recent Ph.D. wvith experience in molecular biology andbiochemistry is desirable. Please send curriculum vitaeand names of three references to: Usha Kasid, Ph.D.,Associate Professor, Room E208, The ResearchBuilding, Georgetown University Medical Center,3970 Reservoir Road, NW, Washington, DC 20007.Ani Equal Oppiortiittity Alfirinalttii' Actioii Eniployer.

POSTDOCTORAL POSITION nowd'available to in-vestigate chaperone-miiediated folding and subsequent as-

semblv of mitochondrial oligomeric proteins (Wynn etal. Bioclieniiistry, 33:8962-8968, 1994). A recent Ph.D.recipient wvith strong background in protein chemistryand methods including physical measurements is sought.Send curriculum vitae with names and telephone numbersof three references to: Dr. David T. Chuang, Depart-ment of Biochemistry, University of Texas Southwest-ern Medical Center, 5323 Harry Hines Boulevard,Dallas, TX 75235-9038. Telephone: 214-648-2457;FAX: 214-648-8856. Ani Equal Opportioiity Emiplyer.

A POSTDOCTORAL POSITION is available to in-vestigate the structure/function relationship of reccmbi-nant GABA-activated chloride channels using molecularbiological and electrophysiological techniques (see Na-ture, 366: 565). Experience in one of the above disciplinesis desirable. Send resumne and list of three references to:

Dr. David S. Weiss, Neurobiology Research Center,1719 Sixth Avenue South, University of Alabama at

Birmingham, Birmingham, AL 35294-0021. The Uimi-iserstty sif Alabauiia at Birptingliaiiii is m Affirniatite ActiotmlEqulalOpportuntty Entpliyer.

Two POSTDOCTORAL POSITIONS, available im-mediately, to study an adhesive multicomponent systemexpressed by an enterobacterial pathogen. Requires expe-rience in 1) molecular genetics (bacterial genetics, recom-binant DNA, mutagenesis, PCR) or 2) glvco-protein/lipidbiochemistry and use ofantibody probes. Send curriculumvitae, description of previous experience and references to:

Dr. Dieter M. Schifferli, University of Pennsylvania,Department of Pathobiology, 3800 Spruce Street,Philadelphia, PA 19104-6049. FAX: 215-898-7887.Affrtkiatitru lctiin /Equial Opportinity Eniplityer.

POSTDOCTORAL POSITIONS

The Gene Therapy Program at the City of Hope Na-tional Medical Center invites applications for POST-DOCTORAL POSITIONS in NIH-funded programsfocusing upon: i) gene transfer into) hematopoictic cells;ii) the basic and clinical aspects of gene therapy for cancer

and viral infections; and iii) development of adeno-asso-ciated virus (AAV) vectors. A Ph.D. and/or M.D. degreeis required. Please send curriculum vitae, statement ofresearch interests, and the names, addresses and tele-phone numbers of three references to: City of Hope,Human Resources, Attn: KW, 1500 East DuarteRoad, Duarte, CA 91010-3000. FAX: 818-301-8448. ..l1:iutii'e Action/1qul' Opportumity Entployer

POSITIONS OPEN

POSTDOCTORAL POSITION available July 1,1995, for twro years, to studs molecular mechanisms ofinflammatory response, including regulation of induciblenitric oxide synthesis. Research funded by NIH traininggrant, including collaborations wvith Department of Sur-gerv. Applicant must have Ph.D. or M.D., with experi-ence in molecular biology highly preferred, and be a U.S.citizen or permanent resident. Send curriculum vitae andlist of three references to: Dr. Sidney Morris, Depart-ment of Molecular Genetics and Biochemistry,W1255 Biomedical Science Tower, University ofPittsburgh, Pittsburgh, PA 15261. FAX: 412-624-1401. A4i Equal OpyysrtunitylAtliroiiatii''.lctistui Eniployer.POSTDOCTORAL POSITION available innmmedi-

ately to study gltutamate-receptor ion channels avithpatch-clamp techniques. The current focus of the svork isoil determining the properties of recombinant channelsexpressed transiently or stably ill HEK 293 cells. We are

also interested in developmental changes in the propertiesof native channels. Send curriculum vitae and the names

of three references to: Dr. James Howe, Department ofPharmacology, Yale University School of Medicine,333 Cedar Street, New Haven, CT 06520-8066.

POSTDOCTORAL POSITIONS asailable immedi-ately. Experience in biochemical and molecular biologicaltechniques to work on glycoprotein hormones and mem-brane receptors. Experience in protein and/or carbohy-drate techniques desirable. Send curriculum vitae to: Dr.0. P. Bahl, Department of Biological Sciences, StateUniversity of New York at Buffalo, 347 Cooke Hall,Buffalo, NY 14260. StU'NY is a Equal OpportuniitylAflir-iati'e Actitii Employer.POSTDOCTORAL FELLOWSHIP POSITIONS

in Cell and Molecular Physiology and Biology at YaleUniversity School of Medicine. M.D.'s with prior trainingin Pediatrics/Internal Medicine or Ph.D.'s. Spectrum ofbasic science disciplines including Molecular and CellularNeurobiology, Epithelial Cell Biology and Immunobiol-ogy with 21 active faculty and labs. Special interests ill-clude mechanisms of cell death. Must be U.S. citizens/permanent residents. Please send curriculum vitae to:

Gabriel G. Haddad, M.D., Department of Pediatrics,Yale University School of Medicine, 333 CedarStreet, FMP 506, New Haven, CT 06520. Yal' iter-sity is anl Equal O)pportittity Aflirniaitii Actiont Ettipliytir.The Department of Pathologyi is seeking senior IN-

VESTIGATORS w ith established research programs.Areas of special interest are signal transduction, cell-cellinteraction and mammalian development. Substantialpackages whill be provided to start tip and sustain thelaboratories of successful candidates. Research space wvillbe in the nest Golding building, scheduled for comple-tion in the spring of 1996. Interested individuals shouldsend a curriculum vitae, names of three references and a

record of grant funding to: Dr. Michael B. Prystowsky,Chairman, Department of Pathology, Albert EinsteinCollege of Medicine, Jack and Pearl Resnick Campus,1300 Morris Park Avenue, Bronx, NY 10461. EqiialOpportiotity Eitiployer.MICROBIOLOGY POSITION available immediate-

lv to study, control of zebra mussels with microbial toxins.Girant-funded, one-year position. Minimum of M.S. in a

biological science and experience in microbiology. Publi-cations, grantxsriting, and histology experience a plus. Sal-ary starts at $24,000 and is commensurate svith experience.Submit curriculum vitae and three references to: Dr.Daniel P. Molloy, Biological Survey, New York StateMuseum, Field Research Laboratory, RD 1-Box 151,Cambridge, NY 12816. Equal ()ppirtitiity Ettilloy(r.

IN-HOUSE EDITORChemistry & Biology

(heliistry E-,, Biiliiy, the nevsest primary journal fromCurrent Biology Ltd, seeks a second In-house EDITORto join the friendly, enthusiastic team in oiir San Franciscooffice. Essential requirements: broad interest in science,preferably ssith a background in chemistry, biochemistryor molecular biology (Ph.D. preferred); excellent con-mand of the English language; ability to communicatecomplicated concepts to a sside audience; organizationand ability to svork to tight deadlinies Psthile maintaining a

sense of humor. To apply, Xsrite immediately to: RebeccaWard, Current Biology Ltd, 251 Hugo Street, SanFrancisco, CA 94122-2603. FAX: 415-566-4594.

SCIENCE * VOL. 268 * 9 JUNE 19951524

....................... .... ......... .......... ................. ... ....-...*.....-....... ....::

The excitemient of pharm-aceutical developmn-entbacked by $20 m-illion annually in R&DI..

...... ....... .............................. ....................................... ...... .. . .. .. ~~~~.............

:::::::. :B :::: :: w i.: .:::::.:::::.....................:.:t::::::::: I::::::::::::::::--::: ::-.wrnfs .

The fulfillment ofseeing your ideas happen. At Schering-Plough,we invest over $620 million annually to advance the processof discovery and development. To the dedicated professional,this means a greater opportunity to see your work extend andenhance lives the world over.

POSTDOCTORAL FELLOWSOur Pharmaceutical Sciences Group has immediate positions in thefollowing areas for talented individuals with excellent communica-tion and interpersonal skills plus a commitment to teamwork.

Formulation Research andDrug DeliveryYou will be part ofa professional team screening drug candidatesusing in vitrolin vivo techniques to assess drug permeability andidentify mechanisms associated with drug absorption and biologicalmembrane transport. To qualify, you will need to be an independentself-starter with a PhD in Pharmaceutical Sciences, Biophysics,Biochemistry, Pharmacology or a related discipline and 0-2 years

of experience with drug permeability studies. Background withCaco-2 cells a plus.

U s i n g S c i e n c e

Polymeric Drug Delivery SystemsYou will conduct research in the area of polymeric drug deliverysystems for a small molecular weight as well as macromolecularprotein drugs. To qualify, you will need a PhD in Chemistry,Chemical Engineering, Polymer Science or a related discipline anda strong background in the characterization of polymers as relatedto transport properties and drug delivery. Experience withbioerodible and biodegradable polymers a plus.

We offer an excellent compensation package including a competitivesalary and comprehensive benefits. For prompt, confidential consid-eration, we invite you to forward a resume indicating your positionof interest and salary requirements to: Human ResourcesDept. AV, Schering-Plough Research Institute, 2015 GallopingHill Road, Kenilworth, NJ 07003-0539. We are an equalopportunity employer. We regret we are unable to respond to each resume.

Only those selectedfor an interview will be contacted

Schering-PloughReeac Instrtute

F o r H u m a n A d v a n t a g e

Clnical ResearchFellow

Cato Research Ltd., a rapidly grow-ing clinical research organizationlocated in Research Triangle Park,NC, has an exciting opportunity for aself-starter with a scientific back-ground who wants to learn and growin a creative environment. TheClinical Research Fellow will receivetraining in the scientific, regulatory,medical and financial aspects of phar-maceutical development. The idealcandidate will possess the following:

. Ph.D. in biological sciences.

. Excellent written and verbal skills.v Initiative and strong interpersonal

skills.v Ability for critical and analytical

thinking.

CRL provides an opportunity for theright individual to become a part ofthe pharmaceutical drug developmentindustry. CRL offers personal andprofessional growth opportunities, a

competitive salary and an excellentbenefits package. For consideration,please send or FAX [(919) 361-22901a resume and writing sample to:DSISC, Cato Research Ltd., 4364S. Alston Ave., Suite 201, Durham,NC 27713-2280. No phone calls or

third party agencies, please. EOE.

DEAN OF THEGRADUATE SCHOOL OF

[iiBIOMEDICAL SCIENCESUnivcrsity of Texas Medical Branch At Galveston

The University of Texas Medical Branch (UTMB) at Galveston is seeking to fill the position ofDean of the Graduate School of Biomedical Sciences. The Graduate Dean has the responsibilityfor the management of graduate education at UTMB. This is done with the assistance of thestaff of the Graduate School and through interaction with the Executive Committee of theGraduate School, which includes the elected Directors of the various graduate programs.The Graduate Dean reports to the Vice President for Academic Affairs. The graduate facultynow numbers 267, and the graduate student body includes 124 Masters, 183 Ph.D., and 31M.D.-Ph.D. candidates.

Graduate degrees are offered at both the Masters and Ph.D. levels. In addition, there is an

active M.D.-Ph.D. program. The three graduate programs at the Masters level are in Nursing,Allied Health and Medical Science. The nine Ph.D. programs are in Cell Biology, CellularPhysiology and Molecular Biophysics, Human Biological Chemistry and Genetics, MedicalHumanities, Microbiology and Immunology, Neuroscience, Experimental Pathology,Pharmacology and Toxicology, and Preventive Medicine and Community Health. A doctoralprogram in Nursing has been approved by the University of Texas and is under review by theTexas Coordinating Board for Higher Education.

Applicants should have a Ph.D. degree or an equivalent advanced research degree, a distin-guished record in science and a demonstrated ability in administration. They should be qualifiedfor a position as tenured full Professor in one of the Departments at UTMB. Criteria for selectionwill include a commitment to the development of the careers of the graduate students, advocacyfor a variety of types of research, including both basic and clinical research, skill in promotingresearch collaborations and multidisciplinary programs, a willingness to foster the support ofalumni and other potential benefactors of graduate education, and such personal qualities as

integrity and vision.

Applicants should send a detailed curriculum vitae and bibliography to Wm. D. Willis, Jr.,M.D., Ph.D., Chairman of the Search Committee for Graduate Dean, Department of

Anatomy and Neurosciences and Marine Biomedical Institute, UTMB, Galveston,Texas 77555-1069. Fax (409) 772-4687; E Mail WDW@MBIAN.UTMB.EDU.

UTMB is an equal opportunity/affirmative action employer m/f/d/v.UTMB hires only individuals authorized to work in the United States.

Innovative research at Sandoz has been enhancing medicine around the world over a century. Pioneering drugs have extended and improved thequality of life for countless individuals and revolutionized basic scientific concepts within the transplantation and mental health fields. Our developmentsare the result of research conducted by professionals who specialize in many different fields. We currently have openings for scientists in our Oncologyand Metabolic Diseases Departments.

FELLOW-TUMOR BIOLOGYThe successful candidate will be responsible for supervisingin vivo screening and testing for a large preclinical oncolo yresearch program. Duties will include supervision of MTDanti-tumor efficacy and pharmacological analysis of novelanti-tumor agents in nude mouse human tumor xenograft,angiogenesis and metastasis models. Responsibilities willalso include development of new in vivo models for the studyof efficacy and mechanism of action of novel agents.Candidates should have a Ph.D. with at least 10 years of rel-evant experience in the areas of in vivo tumor biology andpharmacology. Direct and supervisory experience with awide variety of human tumor xenograft models is required.Candidates should also have significant experience in thearea of preclinical drug development. (Position #3355)

ASSOCIATE FELLOW-METABOLIC DISEASESThis position requires an in vivo physiologist to run a pharma-cology laboratory in metabolic disease research. The incum-bent will supervise 2-4 scientists and take responsibility fordrug discovery, preclinical development and basic research incarbohydrate and lipid metabolism. This will include workingwith a multidisciplinary team of scientists to profile develop-ment compounds, optimize in vivo modeling for metabolic dis-eases an identify new therapeutic targets.A Ph.D. or equivalent in physiology, endocrinology, pharmacol-ogy or a related field and extensive knowledge o carbohydrateand lipid metabolism, and disorders thereof, are required. Thechosen candidate must also have extensive experience with invivo experimentation and data interpretation. Good communi-cation skills and demonstration of creative scientific thinking asevidenced by relevant scientific publications are also required.(Position #3320)

Sandoz offers comprehensive health, dental and savings plans as well as an attractive location in northern New Jersey. For consideration, please speci-fy the number of the position you are responding to and forward your curriculum vitae and the names and addresses of three references to:

SANDOZ PHARMACEUTICALS CORPStaffing Department

Building 122/3East Hanover, NJ 07936

An Equal Opportunity Employer M/F/D/V

Department of Bin and Coitw Sdenceand the Center for Leaming and MemoryCandidates are sought for a tenuretrack faculty position at the level ofAssistant Professor.We are particularlyinterested in individuals who applymolecular, cellular, and genetic approachesto the analysis of the function anddevelopment of the nervous system.The position will require a strongresearch program and a commitmentto excellence in education at the under-graduate and graduate levels.There is anopportunity for a joint appointment inthe Department of Biology.

Applicants should submit a brief coverletter stating research and teachinginterests, a curriculum vitae, andthree letters of recommendation.Representative reprints may beincluded. Send applications to:Chair, Neurobiology SearchCommittee, Dept. of Brain andCognitive Sciences, E25-406,MIT, 77 Massachusetts Avenue,Cambridge, MA 02139-4307.

MIT is an Equal Opportunky/Affirmative Action EmployerMIT is a non-smoking environment

A SANDOZbringing research to life

DIRECTORMolecular DiagnosisThe Department of Pathology and LaboratoryMedicine at the University of Pennsylvaniainvites applications for a clinician-educator trackposition, at the Assistant/Associate Professorlevel, as Director of the Molecular DiagnosisSection in the Division of Laboratory Medicinebeginning no later than July 1, 1996. Thecandidate must hold M.D. and/or Ph.D degreesand preferably be board eligible or boardcertified in Clinical Pathology, AnatomicPathology, Pediatrics or Internal Medicine. Thesuccessful applicant will have a background inmolecular biology and will direct and expand abroad, active program with current strengths inthe genetic diagnosis of cystic fibrosis andneurological disorders, and in the moleculardiagnosis of hematological neoplasia. Theapplicant will also be expected to participate inthe development of a clinical research programin either molecular oncology or human genetics.The environment for collaborative researchwithin the Department and at the University ofPennsylvania is outstanding, including thepresence of the Human Genome Center and theInstitute for Human Gene Therapy. Curriculumvitae, a statement describing previousexperience, and the names of three referencesshould be submitted by September 1, 1995 to:Dr. Steven Spitalnik, Chairman of the SearchCommittee, Department of Pathology andLaboratory Medicine, University ofPennsylvania, 220 John Morgan Bldg.,Philadelphia, PA 19104-6082.

The University ofPennsyllvania is anAffirmative Action/Equal OpportunityEmploy er. Womenand minorities areencouraged to apply,

'ns Ut'

TENURE-TRACK POSITION INOPHTHALMIC RESEARCH

University of MissouriCollege of Veterinary Medicine

The University of Missouri College of Veteri-nary Medicine invites applications for a full-time, tenure-track position at either the assistantor associate professor level with major respon-sibilities in ophthalmic research.The candidate will be expected to develop, incollaboration with existing faculty, an originalresearch program in comparative ophthalmol-ogy. Qualifications include a D.V.M., M.D.,and/or Ph.D., and the ability to develop anindependent and extramurally-funded researchprogram. Expertise in immunologic mecha-nisms and/or infectious ocular diseases is pre-ferred, but individuals with strong research pro-grams in other areas are also encouraged toapply. Depending on the qualifications of theapplicant, the position will be assigned to eitherthe Department of Veterinary Pathobiology orthe Department of Veterinary Biomedical Sci-ences of the College of Veterinary Medicine.Candidates should send a curriculum vitae, aletter describing their research interests, andnames of three references to:

Dr. Mark P. NasisseVeterinary Medical Teaching Hospital

College of Veterinary MedicineUniversity of Missouri379 E. Campus DriveColumbia, MO 65211

Deadline for applications is August 1, 1995.The University of Missouri is an Equal Oppor-tunity/ADA Institution.

1

1111

At Amgen, you'll discover a research environment that emphasizescollaboration, intellectual honesty, scientific integrity, and a supportiveculture. This unique approach has helped us grow into a globalbiotechnology leader in just fifteen years. We currently seek a ResearchAutomation Manager for our Southern California headquarters.

As head of our Research Automation Group, this individual will defineautomation opportunities, implement solutions, evaluate technology,and manage collaborations with vendors and consultants. Candidatesmust have a Ph.D. in the Physical or Life Sciences and experience indeveloping and implementing laboratory automation/robotics. Excellentmanagement and written/verbal communication skills are essential.

At Amgen, you'll find our approach to scientific research as rewarding as

it is effective. We offer a highly competitive compensation and benefitspackage that includes a retirement and savings plan, an on-site fitnesscenter, and three weeks' vacation. Please mail or fax your resume/c.v. to:

Amgen, Staffing, Job Code: OXP-SC-2609, Amgen Center, ThousandOaks, CA 91320-1789. Fax: (805) 499-9981. Principals only, please.EEO-Affirmative Action Employer M/F/D/V. We recognize thatdiverse perspectives are a key factor in the process of discovery.

AMOEN®

CHANGING THEPRACTICE OF MEDICINE

THROUGH MOLECIIAR BIOLOGY.

INCYTE PHARMACEUTICALS is an energetic, entrepreneurialbiotech company applying the tools of computer science to high-throughput cDNA sequencing, bioinformatics, and gene discovery.We offer the following opportunities to join us in the developmentand commercialization of our comprehensive genomic database.

DIRECTOR OF BIOINFORMATICSPh.D. scientist in either Computer Science or Molecular Biology witha broad background in Computational Biology. Must have 3-5 years'experience in applied computational biology or bioinformatics andextensive experience in scientific management. You will head a

world-class bioinformatics group of 25 to 30 people initially, withconsiderable growth potential. Reference DB

DIRECTOR OF SEQUENCING OPERATIONSExperienced manager with strong background in cDNA sequencingand related technologies. Ph.D. scientist or engineer familiar withstate-of-the-art robotics preferred. Candidate must demonstrate abil-ity to lead a large group of scientists in a production-oriented, high-throughput environment using strong management and motivationskills. Ref. DSO

GROUP LEADER, SOFTWARE DEVELOPMENTExperienced manager with background in Computer Science andProgramming in mixed UNIX/Mac/PC environment. Preference willbe given to those experienced in computational biology and/or da-tabases. Will lead a team of programmers in developing relationalbiotechnology database interfaces and automated entry, search andretrieval projects. Ref. GSD

DATABASE MANAGERExperienced manager with strong background in Computer Science

and relational databases to be responsible for a large database ofgenomic information and its linkages to various national and inter-national databases. Will require interaction with and support for in-house scientists in addition to staffing a product development groupand its external pharmaceutical industrial customers. Backgroundin biological applications or biotechnology desired. Ref. DM

GROUP LEADER, MOLECULAR ANALYSISPh.D. Computational Biologist with strong background in proteinbiology and genetics. Will lead a team of scientists involved in queryand analysis of large databases of cDNA, genomic sequence andinter-database search and retrieval software. Ref. GMA

SCIENTISTPh.D. Molecular Biologist with strong background in cDNA sequenc-ing and genomics and the management skills necessary for facilita-tion of operational and supervisory issues for the Sequencing group.Ref. SMB

Incyte offers a premier R&D facility in the foothills of Palo Alto, Cali-fornia, along with competitive salaries, an outstanding benefits pack-age, and significant opportunities for professional growth. Mail/faxyour resume to Incyte Pharmaceuticals, Inc., Attn: KRH/Ref.3330 Hiliview Ave., Palo Alto, CA 94304, FAX 415/852-0195. EOE.

N C Y T EP H A R M A C E U T C A l S. N C.

The Department ofMicrobiology and Molecular Geneticsand the Department of Medicine at the University ofCalifornia, Irvine are jointly seeking applicants for facultypositions at the Assistant or Associate Professor level,depending upon qualifications. As part of our ongoingeffort to expand our program in molecular pathogenesis,we are soliciting applicants who have demonstrated supe-rior talent and productivity in the area ofmolecular mecha-nisms of microbial pathogenesis. His/her previous workshould have been judged by peer review to have beenscientifically rigorous and clinically relevant, and he/sheshould have been successful in obtaining sufficient fundsfrom peer-reviewed grants to support these efforts. Thelatter can include postdoctoral fellowship support for As-sistant Professor candidates.Candidates must have an M.D.JPlh.D. or M.D., and boardeligibility in Infectious Diseases is required. The success-ful candidate will be expected to participate in teaching andrcsearch conferences in both departments.Please send curriculum vitae, summary of research inter-ests and three letters of reference to:

Dr. Rozanne M. Sandri-GoldinSearch Committee Chair

Department of Microbiology and Molecular GeneticsCollege of Medicine

University of CaliforniaIrvine, CA 92717-4025

The University ofCalifornia at Inrine is an equal opportu-nity/affirnative action employer. Women and minoritiesare encouraged to apply. .

a a

9'KX d

M5

ASTRA MERCK

At Astra Merck, Inc., we've put our heads and minds into a new kind ofca n.We are a customer-focused, technologically-enabled business organization hatmarkets pharmaceutical products and services to identified managed care systems,hospital buying groups and other defined market segments.

REGULATORY PROJECT MANAGERPRECLINICAL

Under the guidance of the Director, Preclinical Evaluation and the Director, RegulatoryOperations for Astra Merck, Inc., the Regulatory Project Manager - Preclinical plays a role in new

:,product development by providing timely and critical reviews of GLP preclinical toxicology studyreports. These reviews are used to evaluate new product candidates and to identify strengths and

: weaknesses within a preclinical program. The Regulatory Project Manager also prepares summary::-.-.documents in support of preclinical IND and NDA submissions to the FDA, and assists Regulatory.-A'ffairs staff in responding to AMI and FDA requests concerning Preclinical data. The incumbent

works with the Directors to maintain an updated database of preclinical program issues. In.....tion, the incumbent contributes to the collection, review, writing, editing, and assembly of

U.st.a/.documents for regulatory submissions used to support ongoing clinical programs.Qualifications include a Ph.D. in Toxicology, Pharmacology or a related discipline and at least

wo y"ears of relevant, postdoctoral experience in the pharmaceutical industry. The successful.nd.i wlhave proven experience in evaluating GLP preclinical toxicology, toxicokinetic and

*''pharma."lo'''studies, and be able to effectively communicate this information to multi-disciplinary............. ..........

..m........... ........... .ing of the regulatory requirements for preclinical studies used in INDs and. 'D~- s desiral, a Is ki owledge of the drug development process.We.... o ...dershighl betitive compensactivlommniandtenefitspack rage. nI teres ltedcadidcpiates

Anhould'forw d r o fwthe re'ul rquirementsto:A straM erck,Inc.,Human Resources*D-PM '2 '.'.'D'tsrro~ Wa'e 'A 1'90.87. We are an equal opportunity/affirmatIve

l

A STAFF SCIENTISTposition for a U.S. citizen is avail-able to study osmotic regulation ofgene expression in eukaryotic cells.The candidate should have a Ph.D.and a strong publication record onthe physiology of volume regulatorymechanisms. The position alsorequires more than 5 years post-doctoral experience in molecularbiology techniques including:cDNA and genomic cloning, se-quencing, RNA and PCR technolo-gies, and reporter gene expressionsystems.

Qualified candidates should sendcurriculum vitae and names andaddresses of three references to:

Dr. Arlyn Garcia-PerezLaboratory of Kidney &Electrolyte Metabolism

NHLBINational Institutes of Health

Building 10, Room 6N30710 CENTER DR MSC 1598Bethesda MD 20892-1598

Phone: 301-496-1559Fax: 301-402-1443

Applications must be received byJuly 2, 1995

NIH is an Equal Opportunity Employer

SENIOR CELL BIOLOGISTPRIZM Pharmaceuticals, Inc., is a private companyengaged in the development of theropeutic productsbased on the regulation of growth factors and theirreceptors.

The scientistwe seek must be prepared with a strongscientific background in oncology, growth factors, or

cell signoling to apply significant expertise in cell bi-ology to drug discovery and mechonism-bosed ques-tions. The successful candidate will lead a groupchargedwith designing and implementing microplote-bosed ossays to support discovery and optimizationof lead therapeutic candidates, in addition to investi-gating the cellular mechanism of action of moleculesaimed at diverse molecular torgets. Qualified condi-dates should have 8 to 10 years of postdoctorol ex-

perience. Phormoceuticol or biotechnology experi-ence and additional expertise in receptorAigond in-teroacions and high-throughput screening ore pre-ferred.Moose send your cv. to: PRIZM Pharmaceutical,Inc., Humon Resources, 11035 Roselle Street, SonDiego, CA 92121, FAX 619/625-0050. An equalopportunity employer.

Fa F I Z MPH AR MACE UTI CAL S

HERPETOLOGISTA 12 month/year, tenure track, Assistant Profes-sorship, jointly appointed with the College ofAgriculture and Life Sciences and the TexasAgricultural Experiment Station, to begin Janu-ary 1996, or later. Ph.D. required to teach under-graduate and graduate courses in herpetology,advise students, develop a research program andserve as Curator or Herpetology for the TexasCooperative Wildlife Collections. Letters ofApplication, including teaching and researchgoals; curriculum vitae and names of three refer-ences will be accepted by: Dr. John D.McEachran, Search Committee Chair, De-partment of Wildlife and Fisheries Sciences,Texas A&M University, College Station, TX77843-2258, Phone: (409) 845-5777 by Sep-tember 15, 1995, or until position is filled.

CAESAR KLEBERG CHAIRIN WILDLIFE ECOLOGY

A 12-month/year, tenurable position, jointly ap-pointed with the College of Agriculture and LifeSciences and the Texas Agricultural ExperimentStation, as Professor and Caesar Kleberg Chair inWildlife Ecology beginning January 1996, or

later. Requirements include a Ph.D., 10 yearspost-doctoral experience, an appropriate publi-cation and grantsmanship record, teaching expe-rience, and a strong commitment to an academicprogram integrating theoretical and applied as-

pects of ecology, conservation, and manage-ment. Letters of application, curriculum vitae,statements of teaching philosophy and researchinterests, and the names of three references willbe accepted by: Dr. Nova J. Silvy, DepartmentofWildlifeandFisheries Sciences,TexasA&MUniversity, College Station, TX 77843-2258,Phone (409) 845-0598, by 1 October 1995, or

until position is filled.

Texas A&M University is an affirmative action!equal opportunity employer and welcomes ap-plicationsfrom women and minority candidates.

LEHIGH UNIVERSITYHOWARD HUGHES

UNDERGRADUATE PROGRAMLECTURER

A three year position supported by a HowardHughes Medical Institute Grant to Lehigh Uni-versity to develop additional instructional andresearch opportunities for undergraduates inthe biomedical sciences is available immedi-ately to provide teaching support for under-graduate laboratories in the biological sciencesin cooperation with department faculty. TheHoward Hughes lecturer will assist in the de-sign and implementation of new laboratorymodules and undergraduate laboratories whichsupport programs in molecular biology, biol-ogy, behavioral neuroscience, and biochemis-try. Opportunities exist to perform researchwith undergraduates in these programs and to

develop proposals forextramural fundingbasedon these educational initiatives.

Applicants should have a Ph.D. and a keeninterest in teaching at the undergraduate level.Preference will be given to individuals withprior instructional experience. Individuals witha background in computer-assisted applica-tions in laboratory instruction are particularlyencouraged to apply. Applications fromwomenand underrepresented groups are invited. For-ward aCV and the names ofthree references to:

Howard Hughes ProgramLecturer Search Committeec/o Department of Molecular BiologyLehigh UniversityB217 lacocca Hall, 111 Research DriveBethlehem, PA 18015

Lehigh University is an Affirmative Action/Equal Opportunity Employer.

- lm

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i

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i1

3 Postdoctoral Opportunities

DuPont Ag Products is pleased to announce its newPostdoctoral Fellowship Program. We are seekinghighly motivated and creative scientists to work withmembers of our staff on basic problems of fundamen-tal importance to crop protection discovery research.The program has three immediate openings:1) You will join a team in our Insect Biochemistry andPhysiology Group involved in an ongoing effort todevelop and characterize transgenic cells for use as

tools in our insect discovery efforts. We are seekingcandidates with a strong background in molecularbiology, biochemistry and insect physiology.2) A position is open for an enzymologist to join a

research team working on new approaches for control-ling plant diseases. Your efforts will focus on thediscovery and characterization of fungal enzymes thatmay serve as good targets for inhibitor discovery. Asolid background in biochemistry will be required todetermine catalytic mechanisms and to interact withenzymologists, geneticists, molecularbiologists, chem-ists, and X-ray crystallographers. Molecular biologyexperience is desirable.3) You will join our ongoing effort to understandenzyme catalytic mechanisms. This project involvesthe construction of site-directed mutants and charac-terization of altered enzymes. Plans for this effort are

based on crystallographic studies of enzyme activesites. The successful candidate must have researchexperience in mechanistic enzymology and an excel-lent understanding of biochemistry. Knowledge ofmolecular biology techniques will be an advantage.The Fellowship Program offers acomprehensive pack-age including a novel and exciting training environ-ment, competitive salaries and medical benefits. Weare located in Newark, DE, in close proximity to theUniversity of Delaware, an area that offers an attrac-tive lifestyle with easy access to all the cultural,academic and recreational activities of the easternSeaboard. Additional positions are expected to be-come available in early 1996. To be considered for theabove positions, please forward your resume and a listof references to:

Human ResourcesAttn: Postdoctoral Program

P.O. Box 30Newark, DE 19714-0030

rUU PONI Agricultural Products

DUPONT IS ANEQUAL OPPORTUNITY EMPLOYER

AMERICAN MUSEUM OF NATURAL HISTORYPROGRAM OFFICER

CENTER FOR BIODIVERSITY AND CONSERVATION

The Center for Biodiversity and Conservation ofthe American Museum ofNatural History (AMNH), seeks a Program Officer with training andexperience in conservation biology and biodiversity to complement theextensive research strengths of the Museum in systematics. The ProgramOfficer will build a strong collaborative research program with AMNHcurators and external environmental organizations.Candidates must have the Ph.D. or MS degree in a biodiversity-relatedscience and should have a deep understanding of conservation biology,systematic biology and recognition in research related to these fields.Applicants must have excellent writing and oral communication skills anda demonstrated ability to raise funds for research. Those with interest andexperience in integrating science and policy, knowledge ofenvironmentalorganizations, and leadership of projects involving diverse collaboratorsare particularly encouraged to apply.The Program Officer, together with the Center Director and AMNHcurators, will plan and coordinate a national and international program ofbiodiversity research. In addition, the successful candidate will be ex-pected to provide scientific support for and assist in policy and educationprojects ofthe Center. Depending on candidate qualifications, a portion ofthe Program Officer's time may be devoted to research.The American Museum of Natural History has for 125 years promoted anunderstanding and appreciation of the natural world. It houses the largestnatural history library in the western hemisphere as well as a collection ofover 30 million specimens and artifacts. The institution sponsors over 200curators, scientific support staff, doctoral students, and postdoctoral fel-lows, most of whom conduct research in biodiversity.Applications, including a current curriculum vitae, a narrative statement ofprogram interests, salary requirements and the names, phone and faxnumbers, addresses and e-mail of three references should be sent to:

Francesca T. Grifo, DirectorCenter for Biodiversity and ConservationAmerican Museum of Natural History

Central Park West at 79th StreetNYC, NY 10024

Applications must be received by July 20,1995.

ASSOCIATE DIRECTOR BIOMEDICAL TECHNOLOGYNATIONAL CENTER FOR RESEARCH RESOURCES

NATIONAL INSTITUTES OF HEALTHThe National Center for Research Resources (NCRR) is seeking appli-cants for the position of Associate Director Biomedical Technology,National Center for Research Resources. This position is located inBethesda, Maryland, and is a permanent full-time position with a salaryrange of $92,900 to $115,700 per annum (plus 4.23% locality) commensu-rate with qualifications. Physicians may be eligible for PhysiciansComparability Allowance ranging from $5,000 to $20,000 per year.A recruitment bonus of up to 25 percent of base pay may be available to anon-federal selectee for this position.A relocation bonus of up to 25 percent of base pay (subject to approval)may be available to a permanent Federal employee who must relocate toaccept this position.A one year probationary period must be served by the individual selectedif not currently or previously in the Senior Executive Service.The Associate Director Biomedical Technology, NCRR serves as a trans-NCRR coordinator for biomedical technology, including bioengineering.He/She integrates the research activities of the extramural Biotechnologyarea with the intramural Biomedical Engineering area and assists in set-ting priorities for all NCRR biomedical technology and bioengineeringactivities. Biomedical technology spans resources for molecular and cel-lular structure and function, knowledge engineering, and information tech-nology in medicine as well as biocomputing and biomedical engineering.Biomedical technology also includes shared instrumentation, marinebiotechnology, and generic technology development for biomedicalresearch. Applicants for this Senior Executive Service position must havea Doctor of Medicine or Ph.D. in Biomedical Engineering or one of thehealth sciences (or equivalent combination of experience and training).Send applications to:

Ms. Pathenia Wiggins, National Institutes of HealthNational Center for Research Resources (NCRR)

9000 Rockville Pike, Building 31, Room 3B38Bethesda, MD 20892

For application forms and a copy of the requirements, contact Ms. Wigginsat NCRR on (301) 496-1524. Deadline for applications is August 14,1995.

The NIH is an Equal Opportunity Employer

1

THE RICHARD STOCKTON COLLEGEOF NEW JERSEY

Research Fellow The Richard Stockton College of New Jersey seeks to fill the following

1Pltharmacologist vacancies. All positions are for the FALL 1995 semester.

v R . _ . . ~~~~~~EUKARYOTICMOLECULARBIOLOGY/BIOTECHNOLOGY:Cardlovascular B ologyTenure Track Assistant Professor of Biology. Doctorate required, post-

doctoral experience helpful. Teaching includes Genetics, advanced

Rh6ne-Poulenc Rorer Research & Development, animal ormedical MolecularBiology, introductory Biology and General

a world leader in pharmaceutical research, has Studies courses. Supervise student research.

an opportunity available in the Cardiovascular BIOCHEMISTRY: One-year, Visiting Assistant Professor of Chem-

Biology Department of our Collegeville, istry. Doctorate required, post-doctoral experience helpful. Teaching

sPennsylvania research site. includes General andlor Organic Chemistry, Biochemistry and a course

for non-science students.The successful candidate will design, conduct, and ANATOMY FOR HEALTH PROFESSIONS: One-year, Visitinginterpret laboratory experiments; supervise other Assistant Professor (Doctorate) or Instructor of Biology (active ABD).scientists and direct ongoing programs; and devel- Teaching includes Human Anatomy, Functional Anatomy and courses in

op new ideas for research programs. To qualify, you Introductory Biology and General Studies; Familiarity with computershould have a Ph.D. in Biochemistry, Pharmacology, applications to anatomy teaching and research desirable.

i;and up to 7 years experience in an academic or | | | ECOLOGY: One-year, Half-time Visiting Assistant Professor(Doctor-

ate) or Instructor (active ABD) of Environmental Studies. Teaching

base and technical ability in a variety of in vitro bio includes participation in Ecological Principles and advanced course inchemistry and cell culture assays pertinent to evrnetlbooy ~.mcoilgautcbooy idieoatherothrombosis drug discovery research required. environmental biology, e.g. microbiology, aquatic biology, wildlife or

conservation biology.

Rh6ne-Poulenc Rorer offers a highly competitive All positions require excellence in, and commitment to, undergraduatesalary, excellent benefits, a challenging work envi- teaching. Stockton College is recognized for its rich cultural diversity

ronment, and opportunities for advancement. among the faculty, staff and student body.Qualified candidates should send their resumeincluding salry requirements to: Rh6ne-Poulenc SALARY: $30,529-$38,799 ($15,265-$19,400, half-time), may be

Rore&D elpment, P.O. Box 1200, Mail higher depending on qualifications, experience and increases in the

appropriately established compensation plan. Screening begins June 30,

_6-0107. Equal Opportunity Employer, MiF/DN recommendation

_0107. Equal Opportunity Employer, M/IF/DN. and evidence of completion orexpected date of completion of Doctorate

......-ssss .;-; 0to Dr. Barbara Byrne, Dean, Natural Sciences and Mathematics, TheI: >.:::7::::::::s------------ ....: ..:: .::::::

Richard Stockton College of New Jersey, AA29, Pomona, NJ 08240-

0195. Stockton is an AA/EOE. Women and minorities are encouragedRHONEPOULENCRORER to apply. R504444

Applications and nominations are invited for the position of GLOBAL CAREER OPPORTUNITIES_V'IVl ,rln ll W r Ad TW Brt-1r-XTD~L- END1r f-t-l D A 1D A W1T1VDIRECTOR, UC lDAV IS LIEANTEK AUKIUUMrAKAVivMEDICINE, a new joint venture of the School of VeterinaryMedicine and the School of Medicine of the University of Califor-

nia, Davis. The Director will hold a joint administrative and

professorial appointment in an appropriate department.The Center is a cooperative program between the School of

Medicine and the School of Veterinary Medicine to establish a

multidisciplinary research effort to study comparative biologicalmodels that might elucidate the mechanisms, prevention and/or

treatment of chronic human diseases. The Center will be housed

in a new 21,000 sq. ft. facility, to be located adjacent to the

California Regional Primate Research Center; design of the facil-

ity has been completed and it will be occupied by Fall 1997. When

fully staffed, the Center will house at least eight principal inves-

tigators, along with commensurate staff postdoctoral fellows and

graduate students.

Candidates must have [1] DVM, MD and/or PhD degree [2] a

broad understanding of modern biomedical science; [3] demon-

strated administrative/leadership skills; [4] an active and distin-

guished research record in the use of comparative biologicalmodels that elucidate the mechanisms, prevention and/or treat-

ment of chronic human diseases; [5) demonstrated excellence in

teaching; [6] anationally recognized reputation for career achieve-

ment and leadership; and [7] experience in the acquisition of

extramural funding and a commitment to work in securing addi-

tional funding for the programs of the Center.

Applicants should submit a letter of interest, a curriculum vitae

and the names and addresses of three professional references to

Jean A. Kevern, Personnel Officer, School of Veterinary Medi-

cine, University ofCalifornia, Davis,CA 95616-8734 [telephone:916 752-1384; fax: 916 752-2801]. Nominations should be sent

to the same address. Applications will be accepted until an

individual has been selected. The University of California, Davis

is an affirmative action/equal opportunity employer.

The Biochemistry Department of the University ofZurich invites applications for an

Assistant Professorin

Computational Protein Engineering

Excellent opportunities for collaboration in all as-pects ofprotein biochemistry exist in the departmentand the University, with Macromolecular Recogni-tion defined as an area of future growth.Please submit applications by July 1st to the Dean ofthe Faculty of Science, Prof. Hanns Fischer,Universitat Zurich, Winterthurerstr. 190, CH-8057Zurich, Switzerland. The position is funded by theSwiss Federal Program for Young Scientists, lim-ited to 5 years and restricted to Swiss citizens orinternational candidates with a degree from a Swissacademic institution.For further information, contact Prof. A. Pluckthun,phone (+41-1) 257 5570, FAX (+41-1) 257 5712.

GLOBAL CAREER OPPORTUNITIES

_____________________________________________________________________________ .1~~~~~~~~~~~~~~~~

GLOBAL CAREER OPPORTUNITIES

DIVISION of BIOLOGICAL SCIENCES Th

PROFESSOR OF MOLECULAR FaBIOLOGY AND DIRECTOR OF

THE CENTRE FOR GENOMERESEARCH Moles

Applications arc invited for the established Chair oflMolecular Biology at the University oF Edinburgh,

previously held by Professor Sir Kenneth Murray FRS(currently Bliogen Research 1)rotessor). The Protessor Plant Pathology

sill also be appointed l)irector of the Ccntre for dates should be,

Genome Research (CGR). lar plant patholoThe CCR is an Interdisciplinary Research Centre

tunde(l by BBIISRC to address Fundamental questionsin mammalian biology transgenic embryo expected to partistem cell methods. Excellent research axcilities are undergraduate a

available, man is expecte

Candidates should have top quality researchstanein ngmandisgeonetein an area of work related to rthes erchstanding pending on thet

foresight an'1 abilitv to lead a strong programme. It is position will beinten(le(l to till the post from ured.

1 January 1996. The post is tenured and salary willbe on the 1'rofessorial scale. Candidates sho

Please quote REF: SCI 590243. statement of res

For informal enquiries, please phone Professor term goals), a

W. C. Hill (+44(0)131 650-5525 or Fax -6556), or key publicationProfessor A. ' lfird (-5670) or

I)r M L Hooper (-5828). DekanderPhilFurther particulars including details of the H. Fischer, Wi

application procedure should be obtained from Switzerland.

THE PERSONNEL OFFICE,THE UNIVERSITY OF EDINBURGH, Applications wi

I ROXBURGH STREET, EDINBURGH EH8 9TB mal inquiries ccorTEL: 0131 -650-2511 to the Executiv

(24 hour answering service). ogy, Dr.

Closing (ate: 7 July 1995.

National Institute of Allergy andInfectious DiseasesNational Institutes of Health

PROTEIN X-RAYCRYSTALLOGRAPHERSA tenure-track position with intramuralfunding is available to conduct anoriginal research program and tointeract with other scientists within theNIH intramural program. Ph.D. orM.D. applicants should have a recordof achievement in solving proteinstructures by X-ray crystallography.Salary commensurate wtih creden-tials and research experience.

Qualified and interested candidatesshould send curriculum vitae includ-ing names and addresses of threereferences to:

John E. Coligan, Ph.D., ChiefLaboratory of Molecular Structure

NIAIDINIHTwinbrook II, Room 10312441 Parklawn Drive

Rockville, MD 20852-8190Announcement No. PA-17

Phone: 301-496-3213Fax: 301-402-0284

U.S. Citizenship not required.NIH is an Equal Opportunity Employer

THIS IS A SECOND ANNOUNCEMENT

U.S. - ISRAEL BINATIONAL SCIENCE FOUNDATIONEXECUTIVE DIRECTOR

The U.S.- Israel Binational Science Foundation (BSF) was established in 1972 to supportcooperative science research projects between U.S. and Israeli scientists. Research projects arefunded from the interest on an endowment established in equal shares by the two Governments.The office of the BSF is in Jerusalem.According to this 1972 agreement signed by the two Governments, the Board states thefollowing regulations:(a) "The Executive Director shall be the chief executive officer of the Foundation. He

shall be responsible for the operations and staffing of the Foundation. He shall set inaccordance with the policies, directives and delegations of the Board.

(b) The Executive Director shall be a person of outstanding ability, prominent in thescientific and administration field. He shall be appointed by the Board of Governorsunder a contract not exceeding three years with such compensation and under suchterms and conditions as may be determined by the Board of Governors."

The candidate for Executive Director must be well acquainted with the Israeli and U.S.academic research systems and the usual proposal review procedures. He or she should have aproven scientific record, as well as administrative experience in the management of scientificresearch programs.Curriculum vitae and letters of interest should be submitted by August 1, in the followingmanner:

U.S. applicants should send their material to:Dr. Marcel Bardon, DirectorInternational ProgramsNational Science FoundationArlington, VA 22230Israeli applicants should send their material to:Mr. Amnon Einav, Chief ScientistMinistry of Energy and Infrastructure234 Jaffa RoadJerusalem, Israel

Applicants should be able to assume BSF responsibilities as soon as possible, but no later thanFebruary 1, 1996.

e University of Zurich (Switzerland),culty of Sciences, invites applications for a

Professorship incular Plant Pathology

invited for a Professorship in Molecularat the Institute of Plant Biology. Candi-actively engaged in research of molecu-gy and have an established internationalesearch in this field. The candidate isicipate in the curriculum ofbiology at theand graduate level. Proficiency in Ger-d to be acquired within two years. De-jualification and age of the applicant, thetenurable (Assistant Professor) or ten-

)uld submit a curriculum vitae, a brief;earch interests (including short and longist of publications, copies of five recentIs and three potential referees to:

losophischen Fakulthit II, Professor Dr.'interthurerstr. 190, CH-8057 Zurich,

ill be accepted until July 31, 1995. Infor-oncerning the position may be addressed,e Director of the Institute of Plant Biol-F. Juttner (phone +1 715 2905, FAX

T1i 1 1J JviJJ

ANNUAL REPORT OFMIZUTANI FOUNDATIONRESEARCH GRANT FOR GLYCOSCIENCE (1995)

In 1994, Mizutani Foundation for Glycoscience received 231 research grant applications from 31countries. After a careful evaluation for scientific merit, potentiality and feasibility, the foundationselected 21 applications and awarded them a total of 100,000,000 yen. The winners of this year's grantsare (in alphabetical order):

1) Basu, Manju; University of Notre Dame,USA; "Studies on sialyl-Lewis x glycolipid inhuman neuroblastoma and colon carcinoma"2) Bergstrom, Tomas B.; University ofG6teborg, Sweden; "Hydrophobic interactionsin binding of herpes simplex virus glycoproteinC to the heparan sulfate receptor"3) Chatterjee, Subroto B.; Johns Hopkins Medi-cal Institutions, USA; "Effects of D-PDMP ongalactosyltransferase (GalT-2) and cell prolifera-tion"4) Dennis, James W.; Mount Sinai Hospital,Canada; "GlcNAc-transferase V in cancer anddevelopment"5) Drake, Richard R.; University of Arkansas forMedical Sciences, USA; "Biosynthesis ofheparan sulfate in human myeloma cells"6) Esko, Jeffrey D.; University of Alabama atBirmingham, USA; "Glycoside modulation ofglycosaminoglycan biosynthesis" *7) Feizi, Ten; MRC Glycosciences Laboratory,UK; "Sequences of the endogenous oligosaccha-ride ligands for rat L-selectin"8) Fernig, David G.; University of Liverpool,UK; "Mapping changes in heparan sulphateduring mammary gland development"9) Hart, Gerald W.; University of Alabama atBirmingham, USA; "Alzheimer' s disease andcytoplasmic glycosylation" *

10) Helenius, Ari; Yale University School ofMedicine, USA; "Are lectins involved inglicoprotein folding?"11) Kitajima, Ken; University of Tokyo,Japan; "Function of N-glycanase-catalyzed de-N-glycosylation of glicoproteins"

12) Laine, Roger A.; Louisiana State University& A&M College, USA; "Tandem mass spec-trometry of synthetic isomeric oligosaccharides"13) Ledeen, Robert W.; New Jersey MedicalSchool, USA; "Ganglioside as modulator of theexcitatory opioid receptor"14) Ley, Klaus F.; University of Virginia, USA;"Glycoprotein ligands for L-selectin expressedin microvascular endothelium"15) Li, Yu-Teh; Tulane University, School ofMedicine, USA; "Studies of a KDN-cleavingenzyme"16) Meldal, Morten; Carlsberg Laboratory,Denmark; "Glycopeptide libraries for theidentification of high affinity glycopeptideligands for carbohydrate binding proteins"17) Oriol, Rafael; Institut National de la Sante etde la Recherche Medicale, France; "Character-ization of defective adult and embryonicfucosyltransferase genes"18) Pizzo, Salvatore V.; Duke UniversityMedical Center, USA; "The role of plasminogencarbohydrate in regulating fibrinolysis"19) Reynolds, Colin D.; Liverpool John MooresUniversity, UK; "Biophysical and inhibitionstudies on lectins"20) Wieser, Raimund J.; University of Mainz,Germany; "Structural and functional character-ization of the contactinhibin N-glycans"21) Yamashita, Katsuko; Sasaki Institute,Japan; "Biochemical studies of carbohydrate-deficient glycoprotein syndrome"

*Approved for two years.

Alizutani Foundation for Glycoscience: Sen-i Kaikan, 3-1-11, Nihonbashi-honcho, Chuo-ku,Tokyo 103, Japan (Fax: [81] 3-3246-1265, Phone: [8113-3246-0224). The method of application forthe next year grant may be found in this journal 267, 2052 (1995).

GLOBAL CAREER OPPORTUNITIES

150)< + 3S0t~d~I Rt106

aPiXf )1*ti_; KW) i~9fL-W

TEL : 886-35-7151 31 its 3478FAX : 886-35-715934E-mail : Ishth~life.nthu.edu.tw

The University of Zurich (Switzerland),- >- Faculty of Sciences, invites applications for a

Professorship inDevelopmental Plant Biology

The Institute of Plant Biology invites applications for a Profes-sorship in Plant Development.We are seeking a scientist with aninternational reputation in a relevant field of DevelopmentalPlant Biology. The new professor is expected to establish aresearch group, to develop a strong research programme and toteach at undergraduate and graduate levels of the biologycurriculum. He is also expected to collaborate with existingresearch groups at the institute and other research groups ofdevelopmental biology at the University ofZurich. Proficiencyin German is expected to be acquired within two years.

Depending on the qualification and age of the applicant, theposition will be tenurable (Assistant Professor) or tenured.

Candidates should submit a curriculum vitae, a brief statementof research interests (including short and long term goals), a listof publications, copies of five recent key publications and threepotential referees to:Dekan der Philosophischen Fakultiit II, Professor Dr. H.Fischer, Winterthurerstr. 190, CH-8057 Zurich, Switzer-land.Applications will be accepted until July 31, 1995. Informalinquiries concerning the position may be addressed to theExecutive Director of the Institute of Plant Biology, Prof. Dr. F.Juttner (phone +1 715 2905, FAX +1 716 5165)

ffHZOZ9CH

The Laboratory of Behavioral Biology and Func-tional Toxicology is situated at the Institute of Toxi-cology, Swiss Federal Institute of Technology, near

Zurich, Switzerland.The Laboratory is concerned with research into brainmechanisms involved in attentional, learning, andmemory processes, the development of animal mod-els for psychiatric and neurological disorders, andmechanisms by which psychotropic drugs affect thesebehavioral processes/animal models.The Laboratory has vacancies for one Post-Doctoralposition and several positions for Ph.D. studentsavailable immediately in the above mentioned areas.

Experience in behavioral, neuroanatomical or endo-crinological techniques is preferred.The positions are available forthree years. The electedperson(s) will be expected to collaborate with othermembers in the laboratory. The salary will depend onage and experience. The starting date is negotiable.Please send two copies of your CV, including thenames and addresses of three references, to: Labora-tory of Behavioral Biology, Institute of Toxicology,Schorenstrasse 16, CH-8603 Schwerzenbach, Swit-zerland.

_~ X9 0N ZOWiiAQUATIC ECOLOGY POSTIONS IN SWITZERLAND

The Swiss Federal Institute for Environmental Science and Technology (EAWAG) is a research institutespecializing in basic and applied reserachk with water as the central focus. The EAWAG is part of thefederal university [Swiss Federal Insitute of Technology (ETH-Zurich)].The Limnology/Hydrobiology Department, one ofeleven departments oftheEAWAG, currently consistsof the professor and twelve staff scientists, plus their Ph.D. students and technicians. The following newpositions are part of an expansion that involves strengthenig stream/river ecologu, addina a littoral zone

perspective to lake research, and adding groundwater ecology as a subdiscipline of the department.1. STREAM/RIVER ECOLOGIST (research and teaching) - emphasis on invertebrates at population,community, ecosystems level(s).2. ECOLOGICAL GENETICIST-Aquatic Biota (research and teaching) - to investigate ecological/zoogeographic/evolutionary questions in fresh water systems using molecular techniques.3. RIPARIAN/WETLAND ECOLOGIST (research and teaching) - to investigate plant communitiesassociated with lotic ecosystems. Interest in restoration ecology desirable.4. LITTORAL ZONE ECOLOGIST (research) - to investigate littoral zone processes and littoral-pelagic coupling; macrophytes and/or Aufwuchs.5. POSTDOCTORAL ASSOCIATE: Stream/Groundwater Ecology- a 2 or 3-year position with theprofessor.6. PH.D. STUDENT POSITION: Stream/Groundwater Ecology - highly motivated students to conductreserach leading to the Ph.D. degree under the professor's supervision.Base salary with possibility of teachning supplement.REQUIREMENTS - Ph.D. degree in appropriate field (except position 6), postdoctoral experiencepreferred (positions 1-4). Peer-reviewed publications are considered the strongest evidence of activeresearch contribution to the discipline. Only those fully committe to productive scholarship should apply.SALARIES - highly competitive, the amount dependent upon qualifications and experience.FACILITIES - Most members of the department are housed in the main EAWAG facility at Dubendorf,a few minutes from Zurich. The littoral zone ecologist will be located at the Limnological Research Center

at Kastanienbaum, on the shore of Lake Lucerne. Excellent resources are available for research and

teaching. A state-of-Othe-art Analytical Chemistry Laboratory is a valued component of the department.Possibilities for interdisciplinary reserach are outstanding.TIME FRAME - positions are available from 1 October 1995. Applications are due by 31 August 1995,although the search may be extende if sutiable candidates are not found.

APPLICATION - send a letter of application, a curriculum vitae, transcripts, and the names (address/phone/FAX) of four references to: Prof. J.V. Ward, Dept. ofLimnology, EAWAG/ETH, Uberlandstrasse133, CH-8600, Dubendorf, Switzerland.ADDITIONALINFORMATION - direct to Dr. Peter Bossard Limnological Research Center, CH-6047Kassanienbaum, Switzerland, Phone +41-41-482-120; FAX +41-41-482-168; E-mail bossard@eawag.ch

l

POSITIONS OPEN

POSTDOCTORAL ASSISTANT in Medicine need-ed by a southwest Ohio university to perform physiolog-ical and cell biological studies to defioc the role of pul-monanv vascular smooth muscle and endothelial cell con-traction in vascular wall dysfuiction in response to saso-active agents, hypoxia stimulation and polymorpho-neutrophil (PMN)-released reactive ox)ygen species(ROS). Studies ssill include: isolation of rat pulmonaryartery and vein; contractile force mlecasurenmcnit oni isolatedvessels; measurement of contractile pro)tein mvosin lightchain phosphorylation from tissue homogenate; isolationand actisation of human PMN and measurement of so-peroxide production bya activated PMN. Must have M.D.or Ph.D. in physiology and two years in job described ortwo years of postdoctoral research experience studyingsignal transduction mechanismn involved in pulmonarysascular contractile response to hypoxia and ROS. 9 a.m.to 5 p.m., Monday, through Friday, 40 hours per sweek,$25,000 per year. Send two) curricula vitae and corerletters (no calls) to: L. Eggleston, Job No. 945, OhioBureau of Employment Services, P.O. Box 1618, Co-lumbus, OH 43216.

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AMITOF'S CUSTOM DNA$1.50 per base/50nmole

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NBS traceable calibration standards and controls. Largeassortment of diameters from 0.02 to 2000 pm. micro-speres of polystyrene, glass and fluorescent materials.Free catalog available. Toll Free 800-334-3883.In Calif. 415-424-1177. FAX 415-424-1158 ICircle No. 9 on Readers' Service Card

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:CUSTOM ANTIBODIES:Antibody Only.............. $900.00

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Human Microvascular CellsComplete Cell System

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SCIENCE * VOL. 268 9 JUNE 1995

The ideal statistical software for theday-to-day data analysis needs ofresearchers. SigmaStat's uniqueAdvisor recommends the correct testto run, checks the underlying assump-tions, runs the test and interprets theresults. The perfect statistical softwarefor the nonstatistician!1 -800-4-JANDEL (1-800-452-6335)415-453-7769 (fax)sales@jandel.com Jand2591 Kerner Blvd SCIEUTIFIC SOFTWARESan Rafael, CA 94901

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help--

Cytokines arid Antibodies

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JapanFunakoshi Co., Ltd.9-7, Hongo 2-ChromeBunkyo-ku, Tokyo 1 13, JapanTel: +81 (03) 56841622Fax: +81 (03) 56841633

IL-i a

IL-i,

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-IL-2IL-2 sRaIL-2 sR,IL-3ILA

IL-4sR

jL-5IL-6IL-6 sRIL-7IL-8IL-9

IL-1 0

IL-11-

IL-12

IL-13

ANG

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BTC

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gp130G-CSF

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