participants - springer978-1-4613-0513-2/1.pdf · participants l. abel ... c.r.e. enea, casaccia,...
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Participants
L. ABEL • Department of Cell Biology, Weizmann Institute of Science, Rehovot, Israel 76100
CARMELA R. ABRAHAM • Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115. Present address: Arthritis Center, Boston University School of Medicine, Boston, Massachusetts 02118
G. N. ABRAHAM • Departments of Medicine, and Microbiology and Immunology, and Clinical Immunology Unit, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642
OLAF ADAM • Medical Polyclinic, University of Munich, D-8000 Munich, Federal Republic of Germany
JOSEPH F. ALBRIGHT • Department of Microbiology, George Washington University School of Medicine, Washington, D.C. 20037
JULIA W. ALBRIGHT • Department of Microbiology, George Washington University School of Medicine, Washington, D.C. 20037
CAROLYN M. ALDWIN • Normative Aging Study, Veterans Administration Outpatient Clinic, Boston, Massachusetts 02108
DAVID AMINOFF • Institute of Gerontology, Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109-2007
PETER J. ANDERSON· Department of Biochemistry, University of Ottawa, Ottawa, Ontario K 1H 8M5, Canada
ROBERT J. ANDERSON • Department of Medicine, University of Colorado Health Science Center and VA Hospital, Denver, Colorado 80220
GARY W. ARENDASH • Department of Biology, University of South Florida, Tampa, Florida 33620
PAOLO BAMBERGA • Institute of Internal Medicine, Infectious Disease, and Immunopathology, University of Milan, Padiglione Granelli Polyclinic Hospital, 20122 Milan, Italy
WILMA BARCELLINI • Institute of Internal Medicine, Infectious Disease, and Immunopathology, University of Milan, Padiglione Granelli Polyclinic Hospital, 20122 Milan, Italy
AVI BEN-ABRAHAM • American Cryonics Society, San Francisco, California 94102 D. BEN-MENAHEM • Department of Cell Biology, Weizmann Institute of Science, Re
hovot, Israel 76100 RICHARD N. BERGMAN • Department of Physiology and Biophysics, University of
Southern California Medical School, Los Angeles, California 90033
571
572 PARTICIPANTS
CONSTANTIN A. BONA • Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10037
FRANCISCO A. BONILLA • Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10037
MARIA ORIETTA BORGHI • Institute of Internal Medicine, Infectious Disease, and Immunopathology, University of Milan, Padiglione Granelli Polyclinic Hospital, 20122 Milan, Italy
MATTHEWS O. BRADLEY • Department of Safety Assessment, Merck Institute for Therapeutic Research, West Point, Pennsylvania 19486
ELAINE BRESNAHAN • Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224
JACOB A. BRODY • School of Public Health, University of Illinois at Chicago, Chicago, Illinois 60680
NIAN-SHENG CAl • Departments of Biological Sciences and Chemistry, Illinois State University, Normal, Illinois 61761
FRANCESCO CAV AZZUTI • Department of Geriatric Medicine, Malpighi Hospital USL 28, 40138 Bologna, Italy
H. TAK CHEUNG • Departments of Biological Sciences and Chemistry, Illinois State University, Normal, Illinois 61761
MARl ELLA CHIRICOLO • Department of Experimental Pathology, University of Bologna, 40126 Bologna, Italy
PAUL B. CHRETIEN • Department of Surgery, University of Maryland Hospital, Baltimore, Maryland 21201
GEORGE A. CLARK • Normative Aging Study, Veterans Administration Outpatient Clinic, Boston, Massachusetts 02108
MARIGRAZIA CLERICI • Institute of Internal Medicine, University of Milan, 20122 Milan, Italy
QUINTINA B. CORTEZA • Division of Nephrology, University of Maryland Hospital, Baltimore, Maryland 21201
CARL W. COTMAN • Departments of Psychobiology, Neurology, and Psychiatry, University of California-Irvine, Irvine, California 92717
JOZSEF CSONGOR • First Department of Medicine, University Medical School of Debrecen, 4012 Debrecen, Hungary
BARBARA J. DAVIS • Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642
ALBERTO DEGRASSI • Institute of Clinical Medicine and Gastroenterology, St. Orsola University Hospital, 40138 Bologna, Italy; Institute Rizzoli, University of Bologna, 40 l36 Bologna, Italy
MARIAN C. DIAMOND • Department of Integrative Biology, University of CaliforniaBerkeley, Berkeley, California 94720
MARK A. DILLINGHAM • Department of Medicine, University of Colorado Health Science Center, and VA Hospital, Denver, Colorado 80220
GINO DORIA • Laboratory of Pathology, C.R.E. ENEA, Casaccia, Rome, Italy J. M. EDINGTON • Department of Pathology, New York University Medical Center, New
York, New York 10016 R. EREN • Department of Cell Biology, Weizmann Institute of Science, Rehovot, Israel
76100 WILLIAM B. ERSHLER • Section of Geriatrics and Gerontology, Department of Medi-
PARTICIPANTS 573
cine, University of Wisconsin-Madison, and William S. Middleton VA Hospital, Madison, Wisconsin 53706
NICOLA FABRIS • Gerontology Research Department, Italian National Research Center on Aging, 60100 Ancona, Italy
ANDREA FACCHINI • Institute of Clinical Medicine and Gastroenterology, St. Orsola University Hospital, 40138 Bologna, Italy; and Institute Rizzoli, University of Bologna, 40136 Bologna, Italy
GIANNI FERRARO • Institute of Internal Medicine, Infectious Disease, and Immunopathology, University of Milan, Padiglione Granelli Polyclinic Hospital, 20122 Milan, Italy
GABRIELLA FORIS • First Department of Medicine, University Medical School of Debrecen, 4012 Debrecen, Hungary
DANIELA FRASCA· Laboratory of Pathology, C.R.E. ENEA, Casaccia, Rome, Italy
E. FRI EDMAN • Division of Neurochemistry, Departments of Psychiatry and Pharmacology, Medical College of Pennsylvania, Philadelphia, Pennsylvania 19129
BARBARA G. FROSCHER • Department of Immunology, Scripps Clinic and Research Foundation, La Jolla, California 92037
TAMAs FULOP, JR. • First Department of Medicine, University of Medical School of Debrecen, 4012 Debrecen, Hungary
RUTH GABIZON • Department of Neurology, University of California-San Francisco, San Francisco, California 94143-0518
D. CARLETON GAJDUSEK • Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892
C. JOSEPH GIBBS, JR. • Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892
GEORGE G. GLENNER • Department of Pathology, University of California-San Diego, School of Medicine, La Jolla, California 92093
A. GLOBERSON • Department of Cell Biology, Weizmann Institute of Science, Rehovot, Israel 76100
A. M. GOATE • Department of Biochemistry and Molecular Genetics, St. Mary's Hospital Medical School, Norfolk Place, London W2 lPG, England
EDMOND A. GOIDL • Department of Microbiology and Immunology, School of Medicine, University of Maryland at Baltimore, Baltimore, Maryland 21021
H. S. GOLDSMITH • Department of Surgery, Boston University School of Medicine, Boston, Massachusetts 02118
ALLAN L. GOLDSTEIN • George Washington University Medical Center, Washington, D.C. 20037
P. D. GOREVIC • Clinical Allergy and Rheumatology Unit, Department of Medicine, State University of New York at Stony Brook, Stony Brook, New York 11794
SUSAN R. S. GOTTESMAN • Department of Pathology, New York University Medical Center, New York, New York 10016
STEFAN GRAVENSTEIN • Division of Hematology, Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin 53706
MONICA GRAZIOLI • Institute of Internal Medicine, University of Milan, 20122 Milan, Italy
574 PARTICIPANTS
DARLENE GROTH • Department of Neurology, University of California-San Francisco, San Francisco, California 94143-0518
BHUPENDRA KISHORE GUPTA • Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, Kentucky 40292
MADI GUPTA • Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, Kentucky 40292
NICHOLAS R. HALL • Department of Psychiatry and Behavioral Medicine, and Center of Psychoimmunology, University of South Florida Medical College, Tampa, Florida 33613
ROBERT W. HAMILL • Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642
J. A. HARDY • Department of Biochemistry and Molecular Genetics, St. Mary's Hospital Medical School, London W2 lPG, England
A. R. HAYNES • Department of Biochemistry and Molecular Genetics, St. Mary's Hospital Medical School, London W2 lPG, England
CHARLES H. HENNEKENS • Departments of Medicine and Preventive Medicine, Harvard Medical School, and Brigham and Women's Hospital, Brookline, Massachusetts 02146
KATSUIKU HIROKAWA • Department of Pathology, Tokyo Metropolitan Institute of Gerontology, 35-2, Sakaecho, Itabashi-ku, Tokyo 173, Japan
DONALD K. INGRAM • Molecular Physiology and Genetics Section, Laboratory of Cellular and Molecular Biology, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Francis Scott Key Medical Center, Baltimore, Maryland 21224
MARIE-PAULE JACOB • Laboratory of the Biochemistry of Connective Tissue, CNRS UA 1174, Faculty of Medicine, University of Paris-Val de Marne, 94010 CreteiI, France
L. A. JAMES • Department of Biochemistry and Molecular Genetics, St. Mary's Hospital Medical School, London W2 lPG, England
THOMAS E. JOHNSON • Department of Molecular Biology and Biochemistry, University of California-Irvine, Irvine, California 92717. Present address: Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309
G. JONES • Departments of Medicine, and Microbiology and Immunology, and Clinical Immunology Unit, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642
JOHN JOSSELSON • Division of Nephrology, University of Maryland Hospital, Baltimore, Maryland 21201
MICHIYUKI KASAl • Department of Pathology, Tokyo Metropolitan Institute of Gerontology, 35-2, Sakaecho, Itabashi-ku, Tokyo 173, Japan
AZAD KAUSHIK • Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10037
MARGUERITE M. B. KAY • Departments of Medicine, and Medical Biochemistry and Genetics, and Medical Microbiology and Immunology, Texas A&M University, and Teague Veterans Center, Temple, Texas 76504
E. KENEDI • Department of Chemical Pathology, School of Pathology, Medical School, University of the Witwatersrand, and The South African Institute for Medical Research, Johannesburg 2000, Republic of South Africa
PARTICIPANTS 575
YOUNG TAl KIM • Department of Medicine, Cornell University Medical College, New York, New York 10021
NORMAN R. KLiNMAN • Department of Immunology, Scripps Clinic and Research Foundation, La Jolla, California 92037
RAJABATHER KRISHNARAJ • Division of Geriatric Medicine, Department of Medicine, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612; and Center on Aging/Northwestern University, McGaw Medical Center, Chicago, Illinois 60611
DAVID KRITCHEVSKY • Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104
R. A. KYLE • Department of Medicine, Clinical Immunology Unit, Mayo School of Medicine, Mayo Clinic, Rochester, Minnesota 55905
CHRISTOPHER S. LANGE • Department of Radiation Oncology, SUNY Health Science Center at Brooklyn, Brooklyn, New York 11203
JOHN C. LAROSA • Lipid Research Clinic, George Washington University School of Medicine and Health Sciences, Washington, D.C. 20037
ANDRAs LEOVEY • First Department of Medicine, University Medical School of Debrecen, 4012 Debrecen, Hungary
FEDERICO L1CASTRO • Department of Experimental Pathology, University of Bologna, 40126 Bologna, Italy
PHYLLIS-JEAN LINTON· Department of Immunology, Scripps Clinic and Research Foundation, La Jolla, California 92037
SUSAN J. MARTIN McEVOY • Department of Microbiology and Immunology, School of Medicine, University of Maryland at Baltimore, Baltimore, Maryland 21201
MICHAEL P. McKINLEY • Department of Neurology, University of California-San Francisco, San Francisco, California 94143-0518
THOMAS H. McNEILL • Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642. Present address: Andrus Gerontology Center, University of Southern California, Los Angeles, California 90089
CAMILLO MANCINI • Laboratory of Pathology, C.R.E. ENEA, Casaccia, Rome, Italy FRANCESCO ANTONIO MANZOLI • Institute of Normal Human Anatomy, University
of Bologna, 40138 Bologna, Italy ADRIANA RITA MARIANI • Institute of Normal Human Anatomy, University of Bologna,
40138 Bologna, Italy ERMINIA MARIANI • Institute Rizzoli, University of Bologna, 40136 Bologna, Italy; and
Institute of Clinical Medicine and Gastroenterology, St. Orsola University Hospital, 40138 Bologna, Italy
PETER J. MAYER • Department of Radiation Oncology, SUNY Health Science Center at Brooklyn, Brooklyn, New York 11203
D. MENDELSOHN • Department of Chemical Pathology, School of Pathology, Medical School, University of the Witwatersrand, and The South African Institute for Medical Research, Johannesburg 2000, Republic of South Africa
PIER LUIGI MERONI • Institute of Internal Medicine, Infectious Disease, and Immunopathology, University of Milan, Padiglione Granelli Polyclinic Hospital, 20122 Milan, Italy
EDWIN M. MEYER • Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, Florida 32610
576 PARTICIPANTS
WILLIAM J. MILLARD • Department of Phannacodynamics, College of Phannacy, University of Florida, Gainesville, Florida 32610
VALERY T. MILLER • Lipid Research Clinic, George Washington University School of Medicine and Health Sciences, Washington, D.C. 20037
EUGENIO MOCCHEGIANI • Gerontology Research Department, Italian National Research Center on Aging, 60100 Ancona, Italy
RICHARD A. MUESING • Lipid Research Clinic, George Washington University School of Medicine and Health Sciences, Washington, D.C. 20037
M. J. MULLAN • Department of Neurology, St. Mary's Hospital Medical School, London W2 lPG, England
MARIO MUZZIOLI • Gerontology Research Department, Italian National Research Center on Aging, 60100 Ancona, Italy
PIRUZ NAHREINI • Division of Hematology and Oncology, Departments of Medicine, Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana 46202
WARREN W. NICHOLS • Department of Safety Assessment, Merck Institute for Therapeutic Research, West Point, Pennsylvania 19486
ALEXANDER P. OSMAND • Department of Medicine, University of Tennessee Medical Center, Knoxville, Tennessee 37920
M. J. OWEN • Department of Biochemistry and Molecular Genetics, St. Mary's Hospital Medical School, London W2 lPG, England
MOHAMMAD A. PAHLAVANI • Departments of Biological Sciences and Chemistry, Illinois State University, Normal, Illinois 61761
STEFANO PAPA • Institute of Normal Human Anatomy, University of Bologna, 40138 Bologna, Italy
A. PERL • Departments of Medicine, and Microbiology and Immunology, and Clinical Immunology Unit, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642
CHRISTINE PETERSON • Department of Psychobiology, University of California-Irvine, Irvine, California 92717
HUNTINGTON POTTER • Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115
JENNIFER J. POULAKOS • Department of Phannacology and Therapeutics, College of Medicine, University of Florida, Gainesville, Florida 32610
GORDON D. POWERS • Department of Immunology, Scripps Clinic and Research Foundation, La Jolla, California 92037
MAURO PROVINCIALI • Gerontology Research Department, Italian National Research Center on Aging, 60100 Ancona, Italy
STANLEY B. PRUSINER • Departments of Neurology and Biochemistry and Biophysics, University of California-San Francisco, San Francisco, California 94143-0518
ARLAN RICHARDSON • Departments of Biological Sciences and Chemistry, Illinois State University, Normal, Illinois 61761
SYLVIA C. RILEY· Department ofImmunology, Scripps Clinic and Research Foundation, La Jolla, California 92037
LADISLAS ROBERT • Laboratory of the Biochemistry of Connective Tissue, CNRS UA 1174, Faculty of Medicine, University of Paris-Val de Marne, 94010 Cn'!teil, France
PATRIZIA RODA • Institute Rizzoli, University of Bologna, 40136 Bologna, Italy; and
PARTICIPANTS sn
Institute of Clinical Medicine and Gastroenterology, St. Orsola University Hospital, 40138 Bologna, Italy
P. ROQUES • Department of Neurology, St. Mary's Hospital Medical School, London W2 lPG, England
M. N. ROSSOR • Department of Neurology, St. Mary's Hospital Medical School, London W2 lPG, England
GEORGE S. ROTH • Molecular Physiology and Genetics Section, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Francis Scott Key Medical Center, Baltimore, Maryland 21224
JOHN H. SADLER • Division of Nephrology, University of Maryland Hospital, Baltimore, Maryland 21201
AFRO SALSI • Department of Geriatric Medicine, Malpighi Hospital USL 28, 40138 Bologna, Italy
GABRIELE SARTI • Department of Geriatric Medicine, Malpighi Hospital USL 28, 40138 Bologna, Italy
GIANCARLO SAVORANI • Department of Geriatric Medicine, Malpighi Hospital USL 28, 40138 Bologna, Italy
ROBERT M. SCHMIDT • Health Watch Program, Center for Preventive Medicine and Health Research, Pacific Presbyterian Medical Center and San Francisco State University, San Francisco, California 94132-1789
RISE SCHWAB • Department of Medicine, Cornell University Medical College, New York, New York 10021
PAUL E. SEGALL • Trans Time Inc., Oakland, California 94603 STEVE Y. SHEN • Division of Nephrology, University of Maryland Hospital, Baltimore,
Maryland 21201. Present address: Division of Nephrology, Maryland General Hospital, Baltimore, Maryland 21201
MARCO SINOPPI • Institute of Recovery and Cure of Giovanni XXIII, 40133 Bologna, Italy
GREGORY W. SISKIND • Department of Medicine, Cornell University Medical College, New York, New York 10021
ARUN SRIVASTAVA • Division of Hematology and Oncology, Departments of Medicine, Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana 46202
PATRIZIA STEFANONI • Institute of Internal Medicine, University of Milan, 20122 Milan, Italy
R. CLAYTON STEINER • George Washington University Medical Center, Washington, D.C. 20037
HAL STERNBERG • Department of Physiology and Anatomy, University of CaliforniaBerkeley, Berkeley, California 94720; and Trans Time Inc., Oakland, California 94603
ROBERT C. SWITZER III • Department of Pathology, University of Tennessee Medical Center, Knoxville, Tennessee 37920
SANDOR SZUCS • First Department of Medicine, University Medical School of Debrecen, 4012 Debrecen, Hungary
ROBERT D. TERRY • Department of Neurosciences, School of Medicine, University of California-San Diego, La Jolla, California 92093
J. C. de la TORRE • Division of Neurosurgery, University of Ottawa Health Sciences, Ottawa, Ontario KIH 8M5, Canada
578 PARTICIPANTS
GIUSEPPE TUCCI • Department of Geriatric Medicine, Malpighi Hospital USL 28, 40138 Bologna, Italy
MASANORI UTSUYAMA • Department of Pathology, Tokyo Metropolitan Institute of Gerontology, 35-2, Sakaecho, Itabashi-ku, Tokyo 173, Japan
RENE VAN DE GRIEND • Radiobiological Institute, TNO, 2280 HV Rijswijk, The Netherlands
ZSUZSA VARGA • First Department of Medicine, University Medical School of Debrecen, 4012 Debrecen, Hungary
CARLO VERGANI • Institute of Internal Medicine, University of Milan, 20122 Milan, Italy
ALESSANDRO VISMARA • Institute of Internal Medicine, Infectious Disease, and Immunopathology, University of Milan, Padiglione Granelli Polyclinic Hospital 20122, Milan, Italy
MARCO VITALE • Institute of Normal Human Anatomy, University of Bologna, 40138 Bologna, Italy
HAROLD WAlTZ • Trans Time Inc., Oakland, California 94603 H.-Y. WANG • Division of Neurochemistry, Departments of Psychiatry and Pharmacology,
Medical College of Pennsylvania, Philadelphia, Pennsylvania 19129 RICHARD WEINDRUCH • Biomedical Research and Clinical Medicine Program, Na
tional Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892 PETER WEISWEILER • Metabolic Research Munich, D-8000 Munich 5, Federal Re
public of Germany MARC E. WEKSLER • Department of Medicine, Cornell University Medical College,
New York, New York 10021 GEORGE Z. WILLIAMS • Health Watch Program, Center for Preventive Medicine and
Health Research, Pacific Presbyterian Medical Center and San Francisco State University, San Francisco, California 94132-1789
J. M. WILLIAMS • Departments of Medicine, and Microbiology and Immunology, and Clinical Immunology Unit, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642
R. WILLIAMSON • Department of Biochemistry and Molecular Genetics, St. Mary's Hospital Medical School, London W2 lPG, England
PATRICIA D. WILSON • Department of Physiology and Biophysics, UMNJ-Robert Wood Johnson (formerly Rutgers) Medical School, Piscataway, New Jersey 08854
MEIWEN WU • Health Watch Program, Center for Preventive Medicine and Health Research, Pacific Presbyterian Medical Center and San Francisco State University, San Francisco, California 94132-1789
LUCIO ZANICHELLI • Department of Geriatric Medicine, Malpighi Hospital USL 28, 40138 Bologna, Italy
CARLO ZANUSSI • Institute of Internal Medicine, Infectious Disease, and Immunopathology, University of Milan, Padiglione Granelli Polyclinic Hospital, 20122 Milan, Italy
DORITH ZHARHARY • Department of Immunology, Scripps Clinic and Research Foundation, La Jolla, California 92037
DONATO ZOCCHI • Institute of Recovery and Cure of Giovanni XXIII, 40133 Bologna, Italy
Index
A68 protein in Alzheimer's disease, III Acetylcholine deficiency in Alzheimer's disease,
110 Adeno-associated virus replication in fibroblasts,
98-105 Adenovirus 2 replication in fibroblasts, 90-98 Adenylate cyclase in renal collecting ducts, re
sponse to vasopressin in aging, 291-295 Adrenal tyrosine hydroxylase activity, dietary
restriction affecting, 285, 288-289 Adrenergic receptors in parotid glands, activity
of, 143, 222 age-l gene activity, 46-48 Age-dependent conditions, 138, 141 Age-related conditions, 138-141 Agmatine in temporal cortex, in Alzheimer's
disease, 487 Alzheimer's disease
as age-dependent condition, 138 amyloid gene expression in, 5-6, 40 amyloid i3-protein in, 51-59,76 IXI-antichymotrypsin in amyloid deposits, 76-
85 expression in specific brain areas, 78-82
chromosome 21 in, 40, 41 and Down's syndrome, 40, 51 and effects of cerebral cortical cholinergic
hypofunction, 491-495 FAD marker in, 58 immunochemical markers in, III lactoferrin immunoreactivity in, 109-122 mitogen response of lymphocytes in, 128,
130 molecular genetics of, 39-41 neuritic plaques in, 5-6, 7, 25, 56-57, 76,
110-111 biochemical properties of, 110 distribution of, 110 lactoferrin immunoreactivity with, 114
579
Alzheimer's disease (cont.)
neurofibrillary tangles in, 110-111 neuronal populations in, 110, 439 olfactory tract pathology in, 112, 121 and polyamines in temporal cortex, 485-489 proteolytic enzyme defect in, 59 regional pathology in, 111-112 subtypes of, 126 synapse replacement in, 503-504 thymulin levels in, 127-128, 130 zinc levels in, 127-128, 130
cAMP and action of vasopressin in renal collecting
ducts, 293-294 aging affecting, in cells, 188, 222
Amygdaloid nucleus measurements in aging, 444-445
Amyloid in brain, 3-15 IXI-antichymotrypsin in, 76-85 in congophilic angiopathy with hemorrhage,
55, 56, 83 formation from precursor protein, 4-6, 110 gene expression in Alzheimer's disease, 5-6,
40 mineral deposits affecting, 11 in neuritic plaques in Alzheimer's disease,
5-6,7,25,56-57,76,110-111 in prion disorders, 25 two forms of, 6-8
Amyloid l3-protein in Alzheimer's disease, 51-59, 76 association with IX I-antichymotrypsin,
84-85 gene localization on chromosome 21, 5, 57-
58,83 precursor protein, 57-58, 76 purification and analysis of, 52-55
Amyloidotic polyneuropathy, familial, variant prealbumin in, 57, 84
580
Amyotrophic lateral sclerosis, age-related incidence of, 140
Antibody repertoire in aging, 413-423 al-Antichymotrypsin, 75-85
association with amyloid p-protein, 84-85 in brain amyloid deposits
in Alzheimer's disease, 76-78 expression in specific areas, 78-82 in normal aging monkeys, 82
gene on chromosome 14, 84 Arachidonic acid levels
in aging, 182 and fever production, 319
Aspirin, and risks of cardiovascular disease, 561-568
Atherosclerosis, cholesterol levels in, 252 Autoantibodies
to neurofilaments in subacute spongiform virus encephalopathies, 11-12
to senescent cell antigen, 148-149 Axons
interference with neurofilament transport in, and amyloid formation, 4-6
regeneration affected by blood flow rate, 477-482
sprouting after neuronal loss, 502
B lymphocytes of aged mice, 349-352 cryoglobulin-producing, 357
Band 3 molecule appearance on various cells, 153-154 degradation in aging, 151-153, 155 relation to senescent cell antigen, 150-151, 155 variants of, 156-157
Behavior function in aging, variability of, 507 Biochemical data in healthy aging population,
167-168 Blood flow rate affecting axon regeneration,
477-482 Bone marrow, and T lymphocyte development,
367,376 Brain
amyloidosis, 3-15; see also Amyloid in brain cerebral cortex measurements in aging, 442-
445 circuitry affected by training, 507-508 doparninergic neurons in substantia nigra,
497-499 environments affecting, 445-448
in aging rats, 447-448 postweaned,446-447
Brain (cont.) envirunments affecting (cont.)
prenatal, 445-446 preweaned, 446
INDEX
neuron activity: see Neuronal populations neurotrophic factors in, 504-506 nucleus basalis lesions in aged rats, 491-495 optimistic view of aging in, 441-448 protein kinase C mediation of serotonin re-
lease, 469-475 synapse replacement
in aging, 503 in disease, 503-504 in neuronal loss, 501-502
temporal cortex polyarnines in Alzheimer's disease, 458-459
Bronchitis, chronic, thymopentin therapy in, 551-558
C-peptide levels, glucose affecting, 235 Calcium
intracellular levels in aging, 188-189 and respiratory burst in polymorphonuclear
leukocytes, 222-224 mobilization in aging, 144-145
Caloric intake: see Diet Cancer as age-related conditions, 140-141 Carbohydrate intake, and glucose tolerance in
aging, 240 Cardiovascular disease
cholesterol levels in, 252 prevention trials with aspirin, 561-568
Cellular senescence DNA repair in lymphocytes, 195-203 erythrocyte, 63-72 fibroblast, 89-105 phosphatidylinositol breakdown in poly
morphonuclear leukocytes, 187-193 physiological functions in, 222 and programmed nerve cell death, 208-209
Cerebral cortical thickness measurements in aging, 442-444
Chloroquin affecting aging polymorphonuclear leukocytes, 224
Cholesterol levels and coronary disease, 252 estrogen replacement therapy affecting, 531-
535 weight reduction affecting, 298-299
Cholinergic system hypofunction in cerebral cortex, 491-495 and maze learning in rodents, 457-459
INDEX
Chromatin alterations, and DNA repair in aging lymphocytes, 200, 202
Chromosome 14 gene for <Xl-antichymotrypsin, 84
Chromosome 21 Alzheimer gene on, 40, 41 gene coding for amyloid (3-protein, 5, 57-58,
83 Chromosome anomalies in cryoglobulinemia,
356 Cloning of organs, and life span extension, 212 Co-dergocrine, and maze learning in rodents,
461 Cognition in aging, variability in, 507 Colon cancer, diet role in, 254 Congophilic angiopatby, cerebrovascular
amyloid in, 55, 56, 83 Constipation, fiber intake affecting, 253 Creutzfeldt-Jakob disease
amyloid fibril proteins in, 57 familial, mutations in, II prions in, 25 virus characteristics in, 3-15
Cryoglobulinemia, 356-360 Cryonics, 213-215 Cystatin C in congophilic angiopathy, 51, 56,
83 Cytotoxic T-Iymphocytes in spleens of aged
mice, 425-431
Diabetes mellitus, fiber intake affecting, 254 Diet
and glucose tolerance in aging, 240 linolenate intake affecting fever production,
319-328 and nutritional requirements in aging, 249-
254 caloric intake in, 249 cholesterol in, 252 fat in, 251-252 fiber in, 253-254 mineral sources in, 252 protein in, 250 vitamin sources in, 251
Dietary restriction and gene expression in lymphocytes, 259-268 and lipoprotein levels after weight reduction,
297-300 and longevity studies in animals, 210, 211,
313-316 neuroendocrine effects of, 283-289
581
Digestive diseases in aging, 252-254 Diverticular disease, fiber intake affecting, 253 DNA repair in aging lymphocytes, 195-203 Dopamine receptors, age-related loss of, 143 Doparninergic neurons in substantia nigra of
aging mice, 497-499 Down's syndrome
and Alzheimer's disease, 40, 51 and amyloid in brain, 5, 7 amyloid (3-protein in, 54-55 lactoferrin reactivity in, 114, 117 neurofibrillary tangles in, 4 thymulin levels in, 130
Encephalopatbies, subacute spongiform, autoimmune antibody to neurofilaments in, ll-12
Entorhinal cortex measurements in aging, 444 Erythrocyte senescence, 63-72
and band 3 degradation, 151-153, 155 galactose role in, 67-70, 150 and normal life span, 63 senescence factor glycopeptides in, 67-69 senescent cell antigen in, 147-157 sialic acid content in, 64-65, 150
Estradiol, and hypothalamic neuronal degeneration, 209
Estroghen receptors, age-related loss of, 143 Estrogen replacement tberapy, lipid and lipopro
tein changes from, 531-535
Fat intake in aging, 251-252 Fatty acids
dietary linolenate affecting serum levels of, 324-328
metabolism in aging, 181-185 Fetal neural tissue grafts, and maze learning in
rodents, 461 Fetal thymic extract, and life span extension in
animals, 212 Fever pathogenesis, dietary linolenate in, 319-
328 Fiber intake, recommendations for, 253-254 Fibroblasts
adeno-associated virus replication in, 98-105 delay in, 99-100 and production of progeny virions, 100 and rescue of genome from recombinant
plasmids, 100-105 adenovirus 2 replication in, 90-98
and biological activity of progeny virus, 96-98
582
Fibroblasts (cont.) adenovirus 2 replication in (cont.)
and induction of DNA synthesis, 90-92 and production of progeny virus, 92-96
growth factor in prevention of neuronal atrophy, 505-506
Fimbria-fornix lesions, and maze learning in rodents, 459-460
G protein GTP-binding, in aging polymorphonUclear
leukocytes, 191, 224 and vasopressin effects on renal collecting
ducts, 294-295 Galactose, and erythrocyte senescence, 67-70,
150 Gallbladder disease, fiber intake affecting, 254 Gender differences in aging, 169 Genetics
age-l gene activity, 46-48 and analysis of aging process, 43-48 and dietary restriction affecting gene ex-
pression in lymphocytes, 259-268 molecular
in Alzheimer's disease, 39-41 in cryoglobulinemia, 357-358
Gerstmann-Striiussler disease amyloid plaques in, 6-7 familial, mutations in, 11 prions in, 25
Glial cells, environmental input affecting, 447 Glucagon levels, dietary restriction affecting,
286 Glucose
serum levels dietary restriction affecting, 285 fiber intake affecting, 254
tolerance in aging, 229-243 diet affecting, 240 factors affecting, 230-233 and insulin resistance, 233-234 and interaction between insulin secretion and
insulin action, 237-240 and pancreatic B-cell function, 234-237
Glutamic acid decarboxylase activity in hypothalamic regions, in aging, 209-210
Glycogen deposition in liver, dietary restriction affecting, 285, 288
Glycopeptides, senescence factor, in aging red cells, 67-69
cGMP in cells, aging affecting, 188, 222 Growth factors in brain, 504-506
INDEX
Healthy aging population, Health Watch study of, 163-170
Hematological data in healthy aging popUlation, 167-168
Hemodialysis patients, and thymosin affecting influenza vaccine efficacy, 523-528
Hippocampus thickness measurements in aging, 444
Hormone levels in Alzheimer's disease and in normal aging, 127-128
Hypothalamus role in reproductive function, 209-210 thymus affecting, 335
Idiotypic antibody repertoire in aging, 413-423 Immune system in aging
antibody repertoire in, 413-423 B cell changes in mice, 349-352 clinical significance of senescence in, 401-
403 cytotoxic T-cell precursors in spleen, 425-
431 and efficacy of DNA repair in lymphocytes,
202-203 gene expression affected by dietary re-
striction, 259-268 and influenza vaccine efficacy, 513-518 lymphocyte functions in, 303-310 modulation of T-cell functions in, 385-389 and monoclonal gammopathies, 355-360 natural killer cells in, 405-411 and oxidative processes in polymorphonuclear
leukocytes, 221-225 in pathogenesis of Alzheimer's disease, 125-
131 and resistance to infection, 391-399 and signal-transduction mechanism in poly-
morphonuclear leukocytes, 187-193 T cells in, 363-371 thymic development affecting, 333-334 thymopentin treatment affecting, 537-549 thymus role in, 375-384 zinc affecting, 274-276
Immunoglobulins IgG on senescent red cells, 147-149 monoclonal garnmQpathies, 355-360
Infections, resistance to, in aging, 391-399 Influenza vaccine efficacy
in aging, 513-518 augmentation of, 517 failures in, 516-517 thymosin affecting, 518
INDEX
Influenza vaccine efficacy (cont.) in hemodialysis patients, thymosin affecting,
523-528 Inositol phosphates in cells, in aging, 189-191 Insulin
dietary restriction affecting serum levels of, 285, 288
resistance to, and glucose tolerance in aging, 233-234
secretion interaction with insulin actions, 237-240
Interleukin-2 and cytotoxic T -lymphocyte precursors in
spleens of aged mice, 428-430 expression in lymphocytes, dietary restriction
affecting, 263-265 production affected by thymopentin, 543-549
Interventive gerontology, 208-212 Iron in pathogenesis of Alzheimer's disease,
112-122
Kidney response to vasopressin in aging, 291-295
Kuru prions in, 25 virus characteristics in, 3-15
Laboratory tests in healthy aging population, 163-170
Lactoferrin binding in normal and Alzheimer brain tissue,
117 immunoreactivity in Alzheimer's disease,
109-122 neuroanatomical distribution of, 119-121
Leukocytes, polymorphonuclear phosphatidylinositol breakdown in aging,
187-193, 222 respiratory burst in aging, 221-226
Life span extension by cloning of lost organs, 212 by cryonics, 213-215 by dietary restriction, 210-211
and longevity studies in animals, 313-316 by replacement of lost factors, 211-212 by thymosin injections in mice, 383
Lineoleic acid levels in aging, 182-184 Linolenate intake, and fever pathogenesis, 319-
328 Lipid levels
estrogen replacement therapy affecting, 531-535
583
Lipid levels (cont.)
relation to a-tocopherol levels in aging, 174-178
Lipoprotein levels estrogen replacement therapy affecting, 531-
535 relation to a-tocopherol levels in aging, 174-
178 weight reduction affecting, 297-300
Liver, glycogen deposition in, affected by dietary restriction, 285, 288
Lymphocytes B cells of aged mice, 349-352 cryoglobulin-producing B cells, 357 DNA repair in aging, 195-203 gene expression affected by dietary re
striction, 259-268 mitogen response in Alzheimer's disease,
128, 130 natural killer cells in immunosenescence,
405-411 phenotype and function of clones, 303-310 T cell activity: see T lymphocytes thymopentin affecting, 546-549, 556-558 zinc deficiency affecting, 274-275
Maze learning in rodents, 451-465 and background on Stone maze paradigm,
452-454 cholinergic system in, 457-459 declarative memory and nondeclarative mem-
ory in, 463 DSP-4 affecting, 459 encoding processes in, 463-464 environmental input affecting, 446 heterogeneity in, 507 lesion manipulations affecting, 459-460 neurobiology of, 455-461 neuropsychology of, 461-464 noradrenergic system in, 459 pharmacological interventions affecting, 455-
459 relevance to human condition, 464 representational memory and dispositional
memory tasks in, 462-463 research goals in, 451-452 scopolarnine affecting, 455-459 spatial memory in, 462 therapeutic manipulations affecting, 460-461 working memory and reference memory tasks
in, 461-462 Memory, and maze learning in rodents, 451-
465
584
Mepacrin affecting aging polymorphonuclear leukocytes, 191
N-Methyl-D-aspartate receptors in aged brain, 506-507
Mineral deposits in neurons, and amyloid deposition, 11
Molecular genetics in Alzheimer's disease, 39-41 in cryoglobulinemia, 357-358
Monoclonal gammopathies, 355-360 MPTP, and dopaminergic neurons in substantia
nigra, 497-499
NADPH oxidase in aging polymorphonuclear leukocytes, 223-224
Neomycin affecting aging polymorphonuclear leukocytes, 191, 224
Nerve cell death, programmed, 208-209 dietary restriction affecting, 211
Nerve growth factor, and prevention of neuronal atrophy, 505
Nervous system, central, axon regeneration affected by spinal blood flow rate, 477-482; see also Brain
Neural canal size, and psychoneuroimmunology in adults, 335-342
Neural tissue grafts, fetal, and maze leaming in rodents, 461
Neuritic plaques in Alzheimer's disease, 5-6, 25,56-57,76, 110-111
biochemical properties of, 110 distribution of, 110 lactoferrin immunoreactivity with, 114
Neuroendocrine system development, stress affecting, 334-335
Neurofibrillary tangles in Alzheimer's disease, 110-111 biochemical properties of, 110-111 diseases associated with, 76 distribution of, 110 lactoferrin immunoreactivity with, 114
Neurofilaments autoimmune antibodies to, in subacute
spongiform virus encephalopathies, 11-12
axonal transport of, interference with, 4-6 Neuronal populations
in aging, 435-439, 445 in Alzheimer's disease, 110, 439 degeneration in, and reproductive senescence,
209-210 environmental input affecting, 447
INDEX
Neuronal populations (cont.) lesions affecting maze learning in rodents,
459-460 synapse replacement after losses in, 501, 502
Noradrenergic system, and maze learning in rodents, 459
Nuclear transfer methods in cloning of organisms, 212
Nucleus basalis lesions in adult rats, 491-495 Nutrition: see Diet
Obesity, and weight reduction affecting lipoprotein levels, 297-300
Oleic acid levels in aging, 182 Olfactory tract pathology in Alzheimer's dis
ease, 112, 121 Oxidative processes in aging polymorphonuclear
leukocytes, 221-225
Palmitic acid levels in aging, 182 Pancreatic J3-cell function, and glucose tolerance
in aging, 234-237 Paraprotein synthesis in aging, 355 Parasitic infections, resistance to, in aging,
391-399 Parkinsonism dementia, neurofibrillary tangles
in, 4 Parotid glands, adrenergic receptors in, 143,
222 Pertussis toxin affecting aging poly
morphonuclear leukocytes, 191,224 Phosphatidylinositol breakdown in aging poly
morphonuclear leukocytes, 187-193,222 Phosphorylcholine-responsive B cells in aged
mice, 351-353 Physicians' Health Study of aspirin in preven-
tion of cardiovascular disease, 561-568 Pineal gland, thymus affecting, 335 Plant diseases, subviral pathogens in, 13 Polyamines in temporal cortex in Alzheimer's
disease, 485-489 Polypeptides, infectious: see Viruses,
unconventional Poor early growth, and adult psychoneuroim
munology, 336-342 Prealbumin variant in familial amyloidotic poly
neuropathy, 57, 84 Prion protein in scrapie, 7, 9, 14
immunoaffinity purification and neutralization of,27-32
infectivity of, 25-35
INDEX
Programmed nerve cell death, 208-209 dietary restriction affecting, 211
Prostaglandin biosynthesis in aging, 181-185 Protease inhibitors, and amyloid formation,
84-85 Protein
dietary intake recommendations in aging, 250 synthesis in lymphocytes, dietary restriction
affecting, 265-266 Protein kinase C, and serotonin release in aging,
469-475 Putrescine in temporal cortex in Alzheimer's
disease, 487
Radiation of aging lymphocytes, and DNA repair, 195-203
Receptors age-related loss of, 143 signal transduction mechanism in aging, 188,
222 Reproductive function, senescence of, 209-210
delayed by dietary restriction, 211
Scopolamine, and maze learning in rodents, 455-459
Scrapie amyloid protein in, 6-7 prion protein in, 7, 9, 14
immunoaffinity purification and neutralization of, 27-32
infectivity of, 25-35 virus characteristics in, 3-13
Scrapie-associated fibrils, 8 Senescent cell antigen
appearance on various cells, 149 aut{)antibody to, 148-149 isolation of, 149 relation to band 3, 150-151, 155
Serotonin release, and protein kinase C activity in aging, 469-475
Sex differences in aging, 169 Sialic acid in aging red cells, 64-65, 150 Signal transduction mechanisms, age-associated
changes in, 143-145 in polymorphonuclear leukocytes, 187-193,
222 Spermidine in temporal cortex, in Alzheimer's
disease, 487-489 Spermine in temporal cortex, in Alzheimer's
disease, 487-489 Spinal cord blQ{)d flow rate affecting axon re
generation, 477-481
585
Spleen cytotoxic cells produced in aging, 425-431 and T lymphocyte development, 367-368
Stone maze learning in rodents, 451-465 Stress, and neuroendocrine development, 334-
335 Substantia nigra, dopaminergic neurons in, 497-
499 Synaptic plasticity in aging, 501-508
T lymphocytes cytotoxic precursors in spleens of aged mice,
425-431 developmental aspects in aging, 363-371
bone marrow affecting, 367, 376 in ontogeny, 365 spleen affecting, 367-368 in various tissues, 369
entry of pro-T cells into thymic microenvironment, 377-378
modulation of functions in aging, 385-389 helper cells in, 385-387 suppressor cells in, 387-389
peripheral pool afffected by thymus, 380 proliferation suppression by old thymus, 382-
383 subsets induced by thymus, 381-382 thymic, emigration to peripheral lymphoid
tissue, 379-380 Tau protein in Alzheimer's disease, III Temperature regulation, dietary linolenate af
fecting, 319-328 Thymic extract, fetal, and life span extension in
animals, 212 Thymopentin
in age-associated immune deficiency, 537-549
in chronic bronchitis, 551-558 Thymosin
and influenza vaccine efficacy in aging, 518 in hemodialysis patients, 523-528
and life expectancy in mice, 383 and neural canal size, 337-342 replacement therapy, 212
Thymulin serum levels in Alzheimer's disease, 127-
128, 130 zinc affecting, 274, 275
Thymus development affected by spleen, 367-368 effects on peripheral T-cell pool, 350
586
Thymus (cont.) grafts affecting immune functions in mice,
383 and immune system development, 333-334 induction of T-cell subsets, 381-382 involution in aging, 271-272, 331-332 pro-T cells in, 378 role in aging of immune system, 375-384 suppression of T-cell proliferation, 382-383 T-cell emigration to peripheral lymphoid
tissue, 379-380 0:-Tocopherol levels in aging, 173-178
relation to lipid and lipoprotein levels, 174-178
Training, effects on brain, 507-508 Transthyretin in familial amyloidotic poly
neuropathy, 57, 84 Trimethyltin, and maze learning in rodents, 460 Trypanosomiasis, immunological resistance to,
in aging, 391-399 Tryptophan restriction, and life span extension
in animals, 210 Tumor growth, immune senescence affecting,
402 Tyrosine hydroxylase, adrenal, dietary re
striction affecting, 285, 288-289
Ulcers, gastric, fiber intake affecting, 253
INDEX
Vasopressin, renal response to, in aging, 291-295
Viruses replication in fibroblasts, 89-105 unconventional
immunological inertness of, 8-9 resistance to physical and chemical inac
tivation, 9-11, 14-15 self-replication by autonucleating and auto
patterning, 10, 14 as subviral pathogens, 12-14 in transmissble dementias, 7-15
Vitamin E deficiency, erythrocytes in, 154-155
Weight reduction in postmenopausal women, effects of, 297-300
Zinc and aging process, 276-277 biological role of, 272-274 role in immune system, 274-276 serum levels in Alzheimer's disease, 127-
128, 130 supplementation in old age, 277-279 and thymulin activity, 274, 285