Patrick MeybohmDepartment of Anaesthesiology, Intensive Care and Pain TherapyUniversity Hospital Frankfurt

Patient Blood Managementin Germany

During the last 5 years I have received research grants, consultant/speaker honoria as well asfinancial support for continious education of my department :

German Research Foundation (ME 3559/1-1, ME 3559/3-1), LOEWE, European Union

Abbott GmbH &Co KG Aesculap Akademie GmbHB. Braun Melsungen AG Biotest AGCSL Behring GmbH Dr. F. Köhler Chemie GmbHFresenius Kabi GmbH Fresenius Medical CareHCCM Consulting GmbH Heinen+Löwenstein GmbHPfizer Pharma GmbH PharmacosmosPulsion Medical Systems S.E. Siemens HealthcareVifor Pharma GmbH

COI

GermanPBM Network

(founded 2014)

Patient Blood Management (Frankfurt)

Department of Anaesthesiology, Intensive Care Medicine and

Pain Therapy

Clinical Project to advancePatient Safety

Institute of Transfusion Medicine andImmunohematology,

German Red Cross Blood DonorService

1. Management of pre-operative Anemia►Screening & Diagnosis►Treatment

2. Minimizing Blood Loss & Bleeding

3. Restrictive use of Blood Units

WHO: < 13 g/dl (men); < 12 g/dl (women)

Pre-operative Anemia

Anemia of chronicdisease (≈ 50%)

(cancer, renal insufficiency,

auto immune disease)

Iron deficiency(≈ 30-40%) Others(≈ 10%)Vitamin B12

insufficiency,ideopathic

Anemia walk-in-clinic

Mo-Fr: 08:30 am - 4:00 pm Contact: Sadaf Arefi-Shamsi Tel.: +49 69 6301 87461 patientbloodmanagement@kgu.de

Anemia = „Patient“ + „Made in Hospital®“

Minimising Blood Loss & Bleeding

1. Management of pre-operative Anemia

2. Minimizing Blood loss & Bleeding►Blood sparing techniques►Hemostasis►Intraoperative blood salvage►Coagulation management

3. Restrictive use of Blood Units

Phlebotomy on ICU (1 day)

Hospital-acquired Anemia

Koch CG et al. Ann Thorac Surg 2015Data (n= 1867 cardiac surgery patients: 221,498 lab tests)

5 liters !!!

Fischer D et al. Crit Care. 2014

Restrictive Blood Sampling

Management of Bleeding

Ultima Ratio

Platelets

PPSB (FFP)

FibrinogenTranexamic acid/

Desmopressin

Drug history

Standards(TC > 35ºC; pH > 7.2; Cai > 1.2 mmol/l)

Surgical bleeding

1. Management of pre-operative Anemia

2. Minimizing Blood Loss & Bleeding

3. Restrictive use of Blood Units► Monitoring tolerance of anemia► Restrictive transfusion trigger

Restrictive use of blood units

International Guidelines1. Carson JL, Grossman BJ, Kleinman S, Tinmouth AT,

Marques MB, Fung MK, et al. Red blood celltransfusion: a clinical practice guideline from theAABB*. Annals Internal Medicine. 2012;157(1):49-58

2. Guidelines of the German Medical Associationregarding the use of blood and blood components2014; 1-137

3. Retter A, Wyncoll D, Pearse R, Carson D, McKechnieS, Stanworth S, et al. Guidelines on the management of anaemia and red cell transfusion in adult critically ill patients. British Journal of Haematology. 2013;160(4):445-64

4. Padhi S, Kemmis-Betty S, Rajesh S, Hill J, Murphy MF, Guideline Development G. Blood transfusion: summary of NICE guidance. BMJ 2015;351:h5832.

5. …6. …

www.patientbloodmanagement.eu

www.patientbloodmanager.de

http://www.patientbloodmanager.de/

Prospective multicenter non-inferiority study in German University Hospitals All surgical inpatients (n=129,719) July 2012 to June 2015 Centers switched at different times to PBM

Primary Outcome: Composite safety endpoint of In-hospital mortality, myocardial infarction, ischemic stroke, acute renal failure,

pneumonia, sepsis

Secondary Outcome: Hb at admission and discharge ICU length of stay RBC transfusions

Meybohm P et al. Ann Surg 2016 May 9. [Epub ahead of print]

PBM Study

2013

Centre 1

Centre 2

Centre 3

2014

IM

IM

IM

Centre 4 IM

01.07. 01.07. 01.07.01.01. 01.01. 01.07.

201501.01.

2012

Meybohm P et al. Ann Surg 2016 May 9. [Epub ahead of print]

PBM Study

2013

Centre 1

Centre 2

Centre 3

2014

IM

IM

IM

Centre 4 IM

01.07. 01.07. 01.07.01.01. 01.01. 01.07.

201501.01.

2012

Control

Control

Control

Control

Before(n=54,513 patients)

Meybohm P et al. Ann Surg 2016 May 9. [Epub ahead of print]

PBM Study

2013

Centre 1

Centre 2

Centre 3

2014

IM

IM

IM

Centre 4 IM

01.07. 01.07. 01.07.01.01. 01.01. 01.07.

201501.01.

2012

Control

Control

Control

Control

Before(n=54,513 patients)

PBM

PBM

PBM

* * * * * *

PBM

* * * * *

* * * *

* * *

PBM (n=75,206 patients)

Meybohm P et al. Ann Surg 2016 May 9. [Epub ahead of print]

RBC Transfusions

Meybohm P et al. Ann Surg 2016 May 9. [Epub ahead of print]

PBM Study Results

ransfusionTA omplicationsC

Before Before

-17%

overall safe

A cute kidney injury (in-hospital)

A

-30%

Meybohm P et al. Ann Surg 2016 May 9. [Epub ahead of print]

Hobson, C et al. Circulation 2009;119;2444-2453Data (n= 2973 cardiac surgery patients)

A cute kidney injury (in-hospital)

A

Strengths and Potentials...

Slide Number 1COISlide Number 3Patient Blood Management (Frankfurt)Slide Number 5WHO: < 13 g/dl (men); < 12 g/dl (women)Anemia walk-in-clinicSlide Number 8Anemia = „Patient“ + „Made in Hospital®“Minimising Blood Loss & BleedingPhlebotomy on ICU (1 day)Hospital-acquired AnemiaRestrictive Blood SamplingManagement of BleedingRestrictive use of blood unitsInternational GuidelinesSlide Number 17www.patientbloodmanagement.euwww.patientbloodmanager.deSlide Number 20Slide Number 21PBM StudyPBM StudyPBM StudyRBC TransfusionsPBM Study ResultsSlide Number 27Strengths and Potentials...