PATIENT STRATIFICATION TREAT ThE INdIvIduAl wITh ThE KNOwlEdgE OF All

The Life Sciences Knowledge Management Company

15 year

BIOMAX

A N N I V E R S A RY

www.biomax.com

The Life Sciences Knowledge Management Company. www.biomax.com

Improving patient care by understanding the intrinsic biology of disease

Tailoring treatment of the individual using the knowledge of allSystems MedicinePatient Stratification

Patient stratification involves the use of biomarkers, geneticprofiles, research data and clinical information to create subsets within a patient population allowing patients to be grouped in terms of a therapeutic response.

Stratification reaches beyond current statistical patient evaluation methods and epidemiological predictions to integrate and bring thousands of clinical data points and intrinsic and extrinsic parameters to the patient evaluation process. The result is better decision making on behalf of the individual patient as well as the healthcare delivery organization — a true win-win situation.

Biomax enables patient stratification by providing a computational and conceptual infrastructure as well as solution building for the integration and analysis of diverse data to elicit usable patient knowledge. Benefits include the following:

Improvement of patient care and quality of life

Reduction of costs, unnecessary treatments and patient discomfort

Development of novel approaches to business managementand risk reduction

Systems medicine is the holistic approach to a patient’s care.It incorporates evidence-based medicine with the interactionsbetween all components of health, disease, human genetics,

environment and behavior.

Not only does a systems approach improve therapeutic outcomes for individual patients, it leads to significant reductions in both

healthcare delivery and clinical management costs.

By deciphering the functional and regulatory networks underlying the behavior of complex biological systems and combining them

with clinical data, Biomax is helping organizations succeedin bringing personalized medicine to their operations.

Most importantly, Biomax enables, in a few hours or days,information to be extracted, fine-tuned and ultimately realized as

knowledge in the clinical environment.

• SYNERGY — Modeling and simulation environment for systems medicine using Chronic Obstructive Pulmonary Disease (COPD) as a use case

• AirPROM — Airway Disease PRedicting Outcomes through Patient-Specific Computational Modeling

• MeDALL — Mechanisms of the Development of ALLergy

• SysCLAD — Systems prediction of Chronic Lung Allograph Dysfunction

• BIOBRIDGE — Integrative Genomics and Chronic Disease Phenotypes: Modeling and Simulation Tools for Clinicians

• STATegra — User-driven development of statistical methods for experimental planning, data gathering and integrative analysis of next-generation sequencing, proteomics and metabolomics data

Biomax creates value for clients by eliminating software coding, reducing implementation time and providing a means to bring critical insights to patient stratification.

Biomax has worked independently and in partnership with public and private organizations for several years to develop computational and mathematical tools for disease-specific,systems-wide approaches. Current project examples follow:

The impact of being able to exploit clinical knowledge effectivelyusing state-of-the-art technology cannot be overestimated. This applies to both improved patient care and better management of treatment costs.

Prof. Wouters, Chairman Board of Directors, CIRO+

Prognosis

Prophylaxis

Diagnosis

Therapy

Genetics

Biology

Biochemistry

Medicine

Lifestyle

Behavior

Sociology

etc.

The Life Sciences Knowledge Management Company. www.biomax.com

Solutions for effective management of clinical knowledge Applying semantic integration to clinical data to achieve patient stratification and personalized medicine

Clinical data

Patient stratification

Compare Biomax health Informatics

Biomax™ health InformaticsBiomax™ health Informatics

Biomax provides both conceptual and computational infrastructure for an evidence-based and disease-centric approach to healthcare delivery. Biomax solutions are highly flexible and provide integrated knowledge management using the versatile BioXM™ platform for patient stratification and targeted therapy.

Biomax™ Health Informatics enables clinicians to comprehensively evaluate clinical activity and use this knowledge for better patient care, therapeutic and business management decisions.

Biomax is enabling organizations to achieve the following:

Profile patients against all previouslytreated patients

Predict therapeutic outcome based onholistic assessment

Deliver full transparency on anyclinical activity

COPD is a huge and growing burden for public health worldwide….in Europe, an annual cost of treatment of approximately 20 billion euros. The CIRO+ Data Center allows for the first time a better understanding of patient outcome based on systematic pre- and post-assessment data of more than 3,000 patients over the past 6 years with up to 6,000 clinical data points captured for each patient.

Prof. Wouters, Chairman Board of Directors, CIRO+

Biomax Health Informatics

Therapeutic outcomes

Traditional Software development Adaptable Biomax health Informatics

Recruit, interview and hire a team of developers No new hires required

Write code No need to write code

Long development time of months to years Fully configurable by user within a few weeks or byBiomax as a service

Inflexible to changing requirements and rapiddata growth

Evolving requirements built into the design (reconfigure “on-the-fly”); unlimited scalability

Requires large project groups as domain expertsalong with local IT expertise

Solution building process driven by lean teams or domain experts; does not require local IT expertise

Results (hence success) become visible only atthe end of a (long) project

Fast turnaround times with first results becoming available immediately

Download and configure life science data repositories Life science data repositories included and pre-configured

Uncertain outcome Proven technology and guaranteed outcome

Long-term maintenance costs may increase significantly over the course of a project

Proven low maintenance cost over time and high ROI

Case Study — Chronic Obstructive Pulmonarydisease (COPd)

ObjectivesEnable granular patient stratification scheme

Move away from standard therapeutic approaches

Improve individual patient therapy outcomes

Reduce costs and improve risk management

MethodsUsing a customized Biomax solution, clinical data was semantically integrated and transformed into practical information and insights. Data consisted of 6,000 parameters per COPD patient, which was collectedon thousands of patients over six years.

Results

The resulting patient map confidently identifies parameters for therapy outcome predictions.

A better understanding of the disease and effect of treatment was established.

Transparency on patient care and resource allocation was achieved.

Costs of patient care through more efficient treatment and management were reduced.

The Life Sciences Knowledge Management Company. www.biomax.com

BioXM™ Knowledge ManagementBioXM™ Knowledge ManagementStep 1: design the data model

Step 3: Query and refine results

Diverse data

Step 4: deploy web apps to end-users

Step 2: Import the specific information

Biomax Health Informatics solutions are built using the BioXM™ Knowledge Management Environment. This ready-to-go software platform transforms complex and diverse data into usable information and knowledge by allowing practitioners and business analysts to address specific questions without cost-intensive and time-consuming programming projects. Flexible BioXM technology drives knowledge management toward your specific needs such as:

Expand knowledge — semantically integrate any data from any source seamlessly

Refine decision making — connect the dots explaining biomedical systems

Create new hypotheses — visualize novel relationships between data networks

Ready-to-go software platform provides fast and flexible solution building A graphical representation

Applications using the BioXM platform with virtually limitless possibilities

Keep repositories of scientific data such as experimental results, a corporate gene index, a pheno-type catalog, a patient register or a compound database.

Keep track of ongoing projects with one click to generate table reports and overview graphs.

Generate networks from multiple sources in one step and find previously undetected links in the data.

Identify biomarker candidates based on automated literature analysis and compare the results to experimental results in the same software platform.

Connect clinical data and statistical analyses.

Organize, review, compare, annotate and modify biological pathways originating from different sources.

Classify biological functions using ontologies specific to focused scientific areas.

Easily integrate external statistical packages (R, BioConductor), bioinformatics tools, chemoinformatic algorithms, Web services and more.

See more details about each step by visiting: www.biomax.com/agile

Biomax and BioXM are registered trademarks of Biomax Informatics AG in Germany and other countries. Viscovery is a registered trademark of Viscovery Software GmbH. Registered names, trademarks, etc., used in this document, even when not specifically marked as such, are not to be considered unprotected by law. PATSTRBRO1304

About Biomax

Biomax Informatics AG is a leading provider of customized bioinformatics solutions. The company’s flagship product, the BioXM Knowledge Management Environment, is a powerful decision-support tool enabling measurable productivity increases in biomedical R&D and clinical practice. The easy-to-use and highly configurable software allows domain experts, rather than programmers, to create, structure and visualize complex scientific models. The product is supplemented with sequence analysis, data integration, and text-mining software modules and domain-specific biomedical content solutions, for example in oncology.

Biomax creates value for clients by eliminating the coding process, slashing the implementation time of complex projects, and helping users to harness the information overload and distill critical insights from data. The Biomax worldwide customer community includes companies and research organizations that are successful in the areas of drug discovery, diagnostics, fine chemicals, food production and plant production.

robert-koch-str. 282152 planegggermanytel.: +49 89 895574-0fax.: +49 89 895574-825www.biomax.cominfo@biomax.com

15 year

BIOMAX

A N N I V E R S A RY