aux08 cameron - biological age and maturity cameron.pdfthe questions for boys are: • have you...
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The assessment of biological ageThe assessment of biological age and maturityand maturity
Noël Cameron
School of Sport, Exercise & Health Sciences, p , ,Loughborough University, UK
Email: [email protected]
Variation in the tempo of growth
3 bo s aged3 boys aged 14.75 years
3 girls aged 12 75 years12.75 years
8
Growth analysis requires somatic and developmental variables
At a clinical level the individual status of the child (the amount of deviation from normal) depends on her/his i (h i h i h ) d f h /hi fsize (height, weight, etc.) corrected for her/his stage of
maturity in relation to age
At a sample or population level the average size (e.g. height for age) and the average age of attainment ofheight-for age) and the average age of attainment of developmental milestones (e.g. age at menarche) reflects not only the health and wellbeing of the societyreflects not only the health and wellbeing of the society but also its socio-economic wellbeing
Maturity Processes v E tEventsProcesses:•Skeletal maturation•Dental maturatione ta atu at o•Sexual maturation
Maturity Processes
Atlas v Bone-specific scoring methods
Tanner scaling
Age of EmergenceTooth specific scroingTooth-specific scroing
Maturity Processes v Events: •Menarche•Menarche•Spermarche•Voice change•Voice change•Peak Height Velocity•95% adult height•95% adult height
Maturity Events:Status quo prospectiveStatus quo, prospective, recallFundamental FrequencyFundamental FrequencyModelling
Maturity indicator criteria:Maturity indicator criteria:
1.Universal2 Sequential2.Sequential3.Discrimination4.Reliability5 Validity5.Validity6.Completeness
Six considerations:
1. Maturity v Timey2. Discrete Maturity
IndicatorsIndicators3. Independence of
maturational processesmaturational processes4. Uneven maturation
S5. Sexual dimorphism6. Maturity v size
In vivo assessment of secondary sexualIn vivo assessment of secondary sexual development in normal children was not an
t bli h d d d destablished or recommended procedure…
Marshall & Tanner 1969:“The development of secondary sexual characters wasThe development of secondary sexual characters was studied in photographs taken in the nude at each examination. All the photographs of each girl were later examined togetherAll the photographs of each girl were later examined together. By comparing each picture with the preceding one, changes in the breasts and pubic hair were readily recognized.” (pp 291)the breasts and pubic hair were readily recognized. (pp 291)
Age on reaching stages: g g g“The figures [mean and SD] for PH2 must be treated with reserve as the first appearance of pubic hair cannot readily be pp p yseen on photographs. The mean…is...almost certainly too high and the standard deviation...too large.” (pp 294)
Marshall WA, Tanner JM. Variations in the pattern of pubertal changes in girls/boys. Arch Dis Childh 44/45 291 303/13 23 1969/1970Arch. Dis. Childh. 44/45, 291-303/13-23. 1969/1970.
In vivo assessment of secondary sexual ydevelopment in normal children was not an established or recommended procedureestablished or recommended procedure…
Concerns over:Concerns over:
i ht t i• right to privacy• taboo on touching or palpation• qualifications and background of observer• presence of same sex chaperonep p
In non-clinicalIn non clinical research settings T i iTanner staging is a barrier tobarrier to participant
licompliance because of cultural and religious beliefs andbeliefs and practices
Hand-wrist Radiation exposure values: 0.003 mSv
1/10th exposure for air travellers 1/6th background in UKp g(except Aberdeen 1/3rd)
Alt ti th d fAlternative methods for maturity characteristics?y
• Questionnaires• Questionnaires• Self-assessment (Puberty
Development Scale - PDS)• Blood bio-markers• Blood bio-markers
The questions for girls are: • Have you started puberty i e do you have any pubic hair• Have you started puberty i.e. do you have any pubic hair
or have your breasts enlarged since you were a child?• Do you have regular menstrual cycles i e periods?• Do you have regular menstrual cycles i.e. periods?• If so, have you been having periods for more than two
years?years?• How old were you when you started to have periods?
The questions for boys are: • Have you started puberty i e do you have any pubic hair or• Have you started puberty i.e. do you have any pubic hair or
have your genitalia enlarged since you were a child?• Has your voice broken i e do you speak in a deeper voice• Has your voice broken i.e. do you speak in a deeper voice
then when you were a child? • If so have you been speaking in a deeper voice for more• If so, have you been speaking in a deeper voice for more
than two years? • How old were you when your voice broke?How old were you when your voice broke? • Do you shave?• How often do you shave e.g.How often do you shave e.g.
per week/month?• When did you start shaving?y g
Artículo original
Arch Argent Pediatr 2009; 107(5):423-429 / 423Mét d i i l l ióMétodo no invasivo para la evaluación del desarrollo sexual en ladel desarrollo sexual en la adolescenciaA non invasive method for assessing sexual development at adolescencedevelopment at adolescence
D H i L j t lDr. Horacio Lejarraga et al
The highest concordance were found in the questions: "Have you started puberty?" with Tanner's stages III IVHave you started puberty? , with Tanner s stages III, IV or V (Kappa value= 0.60); "Have you already had your first menstrual period?" with stages IV V (K= 0 69); andfirst menstrual period? with stages IV-V (K= 0.69); and "Do you shave?" with stages IV-V (K= 0.66). In most cases these questions showed high (≥ 0 80) sensitivitycases, these questions showed high (≥ 0.80) sensitivity and specificity for detecting the mentioned puberty periodsperiods.
Lejarraga et al 2009
NB: Self assessment by questions and drawings of Tanner scale
Chavarro et al 2017 Validity of self-assessed sexual maturation against
NB: Self-assessment by questions and drawings of Tanner scale
physician assessments and hormone levels. J.Pediatr. 2017;186:182-8
Chavarro et al 2017 Validity of self-assessed sexual maturation against physician assessments and hormone levels. J.Pediatr. 2017;186:182-8
Puberty Development Scale (PDS) v Picture Based Interview about Puberty (PBIP) vPhysical exam (physician)y (p y )
N=160 boys= 82; girls = 78N 160 boys 82; girls 78
Setting : Wisconsin USASetting : Wisconsin, USAGonadal signals: ♀ AGS, B, Men; ♂ AGS, Voice, facial hairAdrenal signals: ♀/♂ PH, “skin changes”
Shirtcliffe et al Child Dev 2009Shirtcliffe et al Child Dev. 2009
Comp K %Acc. %Acc. ♂
%Acc. ♀
%Over %♂/♀ %Under
%♂/♀
Phys v PDS Gon
0.36 52 54 47 18 15/27 30 31/27
GonPhys v PDS
0.36 50 60 44 29 26/34 21 14/23
AdrPhys v PBIP
0.36 49 41 57 26 35/17 25 24/17PBIP B/GPhys v 0.43 56 54 58 24 26/21 20 19/21yPBIP PHPDS 0 29 44 37 52PDS v PBIP B/G
0.29 44 37 52
PDS v PBIP PH
0.37 52 47 57
PH
Comp K %Acc. %Acc. ♂
%Acc. ♀
%Over %♂/♀ %Under
%♂/♀
Phys v PDS Gon
0.36 52 54 47 18 15/27 30 31/27
GonPhys v PDS
0.36 50 60 44 29 26/34 21 14/23
AdrPhys v PBIP
0.36 49 41 57 26 35/17 25 24/17PBIP B/GPhys v 0.43 56 54 58 24 26/21 20 19/21yPBIP PHPDS 0 29 44 37 52PDS v PBIP B/G
0.29 44 37 52
PDS v PBIP PH
0.37 52 47 57
PH
Comp K %Acc. %Acc. ♂
%Acc. ♀
%Over %♂/♀ %Under
%♂/♀
Phys v PDS Gon
0.36 52 54 47 18 15/27 30 31/27
GonPhys v PDS
0.36 50 60 44 29 26/34 21 14/23
AdrPhys v PBIP
0.36 49 41 57 26 35/17 25 24/17PBIP B/GPhys v 0.43 56 54 58 24 26/21 20 19/21yPBIP PHPDS 0 29 44 37 52PDS v PBIP B/G
0.29 44 37 52
PDS v PBIP PH
0.37 52 47 57
PH
Self-assessment Summary:
• Questions demonstrate a good concordance between self assessment and physician’s assessment
• Self assessments from pictures have moderate concordance with physician’s assessmentsconcordance with physician s assessments
• Concordance from PDS and PBIP is modest except for PBIP and Physicians assessment whichexcept for PBIP and Physicians assessment which is goodB th i l i l t f PH• Boys are worse than girls in general except for PH
• Early and late developers are worse than average developers
But…the timing of the initiation and duration of puberty is fundamentally important in:
• Critical period for social and emotional developmentdevelopment
• The long term effects of early adversity• The development of patterns of habitual dietary• The development of patterns of habitual dietary
intake and physical activityC• Critical changes in body composition and the development of obesity
• The development of risk for CVD, CHD, etc.
If traditional methodsIf traditional methods are no longer acceptable and selfacceptable and self-assessment is good b t t t h tbut not great, what can be assessed as an acceptable maturity indicator of ypubertal initiation and duration?duration?
HPG axis
Threshold l fvalues of
gonadotrophins go adot op sand sex steroids fromsteroids from body fluids?y
Girls:Girls:
FSH, LH, Inhibin (A&B) Estradiol v Tanner stage
XS, N=403 6-20 yrs
Sehested et al J Clin EndocMetab 85(4): 1634-1640. 2000
Boys:
Inhibin B FSH LH
Boys:
Inhibin B, FSH, LH, testosterone, and
t di l Testradiol v Tanner stage
XS N=400 6-20 yrsy
AM Anderson et al J ClinAM Anderson et al J ClinEndoc Metab 82(12): 3976-3981. 19973981. 1997
Importance of scaling by pubertal status p g y prather than age is demonstrated by:
Sims et al 2012 Clin Endocrinol
NHANES III 1988-1994NHANES III 1988-1994
Girls: LH, Inhibin B
N=705
Sims et al NHANES III 88-94 Clin Endoc 2012 77:55-63
Sehested et al J ClinEndoc Metab 85(4): 1634 1640 20001634-1640. 2000
N=689
Sims et al NHANES III 88-94 Clin Endoc 2012 77 55 63
Sehested et al J ClinEndoc Metab 85(4): 1634 77:55-63Endoc Metab 85(4): 1634-1640. 2000
What indicators of maturity were beingWhat indicators of maturity were being used to estimate chronological age (CA)?
• Times of appearance and fusion of• Times of appearance and fusion of ossification centres
• Number of erupted teeth• Present/absent 2y sexual developmentPresent/absent 2y sexual development• Normal/abnormal gait
N l/ b l ki l ti it• Normal/abnormal skin elasticity
What indicators of maturity were being used to estimate chronological age?
• Times of appearance and fusion of fossification centres
• Number of erupted teethNumber of erupted teeth• Present/absent 2y sexual development
N l/ b l it• Normal/abnormal gait• Normal/abnormal skin elasticityy
Validity? Relationship to Chronological age?Validity? Relationship to Chronological age?
Maturity indicators:
T. Wingate Todd (1937) Atlas of Skeletal M t tiMaturation
“…those features…which, because they tend to occur regularly and in a definitive g yand irreversible order, mark…progress towards maturity ”towards maturity.
The future of non-clinical pubertal assessment…p
Culturally sensitive questionnaireCulturally sensitive questionnaireHPG hormones - body fluid analysis
1 Maturity v Time1.Maturity v Time2.Discrete indicators
• Maturity indicators are di t i di t fdiscrete indicators of continuous processes
1 Maturity v Time1.Maturity v Time2.Discrete indicators3 I d d f3. Independence of
processes
• different aspects of maturation are under different biologicaldifferent biological control
1 Maturity v Time1.Maturity v Time2.Discrete indicators3 I d d f3. Independence of
processes 4.Uneven maturation
• no two process mature at the samemature at the same rate
1 Maturity v Time1.Maturity v Time2.Discrete indicators3 I d d f3. Independence of
processes 4.Uneven maturation5.Sexual dimorphismp
M t ti t• Maturation rates differ between the sexes
1 Maturity v Time1.Maturity v Time2.Discrete indicators3 I d d f3. Independence of
processes 4.Uneven maturation5.Sexual dimorphismp6.Maturity v Size
• a general but not specific relationshipspecific relationship exists between size and maturityand maturity
Conclusions:
• Clinical (physicians) assessment were bestassessment were best
• Growth analysis (SITAR) when longitudinal data heightwhen longitudinal data height and foot length(?)
• BiomarkersBiomarkers• Voice change