PEER: Skills for SuccessUniversity of Tennessee-

Knoxville

West Nile Virus

Ethel Stanley

BioQUEST, Beloit College

Sam Donovan

University of Pittsburgh

>South_Africa-99CCAACCACTGTGGATTCGCATGGTAACTACCCCACACAGATTGGGGCCACTCAGGCAG GGAGATTCAGCATCACTCCTGCAGCGCCTTCATACACACTAAAACTTGGAGAGTATGGA GAGGTGACGGTGGACTGTGAACCACGATCAGGGATTGACACCAATGCATACTACGTGAT GACTGTCGGAACAAAGACGTTCTTGGTCCATCGTGAGTGGTTTATGGACCT

>Israel-52CCAACCACTGTGGAGTCGCATGGAAACTACCCCACACAGATTGGGGCCACTCAGGCAG GGAGATTCAGCATCACTCCTGCAGCGCCTTCATACACACTAAAACTTGGAGAGTATGGA GAGGTGACGGTGGACTGTGAACCACGATCAGGGATTGACACCAATGCATACTACGTGAT GACTGTCGGAACAAAGACGTTCTTGGTCCATCGTGAGTGGTTTATGGACCT

>NY-99flamingoCCAACTACTGTGGAGTCGCACGGAAACTACTCCACACAGGTTGGAGCCACTCAGGCAG GGAGATTCAGCATCACTCCTGCGGCGCCTTCATACACACTAAAGCTTGGAGAATATGGA GAGGTGACAGTGGACTGTGAACCACGGTCAGGGATTGACACCAATGCATACTACGTGAT GACTGTTGGAACAAAGACGTTCTTGGTCCATCGTGAGTGGTTCATGGACCT

>NY-99equineCCAACTACTGTGGAGTCGCACGGAAACTACTCCACACAGGTTGGAGCCACTCAGGCAG GGAGATTCAGCATCACTCCTGCGGCGCCTTCATACACACTAAAGCTTGGAGAATATGGA GAGGTGACAGTGGACTGTGAACCACGGTCAGGGATTGACACCAATGCATACTACGTGAT GACTGTTGGAACAAAGACGTTCTTGGTCCATCGTGAGTGGTTCATGGACCT

>Romania-96CCAACCACTGTGGAGTCGCATGGAAACTACTCCACACAGATTGGGGCCACTCAGGCAG GGAGATTCAGCATCACTCCTGCGGCGCCTTCATACACACTAAAGCTTGGAGAATATGGA GAAGTGACAGTGGACTGTGAACCACGGTCAGGGATTGACACCAATGCTTACTACGTGAT GACTGTTGGAACAAAGACGTTTTTGGTCCATCGTGAGTGGTTCATGGACCT

http://www.microbiology.wustl.edu/training/courses/molvir/emergVir

Approximate global distribution of West Nile virus

Solomon, T., Brit. Med. J. 326, 865-869 (2003)

Clinical course of West Nile encephalitis

Solomon, T., Brit. Med. J. 326, 865-869 (2003)

 ReplicationNote: After you click on the link above, choose USA and click GO

https://www1.qiagen.com/GeneGlobe/PathwayView.aspx?pathwayID=472 Vaccinehttp://www3.niaid.nih.gov/news/newsreleases/2005/wnvgraphic.htm CDC- West Nile Virus in Farmed Alligatorshttp://www.cdc.gov/ncidod/EID/vol9no7/03-0085.htm Predicting WNV http://earthobservatory.nasa.gov/IOTD/view.php?id=2172 Global Warming May Lead to More West Nile Virushttp://www.scientificamerican.com/article.cfm?id=west-nile-virus-global-warming 

http://www.bioquest.org/bedrock/problem_spaces/wnv/

What are our questions?

“It’s called West Nile for a reason. . .”

>Stork98TTTAACTGCCTTGGAATGAGCAACAGAGACTTCTTGGAAGGAGTGTCTGGAGCAACATGGGTGGATTTGGTTCTCGAAGGCGACAGCTGCGTGACTATCATGTCTAAGGACAAGCCTACCATCGATGTGAAGATGATGAATATGGAGGCGG

>Goose99TTCAACTGCCTTGGAATGAGCAACAGAGACTTCTTGGAAGGAGTGTCTGGAGCAACATGGGTGGATTTGGTTCTCGAAGGCGACAGCTGCGTGACTATCATGTCTAAGGACAAGCCTACCATCGATGTGAAGATGATG

Malkinson,M., Banet,C., Weisman,Y., Pokamunski S, King,R., Drouet, M.T. and Deubel, V. 2002. Introduction of West Nile virus in the Middle East. Journal Emerging Infect. Dis. 8 (4): 392-397.

Banet-Noach, C., Malkinson, M., Brill, A., Samina, I., Yadin, H., Weisman, Y., Pokamunski, S., King, R., Deubel, V. and Stram, Y. 2003. Phylogenetic relationships of West Nile viruses isolated from birds and horses in Israel from 1997 to 2001. Journal Virus Genes 26 (2), 135-141.

But where did Israel-98 come from?

The stork brought it…