pharmacology-last years' questions

7/30/2019 Pharmacology-Last Years' Questions

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1- Hypokalemia isnt a side effect of :

1) Spiranalactone

2) Amiloride

3) Triamterene

4) Enalapril

5) All of t he above

2- All are nit rate effect s except :1) Bradycardia

2) Headache

3) Cyanosis

4) Flushing

5) Tolerance

3- All are morphine effects except :

1) Miosis

2) Vomiting

3) Constipation

4) Cough

5) Hyposis

4- One is selective B2 agonist :

1) Isoprinaline

2) Noradrenaline

3) Salbutamole

4) Timolol


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5) Amphetamine

5- Carbacol (cholinergic agonist ) :

1) Used in enuresis among children

2) Antagonized by neostigmine

3) Relax skeletal and smooth muscle

4) Increase BP

5) Decrease I OP ( int raocular pressure )

6- One matched correct ly w it h it s source :1) Sulfonamide / synthet ic

2) Insulin / plants

3) Erythropoietin / microbes

4) Digoxin / synthetic

5) None of them

7- All increase drug concent rat ion in blood except :

1) Given parentally

2) Liver and kidney disease

3) c-p 450 inhibitors

4) Combined with drug displace it from its receptor and

having low VD


8- Potency :

1) The ability of drug to bind a receptor

2) The maximum effect of a drug


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3) The effect of drug per unit of w eight

4) The dose needed to reach the maximum effect of the drug

5) None of them

9- All are side effect of fr usemide except :

1) Hyperlipidemia

2) Hyperglycemia

3) Hyperuricemia

4) Hyperkalemia5) Hyponatremia

10-Hair grow th is not iced in w hich drug used in

hypertension :

1) Methyldopa

2) Na nitroprusside

3) Minoxidil

4) Hydralazine

5) Nifedipine

11- Pethidine compared t o morphine :

1) Produces sedation more than restlessness

2) Less antimuscarinic effect

3) More potent

4) Has negative inot ropic effect

5) More antitussive action


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12-Adrenalin used in all except :

1) Asthma

2) Heart block

3) Glaucoma

4) Local bleeding

5) Angina

13-The drug react ivate inhibi ted Ach esterase :

1) Atropine2) Neostigmine

3) Thiosulphate

4) Adrenaline

5) PAM

14-Succinylchol ine used in :

1) Malignant hyperthermia

2) Intestinal and biliary colic

3) Rapid endot racheal int ubation

4) Motion sickness

5) Glaucoma

15-1st pass effect defini t ion :

1) Drug metabolism when given by IV route

2) Drug metabolism when not bounded to plasma albumin

3) Drug metabolism in the liver before dist ribut ion

w hen given internally


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4) Drug metabolism outside the liver

5) Drug elimination upon manipulating urine PH

16-The half life of a drug :

1) The t ime needed for a drug to change

concent rat ion by 50%

2) The time needed for a drug to bind to its receptor

3) The time needed for a drug to excreted completely from

the body

4) The time needed to reach the maximum concentration

17-Zero order k inetic :

1) Few drug follow it

2) Kinetic at high drug concentration

3) Fixed amount of drug metabolized per unit time

4) Rate of metabolism is time independent


18-All are uses of d igoxin except :

1) Heart failure

2) Atrial flutter

3) Atrial fibrillation

4) Ventr icular ectopic

5) Used for all of them

19- All t rue regarding digox in except :


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1) Negative inot ropic agent

2) Negative chronotropic agent

3) Na /K pump inhibitor

4) Given enterally and parentally

5) Characterized by all of them

20-One anti- arrhyt hmic drug acts by inhibit ing

ventr icular excit ation :

1) Digoxin

2) Adenosine3) Metoprolol

4) Verapamil

5) Lignocaine

21-About morphine :

1) Safe to be given in pregnant and lactating women

2) Respiratory center stimulants , useful in asthmatics

3) Mydriatic agent

4) Indicated in post partum urinary retention

5) Cont raindicated in acut e undiagnosed abdominal

pain

22-NE primary t erminated by :

1) Reuptake to neurons

2) Metabolized by MAO

3) Metabolized by Ach-esterase


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4) Passively diffused out of synapses

5) Metabolized by COMT

23-Prazosin :

1) The 1st choice in glaucoma management

2) Used in migraine treatment and prophylaxis

3) Contraindicated in hypertension management

4) Used in benign prostat e hyperplasia BPH

5) Partial opioid agonist

24-Digoxin toxicity in increase in w hich of t he follow ing

condit ions :

1) Hypothyroidism {myxedema}

2) Thiazide diuretics

3) Renal failure

4) Hypokalemia

5) All of t hem

25-Angina is best managed by :

1) Oral propranolol

2) Oral isosorbid dinitrate

3) GTN patches

4) Chewed isosorbid mononitrate

5) GTN subl ingually


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26-Acute morphine t oxicity i s best managed by :

1) naltrexone

2) methadone

3) mepridine

4) Na thiosulpate

5) naloxone

27-all are side eff ects of B blockers except :

1) hyperglycemia

2) arrhythmias3) bradykardia

4) sexual dysfunction

5) cold extremities

28-ant icholinergic best used for m ydriasis :

1) homatropine

2) benzatropine

3) pirenzpine

4) ipratropium

5) probanthine

29-t he name of drug given by the manufacturers is the :

1) chemical name

2) generic name

3) official name


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4) t rade name

5) approved name

30-drug absorpt ion depends in all except :

1) blood flow at absorption site

2) contact time at absorption site

3) lipid solubility

4) volume of dist ribut ion

5) all of the above

31-t herapeutic effects of a drug increase w hen :

1) displaced from albumin

2) bound strongly to plasma protein

3) dissociate from its receptor

4) ionized in liver set of metabolism

5) become water soluble

32-drug enters CNS readily are :

1) lipid soluble

2) highly bound to albumin

3) hydrophilic

4) polar

5) large in weight


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33-one is calcium channel blocker :

1) varapamil

2) clonidine

3) timolol

4) pentazocin

5) minoxidil

34-B blockers used in all except :

1) Angina

2) Hyperthyroidism3) Glaucoma

4) Migraine

5) Asthma

35-Neost igmine indicated in all except :

1) Organophosphate poisoning

2) Post operative urinary retention

3) Tubocurarine poisoning

4) Mysthena gravis

5) All of the above

36- Atropine indicated in all of t he follow ing except :

1) Vomiting

2) Pyloric stenosis

3) Insecticide poisoning

4) Urine retention

5) Preanesthesia


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37-Drug of w ide t herapeutic index :

1) Toxic at low doses

2) Variation in patient response occur at the same dose

3) Minimally bound to plasma protein

4) Safe drug

5) 2 and 4

38-Bioavilabilit y describes :

1) Percentage of drug dose not bind plasma proteins

2) Percentage of drug bind to the intracellular receptor

3) Percent age of drug reaches the plasma unchanged

4) Volume of blood containing drug excreted per unit of time

5) Percentage of drug not metabolized in the cp-450 system

39-Rectal form of drugs include :

1) Ointment

2) Suspension

3) Bolus

4) Patches

5) Suppository

40-All used in hypert ension management except :

1) Alpha adrenergic antagonists

2) Vasodilator


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3) ACE inhibitor

4) Cholinesterase inhibit or

5) Calcium channel blockers

pharmacology-last years' questions

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