physiological influences on development
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Physiological Influences on Development. EDFD127 Week 6 Reading: Stanley, F. (2003). The Real Brain Drain- Why putting children first is important for Australia . . Lecture Outline. Review What is Physiology? Physiology, Learning & Development- the basics - PowerPoint PPT PresentationTRANSCRIPT
PHYSIOLOGICAL INFLUENCES ON DEVELOPMENTEDFD127 Week 6Reading: Stanley, F. (2003). The Real Brain Drain- Why putting children first is
important for Australia.
LECTURE OUTLINE Review What is Physiology? Physiology, Learning & Development- the
basics Physiology, Learning & Development- beyond
the basics Environmental influences on physiological
development Genetic influences on physiological development Recent advances in our understanding of
physiological development- cognitive sciences and neuroscience
REVIEW
Physiology as a context for learning and
development
Society and Culture as a Context for Development
Education and Schools as a Context for Development
Families as a Context for Development
PHYSIOLOGY the internal workings of living things the way an organism works, lives or keeps
going
Concerned with: Metabolism (our internal engine)- hormones and
other chemicals Organs and body systems (immune system)
Enables growth, development and learning
PHYSIOLOGY, LEARNING & DEVELOPMENTTHE BASICS Physiological needs- food, water, shelter,
Physiological structure and functionBeneficial
super efficient gas exchange in the lungs high percentage of fast-twitch muscle fibres super fast conduction time in neurones
Detrimental metabolic disorders, genetic disorders
sleep
BASIC PHYSIOLOGICAL NEEDSNUTRITION
Appropriate nutrition is essential for rapidly growing babies.
Breast milk and infant formulas are especially suited to meet their needs.
Malnutrition during the early years can result in permanent stunting of physical growth and impairment of brain development.
Improved nutrition earlier onset of puberty
(Berk, 2003)
BASIC PHYSIOLOGICAL NEEDSSLEEP
“…just as nutritional status, ambient temperature, level of stress, blood oxygenation, and other variables clearly affect the ability to learn, adequate sleep is vital for optimal performance in learning tasks.”
(Siegel, 2001)
Sleep is essential for rapidly developing teenagers.
Teenagers need as much or more sleep than children- 9 ¼ hours per night.
Many teens are sleep-deprived. feel despondent don’t learn effectively; get poor marks experience drowsiness in the early morning and
mid-afternoon have accidents etc
Because of their deep concern about these issues, sleep researchers are pushing for later school start times for teenagers.
(Carskadon,1999).
PHYSIOLOGY, LEARNING & DEVELOPMENTBEYOND THE BASICS Getting down to the nitty gritty
Nerves; neurones; neurotransmitters
Chemicals- hormones; enzymes; body fluids (blood etc)
Genes
BIG NAMES IN HISTORY Pavlov (1849-1936)
“nervism”-the nervous system (brain and peripheral nerves) controls our behaviour
reflexes- stimulus and response conditioning- cortex involved
Watson (1878-1958); Skinner (1904-1990) Behaviourism learning through reinforcement
COGNITIVE SCIENCE- 1950’S The technological age
Computers- thought processes could be modelled and therefore studied in a scientific manner
Educational Psychology Cognitive load theory Memory- 7 +/-3 rule
MODERN TIMES
Pathology- hormones; neurotransmitters Stress hormones and learning (Yerkes Dodson
curve)
Neurophysiology- CT; MRI; PET scans Mathematical thinking (Geek, 2003)
Genetics and epigenetics
Bridging these areas Relationship between psychological and
physiological health
PSYCHOLOGICAL HEALTH DETERMINES PHYSICAL HEALTH
Basic psychological needs competence, autonomy, relatedness (SDT- Ryan and
Deci) love, friendship, achievement, joy…
Relationship- love and affection Harlow’s classic monkey experiment (Harlow &
Zimmerman, 1959) Meaney’s rat studies (Liu D. et al. 1997)
Romanian orphans (Kaler & Freeman, 2006)
HARLOW’S MONKEY EXPERIMENTS Baby rhesus monkeys given a choice
between two surrogate mothers, one made from a soft material, similar to a parent monkey, and the other was made from wire mesh and had a bottle attached to it.
The monkeys spent most their time with the clothed monkey rather than the one with offers food.
http://rahuldesign.files.wordpress.com/2008/12/harlow-monkey.jpg
MEANEY’S RESEARCH The equivalent of child neglect in rats is restricted licking
and grooming behaviour, restricted vocalising and not nursing in an arched back posture.
Neglected rat pups are less adventurous, don’t learn as quickly, are highly stress reactive, exhibit abnormal socialising behaviours and are physically smaller and sicker than their nurtured counterparts.
In adulthood these rats continue to have problems relating
to other rats, are fearful, stress reactive and anxious and become neglectful mothers themselves.
Young monkeys taken from their mothers show similar developmental abnormalities related to physical, cognitive and social/psychological development.
Both the rats and monkeys show: chronic elevation of stress hormones abnormalities in their brain structure- smaller
brains overall, small hippocampuses, small amygdala, smaller frontal and prefrontal lobes( important for memory, emotion and impulse control, and long term planning)
An environmental insult (social and
psychological neglect) causes changes to both physiology and anatomy.
CHRONIC STRESS IN YOUNG CHILDREN Chronic elevation of stress hormones
in childhood predicts: High stress reactivity in adulthood Brain abnormalitiesImpaired memory, learning problems
emotional and behavioural problems problems with impulse control
Anxiety and depressionDecreased growth hormone
(De Bellis 1999, 2001, 2002)
PHYSIOLOGY AND ENVIRONMENT The family- family functioning (stress, abuse);
maternal health and nutrition; health of siblings Socioeconomic status- poverty, homelessness Cultural background- indigenous peoples Surrounds- environmental toxins (radiation, agent
orange); access to clean water and facilities Prenatal exposure to teratogens- drugs, smoking,
alcohol, radiation, environmental pollution, maternal disease, inadequate nutrition, maternal stress
Birth complications- oxygen deprivation, prematurity Society and culture- public policy
Children from families where conflict between members is the norm and those who are abused or neglected do not cope well. They have chronically high levels of stress hormones.
Child neglect and child abuse are chronic societal problems. There has been more than a doubling in the number of reports of suspected child neglect and and abuse in Australia over the past 12 yrs.
SOCIAL GRADIENT “The differences in a particular characteristic
across the social strata from the most to the least advantaged.”
If there is a difference, then a gradient can be said to exist and we say that there is a disparity.
e.g there is a large disparity for low birth weight whereas there is virtually no disparity for childhood cancers
The ‘paradox of progress’- the differences between the ‘haves’ and the ‘have nots’ have increased despite increases in wealth and living conditions.
(Stanley 2003, p4)
PREVALENCE OF OVERWEIGHT/OBESITY, 7-15 YR OLDS:
1985 2003 Males 9.3% 23.1%Females 10.6% 30.5%
HEALTH DETERMINANTSExerciseDietSocial supportOther
SmokingSleep Education Economic status Environment
(Marmot 1998; Harvard Health 2000; Kahneman, 2004)
1/3
WHAT ABOUT THE OTHER 2/3?
“the control factor”“control over our destiny”
(Marmot, 1998)
Without control we experience stress
Stress
Immune SystemMetabolic
HormonesBrainInsulinCortisol
NeurotransmittersHeartLungsKidney
Gut motilityFat metabolism
ImmunoglobulinsWhite cells
THE PSYCHOBIOLOGICAL STRESS RESPONSE (BRUNNER AND MARMOT 2006, P27)
STRESS IS ALL ABOUT BALANCE
Stressors Family conflict Peer/school
conflict Poor coping
strategies Early deprivation
Coping Resources Physical health Helpful Coping strategies Social resources Personality/Genetics
RESILIENCE
STRESS AND COPING “Stress is a challenge to the systems of
the body such that we are no longer in control.”
“Coping is the capacity to survive the immediate stress and then to return to a state of control.”
McEwan, B. S. 1998. Protective and damaging effects of stress mediators. New England Journal of Medicine 338,
171-179.
POOR COPING If we do not cope well we have
sustained increases in stress hormones (adrenaline and cortisol).
When these hormones remain elevated they cause damage to the body.
Psychological wellness is essential for healthy physical
and neurological development.
CRITICAL PERIODS Variable effects of influences on development
depending on time of exposure Pre-natal- body temp. of mother in first 2 months
of pregnancy; folate Post-natal- affection; congenital cataracts;
language acquisition in deaf children Early childhood- Extreme emotional deprivation
can interfere with the production of growth hormone, thereby stunting children's growth.
More the exception than the rule, especially in terms of learning. Has to be dire circumstances. ‘Good enough’ approach.
PHYSIOLOGY AND NATURE:GENES AND HEREDITY Gene expression determines the characteristics
that make us human and contribute to individual differences in appearance and behavior.
Heredity affects physical growth by regulating the production and effect of hormones.
There are wide variations in normal development e.g. typical age range for walking is 10-13 months but there are some children who walk at 8 months and some who walk at 18 months.
GENETIC DISORDERS Inheritance of harmful genes can cause
developmental problems (Cystic Fibrosis, Fragile-X Syndrome).
Chromosomal abnormalities can cause
developmental problems (Down’s Syndrome). Genetic counseling and prenatal diagnosis
help people at risk for transmitting genetic disorders.
Genotype The pattern of genes a person inherits; a
person’s inborn capacity or potential
Phenotype Traits a person displays resulting from the
interplay of genes and environment
CHROMSOMESChromosomes
In the nucleus of cells Store and transmit genetic information Each cell in the human body contains 23 pairs 22 pairs of autosomes + 1 pair of sex
chromosomes
http://www.accessexcellence.org/AE/AEPC/NIH/images/chromosome.gif
DNA: DEOXYRIBONUCLEIC ACID Chromosomes are made up of DNA
Segments of DNA are called ‘genes’ Feb 2001- 30,000 genes
Genes code for proteins
Proteins make our muscles, skin etc and also enzymes and neurotransmitters etc
http://creationwiki.org/pool/images/thumb/5/54/Chromosome.png/450px-Chromosome.png
PATTERNS OF GENETIC INHERITANCE Two forms of a gene occur at the same place
on the autosomes, one from the mother and one from the father.
Homozygous- 2 copies of the same gene i.e. AA or aa
Heterozygous- 2 different forms of the gene i.e. Aa
PATTERNS OF GENETIC INHERITANCE Genes can be ‘dominant’ or ‘recessive’ or
‘co-dominant’ AA- 2 dominant genes = homozygous dominant Aa- 1 dominant + 1 recessive = heterozygous aa- 2 recessive genes = homozygous recessive
In a heterozygote, the dominant gene is expressed
A heterozygous individual can pass on a recessive gene or a dominant gene.
Dominant RecessiveDark Hair Blonde hair
Curly hair Straight hairNormal hearingFacial dimples No dimplesNormal vision NearsightednessFarsightedness Normal visionNormal vision Congenital cataractsDouble jointedness Normal hairBlood Type A Blood Type O
AA + Aa
AA Aa AA Aa
Aa + Aa
AA Aa Aa aa
SEX CHROMOSOMES 2 sex chromosomes- X and Y XX- female XY- male
X chromosome longer than Y chromosome- more genes on the X
X-LINKED INHERITANCE For some genes, males only have 1 copy on X
chromosome…no corresponding gene on the Y chromosome
If X chromosome gene is faulty in a male, no corresponding gene to counteract and take over
If X chromosome gene is faulty in a female, corresponding gene on other X chromosome can take over
X-linked inheritance- colour blindness, baldness, haemophilia, Duchenne Muscular Dystrophy
OTHER FORMS OF INHERITANCE Many traits or characteristics are polygenic- influenced by a number of genes, e.g. behaviour, cognitive processes, ?ADHD
Some traits are said to have variable penetrance- do not follow classical dominant or recessive inheritance patterns, e.g. Fragile X syndrome.
PHYSIOLOGY IS INFLUENCED BY GENES + ENVIRONMENT Nature via nurture (Matt Ridley, 2003) Diet, heart disease and cholesterol genes Childhood abuse and stress gene Marijuana use and genetic predisposition to
psychosis (Caspi et al., 2005) Depression gene- individuals with one or two
short alleles of the 5-HTT serotonin transporter gene become depressed more often after stressful events than individuals with two long alleles of this gene (Caspi, et. al., 2003)