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Power of the Mind in Health and Healing Keith R. Holden, M.D. Accordo Health Institute 2014 Spring Symposium www.Dr-Holden.com

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Page 1: Power of the Mind - media.virbcdn.commedia.virbcdn.com/files/ea/b1eb973a00b3637a-Power...Power of the Mind in Health and Healing Keith R. Holden, M.D. Accordo Health Institute 2014

Power of the Mindin Health and Healing

Keith R. Holden, M.D.Accordo Health Institute 2014 Spring Symposium

www.Dr-Holden.com

Page 2: Power of the Mind - media.virbcdn.commedia.virbcdn.com/files/ea/b1eb973a00b3637a-Power...Power of the Mind in Health and Healing Keith R. Holden, M.D. Accordo Health Institute 2014
Page 3: Power of the Mind - media.virbcdn.commedia.virbcdn.com/files/ea/b1eb973a00b3637a-Power...Power of the Mind in Health and Healing Keith R. Holden, M.D. Accordo Health Institute 2014
Page 4: Power of the Mind - media.virbcdn.commedia.virbcdn.com/files/ea/b1eb973a00b3637a-Power...Power of the Mind in Health and Healing Keith R. Holden, M.D. Accordo Health Institute 2014

Mindfulness Meditation

Page 5: Power of the Mind - media.virbcdn.commedia.virbcdn.com/files/ea/b1eb973a00b3637a-Power...Power of the Mind in Health and Healing Keith R. Holden, M.D. Accordo Health Institute 2014

Mindfulness Meditation

• Attention in the present moment without judgment

Page 6: Power of the Mind - media.virbcdn.commedia.virbcdn.com/files/ea/b1eb973a00b3637a-Power...Power of the Mind in Health and Healing Keith R. Holden, M.D. Accordo Health Institute 2014

Mindfulness Meditation

• Attention in the present moment without judgment

• Watch, Witness, and Allow

Page 7: Power of the Mind - media.virbcdn.commedia.virbcdn.com/files/ea/b1eb973a00b3637a-Power...Power of the Mind in Health and Healing Keith R. Holden, M.D. Accordo Health Institute 2014
Page 8: Power of the Mind - media.virbcdn.commedia.virbcdn.com/files/ea/b1eb973a00b3637a-Power...Power of the Mind in Health and Healing Keith R. Holden, M.D. Accordo Health Institute 2014
Page 9: Power of the Mind - media.virbcdn.commedia.virbcdn.com/files/ea/b1eb973a00b3637a-Power...Power of the Mind in Health and Healing Keith R. Holden, M.D. Accordo Health Institute 2014

Relaxation & Epigenetics

• Controls oxidative stress

• Improves mitochondrial energy production

• Improves insulin production

• Reduces inflammation

• Improves telomere stability

Page 10: Power of the Mind - media.virbcdn.commedia.virbcdn.com/files/ea/b1eb973a00b3637a-Power...Power of the Mind in Health and Healing Keith R. Holden, M.D. Accordo Health Institute 2014
Page 11: Power of the Mind - media.virbcdn.commedia.virbcdn.com/files/ea/b1eb973a00b3637a-Power...Power of the Mind in Health and Healing Keith R. Holden, M.D. Accordo Health Institute 2014

Mindfulness Meditation -Anti-Inflammatory

• An intensive day of MM acts as an anti-inflammatory in EM

• Mechanism similar to NSAID

• Subset had faster cortisol recovery after social stress test

Page 12: Power of the Mind - media.virbcdn.commedia.virbcdn.com/files/ea/b1eb973a00b3637a-Power...Power of the Mind in Health and Healing Keith R. Holden, M.D. Accordo Health Institute 2014

Mindfulness Meditation- Anti-Inflammatory

• Dusek et al., 2008

• Bhasin et al., 2013

• Creswell et al., 2012

• Black et al., 2013

Mindfulness meditation turns off NFKB

Page 13: Power of the Mind - media.virbcdn.commedia.virbcdn.com/files/ea/b1eb973a00b3637a-Power...Power of the Mind in Health and Healing Keith R. Holden, M.D. Accordo Health Institute 2014

What is the Placebo Effect?

Page 14: Power of the Mind - media.virbcdn.commedia.virbcdn.com/files/ea/b1eb973a00b3637a-Power...Power of the Mind in Health and Healing Keith R. Holden, M.D. Accordo Health Institute 2014

Placebo Effect

• Psychobiological phenomenon

• Starts in the brain

• Results in clinical improvement

• Ritual of therapeutic act

Page 15: Power of the Mind - media.virbcdn.commedia.virbcdn.com/files/ea/b1eb973a00b3637a-Power...Power of the Mind in Health and Healing Keith R. Holden, M.D. Accordo Health Institute 2014

Ritual of Therapeutic Act

Benedetti, F. (2012) Physiological Reviews, 93: 1207-46

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Benedetti et al (2011) Neuropsychopharmacology Reviews, 36: 339-354

Page 17: Power of the Mind - media.virbcdn.commedia.virbcdn.com/files/ea/b1eb973a00b3637a-Power...Power of the Mind in Health and Healing Keith R. Holden, M.D. Accordo Health Institute 2014

Placebo Neurotransmitters

• Opiods

• Cholesytokinin

• Cannabinoids

• Dopamine

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Placebo Pain Relief

• Dorsolateral prefrontal cortex

• Anterior cingulate cortex

• Hypothalamus

• Amygdala

• Periaqueductal grey

• Thalamus

• Insula

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Placebo Immune Response

• Placebo conditioning of immune response

• Flavored drink assoc. with cyclosporin A

• Flavored drink suppressed immune function

Goebel at al. (2002) FASEB Journal, 16(14): 1869-73

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Parkinson’s Disease

de la Fuente-Fernandez et al. (2001) Science 293: 1164-6

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Placebo Mirrors Drugs

• Analgesics morphine and ketorolac

• Immunosuppresant cyclosporin A

• DA agonist apomorphine

• BZD receptor agonist midazolam

• BZD receptor antagonist flumazenil

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Placebo Effect Quantified

• 66 participants - 6 migraine attacks

• Received either placebo or Maxalt 10mg

• Label: placebo, Maxalt or placebo, Maxalt

• Progressive boost w/ labeling

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Mind-Body Connection

• Mindfulness

• Meditation

• Relaxation Response

• Placebo Effect - Power of Belief

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The Future

• Placebo research will prove belief is a powerful epigenetic influencer .

• Healthcare will adopt placebo therapy.

• Mind-body programs will become the standard of care.

• Will become apparent the entire body is conscious down to our DNA.

Page 26: Power of the Mind - media.virbcdn.commedia.virbcdn.com/files/ea/b1eb973a00b3637a-Power...Power of the Mind in Health and Healing Keith R. Holden, M.D. Accordo Health Institute 2014

Power of the Mindin Health and Healing

Keith R. Holden, M.D.Accordo Health Institute 2014 Spring Symposium

www.Dr-Holden.com