Power of the Mindin Health and Healing

Keith R. Holden, M.D.Accordo Health Institute 2014 Spring Symposium

www.Dr-Holden.com

Mindfulness Meditation

Mindfulness Meditation

• Attention in the present moment without judgment

Mindfulness Meditation

• Attention in the present moment without judgment

• Watch, Witness, and Allow

Relaxation & Epigenetics

• Controls oxidative stress

• Improves mitochondrial energy production

• Improves insulin production

• Reduces inflammation

• Improves telomere stability

Mindfulness Meditation -Anti-Inflammatory

• An intensive day of MM acts as an anti-inflammatory in EM

• Mechanism similar to NSAID

• Subset had faster cortisol recovery after social stress test

Mindfulness Meditation- Anti-Inflammatory

• Dusek et al., 2008

• Bhasin et al., 2013

• Creswell et al., 2012

• Black et al., 2013

Mindfulness meditation turns off NFKB

What is the Placebo Effect?

Placebo Effect

• Psychobiological phenomenon

• Starts in the brain

• Results in clinical improvement

• Ritual of therapeutic act

Ritual of Therapeutic Act

Benedetti, F. (2012) Physiological Reviews, 93: 1207-46

Benedetti et al (2011) Neuropsychopharmacology Reviews, 36: 339-354

Placebo Neurotransmitters

• Opiods

• Cholesytokinin

• Cannabinoids

• Dopamine

Placebo Pain Relief

• Dorsolateral prefrontal cortex

• Anterior cingulate cortex

• Hypothalamus

• Amygdala

• Periaqueductal grey

• Thalamus

• Insula

Placebo Immune Response

• Placebo conditioning of immune response

• Flavored drink assoc. with cyclosporin A

• Flavored drink suppressed immune function

Goebel at al. (2002) FASEB Journal, 16(14): 1869-73

Parkinson’s Disease

de la Fuente-Fernandez et al. (2001) Science 293: 1164-6

Placebo Mirrors Drugs

• Analgesics morphine and ketorolac

• Immunosuppresant cyclosporin A

• DA agonist apomorphine

• BZD receptor agonist midazolam

• BZD receptor antagonist flumazenil

Placebo Effect Quantified

• 66 participants - 6 migraine attacks

• Received either placebo or Maxalt 10mg

• Label: placebo, Maxalt or placebo, Maxalt

• Progressive boost w/ labeling

Mind-Body Connection

• Mindfulness

• Meditation

• Relaxation Response

• Placebo Effect - Power of Belief

The Future

• Placebo research will prove belief is a powerful epigenetic influencer .

• Healthcare will adopt placebo therapy.

• Mind-body programs will become the standard of care.

• Will become apparent the entire body is conscious down to our DNA.

Power of the Mindin Health and Healing

Keith R. Holden, M.D.Accordo Health Institute 2014 Spring Symposium

www.Dr-Holden.com