Practice teaching course on liquid biopsy25-27 May 2016 - Madrid, Spain

PRACTICE TEACHING COURSESCIENTIFIC PROGRAMME

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OverviewPersonalized cancer medicine aims to tailor treatments for eachindividual patient at diagnosis and during treatment. To fully enablepersonalized cancer medicine, the availability of easily accessible andminimally invasive tools to determine and follow the molecularmakeup of a patient’s tumor longitudinally is becoming increasinglynecessary. Indeed, molecular characterization of tumors to guidetreatment decisions is currently performed on tumor tissue samplesacquired at the time of diagnosis. However, tumors are highlyheterogeneous and evolve over time, making clinical decisions basedon tumor tissue biopsies suboptimal. Conversely, a liquid biopsy,where the genetic makeup of the tumor can be evaluated through ablood test, might provide a representative portrait of cancer and canbe easily repeated over time. This practice course is aimed to providea substantive overview of the main approaches in the liquid biopsyfield and will offer the possibility to be trained in hands-on laboratorieson the latest liquid biopsy techniques.

Learning objectivesAfter attending this course participants will be able to: • Provide a background on the biology of cancer progression and

dissemination• Review non-invasive methods to track the molecular profile of

cancer• Elaborate clinical and research applications for liquid biopsy

Target audienceClinical oncologists and translational researchers pursuing the desireto increase their knowledge on clinical and biological aspects of liquidbiopsy and who are interested in the validation and application ofliquid biopsy as a biomarker for personalized cancer medicine.

ChairJesús García-FoncillasDepartment of OncologyTranslational Oncology DivisionHealth Research Institute University Hospital "Fundacion Jimenez Diaz"Autonomous University of MadridMadrid, Spain

Practice teaching course onliquid biopsy

CME ProviderEXCEMED is a non profit foundation dedicated, since the last fourdecades, to the development of high-quality medical educationprogramme all over the world.

EXCEMED adheres to the guidelines and standards of the EuropeanAccreditation Council for Continuing Medical Education (EACCME®)which states that continuing medical education must be balanced,independent, objective, and scientifically rigorous.

Continuing medical educationEXCEMED (www.excemed.org) is accredited by the EuropeanAccreditation Council for Continuing Medical Education (EACCME®) toprovide the following CME activity for medical specialists. TheEACCME® is an institution of the European Union of MedicalSpecialists (UEMS), www.uems.netThe CME “Practice teaching course on liquid biopsy” held on 25-27May 2016 in Madrid, Spain, is designated for a maximum of 15(fifteen) hours of European CME credits (ECMEC). Each medicalspecialist should claim only those credits that he/she actually spent inthe educational activity. EACCME® credits are recognized by theAmerican Medical Association (AMA) towards the Physician'sRecognition Award (PRA). To convert EACCME® credit to AMA PRAcategory 1 credit, please contact the AMA.

EXCEMED adheres to the principles of the Good CME Practice group(gCMEp).

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General information

VenueThis course takes place at the:

OncoHealth InstituteAvda. Reyes Católicos, 228040 Madrid, Spain

LanguageThe official language of this course is English.

CME ProviderEXCEMED - Excellence in Medical Education

Senior Programme Manager: Alessia AddessiT +39 06 420413 591 - F +39 06 420413 677alessia.addessi@excemed.org

Medical Advisor: Cristina Raimondicristina.raimondi@libero.it

For any logistic support please contact:

Meridiano Congress InternationalCongress Manager: Luisa Di SalvoT +39 06 88595 301 - F +39 06 88595 234 luisa.disalvo@meridiano.it

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Faculty

OncoHealth Institute, University Hospital "Fundacion Jimenez Diaz"Autonomous University of Madrid, Madrid, Spain

Cristina Caramés

Nerea Carvajal

Cristina Chamizo

Bernard Doger

Manuel Dómine

Jesús García-Foncillas

Tatiana Hernández

Juan Madoz

Javier Martínez Useros

Victor Moreno

Laura del Puerto

Federico Rojo

Sandra Zazo

Programme

Programme

Wednesday, 25 May 2016

09.30 Opening and introductionJesús García-Foncillas (Spain)

09.45 L1: Precision Oncology: new basis for a new paradigmBernard Doger (Spain)

10.45 L2: Biomarkers in colon cancerCristina Caramés (Spain)

11.15 Coffee break

11.45 L3: Biomarkers in lung cancerManuel Dómine (Spain)

12.15 L4: Biomarkers in breast cancerTatiana Hernández (Spain)

12.45 Lunch

13.45 L5: CTCs enumeration: methodologies availableLaura del Puerto (Spain)

14.15 L6: Molecular characterization of CTCsJesús García-Foncillas (Spain)

14.45 L7: Clinical value of CTCs Victor Moreno (Spain)

15.15 Lab I

16.45 End of the first day

Biomarkers in oncologyTeaching Session I

Circulating Tumor Cells, CTCsTeaching Session II

CTCsPractice session I

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Legend: L : Lecture; : Journal Club; : Round table;

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Thursday, 26 May 2016

09.00 L8: Concept of cfDNA and ctDNA Federico Rojo (Spain)

09.30 L9: Detection of single markers in cfDNA:methodologiesSandra Zazo (Spain)

10.30 L10: Whole-genome sequencing in cfDNA:methodologiesNerea Carvajal (Spain)

11.00 Coffee break

11.30 L11: Clinical value of single mutations in ctDNACristina Caramés (Spain)

12.00 L12: Clinical value of whole-genome in cfDNAVictor Moreno (Spain)

12.30 Lunch

13.30 Lab II (Circulating DNA)

14.30 RAS testing as a possible clinical application forliquid biopsy

15.30 Open clinical trials at OncoHealth Institute (liquid biopsy for treatment selection)

16.30 End of the second day

Circulating DNATeaching Session III

Circulating DNAPractice Session II

Friday, 27 May 2016

09.00 L13: ExosomesCristina Chamizo (Spain)

09.30 L14: Tumor-educated platelets Cristina Chamizo (Spain)

10.00 L15: ncRNA in liquid biopsy Javier Martínez Useros (Spain)

10.30 Coffee break

11.00 Round table: Tumor heterogeneity assessment through liquid biopsyJuan Madoz (Spain)

12.00 Journal ClubJesús García-Foncillas (Spain)

12.30 End of the course

New potential for liquid biopsyTeaching session IV

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Disclosure of facultyrelationships

EXCEMED adheres to guidelines of the European Accreditation Councilfor Continuing Medical Education (EACCME®) and all otherprofessional organizations, as applicable, which state thatprogrammes awarding continuing education credits must bebalanced, independent, objective and scientifically rigorous.Investigative and other uses for pharmaceutical agents, medicaldevices, and other products (other than those uses indicated inapproved product labeling/package insert for the product) may bepresented in the programme (which may reflect clinical experience,the professional literature or other clinical sources known to thepresenter). We ask all presenters to provide participants withinformation about relationships with pharmaceutical or medicalequipment companies that may have relevance to their lectures. Thispolicy is not intended to exclude faculty who have relationships withsuch companies; it is only intended to inform participants of anypotential conflicts so that participants may form their own judgements,based on full disclosure of the facts. Further, all opinions andrecommendations presented during the programme and allprogramme-related materials neither imply an endorsement nor arecommendation on the part of EXCEMED. All presentations representsolely the independent views of the presenters/authors.

The following faculty provided information regarding significantcommercial relationships and/or discussions of investigational or non-EMEA/FDA approved (off-label) uses of drugs:

Cristina Caramés Declared no potential conflict of interest

Manuel Dómine Declared no potential conflict of interest

Jesús García-Foncillas Declared no potential conflict of interest

Victor Moreno Declared no potential conflict of interest

The following faculty have provided no information regardingsignificant relationship with commercial supporters and/or discussionof investigational or non-EMEA/FDA approved (off-label) uses of drugsas of 17 May 2016:Nerea CarvajalCristina ChamizoBernard DogerTatiana Hernández Juan Madoz Javier Martínez Useros Laura del PuertoFederico RojoSandra Zazo

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