preexistence and clonal selection of met amplification in egfr mutant nsclc alexa b. turke, kreshnik...

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Preexistence and Clonal Selection of MET Amplification in EGFR Mutant NSCLC Alexa B. Turke, Kreshnik Zejnullahu, Yi-Long Wu, Youngchul Song, Dora Dias-Santagata, Eugene Lifshits, Luca Toschi, Andrew Rogers, Tony Mok, Lecia Sequist, Neal I. Lindeman, Carly Murphy, Sara Akhavanfard, Beow Y. Yeap, Yun Xiao, Marzia Capelletti, A. John Iafrate, Charles Lee, James G. Christensen, Jeffrey A. Engelman, Pasi A. Jänne Cancer Cell Volume 17, Issue 1, Pages 77-88 (January 2010) DOI: 10.1016/j.ccr.2009.11.022 Copyright © 2010 Elsevier Inc. Terms and Conditions

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Page 1: Preexistence and Clonal Selection of MET Amplification in EGFR Mutant NSCLC Alexa B. Turke, Kreshnik Zejnullahu, Yi-Long Wu, Youngchul Song, Dora Dias-Santagata,

Preexistence and Clonal Selection of MET Amplification in EGFR Mutant NSCLC 

Alexa B. Turke, Kreshnik Zejnullahu, Yi-Long Wu, Youngchul Song, Dora Dias-Santagata, Eugene Lifshits, Luca Toschi, Andrew Rogers, Tony Mok, Lecia Sequist, Neal I. Lindeman, Carly Murphy, Sara Akhavanfard, Beow Y. Yeap, Yun Xiao, Marzia Capelletti, A.

John Iafrate, Charles Lee, James G. Christensen, Jeffrey A. Engelman, Pasi A. Jänne 

Cancer Cell Volume 17, Issue 1, Pages 77-88 (January 2010)

DOI: 10.1016/j.ccr.2009.11.022

Copyright © 2010 Elsevier Inc. Terms and Conditions

Page 2: Preexistence and Clonal Selection of MET Amplification in EGFR Mutant NSCLC Alexa B. Turke, Kreshnik Zejnullahu, Yi-Long Wu, Youngchul Song, Dora Dias-Santagata,

Figure 1

Cancer Cell 2010 17, 77-88DOI: (10.1016/j.ccr.2009.11.022) Copyright © 2010 Elsevier Inc. Terms and Conditions

Page 3: Preexistence and Clonal Selection of MET Amplification in EGFR Mutant NSCLC Alexa B. Turke, Kreshnik Zejnullahu, Yi-Long Wu, Youngchul Song, Dora Dias-Santagata,

Figure 2

Cancer Cell 2010 17, 77-88DOI: (10.1016/j.ccr.2009.11.022) Copyright © 2010 Elsevier Inc. Terms and Conditions

Page 4: Preexistence and Clonal Selection of MET Amplification in EGFR Mutant NSCLC Alexa B. Turke, Kreshnik Zejnullahu, Yi-Long Wu, Youngchul Song, Dora Dias-Santagata,

Figure 3

Cancer Cell 2010 17, 77-88DOI: (10.1016/j.ccr.2009.11.022) Copyright © 2010 Elsevier Inc. Terms and Conditions

Page 5: Preexistence and Clonal Selection of MET Amplification in EGFR Mutant NSCLC Alexa B. Turke, Kreshnik Zejnullahu, Yi-Long Wu, Youngchul Song, Dora Dias-Santagata,

Figure 4

Cancer Cell 2010 17, 77-88DOI: (10.1016/j.ccr.2009.11.022) Copyright © 2010 Elsevier Inc. Terms and Conditions

Page 6: Preexistence and Clonal Selection of MET Amplification in EGFR Mutant NSCLC Alexa B. Turke, Kreshnik Zejnullahu, Yi-Long Wu, Youngchul Song, Dora Dias-Santagata,

Figure 5

Cancer Cell 2010 17, 77-88DOI: (10.1016/j.ccr.2009.11.022) Copyright © 2010 Elsevier Inc. Terms and Conditions

Page 7: Preexistence and Clonal Selection of MET Amplification in EGFR Mutant NSCLC Alexa B. Turke, Kreshnik Zejnullahu, Yi-Long Wu, Youngchul Song, Dora Dias-Santagata,

Figure 6

Cancer Cell 2010 17, 77-88DOI: (10.1016/j.ccr.2009.11.022) Copyright © 2010 Elsevier Inc. Terms and Conditions

Page 8: Preexistence and Clonal Selection of MET Amplification in EGFR Mutant NSCLC Alexa B. Turke, Kreshnik Zejnullahu, Yi-Long Wu, Youngchul Song, Dora Dias-Santagata,

Figure 7

Cancer Cell 2010 17, 77-88DOI: (10.1016/j.ccr.2009.11.022) Copyright © 2010 Elsevier Inc. Terms and Conditions

Page 9: Preexistence and Clonal Selection of MET Amplification in EGFR Mutant NSCLC Alexa B. Turke, Kreshnik Zejnullahu, Yi-Long Wu, Youngchul Song, Dora Dias-Santagata,

Figure 8

Cancer Cell 2010 17, 77-88DOI: (10.1016/j.ccr.2009.11.022) Copyright © 2010 Elsevier Inc. Terms and Conditions