presented by joyce liu at 2014 asco annual meeting
DESCRIPTION
A Randomized Phase 2 Trial Comparing Efficacy of the Combination of the PARP-inhibitor Olaparib and the Anti-angiogenic Cediranib Against Olaparib Alone in Recurrent Platinum-sensitive Ovarian Cancer. Presented By Joyce Liu at 2014 ASCO Annual Meeting. - PowerPoint PPT PresentationTRANSCRIPT
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A Randomized Phase 2 Trial Comparing Efficacy of the Combination of the PARP-inhibitor Olaparib and the Anti-angiogenic Cediranib Against Olaparib Alone in Recurrent Platinum-sensitive Ovarian Cancer
Presented By Joyce Liu at 2014 ASCO Annual Meeting
![Page 2: Presented By Joyce Liu at 2014 ASCO Annual Meeting](https://reader036.vdocument.in/reader036/viewer/2022070422/568163a3550346895dd4a98c/html5/thumbnails/2.jpg)
Background: cediranib and olaparib are active agents in ovarian cancer
Presented By Joyce Liu at 2014 ASCO Annual Meeting
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Cediranib and olaparib have synergistic activity in vitro
Presented By Joyce Liu at 2014 ASCO Annual Meeting
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Phase 1 study of cediranib and olaparib demonstrated activity in ovarian cancer patients
Presented By Joyce Liu at 2014 ASCO Annual Meeting
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Study Objectives
Presented By Joyce Liu at 2014 ASCO Annual Meeting
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Study Design
Presented By Joyce Liu at 2014 ASCO Annual Meeting
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Key eligibility criteria
Presented By Joyce Liu at 2014 ASCO Annual Meeting
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Statistical Considerations
Presented By Joyce Liu at 2014 ASCO Annual Meeting
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Study Status and Data Analysis
Presented By Joyce Liu at 2014 ASCO Annual Meeting
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Patient Characteristics
Presented By Joyce Liu at 2014 ASCO Annual Meeting
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Primary Outcome: Cediranib/olaparib significantly increased PFS compared to olaparib alone
Presented By Joyce Liu at 2014 ASCO Annual Meeting
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Secondary Outcome: Cediranib/olaparib significantly increased overall response rate (ORR) compared to olaparib alone
Presented By Joyce Liu at 2014 ASCO Annual Meeting
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Cediranib/olaparib significantly increased PFS in patients without a BRCA mutation
Presented By Joyce Liu at 2014 ASCO Annual Meeting
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Treatment-related Adverse Events
Presented By Joyce Liu at 2014 ASCO Annual Meeting
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Tolerability of cediranib/olaparib combination
Presented By Joyce Liu at 2014 ASCO Annual Meeting
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Conclusions
Presented By Joyce Liu at 2014 ASCO Annual Meeting
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Acknowledgments
Presented By Joyce Liu at 2014 ASCO Annual Meeting