product data sheet fusidate sodium

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Fusidate sodium PRODUCT DATA SHEET Code No.: BIA-F1259 Pack sizes.: 25mg, 100mg Synonyms: Ramycin, NSC 56192, SQ 16603, SQ 16603 Specifications : 751-94-0 CAS # : C31H47NaO6 Molecular Formula : 538.7 Molecular Weight : - Source : White to off white powder Appearance : >98% by HPLC Purity : -20°C Long Term Storage : Soluble in ethanol, methanol, DMF or DMSO. Good water solubility. Solubility Application Notes Sodium fusidate is the more water soluble sodium salt of fusidic acid, a steroidal metabolite of Fusidum coccineum which is a potent Gram positive antibiotic. Fusidic acid inhibits protein synthesis in prokaryotes by inhibiting the ribosome-dependent activity of G factor and translocation of peptidyl-tRNA. Fusidic acid also suppresses NO lysis of pancreatic islet cells. References 1. Fusidic acid: a new antibiotic. Godtfredson W. O. et al., Nature 1962, 193, 987. 2. On the mode of action of fusidic acid. Harvey C. L. et al., Biochemistry 1969, 5, 3320. 3. Mechanism of protein synthesis inhibition by fusidic acid and related antibiotics. Tanaka N. et al., BBRC

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Page 1: PRODUCT DATA SHEET Fusidate sodium

Fusidate sodium

PRODUCT DATA SHEETCode No.: BIA-F1259

Pack sizes.: 25mg, 100mg

Synonyms:Ramycin, NSC 56192, SQ 16603, SQ 16603

Specifications: 751-94-0CAS #: C31H47NaO6Molecular Formula: 538.7Molecular Weight: -Source: White to off white powderAppearance: >98% by HPLCPurity: -20°CLong Term Storage: Soluble in ethanol, methanol, DMF or DMSO. Good water solubility.Solubility

Application NotesSodium fusidate is the more water soluble sodium salt of fusidic acid, a steroidal metabolite of Fusidum coccineum which is a potent Gram positive antibiotic. Fusidic acid inhibits protein synthesis in prokaryotes by inhibiting the ribosome-dependent activity of G factor and translocation of peptidyl-tRNA. Fusidic acid also suppresses NO lysis of pancreatic islet cells.

References1. Fusidic acid: a new antibiotic. Godtfredson W. O. et al., Nature 1962, 193, 987.2. On the mode of action of fusidic acid. Harvey C. L. et al., Biochemistry 1969, 5, 3320.3. Mechanism of protein synthesis inhibition by fusidic acid and related antibiotics. Tanaka N. et al., BBRC

Page 2: PRODUCT DATA SHEET Fusidate sodium

1968, 30, 278.

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