(D,L)-Amide (L)-t-LeucineRacemization of(D)-Amide

OHO

R2 R1

Base 1Base 2+ Enzyme

Enzyme

Crystallization

NH2

NH2

O OH

NH2

O

Intermediates of HIV Protea

Proprietary Gene Expression Sys

Enzyme Application

2’-Deoxy, 2’, 3’-dideoxy, 2’-Ribo, 2’-Fluoro, A

Chiral Aziridines

Z - O

X

NNO

OP

P

Active Pharmaceutical Ingredients (APIs)

Classification Generic Name Cas No. Chemical Structure Offering Stage Specification DMF Status Remark

Anti-viral

D-Cycloserine 68-41-7 Commercial USP Available Anti-Tuberculosis

Terizidone 25683-71-0 Commercial In House Available Anti-Tuberculosis

Atazanavirsulfate 229975-97-7 Pilot USP - Anti-HIV/AIDS

Entecavir 68-41-7　

Commercial In House Available Hepatitis B

Anti-Fungal Voriconazole 137234-62-9 Commercial EP Available Antifungal

Diagnosis

Gadobutrol 138071-82-6 Commercial EP Available MRI ContrastAgent

Gadoteridol 120066-65-8 Under-development - -MRI ContrastAgent

Gadoxetatedisodium 135326-22-6

Under-development - -

MRI Contrast Agent

Anti-Coagulant Clopidogrel bisulfate [Form I] 120202-66-6 Commercial USP Available Anti-thrombotic

CNS Lacosamide 175481-36-4 　 PV Completed In House Available Epilepsy

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* Some of products listed above may be subject to intellectual property (IP) and shall be offered only to eligible relevant IP holder or licensee. In case relevant IP coverage to the user is not available, those products shall be offered for non-commercial research purpose only under buyer's full reponsibility and shall not be used for any other purpose.

O

RO

DMTrO Basep Basep Basep

O

ROH

DMTrO

O

ROH

HO

PN(iPr)2O

NC

Basep Basep Basep

O

HO

DMTrO

O

HR

DMTrO

O

HOH

HO

PN(iPr)2O

NC

2’-Fluoro Phosphoramidites 5’-O-DMT-3’-CEP-2’-F-ribonucleosides (A,C,G,U)

RNA Phosphoramidites (2’-O-TBDMSi) 5’-O-DMT-3’-CEP-2’-O-TBDMSi-ribonucleosides (A,C,G,U)

2’-OMethyl Phosphoramidites 5’-O-DMT-3’-CEP-2’-O-Me-ribonucleosides (A,C,G,U,T)

Precursors of Phosphoramidites (unprotected and protected nucleosides)

2’-O-Methyl ribonucleosides (A,C,G,U) 2-Fluoronucleosides (A,G,C,U) Base Protected ribonucleosides (A,C,G,U) 5’-O-DMT protected ribonucleosides (A,C,G,U)

MOE (2’-O-methoxyethyl)-amidites (A,C,G,U) CEM (2’-O-cyanoethylmethoxy)-amidites(A,C,G,U) LNA (2’,4’-locked)-amidites (A,C,G,T) cEt (2’,4’-constrained ethyl)-amidites (A,C,G,U,T) 3’-Amino-2’,3’-dideoxy-5’-amidites (A,C,G,T) Morpholino-amidates

• Custom manufactured for IP eligible end-users only; subject to IP clarification before supplies.

• Available per inquiry of various types of specialty modified nucleosides and phosphoramidites

Offered Supply Scale : • High throughput-scale to GMP kilogram-scale• Non-GMP grade : nmole to 10-gram scale• GMP-grade : 50-gram ~ 500kg scale

(L)-nucleosides and (L)-/(D)-sugars 2’-Deoxy-D-ribose 1-Chloro-2-deoxy-3,5-bis (O-p-toluoyl)-L-ribofuranose 1-O-Acetyl-2,3,5-O-tribenzoyl-D-ribofuranose

Halogenated and Other nucleosides 5-Fluoro-deoxyuridine (Floxuridine) 5-Iodo-deoxyuridine (Idoxuridine) 5-Methyl-deoxycytidine 5-Methyl-uridine 2’-Deoxyuridine 2’-Deoxyinosine Arabinofuranosyl-2,6-Diaminopurine (Ara-DAP)

Offered Oligo types : • Antisense, siRNA, Aptamer, CpG, Decoy, Diagnostic probes• Various modification and conjugation PEG, Cholesterol, Amino-,Thiol-, Phosphates, etc.

Base : Adenine, Guanine, Cytosine, Uracil P : Acetyl, i-Butyl, Benzoyl, etc R : OH, OTBDMS, F, OMe

DNA Phosphoramidites 5’-O-DMT-3’-CEP-2’-deoxynucleosides (A,C,meC,G,T)

*CEP : ß-Cyanoethylphosphoramidite

Precursors of Phosphoramidites (unprotected and protected nucleosides)

2’-Deoxynucleosides (A,C,meC,G,T,U) Base Protected-2’-deoxynucleosides (A,C,G,T) 5’-O-DMT Protected-2’-deoxynucleosides (A,C,G,T) 5’-O-DMT 3’-O-Succinyl-2’-deoxynucleosides (A,C,G,T)

Base : Adenine, Guanine, Thymine, Cytosine P : Acetyl, i-Butyl, Benzoyl, dmf etcR : OH, O-Succinyl

Amidites & Nucleoside Monomers

For RNAs & 2’-modifies RNAs

Specialty Amidites

For DNAs

Miscellaneous Nucleosides

Oligonucleotides

Pharmaceutical Intermediates

Classification Generic Name Cas No. Chemical Structure Offering Stage Remark

Chiral

(R)-3-(benzyl carbamo)yl-4-(2,4,5-trifluorophenyl)butanoic acid

1246960-25-7[FAA(P1)] Commercial

Intermediates of DPP-IV inhibitors

(2R,3S)-N-(tert-butoxycarbonyl)-3-amino-1,2-epoxy-4-phenylbutane

98760-08-8[RBEP] Commercial

Intermediate of Protease inhibitors (Atazanavir, etc)

Nucleoside

Phosphoramidites(A,C,G,U,T) - Commercial

Starting material of Oligonucleosides

2-Fluoronucleosides(A,G,C) - Commercial

2’-Deoxynucleosides(A,C,G,T,U) - Commercial

2’-OMe-nucleoside - Commercial

Carbohydrate

2’-Deoxy-D-ribose 533-67-9

[2DR] CommercialStarting material of Nucleoside APIs

N-Acetylmannosamine 7772-94-4[NAMH] CommercialStarting material of N-Acetylneuraminic acid

1-Chloro-2-deoxy-3,5-bis(O-p-methylbenzoyl)-L-ribofuranose

3601-89-6[LYII7] Commercial

Intermediate of Telbivudine

Active Pharmaceutical Ingredients (APIs)

Classification Generic Name Cas No. Chemical Structure Offering Stage Specification DMF Status Remark

MetabolicDisease

Sitagliptinphosphate 654671-77-9 PV Completed EP -

Diabetes mellitus

Evogliptin 1246960-27-9 Commercial In House Available Diabetes mellitus

Atorvastatin calciumtrihydrate

344423-98-9 Commercial EP Available Anti-Hyperlipidemia

Rosuvastatincalcium 147098-20-2 Commercial EP -

Anti-Hyperlipidemia

Anti-Hypertensive Valsartan 137862-53-4 Commercial USP - Hypertension

RespiratoryDisease

Formoterolfumarate dihydrate

183814-30-4 Commercial KP - COPD

Others Udenafil 268203-93-6 Commercial In House Available Erectile dysfunction

Product ListProduct List

* Some of products listed above may be subject to intellectual property (IP) and shall be offered only to eligible relevant IP holder or licensee. In case relevant IP coverage to the user is not available, those products shall be offered for non-commercial research purpose only under buyer's full reponsibility and shall not be used for any other purpose.

* Some of products listed above may be subject to intellectual property (IP) and shall be offered only to eligible relevant IP holder or licensee. In case relevant IP coverage to the user is not available, those products shall be offered for non-commercial research purpose only under buyer's full reponsibility and shall not be used for any other purpose.