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Biomaterials 2010

12th International and Interdisciplinary NRW Symposium

Biomaterials and Biomechanics, Fundamentals and Clinical Applications

Essen, March 17 – 19, 2010

Program

Biomaterials 2010 - 2 -

P R O G R A M

Biomaterials 2010 Organizers: H.P. Jennissen (Chairman) M. Laub (Co-Chairman) NRW Organizing Committee: D. Bingmann (Münster) H. de Groot (Campus Essen) R. Dujardin (Düsseldorf) A. Fischer (Campus Duisburg) I. Heschel (Herzogenrath) W. Jahnen-Dechent (Aachen) F. Löer (Campus Essen) U. Müller (Aachen) W. Theisen (Bochum) Local Organizing Committee: S. Madenci W. Schaap J. Piontek K. Zurlinden T. Sänger S. Lüers M. Meißner Technical Committee: J. Küper M. Schmitt M. Steinkamp M. Suslo M. Weber

VDI-Gesellschaft Technologies of Life Sciences/ Düsseldorf

"Control Group Biomaterials"


Welcome to Biomaterials 2010

The field of biomaterials is developing rapidly. At present federal programs are strongly supporting the field in anticipation of the positive results in implantology for an ageing population. A novel aspect of the past years has been to implement the fourth basic material in implantology besides metals, ceramics and polymers – the so-called biomolecular materials. A good question is: what is a biomolecular material? Come to the meeting and find out or inform others of your work! Nanotechnology today is a newspaper and magazine word and it is difficult to differentiate fantasy from reality. Nanofibers and polyelectrolyte multilayers are a reality and fascinating tools on the nanoscale for constructing new materials and surfaces. Tissue engineering is lower-keyed than several years ago. One reason is the paucity of known growth factors and a lack of understanding in their application and action. Otherwise these factors belong to the field of highest growth although their action on periimplant tissue behavior is still a major enigma. Therefore special attention will also be given to angiogenic factors and the delivery of oxygen to tissues. New technologies in biomaterials such as "bone-welding" and non-decaying antibacterial surfaces are in development and reaching the clinics warranting our focussed awareness. In addition advances in clinical biomechanics are having a major impact on patient care. Finally what good are biomaterials if the resulting implants cannot be mass-manufactured and distributed world-wide by the industry? So industrial participation is essential for such a symposium. We want to thank the organizing and technical committees, especially recognizing the efforts of the local organizing committee for reviewing and correcting the abstracts for the scientific program and for organizing the exhibition and special events. We are also greatly indebted to our sponsors and the Lord Mayor of Essen with a very special mention of the IEW – Interessengemeinschaft Essener Wirtschaft e.V., which provided the resources for inviting our international guests, thus giving this meeting the status worthy of a European Capital of Culture 2010. The Organizers Herbert P. Jennissen (Chairman) Markus Laub (Co-Chairman) Speaker Study Group Biomaterials Northrhine Westphalia (NRW)


Proceedings Volumes of Previous Symposia The previous Symposia have been published in the International Journal Materialwissenschaft und Werkstofftechnik (Materials Science and Engineering Technology, Wiley-VCH Verlag). 1st International Essen Symposium 1998 Proceedings (Guest editor: H.P. Jennissen): Materialwiss. Werkstofftech., Vol. 30, pp. 733-885 (1999) 2nd International Essen Symposium 1999 Proceedings (Guest editors: A. Fischer & H. Brauer): Materialwiss. Werkstofftech., Vol. 32, pp. 110-210 (2001) 3rd International Essen Symposium 2000 Proceedings (Guest editor: D. Bingmann): Materialwiss. Werkstofftech., Vol. 32, pp. 891-1019 (2001) 4th International Essen Symposium 2001 Proceedings (Guest editor: A. Fischer): Materialwiss. Werkstofftech., Vol. 33, pp. 705-803 (2002) 5th International Essen Symposium 2002 Proceedings (Guest editor: H.P. Jennissen): Materialwiss. Werkstofftech., Vol. 34, pp. 1033-1197 (2003) 6th International Essen Symposium 2003 Proceedings (Guest editor: D. Bingmann): Materialwiss. Werkstofftech., Vol. 35, pp.949-1034 (2004) 7th International Essen Symposium 2004 Proceedings (Guest editors: A. Fischer, A. Meißner): Materialwiss. Werkstofftech., Vol. 36, pp. 755-841 (2005) 8th International Essen Symposium 2005 Proceedings (Guest editor: M. Epple): Materialwiss. Werkstofftech., Vol. 37, pp. 411-569 (2006) 9th International Essen Symposium 2006 Proceedings (Guest editor: H.P. Jennissen): Materialwiss. Werkstofftech. Vol. 38, pp. 947-1042 (2007) 10th International Essen Symposium 2008 Proceedings (Guest editor: H.P. Jennissen): Materialwiss. Werkstofftech. Vol. 40, pp. 5-118 (2009) 11th International Essen Symposium 2009 Proceedings: Materialwiss. Werkstofftech. to be published This years symposium will also be published in a proceedings volume of the scientific journal Materialwissenschaft und Werkstofftechnik (Materials Science and Engineering Technology). Abstracts can be submitted after the symposium. Deadline will be announced.


Sponsors We are most grateful to the following sponsors who have made this symposium possible. Arbeitsgemeinschaft Biomaterialien NRW e.V.

IEW – Interessengemeinschaft Essener Wirtschaft e.V.

VDI-Gesellschaft Technologies of Life Sciences/ Düsseldorf

Industrial sponsors Fahrzeug-Werke LUEG AG/ Essen

Morphoplant GmbH/ Bochum

Nikon GmbH/ Düsseldorf


Exhibitors BOSE Max-Planck-Str. 36 61381 Friedrichsdorf

botiss dental GmbH Glinkastr. 32 10117 Berlin

LOT-Oriel GmbH & Co.KG Im Tiefen See 58 64293 Darmstadt

Morphoplant GmbH Universitätsstr. 136 44799 Bochum


Miscellaneous and social events Language: The official language of the symposium is English. All abstracts should be in this language. Localities: The conference venue is located at the University Essen - Audimax (S04 T01 A02). Slide and film Facilities are available for 24 x 26 mm slides, Projection: simultaneous projection of: two slides, overhead projection, VHS video and Powerpoint/ Acrobat presentation. Posters: Bulletin boards for poster display: 90 cm (wide) by 120 cm (high). Exhibition: University Essen - Audimax (S04 T01 A02). Social events: March 17, 19:00: Special Symposium event – (included in the Zeche Zollverein World Heritage Site registration fee) guided tour "Zollverein Heritage Trail" after the tour dinner at the Coking Plant Restaurant March 18, 19:00: Reception by the Lord Mayor of Essen and Symposium dinner Symposium Prof. Dr. H.P. Jennissen Scientific Dr. Süreyya Madenci Secretary's Institut für Physiologische Chemie Office: Universität Duisburg-Essen, Universitätsklinikum Hufelandstr. 55 D-45122 Essen Tel.: +49-201-723-4128 Fax: +49-201-723-5944 E-Mail: [email protected] Organization/ Thorsten Sänger Exhibition: Institut für Physiologische Chemie Universität Duisburg-Essen, Universitätsklinikum Hufelandstr. 55 D-45122 Essen Germany Tel.: +49-201-723-4117 Fax: +49-201-723-5944 E-Mail: [email protected] Symposium Audimax (S04 T01 A02) Secretary Desk Tel.: +49-201-183-4477 during the Fax: +49-201-183-4646 Symposium: Homepage: http://www.biomaterials.uni-due.de


How to get around:

Audimax/University (Symposium Venue) Hotel Atelier Garni Unperfecthouse (Get together) Rathaus /City Hall (Reception and Symposium Dinner) Old Synagogue Cathedral (Dom)

Thursday, March 18, 2010 Reception by the Mayor of Essen and symposium dinner (included in the registration fee) The City Hall lies within walking distance of the University (20 min). If you arrive by car, you will find parking space in the underground parking of the City Hall. Please use entrance “Rathaus Galerie”. The reception is given at the 22rd floor.


Tuesday, March 16, 2010

16:00 Registration

19:00 Informal Get-Together at "The Unperfecthouse" (walking distance from the Symposium venue/ University; see page 17)

The Unperfecthouse is one of the largest meeting places in the Ruhr region. Recipient of the 2007 Culture Prize and other awards and distinctions.

Wednesday, March 17, 2010

9:00 WELCOME

Herbert P. Jennissen, University Duisburg-Essen, Essen

Plenary Lecture

9:15 BMPs in bone and cartilage

Hari Reddi, University of California, Sacramento, USA

BIOFACTORS AND BIOCOMPATIBILITY 10:00 – 11:15

Chairmen: S. Vukicevic, H. Reddi 10:00 10:35

The role of BMP-6 in regeneration of bone and pancreas Dynamics of bone healing in association with bone fillers – implications for implant dentistry

Slobodan Vukicevic, University of Zagreb, Zagreb Dieter Bosshardt, University of Bern, Bern

10:55 Mechano sensing of Bone

David Jones, Philipps University, Marburg

11:15 COFFEE BREAK


INTERFACE DESIGN AND BIOMOLECULAR MATERIALS 11:30 – 13:00

Chairman: M. Textor

11:30 12:05 12:30 12:45

Design of interfaces for directing biological response of proteins, cells and bacteria Investigation of a novel functionalized peptide as a biomaterial scaffold for promoting cell adhesion In vivo comparison of osteoinduction by glycosylated and non-glycosylated rhBMP-2

Biological Activity of immobilized rhBMP-2 on Titanium Plasma Sprayed Surfaces

Marcus Textor, ETH Zürich, Zürich Maria Chatzinikolaidou, Institute of Molecular Biology & Biotechnology, Heraklio Kristin Zurlinden, Morphoplant GmbH, Bochum Süreyya Madenci, University Duisburg-Essen, Essen

13:00 LUNCH MOLECULAR DYNAMICS SIMULATION

14:00 - 14:40

Chairman: G. Seifert 14:00 14:20

Molecular dynamics simulations of the BMP-2 interactions with a hydrophobic surface Simulating the bioavailability of carbon nanotubes

Gotthard Seifert, TU Dresden, Dresden Sibylle Gemming, Research Center Dresden-Rossendorf, Dresden

ANGIOGENESIS

14:40 – 16:05

Chairmen: J. Wissler and D. Dohle 14:40 Angiogenesis factors and vascularization

of tissues

Josef Wissler, ARCONS Applied Research, Bad Nauheim

15:15

Chicken chorioallantoic membrane: in vivo model, not only for angiogenesis

Susanne Pasa, University Hospital Essen, Essen


15:30

How to monitor angiogenesis?

Daniel Dohle, University Hospital Essen, Essen

15:45 Angiotropin, a ribonucleoprotein with

angiomorphogen function Josef Wissler, ARCONS Applied Research, Bad Nauheim

16:05 COFFEE BREAK POSTER BREAKOUT SESSION 1

16:20 – 18:00 Oral Poster Exposés

Chairman: D. Bingmann The influence of incorporation of strontium into

gypsum bioceramics on its structural and biological properties

Hadis Bandegani, Materials and Energy Research Center Ceramics Alvand,Tehran

Comparative study of morphological changes

in efferent popliteal lymph nodes after implantation of resorbable magnesium alloy implants in rabbits

Andrea Meyer-Lindenberg, Tierärztliche Hochschule Hannover, Hannover

Parylene coating on stainless steel surface as

a protective layer for medical applications Monika Cieslik, Jagiellonian University, Faculty of Chemistry, Krakow

Comparative Characterisation of the Soft Tissue

Biocompatibility of MgCa0.8 and Stainless Steel 316L: An in vivo Study in Rabbits

Nina Erdmann, Tierärztliche Hochschule Hannover, Hannover

Influence of Laser Welding on the Biocompatibility

of NiTi Shape Memory Alloys at the Weld Seam Area

Jan Erik Habijan, University Hospital Bergmannsheil, Bochum

Initial Bioadhesion on Surfaces in the Oral

Cavity Investigated by Different Surface Science Methods

Christine Müller, TU Kaiserslautern, Kaiserslautern

Tissue-engineered biodegradable cell sheets for

subretinal transplantation Gabriele Thumann, RWTH Aachen, IZKF Biomat, Aachen


Dental Bone Regenerative Materials: Properties

and Differences Matthias Matthes, botiss dental GmbH, Berlin

The influence of surface composition on the

interactions of selected nanoparticles with serum albumin

Lennart Treuel , Universität Duisburg-Essen, Essen

Bio-inspired nanofibers nanocomposite for bone

tissue engineering Ashraf S. A. Abdel Sayed, Martin Luther University Halle/ Saale

18:00 End of Session 19:00 Special Evening Event:

Zeche Zollverein World Heritage Site guided tour "Zollverein Heritage Trail" after the tour dinner at the Coking Plant Restaurant (Ruhr Area "collier’s dish" with two different stews and desserts; drinks not included)


Thursday, March 18, 2010

BIOMOLECULAR MATERIALS 09:00-10:20

Chairman: I. Shapiro 9:00 9:30 10:00

Molecular engineering of orthopaedic implants and allografts: from bench to bedside Development, characterization and clinical use of a biodegradable composite scaffold for bone engineering in oro-maxillo-facial surgery Osseointegration of ultrahydrophilic implants

Irving M. Shapiro, Thomas Jefferson University, Philadelphia John E. Davies, Univ. of Toronto, Toronto Lars Lehmann, University hospital Mannheim, Mannheim

NANOMANUFACTURING OF BIOMATERIALS - POYLELECTROLYTE MULTILAYERS & POLYMERS - 10:20 – 13:10

Chairmen: G. Decher & G. Michler 10:20 Biomaterials from polyelectrolyte multilayers - an

overview

Gero Decher, Université Louis Pasteur, Strasbourg

11:00 Preparation of biomimetic organic-inorganic nanocomposites. Why and how?

Helga F. Milhofer, Hebrew University, Jerusalem

11:30

COFFEE BREAK

11:50 Skeletal muscle cell differentiation on poly-electrolyte multilayer films of controlled stiffness or bioactivity

Catherine Picart, LMGP-MINATEC, Grenoble

12:20 12:50

Polymeric nanofibres - preparation and properties MESO fiber - a novel approach to reinforce micro parts

Goerg Michler, Martin-Luther-University Halle-Wittenberg, Halle Marc Hoffstetter, TU Munich, Munich

13:10 LUNCH


BIOFRICTION AND BIOWEAR 14:10 – 15:40

Chairman: A. Fischer 14:10 Formation of Biofilms and Failure of Artificial

Joints Prashant K. Sharma, UMKG Groningen

14:35

Activity dependences on the wear of TKA

Diego A. Orozco, Rush University Medical Center, Chicago IL

15:00

Wear mechanisms of total disc replacements

Robin Pourzal, University Duisburg-Essen, Duisburg

15:20 Imaging of the bone-implant interface: TEM and

ESEM studies

S. Henning, Martin-Luther-University Halle-Wittenberg, Halle

15:40 COFFEE BREAK BIOFRICTION AND BIOWEAR

16:00 – 16:40

Chairman: A. Fischer 16:00 16:20

The electrochemistry of worn hip surfaces Characterization of worn surfaces and particles by means of nanoprobes

Michael Schymura, University Duisburg-Essen, Duisburg S. Vasnyov, Radboud University, Nanolab, Nijmegen

16:40 COFFEE BREAK


POSTER BREAKOUT SESSION 2 17:00 – 18:00

Chairman: D. Bingmann 17:00 Oral Poster Exposés

New telemetric method for bending force measurement in the rabbit tibia in vivo

Janin Reifenrath, Tier-ärtzliche Hochschule Hannover, Hannover

Self assembling proteins as technology platform

for the development of new bio-composite materials

Tobias Günther, FZ Dresden-Rossendorf, Dresden

Cell biological investigations on BMP-2 modified polyelectrolyte multilayer films

Steffi Grohmann, Institut für Bioprozess- und Analysen -messtechnik e.V., Heilbad Heiligenstadt

Measurements of body movements in medical diagnostic and ergonomic analysis of disabled persons

Michal Rychlik, Poznan University of Technology, Poznan

Tribological Investigation of Empiric Ceramic-on-Metal Hip Bearings

Michele Spinelli, Istituto Ortopedico Rizzoli, Bologna

BMP-2 coating – an improvement for bone regereration in endoprosthesic biometals?

Marcus Jäger, Heinrich-Heine-University, Düsseldorf

18:00 End of Session

19:00 Reception by the Lord Mayor of Essen and Symposium dinner Planned Addresses by: The Lord Mayor of Essen, Reinhard Paß University Rector, Prof. Dr. U. Radtke Dean of Medical Faculty, Prof. Dr. M. Forsting


Friday, March 19, 2010 BIOMOLECULAR MATERIALS

9:00 – 9:40

Chairman: A. Stemberger 9:00 Collagen - a biomaterial in medicine

Axel Stemberger, TU Munich, Munich

9:20 Biofunctional Surface Engineering – The road to

end sterilizable biofunctionalized implant surfaces Martin Scholz, Leukocare AG, Frankfurt

BIOTECHNOLOGICAL APPLICATIONS &

REGULATORY AFFAIRS 9:40 – 11:20

Chairman: R. Ewers 9:40 BoneWelding® Technology: Enhanced Primary

Stability for Load Bearing Implants Jörg Mayer, Spine-welding SA, Schlieren

10:00 Management of craniomaxillofacial trauma with

bioresorbable fixation systems Rolf Ewers, University Hospital Vienna, Vienna

10:20

Polylactide-Algipore® BMP-2-carriers for sustained BMP-2 release from resorbable bone cages

Markus Laub, Morphoplant GmbH, Bochum

10:40

Degradable bone cements for percutaneous Augmentation of bone defects

Christian Müller-Mai, Ruhr-University, Bochum

11:00

Are we testing biomaterials and medical devices adequately?

Jörg Vienken, Fresenius Medical Care, Bad Homburg

11:20 COFFEE BREAK


TISSUE INJURY, PROTECTIVE MEASURES AND BIOMATERIALS 11:40 – 13:20

Chairmen: H. de Groot, C. Mayer 11:40

Tissue injury during orthopaedic surgery. Mechanisms of injury and protective potential of parenterally administrable compounds

Herbert de Groot, University Duisburg-Essen, Essen

12:00 Polymer Nanocapsules as Carrier Systems

Christian Mayer, University Duisburg-Essen, Essen

12:15 Synthetic artificial oxygen carrier

Michael Kirsch, University Duisburg-Essen, Essen

12:30

PEG-coated nanoparticles in blood

Thorsten Bramey, University Duisburg-Essen, Essen

12:40

Biological refinement of biomaterial implants using chitosan siRNA nanoparticles

Hanna Hartmann, University of Tübingen, Tübingen

12:50

Synthesis, Release Properties and Antitumor Activity of Alginate Based Microspheres

Erkesh O. Batyrbekov, Institute of Chemical Sciences, Almaty, Kazakhstan

13:00

Cell therapy for bone regeneration - myth, commerical gimmic or treatment option?

Marcus Jäger, Heinrich-Heine-University, Düsseldorf

13:10 Use of biomatrices after chronic spinal cord

injury in the rat Veronica Estrada, Heinrich-Heine-University, Düsseldorf

13:20 INVITATION TO THE SYMPOSIUM 2011

FAREWELL Herbert P. Jennissen University Duisburg-Essen, Essen

13:30 LUNCH


Posters ID-Number

P-001 Bio-inspired nanofibers nanocomposite for bone tissue engineering A. Abdel Sayed, S. Henning, G. H. Michler Institute of Physics, Martin-Luther-University Halle-Wittenberg, Halle

P-002 Glass ionomer cements – Proposing standard test methods S. Amini, F. Moztarzadeh Biomaterials Group, Faculty of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran

P-003 Hydrothermal Synthesized Hydroxyapatite and Non-Stoichiometric Silicon-Substituted Hydroxyapatite: Synthesis, Characterization and Bioactivity Investigation A. Aminian, M. Solati, A. Farzadi Nanobiomaterials Lab., Biomedical Engineering Faculty, Amirkabir University of Technology, Tehran, Iran

P-004 The influence of incorporation of strontium into gypsum bioceramics on its structural and biological properties H. Bandegani, S. Hesaraki, M. Alizadeh, R.Tabatabaei-Ardakani, S. Shahrabi Ceramics Department, Materials and Energy Research Center, Tehran, Iran

P-005 Synthesis, Release properties and Antitumor activity of Alginate based Microspheres E. Batyrbekov, D. Rakhimbaeva, K. Musabekov, B. Zhubanov Institute of Chemical Sciences, Almaty, Kazakhstan

P-006 The effect of adding colloidal silica to calcium sulphate – hydroxyapatite nanocomposite cement on its mechanical strength and structural degradation S. Borhan, S. Hesaraki, M. Alizadeh, H. Bandegani, M. H. Baroonian Ceramics Department, Materials and Energy Research Center, Tehran, Iran

P-007 Dextran-graft-Polyacrylamide copolymers as agents of mineral dispersion stability regulation N. Kutsevol, T. Bezugla, A.Shyichuk, D.Ziolkowska National Taras Shevchenko University, Department of Chemistry, Kyiv, Ukraine

P-008 Synthesis and prospects of application of water-soluble branched polyelectrolytes M.Bezuglyi, N.Kutsevol, M.Rawiso, A.Rameau, V.Chumachenko and A.Zharmagambetova National Taras Shevchenko University, Department of Chemistry, Kyiv, Ukraine


P-009 Structure peculiarities of spherical polymer brushes dextran-graft-polyacrylamide M. Bezuglyi, Y. Konko, N. Kutsevol National Taras Shevchenko University, Department of Chemistry, Kyiv, Ukraine

P-010 Parylene coating on stainless steel surface as a protective layer for medical applications M. Cieślik, K. Engvall, J. Pan, A. Kotarba Faculty of Chemistry, Jagiellonian University, Krakow, Poland

P-011 Fibrinogen Adsorption Hysteresis on Ultra-Hydrophilic Titanium Surfaces D.-S. Dohle, S.D. Pasa, H. P. Jennissen Institut für Physiologische Chemie, Universität Duisburg-Essen, Universitätsklinikum Essen, Essen, Germany

P-012 Comparative Characterisation of the Soft Tissue Biocompatibility of MgCa0.8 and Stainless Steel 316L: An in vivo Study in Rabbits N. Erdmann, A. Bondarenko, M. Hewicker-Trautwein, N. von der Höh, A. Lucas, A. Meyer-Lindenberg Small Animal Clinic, University of Veterinary Medicine, Hannover, Germany

P-013 Microwave-Assisted Synthesis and Characterization of Biphasic Calcium Phosphate Nanocomposites A. Farzadi, M. Solati-Hashjin, A. Aminian Biomaterial Group, Amirkabir University of Technology (Tehran Polytechnic), Tehran, Iran

P-014 Improvement of Poly(dimethyl siloxane) towards biomedical applications by surface initiated Atom Transfer Radical Polymerization S. Gonçalves, A. Ferreira, J. Teixeira, F. Dourado, L. Rodrigues IBB - Institute for Biotechnology and Bioengineering, Centre of Biological Engineering, Universidade do Minho, Braga, Portugal

P-015 Biomimetic modification of implant surfaces M. Gorbahn, M. Klein, C. Rosin, M. Lehnert, I. Köper, B. Al-Nawas, M. Veith University of Applied Science Gelsenkirchen, Department of Physical Engineering, Recklinghausen, Germany

P-016 Cell biological investigations on BMP-2 modified polyelectrolyte multilayer films S. Grohmann, S. Eisenhuth, H. Rothe, K. Zurlinden, H. Jennissen, H. Füredi-Milhofer, K. Liefeith Institut für Bioprozess- und Analysenmesstechnik e.V., Heilbad Heiligenstadt, Germany

P-017 Ti6Al4V foam spinal cages M. Guden, E. Dizlek, U. Turkan, Ö. Akçalı Department of Mechanical Engineering, Izmir Institute of Technology, Izmir, Turkey


P-018 Self assembling proteins as technology platform for the development of new bio-composite materials T. Günther, U. Weinert, J. Raff, K. Pollmann Institute of Radiochemistry, Forschungszentrum Dresden Rossendorf, Dresden, Germany

P-019 Influence of Laser Welding on the Biocompatibility of NiTi Shape Memory Alloys at the Weld Seam Area J. E. Habijan, H. Gugel, W. Theisen, T. Habijan, M. Köller Bergmannsheil University-Hospital/ Surgical Research, Ruhr-Universität Bochum, Bochum, Germany.

P-020 Design of Hierarchical Biomimetic Bone Scaffold materials: Bacterial Poly (3-hydroxy-butyrate)/Nano-Hydroxyapatite Composites Imam Khasim H.R, S.Henning, G.H.Michler Translational Centre for Regenerative Medicine (TRM), University Leipzig, Leipzig, Germany

P-021 Biological refinement of biomaterial implants using chitosan siRNA nanoparticles H. Hartmann, U. Mittnacht, H. Oliveira, S. Oberhoffner, A.P. Pêgo, B. Schlosshauer NMI Natural and Medical Sciences Institute at the University of Tübingen, Tübingen, Germany

P-022 Insights in peptide affinity towards inorganic surfaces R. Hassert, A.G. Beck-Sickinger Institute of Biochemistry, Leipzig University, Leipzig, Germany

P-023 Impact of plasma-functionalized substrates on the behaviour of musculoskeletal cells A. Heymer, J. Maierle, P. Kluger, H. Walles Fraunhofer Institut für Grenzflächen und Bioverfahrenstechnik, Stuttgart, Germany

P-024 Polyurethane biomaterials for waste water treatment from transition metal ions A. Hubina, N. Kozak , E. Lobko

Institute of Macromolecular Chemistry NAS of Ukraine, Kyiv, Ukraine

P-025 3D Topology and Arrangement of Proteins Inside Ceramide-rich Domains Ch. Imhäuser, H. Gulbins (Grassme) , E. Gulbins, H.-G. Lipinski Biomedical Imaging Group, University of Applied Sciences Dortmund, Dortmund


P-026 Influence of citrate ions on the setting of α-tricalcium phosphate based bone cements Z. Irbe, L. Berzina-Cimdina, L. Vecbiskena Riga Technical University, Riga Biomaterials Research and Development Centre, Latvia

P-027 BMP-2 coating – an improvement for bone regereration in endoprosthesic biometals? M. Jäger, M. Herten, T. Hülsen, C. Boege, C. Zilkens, R. Krauspe Orthopädische Klinik, Universitätsklinikum Düsseldorf, Heinrich-Heine-Universität Düsseldorf, Germany

P-028 Osteogenic in-vitro potential of RGD-labelling of implant surfaces M. Jäger, C. Boege, M. Herten, R. Janissen, T. Hülsen, R. Krauspe Orthopädische Klinik, Universitätsklinikum Düsseldorf, Heinrich-Heine-Universität Düsseldorf, Germany

P-029 On the Definition of Biomaterials Herbert P. Jennissen Institut für Physiologische Chemie, Universität Duisburg-Essen, Universitätsklinikum Essen, Essen, Germany

P-030 "Chondros"-Mechanical Stimulation of Cartilage M. Steinert, R. Abedian, M. Kratz, D. Jones Inst. Experimental Orthopaedics and Biomechanics. Philipps University Marburg, Marburg, Germany

P-031 Mesenchymal stem cell potential of human, primary chondrocytes encapsulated in alginate A. Jonitz, K. Lochner, K. Peters, D. Hansmann, R. Bader University of Rostock, Department of Orthopaedics, Rostock, Germany

P-032 The influence of bioactive Ca-P coatings on reparative bone tissue regeneration Y.A. Kamenchuk, E.A. Zelichenko, T.V. Druzhinina., A.V. Popkov, V.V. Guzeev, A. B. Shashkin, Yu.I. Rogozhkina Interregional orthopedic centre, Seversk, Russia

P-033 Poly(hydroxyethyl starch-HEMA) / Montmorillonite Based Nano-composite Hydrogels: Characterization and Swelling Behaviour E. A. Kamoun, H. Menzel Institut für Technische Chemie, Technische Universität Braunschweig, Braunschweig, Germany

P-034 Screening of cell-substrate interaction with newly developed high volume producible nano- and microstructured surfaces P.J. Kluger, F. Pretzsch, J. Maierle, Simone Wurster, H. Büth, C. Wenzel, C. Brecher and H. Walles FFrraauunnhhooffeerr--IInnssttiittuuttee ffoorr IInntteerrffaacciiaall EEnnggiinneeeerriinngg aanndd BBiiootteecchhnnoollooggyy,, SSttuuttttggaarrtt,, GGeerrmmaannyy


P-035 Biocompatibility and degradation behaviour of degradable magnesium sponges coated with bioglass – method establishment within the framework of a pilot study M. Lalk, J. Reifenrath, N. Angrisani, D. Bormann, A. Meyer-Lindenberg Small Animal Clinic, University of Veterinary Medicine, Hannover, Germany

P-036 Polyelectrolyte multilayers on glass as a model system for the immobilization of rhBMP-2 M. Lange, S. Madenci, J. Piontek, M. Laub, S. Grohmann, K. Liefeith, H. Füredi-Milhofer, H.P. Jennissen Institut für Physiologische Chemie, Universität Duisburg-Essen, Universitätsklinikum Essen, Essen, Germany

P-037 Biofunctionalization of TiO2 for Specific Adsorption of biotinylated Fibronectin M. Lehnert, M. Gorbahn, I. Köper, W. Knoll, M. Veith University of Applied Sciences of Gelsenkirchen, Recklinghausen, Germany

P-038 Characterization of Wear Particles from Surgical Instruments S. Li, R. Pourzal, W. Dudzinski, N. Erol, M. von Knoch, A. Fischer Materials Science, University Duisburg-Essen, Duisburg, Germany

P-039 A novel method for protection of ultra-hydrophilic surfaces from loss of wettability S. Lüers, M. Laub, A. Kirsch and H.P. Jennissen Morphoplant GmbH, Bochum, Germany

P-040 Dependence of rhBMP-2 binding on the number of layer pairs in polyelectrolyte multilayers S. Madenci, M. Laub, H. P. Jennissen Institut für Physiologische Chemie, Universität Duisburg-Essen, Universitätsklinikum Essen, Essen, Germany

P-041 Real-time kinetics of the binding of rhBMP-2 to polyelectrolyte multilayers on quartz glass M. Meißner, S. Madenci, H. P. Jennissen Institut für Physiologische Chemie, Universität Duisburg-Essen, Universitätsklinikum Essen, Essen, Germany

P-042 Dental Bone Regenerative Materials: Properties and Differences D. Tadic, M. Matthes, O. Bielenstein botiss dental GHmbH, Berlin, Germany

P-043 Comparative study of morphological changes in efferent popliteal lymph nodes after implantation of resorbable magnesium alloy implants in rabbits A. Bondarenko, M. Hewicker-Trautwein, N. Angrisani, N. Erdmann, A. Meyer-Lindenberg Small Animal Clinic, University of Veterinary Medicine, Hannover, Germany


P-044 Sol-gel synthesis, characterization and in vitro bioactivity evaluation of SiO2–CaO–P2O5–MgO bioglass F. Moztarzadeh, M. Tahriri, N. Nezafati, A. Ansari Biomaterials Group, Faculty of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran

P-045 Initial Bioadhesion on Surfaces in the Oral Cavity Investigated by Different Surface Science Methods C. Müller, J. Wald,, J. Kirch, A. Lüders, M. Wahl, W. Hoth-Hannig, M. Hannig, M. Kopnarski, C. Ziegler Department of Physics and Research Centre OPTIMAS, University of Kaiserslautern, Kaiserslautern, Germany

P-046 Molecular Dynamics Simulations of Bone Morphogenetic Protein-2 A. F. Oliveira, S. Gemming, G. Seifert Technische Universität Dresden, Physikalische Chemie, Dresden, Germany

P-047 Planar alginate hydrogel prepared by external gelling process E. Papajová, Z. Kroneková, I. Lacík Polymer Institute SAV, Bratislava, Slovakia

P-048 Dependence of rhBMP-2 binding on the surface concentration of aminopropyl groups on glass J. Piontek, R. Zdrenka, H. P. Jennissen Institut für Physiologische Chemie, Universität Duisburg-Essen, Universitätsklinikum Essen, Essen, Germany

P-049 New telemetric method for bending force measurement in the rabbit tibia in vivo J. Reifenrath, D. Gottschalk, N. Angrisani, S. Besdo, A. Meyer-Lindenberg Small Animal Clinic, University of Veterinary Medicine, Foundation, Hannover, Germany

P-050 Measurements of body movements in medical diagnostic and ergonomic analysis of disabled persons M. Rychlik Poznan University of Technology, Institute of Combustion Engines and Transport, Poznan, Poland

P-051 Tribological Investigation of Empiric Ceramic-on-Metal Hip Bearings M. Spinelli, S. Affatato, S. Carmignato, F. Traina,, A. Toni,

Laboratorio di Tecnologia Medica, Istituto Ortopedico Rizzoli, Bologna, Italy

P-052 Influence on Wear Behaviour of the Unicompartmental Knee Prosthesis Under Different Femoral Fixation. M. Spinelli, T.M. Grupp, N. Lopomo, M. Marcacci, S. Affatato Laboratorio di Tecnologia Medica, Istituto Ortopedico Rizzoli, Bologna, Italy


P-053 „Clicking” proteins to solid supports M. Steinhagen, K. Holland-Nell and A. G. Beck-Sickinger Institute of Biochemistry, Leipzig University, Leipzig, Germany

P-054 Numerical Simulation of the human femur osteosynthesis using modular plates based on smart materials D. Tarnita, D. Tarnita, F. Cismaru, C. Berceanu, F. Dumitru University of Craiova, Faculty of Mechanics, Craiova, Romania

P-055 Tissue-engineered biodegradable cell sheets for subretinal transplantation G. Thumann, N. Harmening, A. K. Salz, P. Walter RWTH Aachen, Dep. of Ophthalmology, IZKF Biomat, Aachen

P-056 The influence of surface composition on the interactions of selected nanoparticles with serum albumin L. Treuel, M. Malissek, J.S. Gebauer and R. Zellner Institut für Physikalische Chemie, Universität Duisburg Essen, Essen, Germany

P-057 The increased CaP coating in open Ti-cell Ti6Al4V foams via nitric acid surface treatment U. Turkan, M. Guden Department of Mechanical Engineering, Izmir Institute of Technology, Izmir, Turkey

P-058 The bacterial adhesion on surface treated open cell Ti6Al4V foams U. Turkan, M. Sudagidan, M. Guden Department of Mechanical Engineering, Izmir Institute of Technology, Izmir, Turkey

P-059 Biomechanical analysis of two bone scaffolds for large segmental bone defects J. Wieding, A. Fritsche, P. Heinl, M. Cornelsen, W. Mittelmeier, R. Bader Department of Orthopaedics, Biomechanics and Implant Technology Research Laboratory, University of Rostock, Rostock, Germany

P-060 Bioactive medical devices made from silk M. Wöltje Spintec Engineering GmbH, Aachen, Germany

P-061 Synthesis and Characterization of Silver Nanoparticles and Their Thermophysical Properties M. Yüksel, S. Bucak Yeditepe University, Chemical Engineering, Istanbul, Turkey

P-062 Reagent-free covalent crosslinking of chitosan-gelatin films for medical applications. Part 2 A. Zakhariouta, A. Taralp Sabanci University, Faculty of Engineering and Natural Sc./Materials Sc. Program, Istanbul, Turkey


P-063 The role of oxygen in the sterilization process of dialyzers containing polysulfone/polyvinyl-pyrrolidone hollow fiber membranes C. Zschech, A. Baier-Goschütz Saxonia Medical GmbH, Department Research and Development, Radeberg, Germany

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