programme - alexander von humboldt foundation · programme wednesday, 7 october 2015 5:00 p.m....
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Programme
Bonn, 7 - 10 October 2015
5th Bonn Humboldt Award Winners’ Forum“Frontiers in Neuroscience:Multi-Scale Analysis of the Nervous System –From Molecules to Circuits”
5th Bonn Humboldt Award Winners’ Forum“Frontiers in Neuroscience:Multi-Scale Analysis of the Nervous System –From Molecules to Circuits”
7 - 10 October 2015Bonn
Remarkably, more than a century after Ramon y Cajal and Camillo Golgi received the Nobel Prize (1906) for their epochal work on neuroanatomy, we are still not in possession of a complete “blueprint” of any mammalian nervous system. Moreover, the tools needed to actually assign a specific behavioral function to a specific population of neurons in such a circuit diagram have long been lacking. This often made it impossible at the circuit level to fulfill strict criteria of hypothesis testing, as established in other fields of biology, such as infectiology, since the turn of the 20th century. Thanks to new technologies, however, neu-roscience finally appears to be on the cusp of a new era. New imaging modalities promise to provide structural and functional vistas of the brain that are – on the one hand – suffi-ciently resolved to actually reveal synaptic connectivity, and – on the other hand – comprise the vast expanses of tissue across which neuronal projections span. This, combined with tailored optical and genetic manipulations of well-defined neuronal cell populations, will conceivably provide us with a first comprehensive “parts list” and an actual wiring diagram of mammalian nervous systems, in which we can define functional cellular modules that relate to simple behaviors. While this by no means will conclude neuroscience’s quest for a deep understanding of higher brain function and neuropsychiatric disorders, it will open up a new frontier, which in retrospect might mark our science’s transition from infancy to maturity.
To this exciting current state of neuroscience, fellows and awardees of the Alexander von Humboldt Foundation have made numerous seminal contributions and currently spearhead the ongoing efforts to unify functional and structural analysis approaches. This sympo-sium on “Frontiers in Neuroscience: Multi-Scale Analysis of the Nervous System – From Molecules to Circuits” will serve to highlight these contributions and discuss future de-velopments. Moreover, we will invite a broad range of early career scientists to share their ongoing contributions to the field of neuroscience and discuss the state of the field from the viewpoint of those who will shape it in the years to come. Together we want to celebrate the past and future contribution of scientific exchange across borders in propelling forward the frontiers of neuroscience.
Programme
Wednesday, 7 October 2015
5:00 p.m. Opening Ceremony Lecture Hall IXUniversity of Bonn
Welcome Address Regina-Pacis-Weg 3Professor Dr. Andreas Zimmer 53113 BonnVice-Rector of the University of Bonn
Jürgen NimptschMayor of the City of Bonn
Dr. Enno AufderheideGeneral Secretary of the Alexander von Humboldt Foundation
Keynote Lecture:”The Parallel and Constrained Evolution of Cognition”Professor Dr. Onur GüntürkünRuhr-University Bochum
afterwards Reception SäulenhalleUniversity of Bonn
Thursday, 8 October 2015
9:00 a.m. Welcome and Introduction Conference RoomDr. Steffen Mehlich, Head of Department Sponsorship “Chur I/II”and Network, Alexander von Humboldt Foundation Hotel Bristol Bonn
Professor Dr. Mathias Bähr, Chairman, EuropeanNeuroscience Institute Göttingen
Professor Dr. Hans-Jochen Heinze, University of Magdeburg
9:30 a.m. Scientific Lectures Conference RoomChair: Professor Dr. Thomas Misgeld, „Chur I/II“Technical University Munich Hotel Bristol Bonn
“Targeting Abnormal Neural Circuits in Schizophrenia: From Molecules to Minds“ Professor Dr. Veena Kumari, King‘s College London
10:30 a.m. Coffee and tea break
11:00 a.m. “Cellular dissections of neuronal Conference Roomcircuit function“ “Chur I/II”Professor Dr. Troy Margrie, Hotel Bristol Bonn Medical Research Council (MRC), London
11:45 p.m. “GABAergic neurons control the activity of spatialcoding and synchronous network activity in thehippocampal-entorhinal formation thereby affectingspatial learning“Professor Dr. Hannah Monyer, University of Heidelberg
12:30 p.m. Lunch Restaurant MajesticHotel Bristol Bonn
2:00 p.m. Poster flash talks and poster session Conference Roomwith Early Career Researchers “Chur I/II”
Hotel Bristol Bonn
3:30 p.m. Coffee and tea break
4:00 p.m. “The life and death of the synaptic vesicle“ Conference Room Professor Dr. Silvio O. Rizzoli, “Chur I/II”University of Göttingen Hotel Bristol Bonn
4:45 p.m. “Synapto-nuclear communication in neurons –implications for information storage in the brain“Professor Dr. Eckart Gundelfinger, Leibniz Institute forNeurobiology, Magdeburg
5:30 p.m. Break
6:00 p.m. Dinner Restaurant MajesticHotel Bristol Bonn
7:00 p.m. Walk to Beethoven-Haus, Bonn Meeting Point:Hotel lobby
Hotel Bristol Bonn
8:00 p.m. Lecture Recital Kammermusiksaal“Variations and Passion“ Beethoven-HausGoldberg Trio Bonn Bonngasse 24-26
53111 Bonn
Friday, 9 October 2015
9:00 a.m. Scientific Lectures Conference Room Chair: Professor Dr. Walter Stühmer, “Chur I/II”Max Planck Institute for Experminental Hotel Bristol BonnMedicine, Göttingen
“Ultrafast Synaptic Vesicle Endocytosis“ Professor Erik M. Jorgensen, University of Utah
10:00 a.m. Coffee and tea break
10:30 a.m. “The Role of a unique Synaptotagmin Isofrom Conference Roomin a Post-Synaptic Mechanism of Synaptic “Chur I/II”
Plasticity“ Hotel Bristol BonnDr. Camin Dean, University of Göttingen
11:15 a.m “SK channels and spike timing-dependentsynaptic plasticity“Professor Dr. Greg J. Stuart, Australian National University
12:00 p.m. Lunch Restaurant MajesticHotel Bristol Bonn
1:30 p.m. Scientific Lectures Conference Room Chair: Professor Dr. Hans-Jochen Heinze, “Chur I/II”University of Magdeburg
Hotel Bristol Bonn“The genetic architecture ofneurodegenerative diseases“ Professor Dr. Thomas Gasser, German Center forNeurodegenerative Diseases, Tübingen
2:30 p.m. “Circuits for Social Cognition“Professor Dr. Raymond J. Dolan, University College London
3:15 p.m. Coffee and tea break
3:45 p.m. “GABA Blocks Pathological but Conference RoomNot Acute TRPV1 Pain Signals“ “Chur I/II”Professor Dr. Jan-Erik Siemens, Hotel Bristol BonnUniversity of Heidelberg
4:30 p.m. “MicroRNA-target interactions in neuronalstress responses“Professor Dr. Hermona Soreq,Hebrew University of Jerusalem
5.15 p.m. Break
7:00 p.m. Reception before Conference Dinner Lounge Hotel Bristol Bonn
7:30 p.m. Conference Dinner Restaurant MajesticHotel Bristol Bonn
Dinner Speech:“The Beatles‘ Surprising Contribution To Brain Science“Professor Dr. Josef Rauschecker, Georgetown University, USA
Saturday, 10 October 2015 Cultural Programme: Highlights of the Rheinland around Bonn
Sunday, 11 October 2015 until 11:00 a.m. Checkout and Departure
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Poster session 8 and 9 October 2015*These posters were accepted for a poster flash talk on 8 October 2015.
P01* Dr. Prateep Beed, Charité Universitätsmedizin Berlin“Neuronal Microcircuitry: The fine balance between function and dysfunction“
P02* Dr. Tim Czopka, Technische Universität München “Elucidating mechanisms of myelination during central nervous systemdevelopment and repair in vivo“
P03 Dr. Shiqiang Gao, Universität Würzburg “Optogenetic manipulation of cGMP by the tightly light-regulated guanylyl-
cyclase opsin CyclOp“
P04 Dr. Alexandros Goulas, Universität Hamburg“Principles of ipsilateral and contralateral cortico-cortical connectivity in the
mouse“
P05 Dr. Kathrin Janitzky, Otto-von-Guericke-Universität Magdeburg“Optogenetic silencing of locus coeruleus activity in mice impairs cognitiveflexibility in an attentional set-shifting task“
P06* Dr. Friedrich W. Johenning, Charité Universitätsmedizin Berlin“Ryanodine Receptor Activation induces Long-Term Plasticity of Spine Calcium
Dynamics“
P07 Dr. Jan Christoph Koch, Universitätsmedizin Göttingen“Alpha-Synuclein affects neurite morphology and axonal degeneration in CNS neurons via modulations of autophagy, vesicle transport and axonal energy
supply“
P08* Dr. Fabian Maaß, Universitätsmedizin Göttingen“Biomarker for early diagnosis and disease progression of Parkinson’s disease“
P09* Dr. Carlotta Martelli, Universität Göttingen“Spatial and temporal adaptation in the Drosophila olfactory system“
P10 Dr. Anna-Elisa Roser, Universitätsmedizin Göttingen“miRNAs in neurite outgrowth and regeneration of midbrain neurons“
P11* Dr. Dirk Scheele, Universität Bonn“Hormonal contraception diminishes oxytocin-induced brain reward responses in women viewing the faces of their romantic partners“
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P12* Dr. Keisuke Sehara, Charité - Universitätsmedizin Berlin“Probing intrinsic excitability of cortical neurons in vivo“
P13* Dr. Max-Philipp Stenner, Otto-von-Guericke-Universität Magdeburg“An on-line contribution of the human nucleus accumbens to action“
P14* Dr. Albrecht Stroh, Universitätsmedizin Mainz“Two-photon calcium imaging uncovers novel role of TNF alpha in
neuroinflammation“
P15 Dr. Andrea Toledo Cabeda, Universität Bonn“Merlin outside its comfort zone: neurofibromatosis type 2 in central andperipheral neurons and nerves.“
P16 Adam Tomczak, Max-Planck-Institut für Experimentelle Medizin“Voltage gating of split Kv channels“
P17 Diana Urrego Blanco, Max-Planck-Institut für Experimentelle Medizin“The pRb/E2F1 pathway controls periodic Kv10.1 expression along the cell cycle“
P18 Dr. Johannes Vogt, Universitätsmedizin Mainz“Precise somatotopic thalamocortical targeting is mediated by LPA-dependent PRG2/RDX signaling“
P19* Mengzhe Wang, Technische Universität München“Assembly and disassembly of the axon-glial unit during neuromuscular synapse
elimination“
Professor Dr. Alison L. Barth, Carnegie Mellon University“Computational primitives in neocortical circuits: state-dependent disynaptic inhibition through somatostatin neurons“ (Flash talk only)
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Conference Venues and HotelsGünnewig Hotel Bristol Bonn Prinz-Albert-Str. 253113 Bonn Tel.: +49 (0)228 26 98-0 Fax: +49 (0)228 26 98-2 22 E-Mail: [email protected]/bnbristo
University of BonnRegina-Pacis-Weg 353113 Bonn
Hotel ReservationPlease, check out of your room on departure day no later than 11:00 a.m. If you wish to arrange for a late departure, please contact the Welcome Desk. Please note that all extra charges (e.g. for telephone, parking, taxi, and room service) are at your own expense.
MealsGünnewig Hotels: Breakfast will be served between 6:30 a.m. and 10:30 a.m.Organised meals start with the reception on 7 October 2015 and end with the farewell din-ner at the winery on 10 October 2015.
WiFi Access during the SymposiumThe Hotels Bristol and Residence provide a free WiFi access in the entire hotel.
General Information
Günnewig Hotel ResidenceKaiserplatz 1153113 BonnTel.: +49 (0)228 26 97-0Fax: +49 (0)228 26 97-7 77E-Mail: [email protected]/bnreside
Scientific Lead
Professor Dr. Hans-Jochen Heinze,University of MagdeburgProfessor Dr. Thomas Misgeld,Technical University MunichProfessor Dr. Walther Stühmer,Max Planck Institute for Experimental Medicine, Göttingen
Organiser
Alexander von Humboldt Foundation Jean-Paul-Straße 12 53173 Bonn, Germany Tel./Phone: +49 (0)228 / 833-0 Fax: +49 (0)228 / 833-199 Email: [email protected] www.humboldt-foundation.de
Organisation
lab concepts GmbHAm Hofgarten 1853113 BonnTel./Phone: +49 (0)228 / 24 98 110Fax: +49 (0)228/ 24 98 111E-Mail: [email protected]
Contact during the Conference
Marion Wilde+49 (0) 178 49 80 720
Jean-Paul-Str. 12D-53173 BonnTel.: +49 (0) 228 833-0Fax: +49 (0) 228 833-199E-Mail: [email protected]