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Progress in Building an Industrial Biotechnology Powerhouse December 8, 2014 Karl J Sanford DuPont Palo Alto, CA 94304

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Progress in Building an Industrial

Biotechnology Powerhouse

December 8, 2014

Karl J Sanford

DuPont

Palo Alto, CA 94304

© 2007 E.I. du Pont de Nemours and Company. All Rights Reserved.

Our Strategic Priorities

2

Our strategy is to be a premier market-driven science company and generate

superior shareholder returns.

AGRICULTURE &

NUTRITION

BIOBASED

MATERIALS

ADVANCED

MATERIALS

© 2007 E.I. du Pont de Nemours and Company. All Rights Reserved.

© 2007 E.I. du Pont de Nemours and Company. All Rights Reserved.

The Future is Now – Execute the Plan

© 2007 E.I. du Pont de Nemours and Company. All Rights Reserved.

The Future of 1st Generation Ethanol

Mainstream:

ethanol is becoming fuel, not only biofuel

• A growing market & industry

• Supplied with increasing productivity from field to fuel tank

• Driven by technology improvements

• Commodity CyclicalityReference: Exhibit 1 from

“Global Ethanol Markets”;

Credit Suisse; July 11, 2014

Global Ethanol Demand Forecast

Credit Suisse July 2014

© 2007 E.I. du Pont de Nemours and Company. All Rights Reserved.

DuPont Cellulosic Ethanol

DISTRIBUTION

Ethanol for transportation fuels

Ethanol for laundry formulations

Lignin co-products for energy

CONVERSION

Pre-processing

Fermentation

Recovery

FEEDSTOCK

Non-food biomass

Collected from local

farms

© 2007 E.I. du Pont de Nemours and Company. All Rights Reserved.

DuPont Cellulosic Ethanol in Iowa

© 2007 E.I. du Pont de Nemours and Company. All Rights Reserved.12/10/2014 DuPont Confidential 8

© 2007 E.I. du Pont de Nemours and Company. All Rights Reserved.

The Future of 2nd Generation Ethanol:

Global Biofuels Feedstocks and Opportunity

US: Corn Stover

US: Energy

Crops

China:

Corn Stover

ASEAN: EFB

South America:

Bagasse & Straw

China:

Energy Crop

EU: Straw &

Energy Crop

© 2007 E.I. du Pont de Nemours and Company. All Rights Reserved.

The Petrochemical Industry on One Slide

The source of the Building Blocks is not renewable

Oil &

Natural Gas

Building

Blocks(small simple

molecules)

Intermediates(Bigger or more

functionalized

molecules)

Polymers(Really big

molecules)

Oil & Gas

Companies

Exploration/

Recovery Refining

Chemical

Companies

Chemicals/

MonomersPolymers

Stuff That People Want

(Fibers, films, fuels, solvents, molded articles…

Millions of Years ago…..

Sun

Plants/

Diatoms

GeologicalProcess

© 2007 E.I. du Pont de Nemours and Company. All Rights Reserved.

The Renewably Sourced Materials Industry on One Slide

The source of the Building Blocks is renewable

Feedstocks(carbohydrates,

oils, proteins)

Building

Blocks(small simple

molecules)

Intermediates(Bigger or more

functionalized

molecules)

Polymers(Really big

molecules)

Ag

Processors

Milling/

Digestion

Fermentation &/or

Thermochemistry

DuPont

Chemicals/

MonomersPolymers

Stuff That People Want

(Fibers, films, fuels, solvents, molded articles…

Sun

Crops

Farmers

Last week…..

© 2007 E.I. du Pont de Nemours and Company. All Rights Reserved.

© 2007 E.I. du Pont de Nemours and Company. All Rights Reserved.

Acknowledgements:

Michael Saltzberg

Jan Koninckx

© 2007 E.I. du Pont de Nemours and Company. All Rights Reserved.