proline sulphonamide-catalysed yamada-otani condensation ... · s1 proline sulphonamide-catalysed...

84
S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity Hua Yang, a Somdev Banerjee b and Rich G. Carter b * a College of Chemistry & Chemical Engineering, Central South University, Changsha, Hunan 410083, China. b Chemistry Department, Oregon State University, Corvallis, OR 97331. Electronic Supplementary Information: NMR Spectra Electronic Supplementary Material (ESI) for Organic & Biomolecular Chemistry This journal is © The Royal Society of Chemistry 2012

Upload: others

Post on 10-Jun-2020

10 views

Category:

Documents


0 download

TRANSCRIPT

Page 1: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

S1

Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Hua Yang,a Somdev Banerjeeb and Rich G. Carterb*

a College of Chemistry & Chemical Engineering, Central South University, Changsha, Hunan 410083, China. b Chemistry Department, Oregon State

University, Corvallis, OR 97331.

Electronic Supplementary Information: NMR Spectra

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Page 2: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

S2

Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Table of Contents

Compound Page

# Number 36 S3 38 S5 39 S7 42i S9 42k S11 42l S13 42n S15 42o S17 56 S19

42q S21 42r S23 59 S25

42p S27 23 S29

41a S31 41b S33 41c S35 43a S37 43b S39 43c S41

Compound #

Page Number

43e S45 43f S47 43g S49 43h S51 43i S53 43j S55 43k S57 43l S59

43m S61 43n S63 43o S65 43p S67 43q S69 43r S71 44 S73 45 S75 46 S77 47 S79 48 S81 49 S83

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Page 3: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S3
Page 4: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
Rich Carter
S4
Page 5: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S5
Page 6: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S6
Page 7: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S7
Page 8: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S8
Page 9: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S9
Page 10: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S10
Page 11: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S11
Page 12: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S12
Page 13: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S13
Page 14: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S14
Page 15: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S15
Page 16: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S16
Page 17: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S17
Page 18: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S18
Page 19: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S19
Page 20: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S20
Page 21: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S21
Page 22: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S22
Page 23: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S23
Page 24: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S24
Page 25: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S25
Page 26: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S26
Page 27: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S27
Page 28: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S28
Page 29: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S29
Page 30: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S30
Page 31: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S31
Page 32: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S32
Page 33: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S33
Page 34: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S34
Page 35: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S35
Page 36: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S36
Page 37: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S37
Page 38: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S38
Page 39: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S39
Page 40: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S40
Page 41: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S41
Page 42: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S42
Page 43: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S43
Page 44: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S44
Page 45: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S45
Page 46: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S46
Page 47: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S47
Page 48: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S48
Page 49: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S49
Page 50: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S50
Page 51: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S51
Page 52: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S52
Page 53: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S53
Page 54: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S54
Page 55: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S55
Page 56: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S56
Page 57: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S57
Page 58: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S58
Page 59: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S59
Page 60: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S60
Page 61: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S61
Page 62: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S62
Page 63: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S63
Page 64: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S64
Page 65: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S65
Page 66: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S66
Page 67: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S67
Page 68: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S68
Page 69: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S69
Page 70: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S70
Page 71: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S71
Page 72: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S72
Page 73: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S73
Page 74: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S74
Page 75: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S75
Page 76: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S76
Page 77: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S77
Page 78: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S78
Page 79: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S79
Page 80: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S80
Page 81: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S81
Page 82: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S82
Page 83: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S83
Page 84: Proline Sulphonamide-Catalysed Yamada-Otani Condensation ... · S1 Proline Sulphonamide-Catalysed Yamada-Otani Condensation: Reaction Development, Substrate Scope and Scaffold Reactivity

Electronic Supplementary Material (ESI) for Organic & Biomolecular ChemistryThis journal is © The Royal Society of Chemistry 2012

Rich Carter
S84