Presented by:

• María Gabriela Novoa Villada

Third Semester

Molecular Biology

Protein ZEB1 and resistance to radiation therapy, and antibodies to

damage lungs

Proteins

Macromolecules

Are

Functional unit are amino acids

Principal functions:• Enzymes.• Antibodies.• Regulation many process.• Buffers.• Receptors.

Single gen

Components

Sugary, lung-damaging bacteria subvert antibodiesAugust 11, 2014

Destroyed pathogenic bacteria

Antibodies

Normally

With complement

proteins

forming pores in the membrane

Bacterial lysis

Pulmonar infections

Production IgG2

No Bacterial lysis

Bacterium Pseudomonas

Goes to

1.Cough 2.Chest pain 3.Discouragement

Bronchiectasis

Researchers at the University of

Birmingham

Subgroup with bronchiectasis

studied

IgG2In all

patients Find

IgG2 was observed adhered to extra large sugars in membrane of Psueomona ,

preventing its destruction

IgG2Is not yet known its

antibacterial mechanism

It has allowed to understand why vaccines

with extra-long sugars cause more severe disease

But

In my opinion the studies aimed to find antibodies that prevent adequate treatment of diseases, provide insight into the different mechanism and avoid reducing the risks and adverse effects they bring. Likewise to find new alternatives to treatment and drugs.

Personal opinion

Protein ZEB1 promotes breast tumor resistance to radiation therapyAugust 4, 2014

Protein ZEB1

Resistance with radiation therapy in patients with

cancer

Induces the behavior of

tumor cells like mother cells

Radio therapy:

• Induces cell death through “Breaks DNA”.

• Kills tumor cells making them less able to repair DNA

ZEB1

Promove repair DNA after radio

therapy

increases the response

pathway to DNA damage

through activate ATM gene

stabilizes ChK1 protein

USP7enzyme

active

ZEB1

Epithelial-mesenchymal

transition (EMT)

Confers radio-resistant properties

and property of mother cells

Healing

Induce

Tumoral cells

In my opinion these studies provide insight into new related resistance mechanisms of different cancer treatments. Knowing proteins and enzymes associated with it, allows to consider new strategies and possible treatments aimed at combating proteins, preventing the development of new cancers and less aggressive treatment, even death.

Personal opinion

Both studies help develop new treatments and drugs, focused on preventing the development of pulmonary diseases and resistance to cancer treatments

Is very interesting to know how the body is able to produce antibodies against itself, allowing to development treatments focused on avoiding harm to self. Mechanisms not yet understood.

Cancer, especially breast cancer, has been

increasing in the last years. The studies

focused on finding new causes resistance to

different treatments, give a breakthrough in

medicine, allowing to know possible causes of

treatment failure.

Through studies conducted with genetics and molecular biology may

come to find new explanations to many unknown events in medicine today. It is

important to develop these types of studies in order to find the explanation

for problems such as resistance to treatment and the development of more

severe disease.

Refereces

• Journal reference: Peijing Zhang, Yongkun Wei, Li Wang, Bisrat G. Debeb, Yuan Yuan, Jinsong Zhang, Jingsong Yuan, Min Wang, Dahu Chen, Yutong Sun, Wendy A. Woodward, Yongqing Liu, Douglas C. Dean, Han Liang, Ye Hu, K. Kian Ang, Mien-Chie Hung, Junjie Chen, Li Ma. www.sciencesdaily.com. August 4, 2014.News Available in: http://www.sciencedaily.com/releases/2014/08/140804102940.htm

• Journal reference: T. J. Wells, D. Whitters, Y. R. Sevastsyanovich, J. N. Heath, J. Pravin, M. Goodall, D. F. Browning, M. K. O'Shea, A. Cranston, A. De Soyza, A. F. Cunningham, C. A. MacLennan, I. R. Henderson, R. A. Stockley. www.sciencesdaily.com. August 11,2014. News Available in: http://www.sciencedaily.com/releases/2014/08/140811124322.htm

• Martínez Sánchez, Lina María; Grisales Vargas, Natalia; Toro Montoya, Eduardo Andrés; Sierra Pamplona, Ana Paulina; Orrego Quevedo, Esteban. (2013). Biología Molecular. 7ª Edición. Editorial Universidad Pontificia Bolivariana. pp: 112-115.