psyc550 biological bases of behavior sleep and sex
TRANSCRIPT
PSYC550Biological Bases of
BehaviorSleep and Sex
A Physiological and Behavioral
Description of Sleep• alpha activity
– Smooth electrical activity of 8-12 Hz recorded from the brain; generally associated with a state of relaxation.
• beta activity– Irregular electrical activity of 13-30 Hz recorded from
the brain; generally associated with a state of arousal.• theta activity
– EEG activity of 3.5-7.5 Hz that occurs intermittently during early stages of slow-wave sleep and REM sleep.
• delta activity– Regular synchronous electrical activity of less than 4
Hz recorded from the brain; occurs during the deepest stages of slow-wave sleep.
SWS vs REM• NREM (SWS in stages 3 and 4)
– Alpha, delta, and theta activity– Light, even respiration– Lowered BP– Muscle control is present– Difficult to arouse (especially from stage 4)
• REM– Asynchronized beta– Increased respiration and BP– REM– PGO waves– Spinal paralysis– Dreams– Sexual arousal
A Physiological and Behavioral
Description of Sleep• REM sleep
– A period of desynchronized EEG activity during sleep, at which time dreaming, rapid eye movements, and muscular paralysis occur; also called paradoxical sleep.
• non-REM sleep– All stages of sleep except REM sleep.
• slow-wave sleep– Non-REM sleep, characterized by synchronized EEG
activity during its deeper stages.• basic rest-activity cycle
– A 90-minute cycle (in humans) of waxing and waning alertness, controlled by a biological clock in the caudal brain stem; controls cycles in REM sleep and slow-wave sleep.
Neurotransmitters involved in Sleep
• Serotonin– In raphe and pons– Increased in SWS, decreased in REM
• Dopamine– Decreased in REM
• Norepinephrine– Decreased in REM
• Acetylcholine– Greatly increased in REM
I get 8 hours of sleep each night, without
fail.
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Disorders of Sleep• insomnia
– Discuss sleep hygiene
• drug dependency insomnia– An insomnia caused by the side effects of ever-increasing
doses of sleeping medications.• sleep apnea
– Cessation of breathing while sleeping.• narcolepsy
– A sleep disorder characterized by periods of irresistible sleep, attacks of cataplexy, sleep paralysis, and hypnagogic hallucinations.
• sleep attack– A symptom of narcolepsy; an irresistible urge to sleep
during the day, after which the person awakens feeling refreshed.
People with narcolepsy collapse into sleep from total alertness without
warning.
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http://www.youtube.com/watch?v=tOAvWbspeSQ&feature=related
Narcolepsy• cataplexy
– A symptom of narcolepsy; complete paralysis that occurs during waking.
• sleep paralysis– A symptom of narcolepsy; paralysis occurring just
before a person falls asleep.• hypnagogic hallucination
– A symptom of narcolepsy; vivid dreams that occur just before a person falls asleep; accompanied by sleep paralysis.
• hypocretin– A peptide, also known as orexin, produced by
neurons whose cell bodies are located in the hypothalamus; their destruction causes narcolepsy.
Disorders of Sleep
• REM sleep behavior disorder– A neurological disorder in which the
person does not become paralyzed during REM sleep and thus acts out dreams.
• Night terrors vs nightmares• Somnambulism• Somniloquy• Enuresis• Bruxism
Why do we sleep?
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25% 25%25%25%1. For restoration2. To consolidate
memory3. To remain safe
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relax
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Why Do We Sleep?• sleep-related eating disorder
– A disorder in which the person leaves his or her bed and seeks out and eats food while sleepwalking, usually without a memory for the episode the next day.
• fatal familial insomnia– A fatal inherited disorder characterized by
progressive insomnia.• rebound phenomenon
– The increased frequency or intensity of a phenomenon after it has been temporarily suppressed; for example, the increase in REM sleep seen after a period of REM sleep deprivation.
• adaptive response to danger
Physiological Mechanisms of Sleep
and Waking• locus coeruleus
– A dark-colored group of noradrenergic cell bodies located in the pons near the rostral end of the floor of the fourth ventricle; involved in arousal and vigilance.
• raphe nucleus– A group of nuclei located in the reticular formation of the
medulla, pons, and midbrain, situated along the midline, contains serotonergic neurons.
• tuberomammillary nucleus (TMN)– A nucleus in the ventral posterior hypothalamus, just rostral
to the mammillary bodies; contains histaminergic neurons involved in cortical activation and behavioral arousal.
• ventrolateral proptic area (VLPA)– A group of GABAergic neurons in the preoptic area whose
activity suppresses alertness and behavioral arousal and promotes sleep.
Physiological Mechanisms of Sleep
and Waking• PGO wave
– Bursts of phasic electrical activity in the pons, followed by activity in the lateral geniculate nucleus and visual cortex, a characteristic of REM sleep.
• medial pontine reticular formation (MPRF)– A region that contains neurons involved in
the initiation of REM sleep; activated by acetylcholinergic neurons of the peribrachial area.
Physiological Mechanisms of
Sleep and Waking• magnocellular nucleus
– A nucleus in the medulla; involved in the muscular paralysis that accompanies REM sleep.
Biological Clocks• circadian rhythm
– A daily rhythmical change in behavior or physiological process.
• zeitgebers– A stimulus (usually the light of dawn) that resets the
biological clock that is responsible for circadian rhythms.• suprachiasmatic nucleus (SCN)
– A nucleus situated atop the optic chiasm. It contains a biological clock that is responsible for organizing many of the body’s circadian rhythms.
• melanopsin– A photopigment present in ganglion cells in the retina
whose axons transmit information to the SCN, the thalamus, and the olivary pretectal nucleus.
Biological Clocks
• pineal gland– A gland attached to the dorsal tectum;
produces melatonin and plats a role in circadian and seasonal rhythms.
• melatonin– A hormone secreted during the night by
the pineal body; plays a role in circadian and seasonal rhythms.
Sexual Development
• sry– The gene on the Y chromosome that instructs the
undifferentiated fetal gonads to become testes.• organizational effect (of hormone)
– The permanent effect of a hormone on tissue differentiation and development.
• activational effect (of hormone)– The effect of a hormone that occurs in the fully
developed organism; may depend on the organism’s prior exposure to the organizational effects of hormones.
Sexual Development
• defeminizing effect– An effect of a hormone present early in development that
reduces or prevents the later development of anatomical or behavioral characteristics typical of females.
• androgen– A male sex steroid hormone; stimulates the development of
the Wolffian system. Testosterone is the principal mammalian androgen.
• masculinizing effect– An effect of a hormone present early in development that
promotes the later development of anatomical or behavioral characteristics of males.
• testosterone– The principal androgen found in males.
AIS• androgen insensitivity
syndrome– A condition caused by
a congenital lack of functioning androgen receptors; in a person with XY sex chromosomes, causes the development of a female with testes but no internal sex organs.
Sexual Development
• Turner’s syndrome– The presence of only one sex chromosome
(an X chromosome); characterized by lack of ovaries but otherwise normal female sex organs and genitalia.
Sexual Development
• follicule-stimulating hormone (FSH)– The hormone of the anterior pituitary gland that causes
development of an ovarian follicle and the maturation of an ovum.
• luteinizing hormone (LH)– A hormone of the anterior pituitary gland that causes
ovulation and development of the ovarian into a corpus luteum.
• estradiol– The principal estrogen of many mammals, including
humans.• estrogen
– A class of sex hormones that cause maturation of the female genitalia, growth of breast tissue, and development of other physical features characteristic of females.
Copyright © Allyn & Bacon 2007
Hormonal Control of Sexual Behavior
• oxytocin: The big “O”– A hormone secreted by the posterior pituitary gland;
causes contraction of the smooth muscle of the milk ducts, the uterus, and the male ejaculatory system; also serves as a neurotransmitter in the brain.
• prolactin– A hormone of the anterior pituitary gland, necessary
for production of milk; has an inhibitory effect on male sexual behavior.
• lordosis– A spinal reflex seen in many four-legged animals;
arching of the back in response to approach of a male or to touching the flanks, which elevates the hindquarters.
Hormonal Control of Sexual Behavior
• pheromone– A chemical released by one animal that affects the behavior
or physiology of another animal; usually smelled or tasted.• Lee-Boot effect
– The slowing and eventual cessation of estrous cycles in groups of female animals that are housed together; caused by a pheromone in the animals’ urine; first observed in mice.
• Whitten effect– The synchronization of the menstrual or estrous cycles of a
group of females, which occurs in the presence of a pheromone in a male’s urine.
Hormonal Control of Sexual Behavior
• Vandenbergh effect– The early onset of puberty seen in female animals that are
housed with males; caused by a pheromone in the male’s urine; first observed in mice.
• Bruce effect– Termination of pregnancy caused by the odor of a
pheromone in the urine of a male other than the one that impregnated the female; first identified in mice.
• vomeronasal organ (VNO)– A sensory organ that detects the presence of certain
chemicals, especially when a liquid is actively sniffed; mediates the effects of some pheromones.
• accessory olfactory bulb– A neural structure located in the main olfactory bulb that
receives information from the vomeronasal organ.
Hormonal Control of Sexual Behavior
• medial nucleus of the amygdala– A nucleus that receives olfactory
information from the olfactory bulb and accessory olfactory bulb; involved in the effects of odors and pheromones on reproductive behavior.
• congenital adrenal hyperplasia (CAH)– A condition characterized by hypersecretion
of androgens by the adrenal cortex; in females, causes masculinization of the external genitalia.
Copyright © Allyn & Bacon 2007
Copyright © Allyn & Bacon 2007
Copyright © Allyn & Bacon 2007
Neural Control of Sexual Behavior
• medial preoptic area (MPA)– An area of cell bodies just rostral to the
hypothalamus; plays an essential role in male sexual behavior.
• sexually dimorphic nucleus– A nucleus in the preoptic area that is much larger
in males than in females; first observed in rats; plays a role in male sexual behavior.
• periaqueductal gray matter (PAG)– The region of the midbrain that surrounds the
cerebral aqueduct; plays an essential role in various species-typical behaviors, including female sexual behaviors.
Neural Control of Sexual Behavior
• ventromedial nucleus of the hypothalamus (MH)– A large nucleus of the hypothalamus
located near the wall of the third ventricle; plays an essential role in female sexual behaviors.
The neural structure most involved in female reproductive behavior
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25% 25%25%25%1. Gone after the honeymoon
2. The Medial Preoptic Area (MPA)
3. The Ventromedial Hypothalamus (VMH)
4. The Hippocampus (HPC)
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During paradoxical sleep, you will expect an increase in the
neurotransmitter:
Ser
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Dopam
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Ace
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25% 25%25%25%1. Serotonin2. Norepinephrine3. Dopamine4. Acetylcholine
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