respiratory inhaler check-up service what is the challenge?categorising inhaler devices aerosol...

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1 Respiratory Inhaler Check-up Service Dr Toby Capstick Lead Respiratory Pharmacist Leeds Teaching Hospitals NHS Trust [email protected] 19 th November 2019 What is the Challenge? 1. British Lung Foundation. The Battle for breath. 2016 2. Asthma UK (2014) http://www.asthma.org.uk/asthma-facts-and-statistics 3. Asthma UK. The Asthma UK Data Portal. https://www.asthma.org.uk/get-involved/campaigns/data-portal/ (accessed 27/10/17) 4. DH (2011). An outcomes strategy for COPD and Asthma in England 5. Public Health England. Inhale - INteractive Health Atlas of Lung conditions in England. 2015/16 data. https://fingertips.phe.org.uk/profile/inhale/data 6. Royal College of Physicians (2014). Why asthma still kills: The National Review of Asthma Deaths (NRAD) ASTHMA COPD The Burden of Disease in the UK Inhaler Technique: 46% of people who died from asthma did not had inhaler technique checked & recorded in the prior 12 months. 6 1.2 million people in the UK diagnosed with COPD. 1 2/3 of people with COPD thought to remain undiagnosed. 1 There were 140,000 UK Hospital admissions each year. 1 COPD was responsible for 25,000 – 30,000 deaths annually. 1,4 8 million people in the UK diagnosed with asthma. 1 5.4 million asthmatics in UK 1-2 (1.1 million children) 2 There were 77,124 UK Hospital admissions in 2016/17 3 75% of admissions are avoidable 2 Asthma was responsible for 1,484 deaths in 2017. 2 2/3 of deaths are preventable 2 NHS Digital. Prescription Cost Analysis, England – 2018. Available at: https://digital.nhs.uk/data-and-information/publications/statistical/prescription-cost-analysis/2018 Publication date: 28th March 2019 Prescription Cost Analysis - England, 2018 Overall, £931 million spent on inhalers in England in 2018 £12.65 million spent on inhalers in Leeds in 2018 (↓£14.65 in 2017) BUT, are we getting value for money? 50% have not had inhaler technique checked & recorded in the last 15 months. Top 5 Brands Expenditure 1 Fostair 100/6 MDI £124,619,129 2 Spriva 18mcg HandiHaler refills £52,845,366 3 Braltus 10mcg Zonda £50,002,648 4 Seretide 250/25 MDI £48,765,022 5 Seretide 500 Accuhaler £41,875,352 Top 5 Generics Expenditure 1 Beclometasone/formoterol 100/6 MDI £124,619,129 2 Tiotropium HandiHaler, Zonda £114,231,876 3 Budesonide/formoterol 200/6 DPI Turbohaler, Spiromax, Easyhaler £72,723,129 4 Fluticasone/salmeterol 250/25 MDI £69,721,831 5 Fluticasone/salmeterol 500/50 DPI Accuhaler, Forspiro, Spiromax, Easyhaler £39,586,574 Asthma & COPD: Inhalers in 2010 Bronchodilators SABAs Salbutamol (7+ devices) Terbutaline (1 device) SAMAs Ipratropium (2 devices) LABAs Formoterol (2 devices) Salmeterol (2 devices) LAMAs Tiotropium (2 devices) Corticosteroids ICS Beclometasone (4 devices) Beclometasone extra-fine (3 devices) Budesonide (3 devices) Ciclesonide (1 device) Fluticasone propionate (2 devices) Mometasone (1 device) ICS/LABA Fostair (beclometasone/formoterol) (1 device) Seretide (fluticasone propionate/salmeterol) (2 devices) Symbicort (budesonide/formoterol) (1 device) Asthma & COPD: Inhalers in 2019 Not available as monotherapy Corticosteroids ICS Beclometasone (Clenil Modulite) (2 devices) Beclometasone extra-fine (Qvar, Kelhale) (3 devices) Budesonide (3 devices) Ciclesonide (1 device) Fluticasone furoate Fluticasone propionate (2 devices) Mometasone (1 device) ICS/LABA Aerivio (fluticasone propionate/salmeterol) (1 device) AirFluSal (fluticasone propionate/salmeterol) (2 devices) Aloflute (fluticasone propionate/salmeterol) (1 device) Combisal (fluticasone propionate/salmeterol) (1 device) DuoResp (budesonide/formoterol) (1 device) Flutiform (fluticasone propionate/formoterol) (2 devices) Fobumix (budesonide/formoterol) (1 device) Fostair (beclometasone/formoterol) (2 devices) Fusacomb (fluticasone propionate/salmeterol) (1 device) Relvar (fluticasone fuorate/vilanterol) (1 device) Sereflo (fluticasone propionate/salmeterol) (1 device) Seretide (fluticasone propionate/salmeterol) (2 devices) Sirdupla(fluticasone propionate/salmeterol) (1 device) Stalpex (fluticasone propionate/salmeterol) (1 device) Symbicort (budesonide/formoterol) (2 devices) ICS/LABA/LAMA Trelegy(fluticasone fuorate/vilanterol/umeclidinium) (1 device) Trimbow(beclometasone/formoterol/glycopyrronium) (1 device) Bronchodilators SABAs Salbutamol (6 devices) Terbutaline (1 device) SAMAs Ipratropium (1 device) LABAs Formoterol (4 devices) Salmeterol (2 devices) Indacaterol (1 device) Olodaterol (1 device) Vilanterol LAMAs Aclidinium (1 device) Glycopyrronium (1 device) Tiotropium (3 devices) Umeclidinium (1 device) LABA/LAMAs Anoro (vilanterol/umeclidinium (1 device) Duaklir (formoterol/aclidinium) (1 device) Spiolto (olodaterol/tiotropium) (1 device) Ultibro (indacaterol/glycopyrronium) (1 device) 1 2 3 4 5 6

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  • 1

    Respiratory Inhaler Check-up Service

    Dr Toby Capstick

    Lead Respiratory Pharmacist

    Leeds Teaching Hospitals NHS Trust

    [email protected]

    19th November 2019

    What is the Challenge?

    1. British Lung Foundation. The Battle for breath. 2016

    2. Asthma UK (2014) http://www.asthma.org.uk/asthma-facts-and-statistics

    3. Asthma UK. The Asthma UK Data Portal. https://www.asthma.org.uk/get-involved/campaigns/data-portal/ (accessed 27/10/17)

    4. DH (2011). An outcomes strategy for COPD and Asthma in England

    5. Public Health England. Inhale - INteractive Health Atlas of Lung conditions in England. 2015/16 data. https://fingertips.phe.org.uk/profile/inhale/data

    6. Royal College of Physicians (2014). Why asthma still kills: The National Review of Asthma Deaths (NRAD)

    ASTHMA COPD

    The Burden of Disease in the UK

    Inhaler Technique:

    • 46% of people who died from asthma did not had inhaler technique checked

    & recorded in the prior 12 months.6

    1.2 million people in the UK diagnosed with

    COPD.1

    • 2/3 of people with COPD thought to

    remain undiagnosed.1

    There were 140,000 UK Hospital

    admissions each year.1

    COPD was responsible for 25,000 –

    30,000 deaths annually.1,4

    8 million people in the UK diagnosed with

    asthma.1

    • 5.4 million asthmatics in UK1-2

    • (1.1 million children)2

    There were 77,124 UK Hospital

    admissions in 2016/173

    75% of admissions are avoidable2

    Asthma was responsible for 1,484 deathsin 2017.2

    2/3 of deaths are preventable2

    NHS Digital. Prescription Cost Analysis, England – 2018. Available at:

    https://digital.nhs.uk/data-and-information/publications/statistical/prescription-cost-analysis/2018

    Publication date: 28th March 2019

    Prescription Cost Analysis - England, 2018

    Overall, £931 million spent on inhalers in England in 2018

    £12.65 million spent on inhalers in Leeds in 2018 (↓£14.65 in 2017)

    BUT, are we getting value for money?

    50% have not had inhaler technique checked & recorded in the

    last 15 months.

    Top 5 Brands Expenditure

    1 Fostair 100/6 MDI £124,619,129

    2Spriva 18mcg HandiHaler

    refills£52,845,366

    3 Braltus 10mcg Zonda £50,002,648

    4 Seretide 250/25 MDI £48,765,022

    5 Seretide 500 Accuhaler £41,875,352

    Top 5 Generics Expenditure

    1Beclometasone/formoterol 100/6

    MDI£124,619,129

    2Tiotropium

    HandiHaler, Zonda£114,231,876

    3Budesonide/formoterol 200/6 DPI

    Turbohaler, Spiromax, Easyhaler£72,723,129

    4Fluticasone/salmeterol 250/25

    MDI£69,721,831

    5Fluticasone/salmeterol 500/50 DPI Accuhaler, Forspiro, Spiromax, Easyhaler

    £39,586,574

    Asthma & COPD: Inhalers in 2010

    Bronchodilators

    SABAs

    • Salbutamol (7+ devices)

    • Terbutaline (1 device)

    SAMAs

    • Ipratropium (2 devices)

    LABAs

    • Formoterol (2 devices)

    • Salmeterol (2 devices)

    LAMAs

    • Tiotropium (2 devices)

    Corticosteroids

    ICS

    • Beclometasone (4 devices)

    • Beclometasone extra-fine (3 devices)

    • Budesonide (3 devices)

    • Ciclesonide (1 device)

    • Fluticasone propionate (2 devices)

    • Mometasone (1 device)

    ICS/LABA

    • Fostair(beclometasone/formoterol)

    (1 device)

    • Seretide(fluticasone propionate/salmeterol)

    (2 devices)

    • Symbicort(budesonide/formoterol)

    (1 device)

    Asthma & COPD: Inhalers in 2019

    †Not available as monotherapy

    CorticosteroidsICS

    • Beclometasone (Clenil Modulite) (2 devices)

    • Beclometasone extra-fine (Qvar, Kelhale) (3 devices)

    • Budesonide (3 devices)

    • Ciclesonide (1 device)

    • † Fluticasone furoate

    • Fluticasone propionate (2 devices)

    • Mometasone (1 device)

    ICS/LABA

    • Aerivio (fluticasone propionate/salmeterol) (1 device)

    • AirFluSal (fluticasone propionate/salmeterol) (2 devices)

    • Aloflute (fluticasone propionate/salmeterol) (1 device)

    • Combisal (fluticasone propionate/salmeterol) (1 device)

    • DuoResp (budesonide/formoterol) (1 device)

    • Flutiform (fluticasone propionate/formoterol) (2 devices)

    • Fobumix (budesonide/formoterol) (1 device)

    • Fostair (beclometasone/formoterol) (2 devices)

    • Fusacomb (fluticasone propionate/salmeterol) (1 device)

    • Relvar (fluticasone fuorate/vilanterol) (1 device)

    • Sereflo (fluticasone propionate/salmeterol) (1 device)

    • Seretide (fluticasone propionate/salmeterol) (2 devices)

    • Sirdupla (fluticasone propionate/salmeterol) (1 device)

    • Stalpex (fluticasone propionate/salmeterol) (1 device)

    • Symbicort (budesonide/formoterol) (2 devices)

    ICS/LABA/LAMA

    • Trelegy� (fluticasone fuorate/vilanterol/umeclidinium) (1 device)

    • Trimbow�(beclometasone/formoterol/glycopyrronium) (1 device)

    Bronchodilators

    SABAs

    • Salbutamol (6 devices)

    • Terbutaline (1 device)

    SAMAs

    • Ipratropium (1 device)

    LABAs

    • Formoterol (4 devices)

    • Salmeterol (2 devices)

    • Indacaterol (1 device)

    • Olodaterol� (1 device)

    • † Vilanterol

    LAMAs

    • Aclidinium� (1 device)

    • Glycopyrronium (1 device)

    • Tiotropium (3 devices)

    • Umeclidinium� (1 device)

    LABA/LAMAs

    • Anoro� (vilanterol/umeclidinium (1 device)

    • Duaklir� (formoterol/aclidinium) (1 device)

    • Spiolto� (olodaterol/tiotropium) (1 device)

    • Ultibro� (indacaterol/glycopyrronium) (1 device)

    1 2

    3 4

    5 6

  • 2

    Categorising Inhaler DevicesAerosol

    Aerosol ± Spacer Soft Mist Breath Actuated Aerosol

    MDI Small Vol. Spacer

    Large Vol.

    Spacer

    Respimat Autohaler Easi-Breathe K-haler

    Dry Powder Inhaler (DPI)

    Single dose DPI - Blister Single dose DPI - Capsule

    Accuhaler Ellipta Forspiro Orbicel Aeroliser Breezhaler HandiHaler Zonda

    Reservoir Multidose DPI

    Easyhaler Genuair NEXThaler Novolizer Spiromax Turbohaler Twisthaler

    Generic Prescribing• Budesonide/formoterol ● Beclometasone/formoterol

    • Fluticasone/salmeterol

    • Formoterol

    Symbicort

    Turbohaler

    DuoResp

    Spiromax

    Atimos Modulite

    pMDI

    NEXThalerpMDI

    Formoterol

    Easyhaler

    Foradil

    Aeroliser

    Oxis

    Turbohaler

    Seretide

    Accuhaler

    AirFluSal

    Forspiro

    Fobumix

    Easyhaler

    Aerivio

    Spiromax

    BTS/SIGN Asthma Guidelines 2016

    Stalpex

    Orbicel

    NICE COPD Guidelines 2019

    Switching Inhaler Devices:

    Effect of unconsented switch (Asthma)

    Thomas et al. BMC Pulmonary Medicine 2009;9:1-10

    Treatment Success OR: 0.29 [95% CI: 0.19, 0.44; p

  • 3

    Inhaler Technique: Has it Improved Over 40 Years?

    Systematic review. 144 studies, 54,354 patients

    Sanchis et al. Chest 2016; 150(2):394-406

    Association Between Inhaler Technique and

    COPD exacerbations

    45

    36

    80

    71

    38

    29

    70

    63

    0

    10

    20

    30

    40

    50

    60

    70

    80

    90

    Hospital admissions Emergency dept

    visits

    Antibiotic courses Corticosteroid

    courses

    % o

    f p

    ati

    en

    ts e

    xace

    rba

    tin

    g

    At least 1 Critical Error No Errors

    OR 1.47; p=0.001 OR 1.62; p

  • Slide 18

    M3 Is there a clearer image that can be used ?Michaela, 26/09/2019

  • 4

    Effect of Multiple dosing into Spacers• Single actuations into spacers are recommended

    Barry PW et O’Callaghan C. Eur Respir J., 1994, 7, 1707–1709

    5

    What do Guidelines Recommend?

    BTS/SIGN Asthma Guidelines

    2016

    • Prescribe inhalers only after

    patients have:• Received training in the use of the

    device, and

    • Have demonstrated satisfactory

    technique

    • Before initiating a new drug

    therapy practitioners should

    check:• Adherence with existing therapies

    • Inhaler technique, and

    • Eliminate trigger factors

    NICE COPD Guidelines 2010

    • Inhalers should be prescribed

    only after patients have • received training in the use of the

    device, and

    • have demonstrated satisfactory

    technique

    • Patients should have their ability

    to use an inhaler device regularly

    assessed by a competent

    healthcare professional and, if

    necessary, should be re-taught

    the correct technique

    BTS/SIGN Asthma Guidelines 2016 NICE clinical guideline 101: Chronic

    obstructive pulmonary disease. 2010

    The Service

    • Eligible Patients• Diagnosis of asthma / COPD, on inhaled therapy

    • Registered with Leeds GP

    • Speak & understand English (or translated by pharmacy team)

    • Able to attend both consultations

    • Service allowed once per patient

    • Pharmacy requirements• Use consultation room

    • Provided by Pharmacist or Registered Pharmacy Technician, • Must have completed CPPE Declaration of Competence for Improving Inhaler Technique.

    • Must use In Check DIAL G16 with 1-way inspiratory mouthpieces, & placebos.• Initial supply provided.

    • It is your responsibility to obtain more.• London Medicines Evaluation Network. Availability and supply of respiratory support devices to healthcare

    professionals. http://www.medicinesresources.nhs.uk/upload/Availability%20of%20placebo%20inhalers%20FINAL_June13_LMEN.pdf

    Service Outline

    • Two appointments: baseline & 6-8 weeks later• Take telephone no. and/or email to use as a reminder

    • Patient education:1. Assessment of Asthma Control (ACT) or COPD health status (CAT)

    2. Inhaler technique:• Measure inspiratory flow using In-Check DIAL G16

    • Assess, teach and optimise inhaler technique

    3. Medicines use

    4. Adherence

    5. Smoking cessation

    6. Data recorded on Pharmoutcomes within 48 hours

    7. GP referral: e.g. if alternative device needed

    • NB. If patient has (1) good control (ACT≥20 or CAT

  • 5

    • Patient education:

    1. Assessment of Asthma Control (ACT) or COPD health status (CAT)

    2. Inhaler technique:

    • Measure inspiratory flow using In-Check DIAL G16

    • Assess, teach and optimise inhaler technique

    3. Medicines use

    4. Adherence

    5. Good Clinical Practice: Smoking cessation

    6. Data recorded on Pharmoutcomes within 48 hours

    7. GP referral: e.g. if alternative device needed

    The Consultation

    Resulting Symptoms:• Wheeze• Breathlessness at rest & during

    activities

    • Chest tightness• Cough• Increased mucous & phlegm

    What is COPD?

    Chronic Inflammation:

    • Parenchymal

    destruction

    • Breakdown of

    alveolar attachments

    • Loss of bronchiole

    elasticity

    Narrowing

    of airways

    Chronic irritation by

    tobacco smoke /

    noxious agents:

    • Increased no. of

    goblet cells &

    enlarged

    submucosal glands

    • Impaired mucociliary

    clearance

    • Mucous plugging

    A common, preventable and treatable disease… characterised by persistent

    respiratory symptoms and airflow limitation that is due to airway and/or alveolar

    abnormalities usually caused by significant exposure to noxious particles or gases.

    • Asthma is a chronic inflammatory disorder of the airways

    • Involves a variety of cells and cellular mediators

    • Airflow limitation is widespread, variable, and often reversible

    • Chronic inflammation leads to an increase in airway hyperresponsiveness

    with recurrent episodes of wheezing, coughing, and shortness of breath

    What is Asthma?

    Smooth muscle

    Mucus plug

    Basementmembrane

    Epithelium

    Mucous glands

    Adapted from Jeffery PK. Am J Respir Crit Care Med. 2001;164:S28-S38.

    44

    Normal

    airway

    Asthmatic

    airway

    1. Assessment of Asthma Control (ACT)

    or COPD Health Status (CAT)

    25 26

    27 28

    29 30

  • 6

    COPD Assessment Test (CAT)

    (http://catestonline.org).

    • 8 Questions (max score 40)

    • Score ≤5: normal healthy

    non-smokers

    • 20: high impact

    • >30: very high impact

    • A change of 2 is clinically

    meaningful.

    • Influenza vaccination can reduce hospital admissions for both

    pneumonia and influenza, and reduce mortality risk.

    ACTION

    • Ask whether patient had a flu vaccination during the most recent

    winter

    • If patient did not have their most recent vaccination when due

    • Advise of the benefits and encourage to have it annually

    • During ‘flu season’: offer annual flu vaccination

    • From community pharmacy or GP

    Vaccination

    2. Inhaler Technique

    How Should We Teach Inhaler Technique?

    0%

    10%

    20%

    30%

    40%

    50%

    60%

    70%

    80%

    90%

    100%

    Pren=8

    Postn=7

    Pren=9

    Postn=8

    Pren=9

    Postn=9

    Tu

    rbo

    hale

    r Tech

    niq

    ue S

    co

    re

    Unsatisfactory

    Satisfactory

    Optimal

    VerbalAugmented

    Verbal

    Augmented

    Verbal + PhysicalBasheti IA et al. Respir

    Care 2005;50:617-23.

    • Assess Technique using Placebos

    • “Show and Tell” training method

    • Re-assess technique

    • Complete Inhaler Technique Labels

    • Repeat at frequent intervals

    Impact of “Show and Tell” Inhaler Technique

    Counselling Service

    Basheti IA et al. Patient Education and counseling 2008;72:26-33

    Community Pharmacy Service:Teaching Inhaler Technique Improves Asthma Outcomes

    Basheti IA et al. Patient Education and counseling 2008;72:26-33

    Inhaler Technique

    Asthma Severity

    31 32

    33 34

    35 36

  • 7

    Leeds Community Pharmacy Inhaler Technique

    Service 2018-19

    Capstick T., Burnley M, Higgins H. Data on file.

    Inhaler Technique ResourcesAsthma UK / UK Inhaler Group Videos

    https://www.asthma.org.uk/advice/inhaler-videos/

    Written Resources

    Right Breathe https://www.rightbreathe.com/

    ACTION: Assess & improve inhaler technique• Step 1 - Check inspiratory flow

    • Use In-Check DIAL G16 inspiratory flow meter to measure inspiratory flow through the

    inhaler device(s).

    • Step 2 - Check inhaler technique • Patient should demonstrate how they use their own inhaler (unless newly prescribed).

    • Assess Inhaler technique as

    • ‘Optimal’ (all steps completed correctly),

    • ‘Satisfactory’ (some minor errors, but all critical steps completed correctly), or

    • ‘Unsatisfactory’ (at least one critical error made).

    • Step 3 - Teach correct inhaler technique

    • Pharmacist/Tech should demonstrate correct inhaler technique to the patient.

    • Issue Aerochamber where appropriate

    • Step 4 – Re-check inhaler technique and check understanding

    • After teaching correct technique, the patient should demonstrate how they would use it

    again.

    • This allows Pharmacist/Technician to check understanding & reinforce any difficulties.

    Inhaler Technique Assessment

    Categorising Inhaler DevicesAerosol

    Aerosol ± Spacer Soft Mist Breath Actuated Aerosol

    MDI Small Vol. Spacer

    Large Vol.

    Spacer

    Respimat Autohaler Easi-Breathe K-haler

    Dry Powder Inhaler (DPI)

    Single dose DPI - Blister Single dose DPI - Capsule

    Accuhaler Ellipta Forspiro Orbicel Aeroliser Breezhaler HandiHaler Zonda

    Reservoir Multidose DPI

    Easyhaler Genuair NEXThaler Novolizer Spiromax Turbohaler Twisthaler

    Choosing an Inhaler

    Usmani, Capstick, Chowhan & Scullion. Choosing an appropriate inhaler device for the treatment of adults

    with asthma or COPD. www.guidelines.co.uk/wpg/inhaler-choice [Accessed: November 2017]42

    37 38

    39 40

    41 42

  • 8

    Measuring Inspiratory Flow:

    In-Check DIAL Comparison of Inspiratory Resistance &

    Inspiratory Flow

    Kruger P et al. on behalf of Almirall. ERS Poster 2014

    1. Preparation• Check dose counter• Shake inhaler (where applicable)

    2. Priming• Before first use (where applicable)• Open inhaler / remove cap

    3. Exhaling• Fully and away from mouthpiece

    4. Mouth• Tilt head so that chin is lightly upwards• Place mouthpiece in mouth & close lips for tight seal

    5. Inhalation• DPI: quick and deep inhalation (within 2–3 seconds)• pMDI/SMI: slow and steady inhalation (over 4–5 seconds)

    6. Breath holding• Remove from mouth, hold breath for 5 seconds

    7. Closing and repeating• Close inhaler / replace cap• Repeat as necessary

    For individual devices patients should refer to the Patient Information Leaflet that accompanies the inhaler

    Inhaler Technique: 7 Steps to Success

    Usmani, Capstick, Chowhan & Scullion. Choosing an appropriate inhaler device for the treatment

    of adults with asthma or COPD. Guidelines.co.uk . In Press.

    (adapted from Anna Murphy (simplestepseducation) Seven Step approach)

    Aerosol InhalersMDI SMI

    Respimat

    BA-MDIAutohaler/Easi-Breathe /

    K-haler

    Range of

    Drugs

    • Wide range of

    drugs/classes

    • Compatibility with

    Spacer (needed for many)

    • Long-acting

    bronchodilators

    • SABA (AH / EB)

    • ICS (AH / EB)

    • ICS/LABA

    Dose

    Delivery

    • Low IFR needed

    • Many inhale too fast

    • Low IFR needed

    • Efficient dose delivery

    • Low IFR needed

    Ease of Use • Moderate dexterity

    • Coordination required

    • Many use incorrectly

    • Haleraid available

    • High dexterity

    • Complex

    loading/priming

    • Locks when empty

    • Low dexterity

    Dose

    Counter

    • Dose counter: ICS/LABA

    (not SABA or ICS)

    • Dose indicator • None

    Feedback • Taste / sound • Taste / click • Taste / click

    Single Dose DPI - BlistersAccuhaler Ellipta Forspiro

    Range of

    Drugs

    • SABA

    • LABA

    • ICS; ICS/LABA

    • ICS/LABA

    • LAMA

    • LAMA/LABA

    • FP/Salm only (1

    strength)

    Dose

    Delivery

    • Medium-low airflow

    resistance

    • Relatively consistent

    across IFR 30-90L/min

    • Do not invert

    • Medium-low airflow

    resistance

    • Consistent across IFR

    43-130L/min

    • Do not invert

    • Medium-low airflow

    resistance

    • Relatively consistent

    across IFR 30-90L/min

    • Do not invert

    Ease of Use • Low-moderate dexterity

    • Gritty if not used

    correctly

    • Low dexterity

    • Simple device

    • Moderate-high

    dexterity

    Dose

    Counter

    • Small dose counter • Large dose counter • Dose counter

    Feedback • Taste • Taste • Taste

    • Visual: loading of doses

    & used blisters

    Single Dose DPI - CapsuleBreezhaler HandiHaler Zonda

    Range of

    Drugs

    • LABA

    • LAMA

    • LAMA/LABA

    • LAMA • LAMA

    Dose

    Delivery

    • Low airflow resistance

    • Relatively consistent

    across IFR 50-100L/min

    • Do not invert

    • Risk of inhaling capsule

    fragments

    • High airflow resistance

    • Relatively consistent

    across IFR 28-60L/min

    • Do not invert

    • Risk of inhaling capsule

    fragments

    • High airflow resistance

    • No data on drug

    delivery?

    • Do not invert

    • ? Risk of inhaling

    capsule fragments ?

    Ease of Use • High dexterity

    • Significant manipulation

    • Redesigned blisters

    easier to open

    • High dexterity

    • Significant manipulation

    • Blisters difficult to open

    • High dexterity

    • Significant manipulation

    • Capsules in bottle

    Dose

    Counter

    • Capsule count (in

    blister)

    • Capsule count (in

    blister)

    • Capsule count (in

    blister)

    Feedback • Taste

    • Whirring/vibration

    • Visual: transparent caps

    • Taste

    • Whirring/vibration

    • Visual: open caps

    • Taste

    • Whirring/vibration

    • Visual: transparent caps

    43 44

    45 46

    47 48

  • 9

    Reservoir Multidose DPI (1)Easyhaler Spiromax Turbohaler

    Range of

    Drugs

    • SABA

    • LABA

    • ICS

    • ICS/LABA (due 2017)

    • ICS/LABA • SABA

    • LABA

    • ICS

    • ICS/LABA

    Dose

    Delivery

    • High airflow resistance

    • Consistent across IFR 30-

    60L/min

    • Do not invert

    • Medium airflow

    resistance

    • Higher dose delivery at

    faster IFRs (90 vs 40 L/min)

    • Do not invert

    • Medium-high airflow

    resistance

    • Higher dose delivery at

    faster IFRs (90 vs 40 L/min)

    • Do not invert

    Ease of Use • Low dexterity

    • Prime in vertical position

    • Low dexterity

    • Simple device

    • Prime in vertical-

    horizontal position

    • Moderate dexterity

    • Prime in vertical position

    • Turn aid available

    Dose

    Counter

    • Dose counter (steps of

    10)

    • Dose counter (steps of

    2)

    • Dose counter (Symbicort –

    steps of 20) or indicator

    Feedback • Taste

    • Window shows unused

    doses

    • Taste • Generally no taste

    Reservoir Multidose DPI (2)Genuair NEXThaler

    Range of

    Drugs

    • LAMA

    • LAMA/LABA

    • ICS/LABA

    Dose

    Delivery

    • Medium airflow

    resistance

    • Consistent

    • No delivery

  • 10

    Evidence for the Side Effects of ICS

    Price et al. Prim Care Respir J 2013; 22(1): 92‐100

    • MHRA May 2006:• Prolonged use of high doses of ICS…carries a risk of systemic side effects...• Corticosteroid treatment cards should be routinely provided for…high doses of ICS.

    • MHRA, September 2010:• Inhaled (and intranasal) corticosteroids...

    • High Dose Inhaled Corticosteroid Warning Cards, 2014• For all patients Rxed high doses of ICS (≥1000mcg BDP/day).• Consider for medium doses of ICS (e.g. 800mcg BDP/day) + Intranasal steroids

    • Further information:• https://www.networks.nhs.uk/nhs-networks/london-lungs/documents/inhaled-

    corticosteroids-in-adults/view

    • https://www.networks.nhs.uk/nhs-networks/london-lungs/documents/high-dose-inhaled-corticosteroid-alert-card-order-form

    Risks of High Dose Inhaled Corticosteroids

    MHRA. Current Problems in Pharmacovigilance 2006

    MHRA. Drug Safety Update 2010.

    4. Adherence

    What is Non-adherence?

    • Unintentional Non˗adherence:

    • The patient wants to follow the agreed treatment but is prevented from doing so by barriers that are beyond their control:

    • Poor recall / forgetfulness

    • Have difficulties in understanding the instructions

    • Problems with using the treatment

    • Inability to pay for the treatment

    • These should be relatively straight forward to address

    NICE CG76. Medicines adherence… 2009

    What is Non-adherence?

    • Intentional Non˗adherence

    • The patient decides not to follow the treatment recommendations:

    – Beliefs: Views about prescribed medications

    Necessity: Beliefs about the necessity of medication to maintain health

    Concerns: Beliefs about potential consequences of using medicines

    • These are potentially more difficult to address

    Menckeberg TT et al. J Psychosomatic Research 2008

    NICE CG76. Medicines adherence… 2009

    55 56

    57 58

    59 60

  • 11

    ACTION:

    • EXPLORE and identify reasons for reported non-

    adherence

    • (e.g. due to beliefs, device, medicine, or side-effects).

    • ASK the patient how they feel about using their COPD

    inhalers.

    • Do they have any concerns about using these medicines?

    • DISCUSS and agree strategies and solutions to

    improve adherence with the patient.

    • A patient-centred approach should be used at all times

    Medication Adherence• How are you getting on with this medicine / inhaler?

    • An open question to get the patient talking about issues that are important

    to them

    • When and how often do you use this medicine / inhaler?

    • Are you having any problems with this medicine/ inhaler, or concerns

    about taking or using it?

    • It may be important to assure the patient that it is normal to have concerns

    about taking any medicine

    • Do you think this medicine / inhaler is working?

    (Prompt- is this different from what you were expecting?)

    • Patients should understand their medicines & benefits in COPD

    • Do you think you are getting any side effects or unexpected effects?

    • Consider filling in a Yellow Card if severe or ▼ drugs

    • Allows discussion about managing/preventing side effects

    Framework for discussions

    How can we improve adherence?

    • Explore reasons for non-adherence– Unintentional: Rx charges, inhaler technique, memory, understanding

    – Intentional: Understand the patient (beliefs)

    • Involve the patients– Good communication

    – Shared decision making

    – Non-judgemental questioning

    • Possible Solutions– Education, education, education

    • Understanding medicine & condition

    • Inhaler technique

    – Address factors & concerns

    – Link to personal goals

    – Alter regimen, e.g. device(s), OD / BD inhaler

    – Consider daily routine (daily prompts to take remind patient)

    Possible Causes of Non-Adherence

    Beliefs Device Medicine

    • Denial of condition

    • Concern about quantity

    • Misunderstand

    condition

    • Misunderstand

    treatment

    • Fear of side-effects

    • Embarrassment

    • Dexterity problems

    • Incorrect technique

    • Incorrect cleaning of

    spacer

    • Frequency of dosing

    • Several different

    medicines

    • Actual side-effects

    • Forgetfulness

    • Cost of prescription

    • Information and education about COPD & medicines to address

    beliefs & concerns

    • Set realistic expectations (e.g. ICS do not have an immediate effect

    on symptoms)

    • Advice on use and care of inhaler devices & spacers

    • Addressing forgetfulness: reminders, location etc.

    • Managing and avoiding ADRs

    Adherence Interventions

    5. Smoking Cessation

    61 62

    63 64

    65 66

  • 12

    FEV1 (% of value at age 25)

    COPD & smoking

    Fletcher CM, Peto R. The natural history of chronic airflow obstruction. BMJ 1977; 1(6077):1645-1648

    100

    75

    50

    25

    025 50 75

    Never smoked or notsusceptible to smoke

    Smoked regularlyand susceptibleto its effects

    Stopped at 45

    Stopped at 65

    Disability

    Death

    Age (in years)

    • Stopping smoking is the most important & cost-effective

    intervention in COPD

    ACTION:

    • Give very brief advice (30 seconds)

    • Ask / Advise / Act

    • Refer to local NHS stop smoking service:

    • Web: https://oneyouleeds.co.uk/be-smoke-free/

    • CPPE/NCSCT Training:

    • Stop smoking NCSCT practitioners

    assessment: knowledge and skills

    • Learning about stop smoking support

    Smoking History

    Very Brief Advice

    ‘Do you or anyone else in your

    household smoke?’

    www.ncsct.co.uk

    Very Brief Advice

    ‘Do you know that stopping smoking

    can improve breathlessness, reduce

    hospital admissions, help prevent

    disease progression and increase life

    expectancy?’

    ‘It’s never too late to stop.’

    ‘Have you ever thought of stopping or

    tried to stop before? I can tell you

    where to get the best help.’www.ncsct.co.uk

    Very Brief Advice

    ‘The Local NHS Stop Smoking Service

    can offer you support and advice on

    quitting. You are up to 4 times more

    likely to stop with the support from the

    service’

    ‘The Stop Smoking Service can make

    this much easier for you.’

    ‘Shall I refer you? It really is the best

    thing you can do right now.’

    ‘It’s a free advice service’

    www.ncsct.co.uk

    • Signpost patients to patient resources on the internet, e.g.

    • British Lung Foundation (https://www.blf.org.uk/)

    • Asthma UK (https://www.asthma.org.uk/)

    • Inhaler technique videos e.g.

    • Asthma UK (https://www.asthma.org.uk/advice/inhaler-videos/#Videos)

    • Right Breathe (https://www.rightbreathe.com/)

    • BLF Breathe Easy support groups (https://www.blf.org.uk/support-

    for-you/breathe-easy)

    • Bradford (Undercliffe Cricket Club)

    • West Leeds (St James’s Church, Pudsey)

    • ‘Yeadon’ (Guiseley Theatre)

    Further support for patients

    67 68

    69 70

    71 72

  • 13

    • Summarise key points:

    • Smoking cessation, inhaler technique & adherence,

    vaccination, healthy lifestyle

    • Confirm issues being referred to their GP

    • And send it to the GP!

    • Ask if they have any final questions.

    • Arrange follow-up appointment.

    • Record consultation on PharmOutcomes – within 48hrs

    End of Consultation

    73