RESPON REGENERATIF

Dr ASWIYANTI ASRI,M.Si.Med,SpPADr ASWIYANTI ASRI,M.Si.Med,SpPA

S 2 BIOMEDIK

REGENERASI• pertumbuhan sel dan jaringan

untuk menggantikan struktur yang hilang.

• Renewal of a damaged tissue or a lost appendages that is identical to the original one

• Istilah regenerasi biasanya dipakai pada pertumbuhan hepar atau ginjal setelah hepatektomi atau nefrektomi parsial

REGENERASI• Semakin tinggi tingkat

perkembangan spesies maka makin terbatas kemampuannya beregenerasi.

• Stem cells : self renewal and producing clonal progeny

• Embryonic and adult stem cells

Stem cells• The ability to divide without limit and to avoid

senescence and maintain genomic integrity• The ability to intermittenly undergo division or to

remain quiescent• The ability to propagate by self-renewal and

differentiation• The absence of lineage markers• The shared presence of certain growth and

transcription markers common to uncommitted cells

Adult stem cells

Bone marrow-derived

stem cells

Tissue stem cells(some may be Bone-marrow

Derived)

Tissue mesenchymal(mesoderm-derived)

Stem cellsoutside

Bone marrow

# hematopoietic stem cells

# multipotentBone marrow-

derived stem cells

Constantly renewing (labile cells)

Epithelial-like cells : epidermis (unipotent basal keratinocyte stem cells)

Persistent (stable cells)

Epithelial, parenchyma : liver (hepatocyte), kidney (putative kidney renal epithelial progenitor

Tissue Stem Cells

Tissue mesenchymal (mesoderm-derived) Stem cells

•Progenitors of connective tissue cells•Isolated from several tissues

•Muscle cells•Skeletal : satellite cells

•Cardiac : cardiac progenitor cells

Tipe Jaringan

J. Stabil

J. Permanen

J. Labil •Tingkat replikasi rendah•Stimulasi tertentu dapat membelah diri•Fase G0 siklus sel•Sel parenkim hepar

•Sel telah keluar dari siklus sel•Tidak mengalami mitosis•Neuron, sel otot jantung

•sel yang selalu berproliferasi disepanjang hidupnya dan menggantikan sel-sel yang telah rusak.

•epitel berlapis gepeng pada kulit, rongga mulut, vagina dan servik.

Self Renewal

Topic Goes Here

• Subtopic goes here.

Penyembuhan luka dan faktor-faktor pertumbuhan. Sel yang terlibat didalam luka ditampilkan dalam urutan dari kiri ke kanan serta grafik warna memperlihatkan rentang hari dari masing-masing sel didalam luka. (Sumber : Rosenberg dkk, 2006)

STEM CELL

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