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RISK-ADJUSTED OUTCOMES: PROSTATECTOMY PRASANNA SOORIAKUMARAN (PS) OXFORD

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Page 1: Risk-adjusted outcomes: prostatectomy - BAUS · PDF file•Risk-adjusted outcomes per endpoint ... Definition of oncologic and functional success after radical prostatectomy ... Pentafecta

RISK-ADJUSTED OUTCOMES: PROSTATECTOMY

PRASANNA SOORIAKUMARAN (PS)

OXFORD

Page 2: Risk-adjusted outcomes: prostatectomy - BAUS · PDF file•Risk-adjusted outcomes per endpoint ... Definition of oncologic and functional success after radical prostatectomy ... Pentafecta

OUTLINE OF TALK• Endpoints

• Predictors

• Risk-adjusted outcomes per endpoint

• Outcome prediction tools

• Summary

Page 3: Risk-adjusted outcomes: prostatectomy - BAUS · PDF file•Risk-adjusted outcomes per endpoint ... Definition of oncologic and functional success after radical prostatectomy ... Pentafecta

OUTCOMES AFTER RADICAL PROSTATECTOMY

Page 4: Risk-adjusted outcomes: prostatectomy - BAUS · PDF file•Risk-adjusted outcomes per endpoint ... Definition of oncologic and functional success after radical prostatectomy ... Pentafecta

OUTCOMES AFTER RADICAL PROSTATECTOMY

Page 5: Risk-adjusted outcomes: prostatectomy - BAUS · PDF file•Risk-adjusted outcomes per endpoint ... Definition of oncologic and functional success after radical prostatectomy ... Pentafecta

OUTCOMES AFTER RADICAL PROSTATECTOMY

Page 6: Risk-adjusted outcomes: prostatectomy - BAUS · PDF file•Risk-adjusted outcomes per endpoint ... Definition of oncologic and functional success after radical prostatectomy ... Pentafecta

OUTCOMES AFTER RADICAL PROSTATECTOMY

Page 7: Risk-adjusted outcomes: prostatectomy - BAUS · PDF file•Risk-adjusted outcomes per endpoint ... Definition of oncologic and functional success after radical prostatectomy ... Pentafecta

PREDICTORS

PATIENT

CARETUMOUR

Page 8: Risk-adjusted outcomes: prostatectomy - BAUS · PDF file•Risk-adjusted outcomes per endpoint ... Definition of oncologic and functional success after radical prostatectomy ... Pentafecta

COMPLICATIONS

Page 9: Risk-adjusted outcomes: prostatectomy - BAUS · PDF file•Risk-adjusted outcomes per endpoint ... Definition of oncologic and functional success after radical prostatectomy ... Pentafecta

COMPLICATIONS

Page 10: Risk-adjusted outcomes: prostatectomy - BAUS · PDF file•Risk-adjusted outcomes per endpoint ... Definition of oncologic and functional success after radical prostatectomy ... Pentafecta

CONTINENCE

Page 11: Risk-adjusted outcomes: prostatectomy - BAUS · PDF file•Risk-adjusted outcomes per endpoint ... Definition of oncologic and functional success after radical prostatectomy ... Pentafecta

POTENCY

Page 12: Risk-adjusted outcomes: prostatectomy - BAUS · PDF file•Risk-adjusted outcomes per endpoint ... Definition of oncologic and functional success after radical prostatectomy ... Pentafecta

POSITIVE SURGICAL MARGINS

Page 13: Risk-adjusted outcomes: prostatectomy - BAUS · PDF file•Risk-adjusted outcomes per endpoint ... Definition of oncologic and functional success after radical prostatectomy ... Pentafecta

BIOCHEMICAL RECURRENCE

Page 14: Risk-adjusted outcomes: prostatectomy - BAUS · PDF file•Risk-adjusted outcomes per endpoint ... Definition of oncologic and functional success after radical prostatectomy ... Pentafecta

BIOCHEMICAL RECURRENCE

Page 15: Risk-adjusted outcomes: prostatectomy - BAUS · PDF file•Risk-adjusted outcomes per endpoint ... Definition of oncologic and functional success after radical prostatectomy ... Pentafecta

BIOCHEMICAL RECURRENCE

Page 16: Risk-adjusted outcomes: prostatectomy - BAUS · PDF file•Risk-adjusted outcomes per endpoint ... Definition of oncologic and functional success after radical prostatectomy ... Pentafecta

BIOCHEMICAL RECURRENCE

Page 17: Risk-adjusted outcomes: prostatectomy - BAUS · PDF file•Risk-adjusted outcomes per endpoint ... Definition of oncologic and functional success after radical prostatectomy ... Pentafecta

BIOCHEMICAL RECURRENCE

Page 18: Risk-adjusted outcomes: prostatectomy - BAUS · PDF file•Risk-adjusted outcomes per endpoint ... Definition of oncologic and functional success after radical prostatectomy ... Pentafecta

REAL ONCOLOGY

Page 19: Risk-adjusted outcomes: prostatectomy - BAUS · PDF file•Risk-adjusted outcomes per endpoint ... Definition of oncologic and functional success after radical prostatectomy ... Pentafecta

REAL ONCOLOGY

Page 20: Risk-adjusted outcomes: prostatectomy - BAUS · PDF file•Risk-adjusted outcomes per endpoint ... Definition of oncologic and functional success after radical prostatectomy ... Pentafecta

REAL ONCOLOGY

Page 21: Risk-adjusted outcomes: prostatectomy - BAUS · PDF file•Risk-adjusted outcomes per endpoint ... Definition of oncologic and functional success after radical prostatectomy ... Pentafecta

SUMMARY

• Outcomes include complications, oncology and function

• Patient, tumour and care factors affect outcome

• Complications appear to be affected by hospital volume and surgical modality

• Age, BMI, comorbidities, LUTS, prostate volume affect continence recovery

• Potency is affected by age, comorbidities, premorbid potency, and NS extent

Page 22: Risk-adjusted outcomes: prostatectomy - BAUS · PDF file•Risk-adjusted outcomes per endpoint ... Definition of oncologic and functional success after radical prostatectomy ... Pentafecta

SUMMARY

• PSM and BCR predictors are uncertain, but multifocal/ >3mm margins and the surgeon seem to matter

• Socioeconomic status, race, and CAPRA scores affect prostate-cancer survival

• Comorbidities affect other-cause survival and should be included in outcomes assessment

Page 23: Risk-adjusted outcomes: prostatectomy - BAUS · PDF file•Risk-adjusted outcomes per endpoint ... Definition of oncologic and functional success after radical prostatectomy ... Pentafecta