ruminant product profiles - virbac · ruminant product profiles ... cooperia spp - small intestinal...

Ruminant Product Profiles

Abacare® LVIntracillin® 1000 Milking

CowOxyfoam Forte

Aerotet ForteHeadStart & HeadStart

GoldPenClox™ 1200 HPMC

Amphoprim Bolus Intracillin® 300 Injection Phenax® Classic

Amphoprim Injection Intracillin® LA Diarrest™ & Revive

Bovipen® Lepto 2-Way & Lepto 3-Way

SMARTShot® B12+ Se

Campylovexin® Masticillin® RTU Injection SMARTShot B12 Prime Lamb

Cefaguard™ RTU Injection Metri-Clean™ Tetraguard® LA

Combat Nitromec® Injection

Multimin® + Cu TopLine

Copperguard® Neoprinil® Pour On Tyloguard® RTU Injection

Duocare LV + Se® Nitroclox™ LA Vibrostrep®

FlukeCare® + Se Ovastim®

Flumenil Pour On® Ovipen®

TopLineFor the treatment and control of Abamectin sensitive internal and external parasites of beef and dairy cattle.

State-of-the-art science, the last word in Abamectin pour-on formulations for cattle.

• Persistent activity against biting and sucking lice for 56 days

• Nil Milk withhold

• Rain fast

INDICATIONS:For the treatment and control of adult and immature stages of Gastro-intestinal roundworms: • Ostertagia ostertagi - Small brown stomach worms• (including inhibited stages)• Trichostrongylus axei - Stomach hair worm• Trichostrongylus colubriformis – Hair worm• Haemonchus spp – Barber’s pole worm• Oesophagostomum radiatum - Nodule worm• Cooperia oncophora* – Small intestine worm• Cooperia punctata* - Small intestine worm• Nematodirus spathiger - Thin necked intestinal worm• Oesophagostomum venulosum - Large bowel worm• Trichuris spp - Whipworm• Strongyloides papillosus - Intestinal worm* Active against immature stages of some New Zealand ML resistant strains of Cooperia spp.

LUNGWORM:• Dictyocaulus viviparus.

SUCKING LICE AND BITING LICE:• Linognathus vituli – Long nosed sucking louse• Haematopinus eurysternus – Short nosed sucking louse• Damalinia bovis - Biting louse• Solenopotes capillatus – Little blue sucking louse.

PERSISTENT ACTIVITY:At the recommended dose rate, TopLine effectively prevents reinfestation from the biting louse Damilinia bovis and the sucking louse Linognathus vituli for at least 56 days.

RAIN RESISTANCE:For best results it is recommended that TopLine be applied to dry animals. However, rainfall before and after use will not affect efficacy.

PRODUCTION ENHANCEMENT:Increases milk production in grazing dairy cows. Data has shown that milk production increases by a median of approximately +0.6kg liquid milk per day when cows or heifers infected with gastrointestinal nematode parasites are treated with an effective anthelmintic; this increase occurs without any reduction in milk quality.

SIMULTANEOUS USE WITH SELENIUM POUR-ON PRODUCTS: Studies show that the use of this product at the recommended dose at the same time as selenium pour-on products should not adversely affect efficacy against abomasal and small intestinal nematodes.

DESCRIPTION:ACTIVE CONSTITUENT: 10mg/mL (1% w/v) Abamectin. Available in 2.5L and 5L.

MODE OF ACTION: Topline contains Abamectin, a member of the Avermectin family of drenches. It is effective against sensitive strains of internal and external parasites:

WITHHOLDING PERIODS: MEAT: 35 days.MILK: Nil.

DOSAGE:For topical application to cattle. 1mL/20kg body weight (500µg abamectin / kg liveweight). Cattle in excess of 650 kg should be dosed at 1 mL per 20 kg bodyweight.

The following graph shows a dose rate guide for cattle. Registered pursuant to the ACVM Act 1997, No. A10067.See www.foodsafety.govt.nz for registration conditions.

Liveweight kg Dose Volume =mL Cattle Treated per 5L

50 2.5 2000

100 5 1000

150 7.5 666

200 10 500

250 12.5 400

300 15 333

350 17.5 285

400 20 250

450 22.5 222

500 25 200

550 27.5 181

600 30 166

650 32.5 153

Head Office:26-30 Maui Street, Hamilton, New Zealand

Phone: +64 7 849 6782 • Fax: +64 7 849 5079Freephone: 0800 VIRBAC (847 222)

www.virbac.co.nzShaping the future of animal health

For the treatment and control of Abamectin sensitive strains of internal parasites (including benzimidazole, levamisole and morantel resistant strains) of sheep and lambs.

• Low Volume

• Broad Spectrum

• Mixing with Duocare® LV + Se provides a triple combination drench





• Rain fast














50 2.5 2000

100 5 1000

150 7.5 666

200 10 500

250 12.5 400

300 15 333

350 17.5 285

400 20 250

450 22.5 222

500 25 200

550 27.5 181

600 30 166

650 32.5 153




INDICATIONS:DuoCare® LV + Se contains Levamisole, a member of the imidazothiazole (“clear”) family of chemicals and Fenbendazole, a member of the benzimidazole (“white”) family of chemicals. It is effective against sensitive and single-resistant mature and immature strains of the roundworms listed below:Haemonchus contortus - Barber’s pole worm, Teladorsa-gia [Ostertagia] spp - Small brown stomach worm, Tricho-strongylus spp - Black scour worm (including moderately macrocyclic lactone resistant strains), Cooperia spp - Small intestinal worm, Nematodirus spp - Thin necked intestinal worm, Strongyloides papillosus - Intestinal threadworm, Bunostomum spp - Hookworm, Oesphagostomum spp - Nodule worm, Chabertia ovina - Large mouthed bowel worm, Dictyocaulus filarial - Large lungworm, It will aid in the control of Moniezia spp - Tapeworm.

COMBINED USE:Combined use of drench actives may improve efficacy and slow the development of resistance. AbaCare® LV can be combined in equal volumes with DuoCare® LV + Se (A10301) to produce a stable mixture for oral dosing of sheep and lambs. The mixture contains 1.0g/L Abamectin and 40g/L Levamisole HCI, 25g/L Fenbendazole & 0.5g/L Selenium. This combined solution must be well mixed before use and dosed at a rate of 1mL/5kg bodyweight. The mixture remains stable for up to 3 months if stored as per label conditions.

DOSAGE:1mL per 10kg bodyweight.

Liveweight (kg) Dose Volume (mL)

Sheep Treated per 10L

15-20 2 5000

21-30 3 3333

31-40 4 2500

41-50 5 2000

51-60 6 1666

61-70 7 1428

71-80 8 1250

Animals in excess of 80kg to be dosed at 1mL per 10kg.

WITHHOLDING PERIODS:MEAT: Within 21 days of the last treatment.MILK: Not less than 35 days following the last treatment.

PACK SIZE:10L.

CONTRAINDICATIONS:Do not use in lambs under six (6) weeks of age or less than 15 kg bodyweight.

Abacare® LV

1

Aerotet ForteAn aerosol for the treatment of topical superfi cial infections of the skin and open wounds due to tetracycline sensitive organisms, and to aid in the treatment of foot and hoof infections in cows and horses. Containing gentian violet.

Broad spectrum antibacterial spray

• Marks treated areas

• Nil withholding

• Propylene Glycol for emollient eff ect

ACTION:Oxytetracycline is a broad-spectrum antibacterial, specifically inhibiting protein synthesis in susceptible organisms.

A very broad anti-infective action is obtained due to the additive effect of all ingredients - oxytetracycline, gentian violet, propylene glycol and isopropyl alcohol.

The high proportion of propylene glycol in the base gives an emollient effect. Gentian violet is an astringent antiseptic healing aid, and also offers obvious marking of treated areas.

PRECAUTIONS:Keep out of reach of children. Not to be taken or administered orally. Do not inhale vapour; use in a well-ventilated area. Do not apply to eyes or other mucous membranes. Contents under pressure. Do not puncture or incinerate. Keep away from naked flames.

DESCRIPTION:An aerosol can of 200g, delivering 4.4% OXYTETRACYCLINE HCl and 0.4% GENTIAN VIOLET in an emollient solution for external application, with hydrocarbon as the propellant.

WITHOLDING PERIODS: NIL

DOSAGE:Clean the area of any discharges or debris prior to application. For foot infection, trim the hoof to expose infection. Shake can well. Holding the can 10-15cm from the affected area, spray a 1-2 second burst, or more as required. Keep the area dry following application. Repeat the administration every 12 hours or as required.

Registered pursuant to the ACVM Act 1997, No A6115. See www.foodsafety.govt.nz for registration conditions. Only available under Veterinary Authorisation.




Aerotet Forte

2

Amphoprim Bolus

DESCRIPTION:An antibacterial tablet, containing the active ingredients 1g SULPHAMETHOXYPYRIDAZINE and 200mg TRIMETHOPRIM. White scored tablets, for oral or intrauterine administration, available in packs of 20.

CONTRAINDICATIONS: Amphoprim bolus is contraindicated in cases of renal or hepatic insufficiency, and should not be used in animals with known sulphonamide sensitivity.

DO NOT USE IN BOBBY CALVES.

WITHOLDING PERIODS: MEAT: 21 days.MILK: 5 days.

DOSAGE & ADMINISTRATION:Oral Administration: Given orally whole, or dissolved in water.Cattle, calves, horses, foals, sheep and goats. Standard oral dose is one bolus per 50kg bodyweight, once daily for 3-5 days. Calves: in cases of severe bacterial diarrhoea or pneumonia, the dose rate should be increased to 2 Boluses per 50kg bodyweight daily for 3-5 days.

Intrauterine Application: For metritis in cows and mares, place one bolus into the uterus. Repeat in 24 - 48 hours if required.

Ensure adequate drinking water is available during treatment.

Registered pursuant to the ACVM Act 1997, No. A 4807. See www.foodsafety.govt.nz for registration conditions. Only available under Veterinary Authorisation.

INDICATIONS:Amphoprim Bolus is indicated in the treatment of a wide range of primary and secondary bacterial infections due to Gram positive and Gram negative organisms.

These include:

(a) respiratory bacterial infections especially pneumonia and bronchitis;

(b) urogenital infections - pyometra, metritis, vaginitis, nephritis;

(c) gastro-intestinal infections including those caused by Salmonella spp, and E. coli pathogenic strains;

(d) local and generalised infections e.g. wound infections, joint infections, septicaemias etc

MODE OF ACTION:The sulphamethoxpyridazine - trimethoprim combination synergises to inhibit bacterial cell metabolism, by blocking 2 sequential steps of the enzymatic pathway leading to the synthesis of bacterial folic acid. The effect is bactericidal in susceptible organisms, including Gram positive and Gram negative bacteria.

Sulphamethoxypyridazine and trimethoprim are readily absorbed from the gastrointestinal tract and give effective blood levels for up to 24 hours

Sulphamethoxypyridazine & Trimethoprim for the treatment of a wide range of primary and secondary bacterial infections.

Broad spectrum Sulphonamide antibiotic tablet

• Once a day administration

• Eff ective blood levels for up to 24 hours

• Oral or intrauterine administration




Amphoprim Bolus

3

Amphoprim InjectionContains 4g Trimethoprim & 20g Sulphadimethyl Pyrimidine. For use in horses, cattle, pigs, sheep, dogs and cats for the treatment of diseases of the: Respiratory tract, Digestive tract, Urogenital tract, Local and generalised infections.

Broad spectrum Sulphonamide antibiotic injection

• By Subcutaneous, intramuscular or intravenous injection

• Water based

• Milk withholding 48 hours

INDICATIONS:For use in horses, cattle, pigs, sheep, goats, dogs and cats for the treatment of diseases of the:• Respiratory tract; pneumonia, bronchitis,• Digestive tract; gastritis, enteritis, gastroenteritis, traumatic

reticulitis,• Urogenital tract; pyometra, metritis, vaginitis, nephritis,• Local and generalised infections; mastitis, foot infections,

wound infections, septicaemias.

Up to 80% of Staphylococcus intermedius isolates have been shown to be susceptible to sulphadimethyl pyrimidine/ trimethoprim. High percentages of sensitivity are also found in infections with Proteus mirabilis, Bacillus anthracis, Hemophilus influenza, Pasteurella spp, Salmonella spp., Escherichia coli., Staphylococcus spp. andStreptococcus spp.

Leptospira, Pseudomonas, Erysipelothrix and M. tuberculosis organisms are NOT sensitive to sulpha-trimethoprim.

Amphoprim offers a cost-effective option for those conditions where susceptible infection is present.

MODE OF ACTION:The Sulphadimethyl pyrimidine - trimethoprim combination acts synergistically to inhibit bacterial cell metabolism by blocking two sequential steps of the enzymatic pathway leading to the synthesis of bacterial folic acid. The effect is bactericidal in susceptible organisms, including Gram-positive and Gram-negative bacteria.

There are advantages having a water based injectable: ease of injection, less risk of intravascular heamolysis or extravascular necrosis, neutral pH and faster bioavailability.

DESCRIPTION:

A sterile, water based, pale yellow, solution for injection containing the active ingredients SULPHADIMETHYL PYRIMIDINE 200 mg/mL and TRIMETHOPRIM 40 mg/mL. Available in 100 mL glass multi-dose bottles.

CONTRAINDICATIONS:

Do not administer to animals with known sulphonamide sensitivity.

WITHHOLDING PERIODS:

MEAT: 5 days.

MILK: 2 days.

HORSES: 63 days.

DOSAGE & ADMINISTRATION:

General: 1 mL/15 kg bodyweight daily by subcutaneous, intramuscular or intravenous injection for 3 - 5 days. For i.m or s.c injections over 5 mL administer in 2 or more sites. Note: the recommended dose should not be exceeded in the horse. Give in the anterior half of the neck in food producing animals.





Amphoprim Injection

4

Bovipen®

CONTRAINDICATIONS:

Not for use in bobby calves. Not to be used in animals with a known history of sensitivity to products containing penicillin or its analogues. Not to be used for the treatment of infections caused by organisms known to be resistant to penicillin.

SPECIAL PRECAUTIONS:

Penicillins may cause hypersensitivity (allergy) following injection, ingestion or skin contact. Do not handle this product if you know you are sensitised to, or if you have been advised not to work with, such preparations. Handle this product with great care to avoid exposure, taking all recommended precautions.

OTHER INFORMATION:

Protect from direct sunlight. Store below 18°C. Product may be refrigerated. Do not freeze. Shake well before use. Keep out of reach of children.

Restricted Veterinary Medicine. Available only under veterinary authorisation.

Registered pursuant to the ACVM Act 1997, No. A7186.

Registered to: Stockguard Laboratories (NZ) Ltd, 26-30 Maui St, Pukete Park, Hamilton, New Zealand.

Distributed by: Virbac New Zealand, 26-30 Maui St, Pukete Park, Hamilton, New Zealand.

MODE OF ACTION:

Procaine penicillin is a moderately soluble drug that provides a therapeutic effect from a single injection for the 24 hours before the next injection is to be given. Penicillin inhibits cell wall synthesis in susceptible bacteria.

INDICATION:

First-line treatment for unspecified infections and treatment of known and common infections caused by penicillin-sensitive Gram+ve organisms, (eg. clostridial infections) in cattle.


Administer 16mL of Bovipen®/400kg b.w. in the anterior half of the neck (close to the head), by i/m or s/c injection. When used prophylactically (in the absence of clinical symptoms),

administer the dose once only by i/m or s/c injection. Where a clinical infection is being treated, administer the dose daily for 3 days.


MILK: Milk intended for human consumption must be discarded during treatment and for the following times after the last treatment:

one dose – 48 hours (4 milkings);

two doses – 60 hours (5 milkings);

three or more doses – 72 hours (6 milkings).

MEAT: 10 days.

A sterile, aqueous suspension of 300,000i.u./mL procaine penicillin G. Manufactured in New Zealand and available in durable 200 mL plastic pillow packs.

• Cattle species-specifi c injectable penicillin

• Convenient Plastic Pillow pack

• Needles & syringe supplied

Shaping the future of animal health



www.virbac.co.nz

Bovipen®

5


Campylovexin®

Provides protection against all the strains of Campylobacter in New Zealand. Stimulates immunity to C. fetus fetus thus protecting sheep against Campylobacter abortion.

The only Campylobacter vaccine with proven effi cacy against all known New Zealand strains of C. fetus fetus.

• Proven in the fi eld for 30 years

• Proven to reduce abortion rates

• Shown to improve tailing % by 9.3%

CAMPYLOVEXIN® PROTECTS AGAINST ALL 26 NEW ZEALAND STRAINS OF CAMPYLOBACTER FETUS FETUS:Campylovexin® is the only vaccine proven to protect against all 26 strains of Campylobacter fetus fetus so far identified in New Zealand. Its effectiveness has been conclusively proven in a three year PhD research investigation – and in thirty years of successful use on New Zealand farms. Tens of millions of sheep and thousands of farmers bear testament to how well Campylovexin® protects against one of the major causes of reduced lambing performance.

DOSAGE & ADMINISTRATION:Administer by subcutaneous injection only. Inject 2mL in the anterior half of the neck. EWES: In the first year give a sensitiser and booster dose 4-8 weeks apart. Both vaccinations should be given prior to mating. In following years an annual booster should be administered prior to mating. NEW STOCK being introduced to the breeding flock: Give 2 vaccinations 4-8 weeks apart, prior to mating.

DESCRIPTION:Inactivated vaccine of ovine Campylobacter fetus fetus. Packs of 250mL and 500mL.

MODE OF ACTION: Stimulates production of antibodies against C. fetus fetus.

INDICATIONS:

For use where there is risk of abortion due to C. fetus fetus. Protects against C. fetus fetus abortions in sheep and consequently can contribute toward improving lambing performance.

SIDE EFFECTS: A slight reaction may occur at the site of injection but will normally disappear in a few weeks. Occasionally, for

up to a week after vaccination, some ewes may develop symptoms ranging from mild loss of appetite through to ataxia, recumbency and death. Affected ewes may respond to treatment with metabolic solutions containing calcium and magnesium but hypomagnesaemia is not necessarily the primary cause.

CONTRAINDICATIONS: Do not use within 1 week of start of mating (see side effects).

WITHHOLDING PERIOD: Meat and Milk: NIL

Registered pursuant to the ACVM Act 1997 No. A4130. See www.foodsafety.govt.nz for registration conditions. Only available under Veterinary Authorisation.

Number of ewes Campylovexin® investment Extra Lambs At $50 At $60 At $80 At $100

1000 $640 93 $4650 $5580 $7440 $9300

2000 $1280 186 $9300 $11160 $14880 $18600

3000 $1920 279 $13950 $16740 $22320 $27900

4000 $2560 372 $18600 $22320 $29760 $37200

5000 $3200 465 $23250 $27900 $37200 $46500

Return on investment 627% 772% 1063% 1353%



www.virbac.co.nz

Campylovexin®

6Continued over page...

Ten years’ worth of scanning information involving more than 600 sets of flock data has thrown new light on the path to better productivity. It highlighted a range of management practices (e.g. shearing dates, grazing policy) that impact on both conception rates and tailing percentages.

One key factor in lambing performance identified in the analysis is vaccination against Campylobacter disease with Campylovexin®. Analysis of the scanning data showed that vaccinated flocks enjoyed significantly better protection against losses caused by Campylobacter disease than unvaccinated flocks on the same property. Campylobacter disease is a major cause of lambing losses. These can manifest themselves as abortion ‘storms’ or more isolated and hard-to-detect abortions.

Analysis of the scanning data has shown a positive response to vaccination, even on properties where Campylobacter has never been diagnosed.

Cost Benefit Analysis of using Campylovexin®.

Animals are vaccinated to:

a. Prevent abortions – to protect ewes against contracting campylobacter disease, and aborting their foetuses. Abortions mainly occur after the third month of pregnancy.

b. To prevent infected ewes spreading the disease to other ewes. An aborting ewe rarely shows a systemic effect, however, C. fetus fetus may persist in the uterine discharge for up to 6 weeks.

Campylobacter jejuni is commonly isolated from the faeces of normal healthy domestic animals, poultry, pigs, cattle, sheep and wild birds. As examples, Meanger and Marshall2 found up to a third of cows sampled in a NZ study were intestinal carriers. Adhikari et al3 found C. jejuni in the faeces of 54% of dairy cows, 40% of urban sparrows, 11% of rodents and 9% of flies. Furthermore, it is often reported as a contaminant of sheep and cattle carcasses at meat plants and in unpasteurised milk.

The role of C. jejuni as a primary pathogen is uncertain. It has been isolated from scouring cattle and sheep. It is considered as a minor cause of abortion in sheep in New Zealand. It is not considered a cause of infertility. Most animals have antibodies against this organism from natural exposure to this ubiquitous organism.

Data from Gribbles Veterinary Pathology shows that the majority of campylobacter cases are due to C. fetus fetus not C. jejuni.

Data from Gribbles Veterinary Pathology shows that the majority of campylobacter cases as a % of total submissions in both 2004 (11.2 vs. 1.1%) and 2005 (14.5 vs. 1.8%) were due to C. fetus fetus not C. jejuni.

1. A report on sheep abortion diagnoses in South Otago for 1999 shows 17.2% of all cases due to C. fetus fetus and 3.1% due to C. jejuni5.

2. A study of 85 campylobacter sheep abortion isolates in 1999 from 28 Hawkes Bay farms showed 81 (95%) isolates from 25 (89%)

c. To prevent reduced fertility – recent evidence based on response to vaccination suggests C. f fetus is also a cause of reduced fertility.

Profitability – Abortions on farm are a production loss as is reduced fertility, even low levels can have a significant impact on the farm business profitability.

Campylobacter leads to significant losses in productivity. It is one of the leading causes of ewe abortions, and it produces weakened lambs that are much more likely to not survive. These losses are preventable. Vaccination with Campylovexin® as part of your clients’ lambing performance programmes will protect against abortions, increase lamb viability and significantly improve productivity for your clients. Analysis of nine years of largescale scanning data demonstrates the benefits of vaccinating with Campylovexin®. Camplyovexin® provides maximum protection for the flock – achieving maximum productivity.

New Zealand produced Campylobacter vaccine protects against lamb losses.

Vaccinating against Campylobacter disease protects unborn lambs from the infectious bacteria that invade the placenta and foetus. By protecting these lambs and helping prevent abortion losses, your tailing percentages can be significantly improved. Even if campylobacter has not been diagnosed on your farm, the disease may well be present. Preventative vaccination could help eliminate a hard-to-detect but important cause of lamb losses.

farms were C. fetus fetus and 4 (5%) isolates from 3 (11%) of farms were C. jejuni6.

3. A detailed study1,7 of 320 NZ wide sheep abortion campylobacter isolates from 221 farms in 2000 showed that 92% of isolates from 90% of farms were C. fetus fetus and 10% from 8% of farms were C.jejuni. C. coli was isolated once. Regionally there was considerable variation, however given the small number of isolates in some regions this data must be interpreted with caution.

In summary, the great majority of campylobacter abortions in sheep are caused by C. fetus fetus. C.jejuni is isolated in a minor number of sheep abortions that appear to be regional in nature.

Vaccination against Campylobacter disease improves productivity.

C. jejuni is considered as a minor cause of abortion in sheep in New Zealand, and it is not considered a cause of infertility.

1. Grogono-Thomas et al (2003) Role of S-layer protein antigenic diversity in the immune responses of sheep experimentally challenged with C.fetus susp. fetus. Infection and immunity 71, 147-54. 2. Meanger JD and Marshall RB (1989) Seasonal prevalence of thermophillic campylobacter infections in dairy cattle and a study of infection in sheep. NZVJ 37 p18-20. 3. Adhikari B.et al (2203) Prevalence and clonal diversity of C. jejuni from dairy farms and urban sources. NZVJ 52 (6) p378-83. 4. AgVax Developments Ltd. Media material 2005. Proc 30th An. Sem., Soc. of S & B C Vets, NZVA p31 -36. 5. Smart JA (2000) Latest experiences of Salmonella Brandenburg. Proc 30th An. Sem.,Soc. of S & B C Vets NZVA p137-150. 6. Mannering SA, et al (2003) Pulsed-field gel electrophoresis typing of Campylobacter fetus fetus sheep abortions in the Hawkes Bay region of New Zealand. NZVJ 51(1) p33-37. 7. Mannering SA, et al (2004) Pulsed-field gel electrophoresis typing of Campylobacter fetus fetus isolated from sheep abortions in NZ. NZVJ 52 (6), p358-363.

C. jejuniC. fetus fetus

20

15

10

5

0

% o

f cas

es

Total 2004 Total 2005

Campylovexin®

7

Ten years’ worth of scanning information involving more than 600 sets of flock data has thrown new light on the path to better productivity. It highlighted a range of management practices (e.g. shearing dates, grazing policy) that impact on both conception rates and tailing percentages.

One key factor in lambing performance identified in the analysis is vaccination against Campylobacter disease with Campylovexin®. Analysis of the scanning data showed that vaccinated flocks enjoyed significantly better protection against losses caused by Campylobacter disease than unvaccinated flocks on the same property. Campylobacter disease is a major cause of lambing losses. These can manifest themselves as abortion ‘storms’ or more isolated and hard-to-detect abortions.

Analysis of the scanning data has shown a positive response to vaccination, even on properties where Campylobacter has never been diagnosed.

Cost Benefit Analysis of using Campylovexin®.

Animals are vaccinated to:

a. Prevent abortions – to protect ewes against contracting campylobacter disease, and aborting their foetuses. Abortions mainly occur after the third month of pregnancy.

b. To prevent infected ewes spreading the disease to other ewes. An aborting ewe rarely shows a systemic effect, however, C. fetus fetus may persist in the uterine discharge for up to 6 weeks.

Campylobacter jejuni is commonly isolated from the faeces of normal healthy domestic animals, poultry, pigs, cattle, sheep and wild birds. As examples, Meanger and Marshall2 found up to a third of cows sampled in a NZ study were intestinal carriers. Adhikari et al3 found C. jejuni in the faeces of 54% of dairy cows, 40% of urban sparrows, 11% of rodents and 9% of flies. Furthermore, it is often reported as a contaminant of sheep and cattle carcasses at meat plants and in unpasteurised milk.

The role of C. jejuni as a primary pathogen is uncertain. It has been isolated from scouring cattle and sheep. It is considered as a minor cause of abortion in sheep in New Zealand. It is not considered a cause of infertility. Most animals have antibodies against this organism from natural exposure to this ubiquitous organism.

Data from Gribbles Veterinary Pathology shows that the majority of campylobacter cases are due to C. fetus fetus not C. jejuni.

Data from Gribbles Veterinary Pathology shows that the majority of campylobacter cases as a % of total submissions in both 2004 (11.2 vs. 1.1%) and 2005 (14.5 vs. 1.8%) were due to C. fetus fetus not C. jejuni.

1. A report on sheep abortion diagnoses in South Otago for 1999 shows 17.2% of all cases due to C. fetus fetus and 3.1% due to C. jejuni5.

2. A study of 85 campylobacter sheep abortion isolates in 1999 from 28 Hawkes Bay farms showed 81 (95%) isolates from 25 (89%)

c. To prevent reduced fertility – recent evidence based on response to vaccination suggests C. f fetus is also a cause of reduced fertility.

Profitability – Abortions on farm are a production loss as is reduced fertility, even low levels can have a significant impact on the farm business profitability.

Campylobacter leads to significant losses in productivity. It is one of the leading causes of ewe abortions, and it produces weakened lambs that are much more likely to not survive. These losses are preventable. Vaccination with Campylovexin® as part of your clients’ lambing performance programmes will protect against abortions, increase lamb viability and significantly improve productivity for your clients. Analysis of nine years of largescale scanning data demonstrates the benefits of vaccinating with Campylovexin®. Camplyovexin® provides maximum protection for the flock – achieving maximum productivity.

New Zealand produced Campylobacter vaccine protects against lamb losses.

Vaccinating against Campylobacter disease protects unborn lambs from the infectious bacteria that invade the placenta and foetus. By protecting these lambs and helping prevent abortion losses, your tailing percentages can be significantly improved. Even if campylobacter has not been diagnosed on your farm, the disease may well be present. Preventative vaccination could help eliminate a hard-to-detect but important cause of lamb losses.

farms were C. fetus fetus and 4 (5%) isolates from 3 (11%) of farms were C. jejuni6.

3. A detailed study1,7 of 320 NZ wide sheep abortion campylobacter isolates from 221 farms in 2000 showed that 92% of isolates from 90% of farms were C. fetus fetus and 10% from 8% of farms were C.jejuni. C. coli was isolated once. Regionally there was considerable variation, however given the small number of isolates in some regions this data must be interpreted with caution.

In summary, the great majority of campylobacter abortions in sheep are caused by C. fetus fetus. C.jejuni is isolated in a minor number of sheep abortions that appear to be regional in nature.

Vaccination against Campylobacter disease improves productivity.

C. jejuni is considered as a minor cause of abortion in sheep in New Zealand, and it is not considered a cause of infertility.

1. Grogono-Thomas et al (2003) Role of S-layer protein antigenic diversity in the immune responses of sheep experimentally challenged with C.fetus susp. fetus. Infection and immunity 71, 147-54. 2. Meanger JD and Marshall RB (1989) Seasonal prevalence of thermophillic campylobacter infections in dairy cattle and a study of infection in sheep. NZVJ 37 p18-20. 3. Adhikari B.et al (2203) Prevalence and clonal diversity of C. jejuni from dairy farms and urban sources. NZVJ 52 (6) p378-83. 4. AgVax Developments Ltd. Media material 2005. Proc 30th An. Sem., Soc. of S & B C Vets, NZVA p31 -36. 5. Smart JA (2000) Latest experiences of Salmonella Brandenburg. Proc 30th An. Sem.,Soc. of S & B C Vets NZVA p137-150. 6. Mannering SA, et al (2003) Pulsed-field gel electrophoresis typing of Campylobacter fetus fetus sheep abortions in the Hawkes Bay region of New Zealand. NZVJ 51(1) p33-37. 7. Mannering SA, et al (2004) Pulsed-field gel electrophoresis typing of Campylobacter fetus fetus isolated from sheep abortions in NZ. NZVJ 52 (6), p358-363.

C. jejuniC. fetus fetus

20

15

10

5

0

% o

f cas

es

Total 2004 Total 2005

Campylovexin®





• Rain fast














50 2.5 2000

100 5 1000

150 7.5 666

200 10 500

250 12.5 400

300 15 333

350 17.5 285

400 20 250

450 22.5 222

500 25 200

550 27.5 181

600 30 166

650 32.5 153




Cefaguard™


Shake the vial vigorously until the deposit has been evenly re-suspended. Administer by i/m or s/c injection into the anterior half of the neck. Inject no more than 10mL/injection site.

CATTLE: For BRD and footrot, 1mg/kg (2mL/100kg b.w) daily for 3 days. Repeat on days 4 and 5, if required.

For acute post partum metritis, 2.2mg/kg (4.4mL/100kg b.w) daily for 5 days.

PIGS: 3mg/kg (3mL/50kg b.w) daily for 3 days.


MILK: Nil.MEAT: 2 days.

SIDE EFFECTS:

Muscle discolouration may be observed around the injection site for up to 11 days.

CONTRAINDICATIONS:

Not for use in bobby calves. Do not use in animals with a known hypersensitivity to cephalosporins or other beta-lactam antibiotics such as penicillin.


Beta-lactam antibiotics may cause hypersensitivity (allergy) following injection, ingestion or skin contact. Do not handle this product if you know you are sensitised to, or if you have been advised not to work with, such preparations. Handle this product with great care to avoid exposure, taking all recommended precautions.

OTHER INFORMATION:

Store below 25°C. Do not freeze. Protect from sunlight. Contents should be used within 42 days after the first dose is removed.





MODE OF ACTION:

Ceftiofur is a broad-spectrum, third generation cephalosporin antibiotic, active against both Gram+ve and Gram-ve bacteria. It interferes with cell wall synthesis and is resistant to beta-lactamases.

INDICATION:

CATTLE: Treatment of bovine footrot, acute metritis and respiratory disease (BRD) associated with Pasteurella haemolytica, P. multocida and Haemophilus somnus; footrot associated with Fusobacterium necrophorum and Bacteroides melaninogenicus; and acute metritis (0–14 days post partum) associated with bacteria susceptible to ceftiofur.

PIGS: Treatment of swine bacterial respiratory disease associated with Haemophilus pleuropneumoniae, Pasteurella multocida, Salmonella choleraesuis and Streptococcus suis type 2.

A sterile suspension containing 50mg/mL ceftiofur, as the hydrochloride. Manufactured in New Zealand. Available in 30 mL plastic bottles with 3 syringes and 3 needles.

• Nil milk withholding

• 3 x 30mL plastic bottles - one bottle, one cow

• Subcutaneous or Intramuscular injection




www.virbac.co.nz

CefaguardTM RTU Injection

8

A sterile suspension containing 50mg/mL Ceftiofur, as the hydrochloride. Available in packs containing 4 ready to use 30mL vials, 4 syringes and 4 needles.

4 x 30mL plastic vials - one bottle, one cow


MILK: NilMEAT: Nil

CONTRAINDICATIONS:

Excessive copper is toxic. Only use this product if copper deficiency has been diagnosed. Do not use in conjunction with other forms of copper supplementation. Do not administer at the same time as any other treatment, eg. drenches or vaccines. Do not use in animals with impaired liver function. Do not use in cattle under 4 months of age, as young animals are more susceptible to copper toxicity.

SIDE EFFECTS:

Localised tissue reaction may occur at the injection site, especially in young deer.


Only treat animals in good health. Minimise stress to the animals during administration.

HUMAN FIRST AID, SYMPTOMS OF POISONING:

Accidental self-inoculation of copper may cause serious tissue damage. Seek urgent medical advice.

OTHER INFORMATION:

Store below 30°C, out of direct sunlight.





MODE OF ACTION:

After injection, the copper in this product is absorbed from the injection site and transported to the liver where it is stored until required during times of inadequate copper intake. It is then slowly released into the blood to maintain adequate serum copper levels.

INDICATION:

Prevention and treatment of copper deficiency in cattle, sheep and deer.


Shake thoroughly before use to ensure a uniform suspension. By s/c injection only. Administer in the anterior half of the neck. In cattle, sheep and deer, the dose may be repeated every 4 months.

CATTLE over 4 months of age: 2mL. Dose may be increased up to a maximum of 4mL if severe copper deficiency has been confirmed by clinical symptoms or liver biopsy.

ADULT SHEEP: 1mL.

DEER: 1mL/50kg b.w.

Copperguard®

A sterile suspension of calcium copper edetate containing 50mg/mL copper. Manufactured in New Zealand. Available in 200mL pillow packs and supplied with specially designed Copperguard® injector.

• Calcium Copper edetate

• Nil milk withholding

• Easy syringeability, plastic pillow pack




www.virbac.co.nz

Copperguard®

9

A sterile suspension of calcium copper edetate containing 50mg/mL of copper. Available in 200mL pillow packs.





• Rain fast














50 2.5 2000

100 5 1000

150 7.5 666

200 10 500

250 12.5 400

300 15 333

350 17.5 285

400 20 250

450 22.5 222

500 25 200

550 27.5 181

600 30 166

650 32.5 153




Dual Levamisole and Fenbendazole combination with selenium for adult sheep and lambs.

• Low Volume

• Broad Spectrum

• Mixing with AbaCare® LV provides triple combination





• Rain fast














50 2.5 2000

100 5 1000

150 7.5 666

200 10 500

250 12.5 400

300 15 333

350 17.5 285

400 20 250

450 22.5 222

500 25 200

550 27.5 181

600 30 166

650 32.5 153




INDICATIONS:DuoCare® LV + Se contains Levamisole, a member of the imidazothiazole (clear) family of chemicals and Fenbendazole, a member of the benzimidazole (white) family of chemicals. It is effect against sensitive and single-resistant mature & immature strains of the Roundworms listed below: Haemonchus contortus - Barber’s pole worm, Teladorsagia [Ostertagia spp] circumcincata - Small brown stomach worm, Trichostrongylus spp - Black scour worm, including moderately macrocyclic lactone resistant strains, Cooperia spp. - small intestinal worm, Nematodirus spp. - thin necked intestinal worm, Strongyloides papillosus - Intestinal threadworm, Bunostomum spp. - Hookworm, Oesophagostomum spp. - Nodule worm, Chabertia ovina - Large mouthed bowel worm, Dictyocaulus filaria - Large lungworm, it will aid in the control of (Moniezia spp.) Tapeworm.

COMBINED USE:Combined use of drench actives may improve efficacy and slow the development of resistance. DuoCare® LV + Se can be combined in equal volumes with AbaCare® LV (A10306) to produce a stable mixture for oral dosing of sheep and lambs. The mixture contains 40g/L Levamisole HCI, 25g/L Fenbendazole, 0.5g/L Selenium and 1.0g/L Abamectin. This combined solution must be well mixed before use and dosed at a rate of 1mL/5kg bodyweight. The mixture remains stable for up to 3 months if stored as per label conditions.

DOSAGE:1mL per 10kg bodyweight. Sheep over 75kg to be dosed at 1mL per 10kg bodyweight.


Sheep Treated per 10L

15-20 2 5000

21-25 2.5 4000

26-30 3 3333

31-35 3.5 2857

36-40 4 2500

41-45 4.5 2222

46-50 5 2000

51-55 5.5 1818

56-60 6 1666

61-65 6.5 1538

66-70 7 1428

71-75 7.5 1333

WITHHOLDING PERIODS:MEAT: Within 10 days of the last treatment.MILK: Not less than 8 milkings or approximately 96 hours following the last treatment.

PACK SIZE:10L.

CONTRAINDICATIONS:Do not use in lambs under six (6) weeks of age or less than 15 kg bodyweight.

Duocare® LV + Se

10


FlukeCare® +SeFor the treatment and control of benzimidazole sensitive mature and immature roundworms, lungworms and early immature (including 2 week old fl uke), mature and immature liver fl uke (Fasciola hepatica) in cattle and sheep.

Use the most eff ective double combination broad spectrum drench for treating liver fl uke.

• All three stages of liver fl uke with superior control of early immature liver fl uke

• Broad Spectrum anthelmintic

• Synergistic anthelmintic combination - Patent WOY 1994/028887

WHAT IS FLUKECARE® + SE?• Effective control of liver fluke from 2 week old to adult

stages.• Patented formulation of triclabendazole and oxfendazole.• Liquid oral drench with free flowing formulation.• Contains selenium.• Oral drench to give control of benzimidazole sensitive

roundworms and lungworms.

WHY USE FLUKECARE® + SE?• Liver fluke has a huge impact on profits if left untreated.• Roundworms - Controls all benzimidazole sensitive major

mature and immature roundworms (including inhibited Ostertagia) and lungworms.

• Suitable for dairy cows - Ideal dry-off treatment for dairy cattle (35 day milk withold).

• New improved formulation - flows through drenching equipment easily even at low temperatures.

DESCRIPTION:Contains 12mg/kg of triclabendazole, 45.3mg/kg of Oxfendazole and 0.1mg/kg of selenium. Available in a 10L drum.

WITHHOLDING PERIODS: MEAT: 28 daysMILK: 35 days.

COMBINED USE:MEAT: 21 daysMILK: 35 days

Registered pursuant to the ACVM Act 1997, No. A10203. See www.foodsafety.govt.nz for registration conditions.

DOSAGE:1mL per 10kg bodyweight orally.

DRENCHABILITY - MAXIMUM FORCE REQUIRED TO EXPEL DRENCH THROUGH EQUIPMENT.

22

20

18

16

14

12

10

Kg fo

rce

Water FlukeCare® + Se

Fasimec® Pour on

for cattle

Fasinex® 240

DOSE RATE GUIDE: CATTLE

Liveweight kg Dose Volume mL Cattle Treated per 10L

Up to 100 1mL per 10kg

101 - 150 15 666

151 - 200 20 500

201 -250 25 400

251 - 300 30 333

301 - 400 40 250

401 - 500 50 200

501 - 600 60 166

601 - 650 65 153

DOSE RATE GUIDE: SHEEP

Liveweight kg Dose Volume mL Sheep Treated per 10L

11 - 15 1.5 6666

16 - 20 2 5000

21 - 30 3 3333

31 - 40 4 2500

41 - 50 5 2000

51 - 60 6 1666

61 - 70 7 1428

71 - 75 7.5 1333



www.virbac.co.nz

FlukeCare® + Se


Liver Fluke bites profits!Impact on milk production• Suggested values for milk loss due to liver fluke infection are up

to 1 kg/day over a lactation1.• A heavy infection can cost around 300L in lost milk production per

cow per year. The effect of liver fluke (fasciola hepatica) on milk production is well documented2. In high risk fluke areas fluke is a significant threat to milk production.

• In cattle, fluke can cause a loss in body condition, a drop in milk yield and fertility, and sometimes diarrhoea. It can also increase susceptibility of the animals to other infections and metabolic disorders.

• A high incidence of liver fluke infestation can reduce milk butterfat concentration3.

Impact on Reproduction• Liver fluke infections have been shown to reduce conception rates

in heifers by 50%4.

Impact on growth rate• Liver fluke infection in growing cattle has been shown to depress

live weight gain by between 0.07 kg/week and 1.2 kg/week, depending on the size of the fluke burden1.

• A heavy infection can cost up to 28.5%5,6 in reduced weight gain. Liver fluke (fasciola hepatica) can affect weight gains in young growing cattle – having a direct effect on your income.

• The graph below charts the reduction in body weight expressed as weight loss in grams per week on calves in differing severity of liver fluke infection.

Impact on weaning weights• Crossland et al (1977), cited by Clarkson showed that ewes with 33

flukes had a 14% reduction in output, attributed to fewer births, lower birth weights and decreased weight gains of Iambs. 7

• Reid & Armour (1978), cited by Clarkson showed that lambs from ewes with 40 flukes were 5 kg lighter at weaning than lambs from ewes with only 2 flukes7.

Impact on wool yield• Roseby (1970), cited by Clarkson obtained a reduction in

production of 20-39% of wool in ewes with 186 flukes compared with uninfected controls7.

• Edwards, al-Saigh, Williams and Chamberlain (1976), cited by Clarkson showed that infection with 100,500 and 1,000 met a cercariae (mc) reduced wool production over a year by 24%, 30% and 44%, respectively7.

• Hawkins & Morris (1978), cited by Clarkson showed that sheep harbouring 45 flukes had a 14% reduction in wool, 67 flukes a 22% reduction and 230 flukes a 33% reduction7.

• A study in 1984 showed that when sheep were infected with liver fluke for between 8 to 12 weeks, the reduction in appetite alone caused a reduction in wool growth of between 19.5% to 21.3%8. When fluke were stopped in their tracks and killed early in their life cycle at 4 weeks of age, the suppression of appetite still had an impact on wool growth but at a significantly lower level than older infections.

• Each fluke can cause the loss of 0.5ml of blood per day from the liver. A moderate infestation in cattle of 100-200 fluke can lead to blood loss of up to half a litre each week, so often infected animals can be anaemic.

Why is it important to control immature liver fluke as early as two weeks?Removal of liver fluke at the earliest possible stage reduces the damage sustained to the liver. Studies have shown that the earlier fluke can be removed the greater the productivity response (growth rates).*Studies undertaken by NSW DPI showed that FlukeCare® + Se• Removed virtually all fluke aged 2 and 4 weeks (99% + efficacy)• There was no visual damage to the livers of cattle treated with

FlukeCare® + Se.

FlukeCare® +Se

1. The University of Reading, Department of Agricultural and Food Economics, The Economics of Fascioliasis (Liver fluke). 2. Ross, JG. (1970). British Veterinary Journal, 126: xiii - xv. 3. Department of Agriculture and Rural Development, Technical Note, Dairy, 13, April 2003. 4. Oakley, G.A., et al (1979).Veterinary Record, 104:503-507. 5. Dargie, JD. (1986) In Ed. MJ Howell, Parasitology-Quo Vadit. 1986,pp. 453-463. 6. Hutton Oddy, Meat and Livestock Australia, 2003 Armidale Feeder Steer School. 7. M. J. CLARKSON (1998) University of Liverpool. 8. C.D. Hawkins. Veterinary Parasitology, 15 (1984) 117-123. * Virbac data on file.

Reduction of milk production in cows affected with liver fluke3

FlukeCare® + Se Triclabendazole at 10mg per kg

pour on (tric + aba)

Reduction of body weight in calves infected with liver fluke2

The impact of reduced feed intake due to liver fluke on wool growth (shown as % reduction in wool growth)8

DPI Study: Efficacy on 2 week old stages* % Reduction in total fluke count - 2 weeks

0

100

200

300

4000 300

Range in production loss due to liver fl uke

Duration of infection (weeks)

Loss

of m

ilk p

rodu

ctio

n in

lit

res

per c

ow p

er la

ctat

ion

0

200

400

600

800

1000

1200

0

-10

-20

-30

-40

100

80

60

40

20

0

Redu

ctio

n in

gro

wth

rate

gra

ms/

wee

kRe

duct

ion

in w

ool g

row

th (%

)

200 Flukes present in liver

30 - 80 Flukes present in liver

-1200g-200g

4 weeks

8 weeks

12 weeks

26 weeks

12

Scientifically formulated to kill ticks at every stage of the lifecycle – larvae, nymph and adult in deer, dairy and beef cattle.

• Treats and controls all 3 stages of lifecycle• Nil meat and milk withholding • Rainfast





• Rain fast














50 2.5 2000

100 5 1000

150 7.5 666

200 10 500

250 12.5 400

300 15 333

350 17.5 285

400 20 250

450 22.5 222

500 25 200

550 27.5 181

600 30 166

650 32.5 153




DESCRIPTION:ACTIVE CONSTITUENT: 10g/L Flumethrin.Available in 1L and 5L.

MODE OF ACTION:Flumenil® Pour On is active against all 3 stages of the New Zealand cattle tick (Haemaphysalis longicornis) lifecycle. It also causes infertility of ticks which survive treatment, by inhibiting egg laying or rendering eggs sterile. This action helps reduce contamination of pas-ture.

WITHHOLDING PERIODS:Cattle and DeerMEAT: Nil.MILK: Nil.

DOSAGE AND ADMINISTRATION:Apply Flumenil® Pour On evenly along the midline of the back from the front of the shoulders to the tail head. Use a plastic measuring cup or automatic drenching gun to apply.

CATTLE (liveweight) DOSE VOLUME

Up to 200kg 20mL

200 to 300kg 30mL

301 to 400kg 40mL

Over 400kg 50mL

DEER DOSE VOLUME

Up to 6 months 10mL

Yearlings and adults 20mL

Flumenil® Pour On spreads through the oils of skin and hair coat of all of parts of the animal’s body. Behaviours such as grooming, tail swishing and scratching, aid the movement of active ingredient to the extremities of the body, which are often affected by ticks.

Retreatment should be undertaken when ticks start to reappear.

For optimum control of ticks on deer, breeding hinds should be treated every three weeks from August to fawning. This program will reduce the number of nymphs reaching the adult stage, which infest fawn during Novem-ber/December. Treatment of hinds can be continued after fawning if this is practical. Other stock should be treated every three weeks from August, or as required.

RAIN RESISTANCE:Control of ticks is not affected by rain falling within a few hours of treatment.

Registered pursuant to the ACVM Act 1997, No A11279.

See www.foodsafety.govt.nz for registration conditions.

Flumenil® Pour On

13


HeadStart HeadStart Gold

DESCRIPTION:A dark brown thixotropic gel; a stabilised emulsion for oral administration to cows. Contains refined food-grade ingredients. 1L, 5L, 20L, 60L and 200L containers.

MODE OF ACTION: Calcium is provided for Immediate and sustained availability. The total dose is effective protection from hypocalcaemia. Provides immediately available energy sources, which can be metabolised by the cow to provide glucose. Monopropylene glycol is a recognised source of glucose for the cow; however propionate has been shown to have superior value for this purpose.

INDICATIONS: CATTLE: Using 1L of HeadStart or 750mL of HeadStart Gold, within 12 hours of calving assists recovery from hypocalcaemia, will boost appetite and metabolism and has shown to provide an increase in production.

SHEEP: Use 100ml of HeadStart or 75mL of HeadStart Gold to stimulate appetite and help control sleepy sickness and milk fever in pregnant ewes.

CONTAINS:PROVIDES PER 1L:Calcium (Elemental) 45g, Magnesium (Elemental) 9.2g, Available energy 15MJ.

PROVIDES PER 100ML:Calcium (Elemental) 4.5g, Magnesium (Elemental) 0.92g, Available energy 1.5MJ.

WITHHOLDING PERIODS: MEAT AND MILK: Nil

Calcium and energy starter drench to stimulate appetite and metabolism

Only starter drench proven to stimulate production, boosting energy, appetite and metabolism.

• Proven increased energy

• Proven increased Calcium and Magnesium

• Proven higher milk solid production

The Gold Standard transitional oral drench for calving and lambing.

...as good as gold.

• Low volume 750mL cattle dose

• Researched and scientifi cally developed

• Proven to deliver

Vitamin B Complex

Yeast extract fortifi ed

with Vitamin B

Complex stimulates

both metabolism and

appetite.

Energy sources

Proven and eff ective

sources of energy including

propionate. The key to

energy is the combination of

quick and sustained release.

HeadStart provides both.

Calcium

HeadStart contains

two forms of calcium:

Calcium Propionate is the only form of

readily absorbed calcium that provides both

energy and a sustained release of calcium.

Calcium Chloride provides a readily

absorbed form of calcium for immediate

utilisation when speed is the key.

Magnesium

Readily absorbed source of

magnesium to help prevent

hypomagnesaemic tetany

(grass staggers).

Readily available

Added Cobalt!

Sustained

availability.



www.virbac.co.nz

HeadStart HeadStart Gold


TrialsStudy 1: Increased CalciumCows treated with HeadStart within 12 hours of calving demonstrated a statistically significant increase in blood calcium.

Study 2: Increased MagnesiumCows treated with HeadStart within 12 hours of calving demonstrated a statistically significant increase in blood magnesium.

Study 3: Improved EnergyCows treated with HeadStart demonstrate a positive energy balance as indicated by NEFA levels. Negative energy balance after calving can cause poor reproductive performance and limits production through reduced milk protein and lactose.

Study 4: Higher (MS) ProductionCows treated with 1L HeadStart within 24 hours of calving demonstrated a statistically significant higher milk solids production for a whole season (+8kg) than cows not treated with HeadStart.* Virbac Data on file.

Mean blood calcium

Mean blood magnesium

Energy balance

Kg Milk Solids for Total Lactation

2.32

2.30

2.28

2.26

2.24

2.22

2.20

2.18

2.14

0.90

0.89

0.88

0.87

0.86

0.85

0.84

0.83

0.82

4.5

5.0

5.5

6.0

6.5

7.0

7.5

8.0

446

444

442

440

438

436

434

432

mm

ol/

Lm

m o

l/L

mm

ol/

Lm

m o

l/L

Hours

Hours

Hours

HeadStartControls

0

0

0

6

6

6

Calcium

Magnesium

NEFAs

HeadStart

445

437

15

Intracillin® 1000 Milking Cow


MILK: For either 3 or 6 treatments, 96 hours (8 milkings) following the last treatment.

3 x Intracillin 1000 + 1 x Masticillin - 108 hours (9 milkings) following the last treatment

MEAT: 28 days.

CONTRAINDICATIONS:

Not for the treatment of infections caused by organisms that are not susceptible, or have developed resistance, to penicillin. Not to be used in animals with a known history of sensitivity to penicillin-containing products.



OTHER INFORMATION:

Store below 25°C. DO NOT REFRIGERATE.





MODE OF ACTION:

The high dose of penicillin in this product makes it a very effective treatment for the majority of cases of mastitis in dairy cattle caused by Gram+ve bacteria. Particularly effective against Streptococcus uberis, which is responsible for up to 75% of spring mastitis in New Zealand.

INDICATION:

Treatment of mastitis infections in lactating cows.


Clean and disinfect the udder, paying particular attention to the teat orifice. Administer 1 syringe per infected quarter. The contents of 1 syringe should be infused into the teat

canal of each infected quarter immediately following each of 3 consecutive milkings, ie. three 12-hourly doses. Massage the infused contents of each syringe up the teat canal. If required, an extended treatment of 6 syringes (1 after each of 6 successive milkings) may be given. For difficult mastitis cases, treatment may be combined with a course of the parenteral, Masticillin. For details, see the leaflet provided with the product.

An oily suspension containing 1,000,000 i.u. procaine penicillin G per single-dose syringe. Available in boxes of 21 single-dose syringes.

• 1000mg Procaine Benzyl Penicillin

• Registered extended therapy claim of 6 tubes given 12 hours apart

• Registered milk withholding for combination therapy with Masticillin® RTU Injection




www.virbac.co.nz

Intracillin® 1000 Milking Cow

16

Intracillin®

A sterile, aqueous suspension of 300,000i.u./mL procaine penicillin G. Manufactured in New Zealand. Available in 100mL and 200mL pillow packs.


• Variable dose range of 10,000iu - 25,000iu penicillin/kg

• Needles and syringe supplied

MODE OF ACTION:

Procaine penicillin is a moderately soluble drug that provides a therapeutic effect from a single injection for the 24 hours before the next injection is to be given. Penicillin inhibits cell wall synthesis in susceptible bacteria.

INDICATION:

First-line treatment for unspecified infections and treatment of known and common infections caused by penicillin-sensitive Gram +ve organisms, eg. clostridial infections.


Usual dose ranges from 10,000i.u. to 25,000i.u. penicillin/kg b.w. depending on the severity of the infection being treated.

Lower doses may lead to a build-up of resistant bacteria. Higher doses may be used at the discretion of a veterinarian. CATS and DOGS: 0.5–4mL.

SHEEP, CALVES, FOALS and PIGS: 3–8mL.

DAIRY COWS (400kg): 16mL.

HORSES and CATTLE (up to 500kg): 10–20mL.

HORSES and CATTLE (over 500kg): 20–50mL.

When used prophylactically (in the absence of clinical symptoms), administer the dose once only by i/m or s/c injection. Where a clinical infection is being treated, administer the dose daily for 3 days. In food-producing animals, to minimise tissue rejection at slaughter product must be injected in the neck behind the ear.


BOVINE MILK: Milk intended for human consumption must be discarded during treatment and for the following times after the last treatment: One dose – 48 hours (4 milkings); two doses – 60 hours (5 milkings); 3 or more doses – 72 hours (6 milkings).

OVINE MILK: 35 days after the last treatment.

MEAT: Cattle, Sheep and Pigs 10 days, Horses 63 days.

CONTRAINDICATIONS:

Not for use in bobby calves. Not to be used in animals with a known history of sensitivity to products containing penicillin or its analogues. Not to be used for the treatment of infections caused by organisms known to be resistant to penicillin. No products containing procaine and/or procaine penicillin are to be used in race horses within 504 hours (21 days) of racing.



OTHER INFORMATION:









www.virbac.co.nz

Intracillin® 300 Injection

17

A sterile, aqueous suspension of 300,000i.u./mL procaine penicillin G. Available in 200mL pillow packs.

Intracillin® L.A.


Usual dose ranges from 10,000i.u. to 25,000i.u. penicillin/kg b.w, depending on the severity of the infection being treated. Lower doses may lead to a build-up of resistant bacteria. Higher doses may be used at the discretion of a veterinarian. General guidelines:

CATS AND DOGS: 0.5–4mL.

SHEEP, CALVES, FOALS and PIGS: 3–8mL.

DAIRY COWS 400kg (Single dose only): 16mL. HORSES and CATTLE (up to 500kg): 10–20mL.

HORSES and CATTLE (over 500kg): 20–50mL.

Administer 1 injection of the selected dose immediately. In all species, except dairy cows, another dose is recommended 48 hours later, and a third injection may be administered in another 48 hours, if necessary. For larger doses, consider dividing the dose and inject one half in each side of the neck.


BOVINE MILK: 108 hours (9 milkings).

OVINE MILK: 35 days after last treatment.

MEAT: Cattle, Sheep and Pigs 30 days. Horses 63 days.



OTHER INFORMATION:






MODE OF ACTION:

Procaine penicillin is a moderately soluble drug that provides a therapeutic effect from a single injection for up to 24 hours. Benzathine penicillin gives this product a long-acting effect for sustained treatment of difficult, penicillin-sensitive infections or continued therapy where daily injection is not practical. Offers prolonged protection when used as a preventative treatment in the absence of clinical symptoms. Penicillin inhibits cell wall synthesis in susceptible bacteria.

INDICATION:

First-line treatment for unspecified infections and treatment of known and common infections caused by penicillin-sensitive Gram+ve organisms, eg. clostridial infections.

CONTRAINDICATIONS:

Not for use in bobby calves. Not to be used in animals with a known history of sensitivity to products containing penicillin or its analogues. Not to be used in the treatment of infections caused by organisms known to be resistant to penicillin. No products containing procaine and/or procaine penicillin are to be used in race horses within 504 hours (21 days) of racing.

A sterile, aqueous suspension of 150,000i.u./mL procaine penicillin G and 150,000i.u./mL benzathine penicillin G. Manufactured in New Zealand and available in 100mL pillow packs.

• 108 hour milk withholding time

• Variable dose range of 10,000iu - 25,000iu penicillin/kg

• Convenient Plastic Pillowpack




www.virbac.co.nz

Intracillin® LA

18


Lepto 2-Way Lepto 3-Way

DESCRIPTION:Lepto 2 Way: This vaccine is prepared from cultured strains of Leptospira interrogans serovars hardjo and pomona.

Lepto 3 Way: This vaccine is prepared from cultured strains of Leptospira interrogans serovars hardjo, copenhageni (icterohaemorrhagiae) and pomona.

MODE OF ACTION: Stimulates the immune system to produce antibodies against the organisms L. interrogans serovars hardjo, and pomona (Lepto 2 Way), and L. interrogans copenhageni (Lepto 3 Way), the main causes of leptospirae infection in cattle.

In cattle challenged with live cultures of the serovar L. hardjo shedding of leptospirae in the urine was prevented by vaccination with Lepto 2-Way and Lepto 3 Way.

ADMINISTRATION: 2 mL by subcutaneous injection, given into the anterior half of the neck.

Registered pursuant to the ACVM Act 1997 No. A9166, A8314. See www.foodsafety.govt.nz for registration conditions. Only available under Veterinary Authorisation.

For the control of leptospirae infection in cattle by immunisation against Leptospirae interrogans serovar hardjo and L. interrogans serovar pomona.

To prevent urinary shedding of leptospirae of the named serovars, and thus reduce the risk of human Leptospirosis infection.

• Low risk of site reactions after vaccination

• Duration of protection for at least 12 months after primary vaccination

• Ease of use, minimal agitation required

For the control of leptospirae infection in cattle by immunisation against Leptospirae interrogans serovar hardjo, L. interrogans serovar copenhageni (icterohaemorrhagia) and L. interrogans serovar pomona.

To prevent urinary shedding of leptospirae of the named serovars, and thus reduce the risk of human Leptospirosis infection.

• Low risk of site reactions after vaccination

• Duration of protection for at least 12 months after primary vaccination

• Ease of use, minimal agitation required

INDICATIONS:For the control of leptospirae infection in cattle by immunisation against Leptospirae interrogans serovar hardjo and L. interrogans serovar pomona (Lepto 2 Way) and L. interrogans copenhageni (Lepto 3 Way). To prevent urinary shedding of leptospirae of the named serovars, and thus reduce the risk of human Leptospirosis infection.

DOSAGE:Cattle:2 mL by subcutaneous injection, given into the anterior half of the neck; with a further dose of 2 mL given four to six weeks later. Note: the dose of 2 mL is recommended for all life-stages. All animals then require a single 2 mL booster injection each 12 months.

HERD VACCINATION:To begin a herd vaccination program all animals must be vaccinated in the autumn, with a second dose given 4-6 weeks later. An annual booster dose must be given each autumn. Calves, cows and pigs intended for introduction to a herd must receive 2 doses, 4 - 6 weeks apart. This programme is applicable to dairy or beef herds.

VACCINATION OF CALVES:Early vaccination of calves is advisable to protect against acute Leptospirosis (“red-water”), and to minimise the risk of animals becoming carriers prior to vaccination. A course may begin from 12 weeks of age, but in this case it is essential to administer a booster dose at 6 to 9 months of age, to align with future herd vaccination.

In all cases, two doses should be given, 4-6 weeks apart, and finishing no later than 9 months of age, and a booster vaccination should be given within 12 months. This may require a further single dose of vaccine to align calves vaccinated out of season (i.e. when young, or in a town supply herd), with the annual herd booster in autumn.

INTRODUCED STOCK:In the absence of known prior vaccination, dose twice at a 4-6 week interval. To eliminate possible shedding from animals already leptospirosis infected, a course of dihydrostreptomycin (3 days @ 25 mg/kg) is recommended.



www.virbac.co.nz

Lepto 2-Way Lepto 3-Way


Extensive controlled challenge trials and a New Zealand study confirm Lepto 2-Way and Lepto 3-Way’s ability to:

Lepto 2-Way and Lepto 3-Way

Prevent cattle shedding and Renal ColonisationPrevention from shedding viable leptospires in vaccinated cattle after challenge with live cultures of all three serovars compared to unvaccinated controls and therefore providing protection against L. hardjo, L. pomona, L. icterohaemorrhagiae bacteraemia.

Vaccinates challenged with either L. pomona or L. icterohaemorrhagiae failed to demonstrate viable leptospires in serial urine samples for all animals on all occasions of sampling.

Excellent results were also seen for L. hardjo most clearly demonstrated when only a single sensitiser vaccination prevented viable leptospires being recovered from serial urine samples after challenge. The entire unvaccinated control group had leptospires recovered on at least one occasion demonstrating that challenge was highly effective.

Provide Protective Antibody ResponseMicro agglutination titres (MAT) to all three serovars (hardjo, pomona and icterohaemorrhagiae) show a significant rise in vaccinated animals, whether they received one or two vaccinations. As would be expected, the titre rise was higher in the group that received the two vaccinations at a four week interval.

The MA antibody titres followed the pattern that would be expected. Importantly they remained negative in the unvaccinated control group (indicating no natural infection or challenge occurred).

Provide 12 months Duration of ImmunityIn the majority of animals, MA titres decline by 6 months post vaccination so some other means of determination of duration of immunity is required. The indirect passive protection test involves removing serum from vaccinated cattle at defined times

after vaccination and administering it to laboratory animals that are then challenged with leptospires. Fatalities and subsequent recovery of leptospires from kidneys in negative controls are compared to serum treated animals. Protection for a minimum of 12 months was demonstrated against L. pomona and 18 months for L. icterohaemorrhagia in these studies

Provide full protection against all serovars contained in each vaccineChallenge studies using micro-agglutination titre levels, passive protection models and leptospiral survival in bovine blood. These forms of testing are robust methods of testing.

The Passive Protection test is an animal model used to prove that antibodies developed in cattle after vaccination with Lepto 2-Way and Lepto 3-Way are protective against challenge. This form of testing is also commonly used in batch potency testing.

New Zealand trial work conducted in 2007 with Lepto 3-Way supports that annual vaccination timing is important to provide adequate levels of colostrum transfer.In this study it was found that calves from cows or heifers vaccinated less than 60 days before they calved were more likely to record low or negative MA titres to leptospira hardjo (Chart 1). Whilst even low titres may still be protective, higher levels are more likely to protect for longer. The data demonstrates that as the period between vaccination and calving increases towards 90 days, the prevalence of low titres to L. hardjo decreases. Immunoglobulin levels measured in this study also support the suggestion that higher overall levels of IgG derived from colostrum in neonatal calves is associated with higher serum MA titres to leptospira serovar hardjo.

To ensure calves are given the best opportunity from birth to be adequately protected against leptospirosis it is important to consider the following points

• Cows / Heifers are in good health and adequately fed.

• Vaccination is performed with a vaccine that stimulates antibody production and in New Zealand, one that also demonstrates proven lack of renal shedding after challenge by L. hardjo-bovis.

• Timing vaccination to allow for maximum antibody concentration coincident with synthesis of colostrum in the mammary gland. Therefore optimum timing depends upon:

• Calving date.• Time before calving that colostrum is synthesised.• Time between vaccination and maximum antibody titres

expected in the dam.• Adequate ingestion of colostrum by the calf after birth to

achieve transfer of antibodies.

• Lepto 2-Way information outlined in this information is relevant to the two serovars contained in the vaccine which is L. hardjo and L. pomona.

• Lepto 3-Way outlined in this information is relevant to the three serovars contained in the vaccine which is L. hardjo, L. pomona and L. icterohaemorrhagiae.

• For additional information regarding trial work conducted with Virbac Lepto 2-Way or Lepto 3-Way, please refer to the Technical Update.

Titres <1:100 Titres =>1:100

100%

80%

60%

40%

20%

0%

90 80 70 60 50 40 30 20 10 0Booster days before calving

Freq

uenc

y

Based on the fact that MATs of 1:100 and over should be protective, the following graph demonstrates that the earlier before calving a booster is given the higher the frequency of protective MATs (pink trend line) and the lower the frequency of unprotective MATs (blue trend line). At about 40-50 days pre-calving there is a 50-50 chance of calves having protective levels of antibodies and at 75 - 80 days there are high levels of protection. With the low numbers of results here this is an approximation.

20

Masticillin® RTU Injection


Only 1 treatment is required. Shake well before use. Inject two 15mL doses, by i/m or s/c injection, one each side of the anterior half of the neck. For difficult mastitis cases, treatment may be combined with a course of the intramammary, Intracillin 1000 Milking Cow. For details, see the leaflet provided with the product.


MILK: 132 hours (11 milkings) or 6 milkings (144 hours) if milking once a day.

1 x Masticillin + 3 x Intracillin 1000 - 108 hours (9 milkings) following the last treatment

MEAT: 10 days. Bobby calves from treated cows 4 days. Calf must be removed from dam within 24 hours of calving.

CONTRAINDICATIONS:

Do not give the full 30mL dose at one injection site; 20mL syringes are supplied with the product to help prevent this occurring. Not for the treatment of infections caused by organisms that are not susceptible to penicillin. Not to be used in animals with a known history of sensitivity to penicillin-containing products.



OTHER INFORMATION:

Store below 18°C. Product may be refrigerated. Do not freeze.





A sterile, aqueous suspension containing 15 million i.u. micronised procaine penicillin G in an aqueous suspension formulated for extended activity. Manufactured in New Zealand. Available in packs containing 3 ready to use 30mL vials, 3 syringes and 3 needles.

• Single treatment of high-dose micronised procaine penicillin

• Registered shorter Bobby Calf Meat withholding

• Needles & syringes supplied

• Registered milk withholding for combination therapy with Intracillin® 1000 MC

• New Zealand trial work

MODE OF ACTION:The high dose of penicillin, together with the unique formulation of Masticillin®, ensure that effective levels are maintained in the udder for a duration that is sufficient to provide bactericidal activity against sensitive organisms. Therapeutic levels of penicillin persist in the milk following a single treatment for much longer than the levels following multiple injections with penethamate hydriodide at an equivalent dose. The pharmacokinetic properties ensure penetration of the mammary tissue, particularly of inflamed quarters, with high penicillin concentrations being achieved at the site of infection.

INDICATION: Treatment of clinical and subclinical mastitis sensitive to penicillin, including that caused by Streptococcus uberis.




www.virbac.co.nz

MasticillinTM RTU Injection

21

TM

A sterile, aqueous suspension containing 15 million i.u. micronised procaine penicillin G in an aqueous suspension formulated for extended activity. Available in packs containing 4 ready to use 30mL vials, 4 syringes and 4 needles.

Metri-Clean™


Thoroughly clean the vulva area. Take a single syringe and using aseptic procedures as much as possible to avoid contaminating the pipette, insert the tip of the syringe firmly into the end of the pipette. Glove 1 hand and insert it into the animal’s rectum to locate the cervix. Gently grasp the cervix and by gently oscillating it, introduce the pipette into the lumen of the uterus. Depress the syringe plunger to infuse the contents of the syringe into the uterus (some product will remain in the pipette). Usually 1 treatment is sufficient for a complete cure. Can be used 1 day after insemination.


MILK: NIL.

MEAT: 4 days.

CONTRAINDICATIONS:

Do not administer to animals known to be allergic to cephalosporins. Do not administer with other antibiotic preparations.


Beta-lactam antibiotics may cause hypersensitivity (allergy) following injection, ingestion or skin contact. Do not handle this product if you know you are sensitised to, or if you have been advised not to work with, such preparations. Handle this product with great care to avoid exposure, taking all recommended precautions.

OTHER INFORMATION:

Store at 15-25°C.





MODE OF ACTION:

Cephapirin is a first-generation cephalosporin. It has a broad spectrum of activity against a range of Gram+ve and Gram-ve bacteria through interference with cell wall synthesis. It is a penicillinase-resistant, beta-lactam antibiotic and is active in the infected uterus. After a single treatment, the concentration of cephapirin in the tissue remains above the MIC’s of sensitive bacteria for at least 24 hours.

INDICATION:

Treatment of subacute and chronic endometritis (inflammation of the uterus lining) in cows, caused by cephapirin-sensitive bacteria. Also for the treatment of repeat breeder cases (more than three unsuccessful inseminations) when bacterial infection is the suspected cause.

Each 19-gram dose contains 500mg cephapirin as the benzathine salt. Available in pails of 20 or 50 single dose syringes and 500mL (25-dose) pillow packs. Snap-lock catheters (pipettes), plastic gloves and Metri-Clean™ multi-dose applicators are provided.

• Syringes packaged in plastic buckets in two convenient sizes – 20’s or 50’s

• Packets of pipettes supplied at no charge

• Full length gloves supplied at no charge on request

• Easy cap removal




www.virbac.co.nz

Metri-CleanTM

22

5

Multimin® + Cu

23

Multimin® + Cu is a unique concept of trace element supplementation for New Zealand farmers. Multimin® + Cu is designed to be administered strategically to optimise the essential trace elements – selenium, copper, zinc and manganese.

• Zinc (40mg/mL) as disodium zinc EDTA• Copper (15mg/mL) as copper disodium EDTA• Manganese (10mg/mL) as disodium manganese EDTA• Selenium (5mg/mL) as sodium selenite

It is formulated to optimise trace elements when there is a short-term deficiency caused by a stress, or a single critical event.

New Zealand clinical trials prove that the strategic use of Multimin® + Cu delivers a significant improvement in reproduction, immunity, growth and production.

Multimin® + Cu comes as an easy to use injection for maximum effectiveness:• Bypasses gut so does not react with minerals in the

environment which may decrease absorption and availability of the minerals

• Formulation minimises site reaction• Nil meat or milk withholding period• No colour staining on tissue

A patented subcutaneous or intramuscular injectable for cattle and intramuscular for deer. A supplemental source of chelated Zinc, Manganese and Copper plus selenium as sodium selenite.

MultiMin is the only multiple trace-element injectable for improving reproduction, immunity, growth & production.

• Scientifi cally balanced ratios of trace minerals

• pH neutral formulation

• New Zealand trial proven

MultiMin supplies the mineral component of various enzymes. It leads to a signifi cant increase in enzyme levels. Increased enzyme levels lead to increased natural resistance and better reproduction effi ciency.

Optimal level

MultiMinControl

Time

Eg. C

alvi

ng

Eg. B

reed

ing

Use MultiMin 3 - 4 weeksprior to a life-stage event

Trace element level after use of MultiMin

Trace element level when MultiMin is not used

Elevating mineral status at calving and breeding is critical for:• Calf performance• Cow reproductive

performance

Life-stage event Dry-off Parturition Pre-mate Mating

Strategic treatment may be more important as animals are managed for higher performance. Strategic treatment can mitigate potential insuffi ciency at critical times.

DESCRIPTION:Zinc, copper, manganese and selenium delivered as an easy to use low volume aqueous injectable solution. MultiMin is pH neutral and tissue friendly. Copper, manganese and zinc are highly bio-available due to chelation.

INDICATIONS: To optimise the trace element status of cattle & deer at critical times.

CONTAINS:• Four trace elements:• Zn (40mg/mL) as disodium zinc EDTA• Cu (15mg/mL) as copper disodium EDTA• Mn (10mg/mL) as disodium manganese EDTA• Se (5mg/mL) as sodium selenite

MODE OF ACTION: Cattle - intramuscular and subcutaneousDeer - intramuscular only

DOSAGE:Cattle < 1 year: 1mL per 50kgCattle >1 <2 years: 1mL per 75kgs Cattle >2 years: 1mL per 100kgsDeer: 1mL/100kgs

Registered pursuant to the ACVM Act 1997, No A9374. See www.foodsafety.govt.nz for registration conditions.

MultiMin should not be used with concurrent copper and selenium.




Multimin®

Multimin®

Multimin® + Cu will soon be available in a convenient 200mL pack. This will provide greater flexibility for small, medium and large farming operations to use Multimin® + Cu in a wider range of species (Cattle and Deer) and stock class (calves, heifers, cows, bulls, hinds, stags and fawns).

Along with a 200mL pack joining the 500mL in the range, Multimin® + Cu also has a new look – keep an eye out for the shiny, gold packaging.

When to give Multimin® + Cu:The ideal time to give administer Multimin® + Cu is around four weeks before stressful times such as mating, calving, transport and weaning. This ensures trace elements are fully accessible and available to the stock when they need it.





• Rain fast














50 2.5 2000

100 5 1000

150 7.5 666

200 10 500

250 12.5 400

300 15 333

350 17.5 285

400 20 250

450 22.5 222

500 25 200

550 27.5 181

600 30 166

650 32.5 153








• Rain fast














50 2.5 2000

100 5 1000

150 7.5 666

200 10 500

250 12.5 400

300 15 333

350 17.5 285

400 20 250

450 22.5 222

500 25 200

550 27.5 181

600 30 166

650 32.5 153








• Rain fast














50 2.5 2000

100 5 1000

150 7.5 666

200 10 500

250 12.5 400

300 15 333

350 17.5 285

400 20 250

450 22.5 222

500 25 200

550 27.5 181

600 30 166

650 32.5 153




For the treatment and control of internal and external parasites of beef and dairy cattle (including lactating cows) and internal parasites of deer, including lungworm and sucking & biting lice.

• Persistent activity against a broad spectrum of parasites

• Nil milk, meat and bobby calf withholding periods

• Rainfast





• Rain fast














50 2.5 2000

100 5 1000

150 7.5 666

200 10 500

250 12.5 400

300 15 333

350 17.5 285

400 20 250

450 22.5 222

500 25 200

550 27.5 181

600 30 166

650 32.5 153




INDICATIONS:Eprinomectin is a member of the avermectin/milbemycin class of endectocides.For the treatment and control in all ages of beef and dairy cattle (including lactating cows) of: Adult and Immature Gastrointestinal worms: Ostertagia ostertagi (including inhibited immature), Ostertagia lyrata (Adult Only), Haemonchus contortus, Trichostrongylus axei, Trichostrongylus colubriformis, Oesophagostomum radiatum, Nematodirus helvetianus, Bunostomum phlebotomum, Trichuris discolour (Adult Only), Trichuris globulosa (Adult Only), Cooperia oncophora, Cooperia punctate and Cooperia surnabada. Lungworms: Adult and immature Dictyocaulus viviparous.Sucking Lice and Biting Lice: Bovicola bovis, Linognathus vituli, Haematopinus eurysternus and Solenopotes capillatus.Sarcoptic and chorioptic mites: Sarcoptes scabiei var bovis and Chorioptes bovis.

And for the treatment and control in all ages of deer of:Adult and Immature Gastrointestinal worms: Ostertagia circumcincta, Ostertagia leptospicularis, Trichostrongylus axei and Oesophagostomum venulosum.Lungworms: Dictyocaulus ekerti (viviparous)

For best results Neoprinil® Pour On for Cattle and Deer should be part of a total parasite control program. Check the effectiveness of anthelmintics at least annually.

INCREASE MILK PRODUCTION:Increases milk production in grazing dairy cows. Data has shown that milk production increases by a median of approximately +0.6kg liquid milk per day when cows or heifers infected with gastrointestinal nematode parasites are treated with an effective anthelmintic; this increase occurs without any reduction in milk quality.

DESCRIPTION:ACTIVE CONSTITUENT: 5g/L Eprinomectin.

MODE OF ACTION:Neoprinil® Pour On for Cattle and Deer contains Eprinomectin which provides activity against a broad spectrum of internal and external parasites.

WITHHOLDING PERIODS:MEAT: Nil.MILK: Nil.

DOSAGE:1mL/10kg.


50 5.0

51-75 7.5

76-100 10

101-125 12.5

126-150 15

151-175 17.5

176-200 20

201-250 25

251-300 30

301-350 35

351-400 40

401-450 45

451-500 50

501-550 55

551-600 60

601 65

PACK SIZE:2.5L, 5L & 20L packs.

Registered pursuant to the ACVM Act 1997, No A11278.See www.foodsafety.govt.nz for registration conditions.

Neoprinil® Pour On

24

Nitroclox™ LA


Clean and disinfect the udder, paying particular attention to the teat orifice. Administer the entire contents of 1 syringe per infected quarter immediately following milking. Massage the infused contents of each syringe up the teat canal. Repeat the treatment twice more at 24 hour intervals, i.e. 3 x 24 hourly treatments. Three syringes provide a full course of treatment. If required, an extended treatment of 6 syringes at 24-hour intervals may be given.


MILK: When milking twice a day: for 3 to 6 x 24-hour doses or 3 x 48-hour doses, 84 hours (7 milkings) following the last treatment.

When milking once a day: 3 x 24-hour doses, 72 hours (3 x once-a-day milkings) following the last treatment.

MEAT: 7 days.

CONTRAINDICATIONS:

Not for the treatment of infections caused by organisms that are not susceptible, or have developed resistance, to cloxacillin. Not to be used in animals with a known history of sensitivity to products containing penicillin.



OTHER INFORMATION:

Store below 25°C. DO NOT REFRIGERATE.





MODE OF ACTION:

Cloxacillin, is a semi-synthetic isoxazolyl penicillin. There are a considerable number of reports in the literature showing that Streptococcus uberis is the main cause of mastitis in the early part of the lactation season and that penicillin is the drug of choice for such infections. Later in the season, Staphylococcus aureus and other pathogens become more important. Penicillin alone is not effective against many strains of S. aureus because it is inactivated by the beta

lactamase enzymes these strains produce. Cloxacillin is resistant to the action of beta lactamases and so is effective against all strains of S. aureus, as well as streptococci and Trueperella pyogenes.

INDICATION:

Treatment of mastitis infections in lactating cows.

Nitroclox™ LA is an intramammary formulation containing 200mg cloxacillin in a long-acting base. Available in boxes of 21 single-dose syringes.

• Flexible treatment options - 24 or 48 hourly treatment intervals, TAD, OAD

• Registered extended therapy claim of 3 to 6 tubes given 24 hours apart





www.virbac.co.nz

NitrocloxTM LA

25

Combat Nitromec® InjectionTriple active broad spectrum anthelmintic fl ukicidal injection for cattle.

It’s easy to see the benefi ts of using Combat Nitromec® Injection, the world’s fi rst triple active broad spectrum anthelmintic fl ukicidal injection for cattle that treats all three stages of liver fl uke infection.

• The only injectable that treats all three stages of liver fl uke with superior control of early immature liver fl uke.

• Proven superiority over pour-on fl ukicides.

• Potent 3-in-1 combination of Nitroxynil, Clorsulon & Ivermectin.

MODE OF ACTION: Nitroxynil is a halogenated phenol with activity against adult stages of liver fluke and some parasitic nematodes by uncoupling of oxidative phosphorylation and changes in the permeability of fluke muscle membranes. Clorsulon is a benzenesulphonamide that is believed to inhibit glycolysis in fluke leading to starvation and death. Ivermectin has its lethal effect on invertebrates through its action upon muscle glutamate gated chloride channels causing irreversible chloride-dependent depolarisation. Somatic and pharyngeal muscles become paralysed leading to death of the parasites.

INDICATIONS:For the treatment and control of the following Ivermectin sensitive internal and external parasites of Cattle:

Gastro-intestinal roundworms: For the control of adult and immature:• Ostertagia ostertagi – Small brown stomach worms

(including third and fourth stage larvae and inhibited immatures)

• Haemonchus spp. – Barber’s pole worm• Trichostrongylus axei – Stomach hair work (including third

and fourth stage larvae)• Trichostrongylus colubriformis – Intestinal hair worm

• Cooperia spp – Small intestinal worm (including third and fourth stage larvae)

• Oesophagostomum radiatum – Nodule worm (including third and fourth stage larvae)

• Bunostomum phlebotomum – (including third and fourth stage larvae)

And adult stages of:• Trichuris spp. – Whipworm• Strongyloides papillosus – Intestinal worm

Lungworms: • adult and immature including inhibited stages of

Dictyocaulus viviparus

Sucking Lice: • Linognathus vituli – Long nosed sucking louse• Haematopinus eurysternus – Short nosed sucking louse• Solenopotes capillatus – Little blue sucking louse

And also aids in control of:Biting Lice: Bovicola (Damalinia) bovis

For the treatment and control of:

Early Immature (including 2-week old), Immature and Adult Liver Fluke: Fasciola hepatica

WARNING:Do not use on lactating cows or pregnant cattle that may in the future produce milk for human consumption.

WITHHOLDING PERIOD:

MEAT: Animals producing meat and offal for human consumption must not be sold for slaughter either during treatment or within 56 days of the last treatment. Calves born to cows treated with Combat Nitromec® during pregnancy must not be slaughtered from human consumption within 56 days of calving. Where intramuscular injection may have occurred, animals producing meat and offal for human consumption must not be slaughtered within 91 days of the last treatment.

MILK: Do not use on lactating cows or pregnant cattle that may in the future produce milk for human consumption.

STORAGE: Store below 30°C. Store bottle in carton to protect from light. Store locked up. Keep out of reach of children.

Registered pursuant to the ACVM Act 1997, No. A10223. See www.foodsafety.govt.nz for registration conditions.




Nitromec® Injection

26


Ovastim®

An easy to use PAR that increases the eggs available in a ewe for fertilisation by the ram, increasing fecundity and encouraging twinning. Contains polyandroalbumin as the active ingredient.

Ovastim® is a vaccine used to increase the fecundity in breeding ewes.

• Proven by New Zealand and Australian trials

• Can be used at the same time as Campylovexin®

• Up to 24 months between booster vaccinations

INDICATIONS:Ovastim® is a conjugated sterate, which will increase the ovulation rate in prime lamb producing ewes and consequently will increase the number of lambs born. Ovastim® is not recommended for Merino ewes. Encouraging multiple births in Merino flocks is not good farming practice. Ewes in poor condition, due to inadequate nutrition or disease such as parasitic disease, may not respond.It is essential that the flock be managed as a twin bearing flock. Adequate nutrition, shelter and supervision must be provided to ensure maximum survival. Above average Increase in body weight of ewes is an indicator of potential twins. These ewes should be drafted from the main mob and managed as for twin births and survival. Ovastim® is suited to high yielding lamb production systems and rapid breeding of replacement stock.

WHEN DO I USE OVASTIM®?Flexibility the key for Farmer use! Ovastim® recommended treatment protocol.

PRIMARY COURSE• 2 injections required• 1st dose : 2ml dose given 6-9 weeks before mating

(sensitiser)• 2nd dose: 2ml dose given 3-4 weeks before mating (booster)

Note:1. There must be at least 3 weeks between the sensitiser and

booster2. There must be at least 3 weeks between the booster and

ram joining3. There is some flexibility regarding the period between

sensitiser and booster (3-6 weeks is acceptable).

ANNUAL BOOSTERPreviously treated ewes should be given one 2ml dose 3-4 weeks before mating. A single booster vaccination administered up to 24 months (2 years) after previous vaccination has been demonstrated by trial work, to result in an increase in fecundity.

PRIMARY COURSE

1ST DOSE

9 WEEKS 6 WEEKS 3 WEEKS INTRODUCE RAMS

2ND DOSE

DESCRIPTION:Ovastim® is a sterile, clear & colourless solution containing Polyandroalbumin 600mg/L. For subcutaneous injection, available in 100 mL (50 dose) glass multidose vials and a 1L Flexipack (500 doses).

MODE OF ACTION:Ovastim causes a specific androstenedione antibody response, which increases ovulation. Ovulation rate is the most important determinant in the number of lambs born. The increase in lambs is primarily through an increase in the number of twin births. Ovastim® produces a natural response and does not adversely affect the survival rate or growth rate of lambs.


MEAT AND MILK: Nil

DOSAGE:Not for use in rams. Not recommended for merino ewes. Administer by subcutaneous injection only.

Registered pursuant to the ACVM Act 1997, Nos A8081, A4130. See www.foodsafety.govt.nz for registration conditions. Only available under Veterinary Authorisation.



www.virbac.co.nz

Ovastim®


Ovastim®

Ovastim® trial support• Consistent results support Ovastim® use• Over 50 farms (including both research and commercial farms)• Trials conducted in New Zealand and Australia involving thousands of sheep• Representative breeds of sheep and farm management systems used.

Ovastim® - New Zealand trial summary

Number of farms Average increase in ovulation rate

Average increase in lambing rate*

Average increase in weaning rate**

28 63% 29% 27%

* Lambing rate defined as number of lambs born per ewe joined. ** Weaning rate defined as number of lambs weaned per ewe joined. All trials were conducted using a 6 week mating period.

New Zealand Trials:Ovastim® has been proven under New Zealand conditions to successfully “booster” the immune response to androstenedione previously sensitised by other commercially available androstenedione vaccines.

Study Objective:To conduct a field trial to assess the potency of Ovastim® and another commercially available androstenedione-protein complex and to compare results from treated ewes with results from untreated control ewes.

Conclusions:Ovastim® effectively boosters the immune response previously sensitised by other commercially available androstenedione vaccines. Treatment with both Ovastim® and the commercially available androstenedione vaccine results in an increase in the titres of androstenedione antibody and the number of lambs produced per ewe when compared to control (untreated) ewes.

$1.50 per lamb dose Extra lamb income at:

Number of ewes Ovastim® investment Extra lambs At $50 At $60 At $80 At $100

1000 $ 1500 290 $14500 $ 17400 $ 23200 $ 29000

2000 $ 3000 580 $ 2900 $ 34800 $ 46400 $ 58000

3000 $ 4500 870 $ 43500 $ 52200 $ 69600 $ 87000

4000 $ 6000 1160 $ 58000 $ 69600 $ 92800 $ 116000

5000 $ 7500 1450 $ 72500 $ 87000 $ 116000 $ 145000

Return on Investment 867% 1060% 1447% 1833%

Androvax® is a registered trademark of Schering-Plough Intervet.

Control Androvax® Ovastim®

Scanning results1.95

1.9

1.85

1.8

1.75

1.7

1.65

1.6

1.55

Num

ber o

f lam

bs p

er

ewe

scan

ned

Return on Investment: Estimation based on 29% lamb percentage increase - New Zealand trials average increase in lambing percentage.

28

Ovipen®


Administer 1mL/10kg b.w, in the anterior half of the neck (close to the head), by i/m or s/c injection.


MILK: 35 days after last treatment.

MEAT: 30 days.

CONTRAINDICATIONS:

Not to be used in animals with a known history of sensitivity to products containing penicillin or its analogues. Not to be used for the treatment of infections caused by organisms known to be resistant to penicillin.



OTHER INFORMATION:






MODE OF ACTION:

Procaine penicillin is a moderately soluble drug that provides a therapeutic effect from a single injection for up to 24 hours. Benzathine penicillin gives this product a long-acting effect for sustained treatment of difficult, penicillin-sensitive infections or continued therapy where daily injection is not practical. Offers prolonged protection when used as a preventative treatment in the absence of clinical symptoms. Penicillin inhibits cell wall synthesis in susceptible bacteria.

INDICATION:

Long-acting treatment of infections in sheep caused by organisms that are susceptible to treatment with penicillin.

A sterile, aqueous suspension of 150,000i.u./mL procaine penicillin G and 150,000i.u./mL benzathine penicillin G. Manufactured in New Zealand and available in 100mL pillow packs.

• Ovine species-specifi c injectable LA penicillin

• High dose of 1mL/10kg





www.virbac.co.nz

Ovipen®

29

Oxyfoam ForteFoaming pessary for therapy and/or prophylaxis of puerperal genital infections in cows. For use in the treatment of abortion, retained placenta, endometritis, and pyometritis, when oxytetracycline sensitive organisms are present.

Infection prevention.

• Superior Foaming Action

• Broad Spectrum

• Practical Waterproof Packaging

ACTION:The broad-spectrum antibiotic oxytetracycline is effective in the treatment and prevention of puerperal infections, because it has a pronounced effect on a wide range of Gram-positive and Gram-negative bacteria.

On contact of the tablet with the uterine fluids, at least 2 litres of carbon dioxide foam is produced, which spreads the antibiotic throughout the uterine cavity, and ensures intimate contact with the entire endometrium.

INDICATIONS:For therapy and/or prophylaxis of puerperal genital infections in cows. For use in the treatment of abortion, retained placenta, endometritis, and pyometritis, when oxytetracycline sensitive organisms are present. An adjunct in treatment of prolapse of the uterus and/or vagina and complicated parturition: when these conditions may include or predispose to infection.

Oxyfoam pessaries have superior foaming characteristics from a competitor 1g oxytetracycline pessary with which it was compared. It could be extrapolated that this could mean that intrauterine dispersion of oxytetracycline would be superior for Oxyfoam compared with its competitor product. It would also take a smaller volume of water to disperse the Oxyfoam pessary in a dry uterus.

PRECAUTIONS:

Resistance may develop to any chemical. Ask your local veterinarian or animal health advisor for recommended parasite management practices for your area to reduce the development of resistance.

WITHOLDING PERIODS: MILK: 96 hoursMEAT: 7 days

DOSAGEDo not insert the desiccant tablet with the pessary (only the pessary is required).

Cow: Prophylaxis : 1 pessary

Therapy : 1 - 2 pessaries

Dosage may be repeated at the discretion of the veterinarian at intervals of 24 - 48 hours.





Oxyfoam Forte

30

PenCloxTM 1200High Potency Milking CowPenClox™ 1200

CONTRAINDICATIONS:

Bobby calves: milk from treated cows should not be fed to bobby calves during the treatment or with-holding period.

FIRST AID:

The main health hazard from this material is the risk of sensitisation through continuous or repeated exposure. Sensitisation can lead to allergic reactions, ranging from a skin rash to anaphylactic shock (which may be fatal). Any person showing signs of sensitisation to Penicillin should be excluded from any situation where contact with this product may occur.





The entire contents of one syringe should be infused into the teat canal of each infected quarter immediately following milking. Repeat the treatment twice more at 24-hour intervals. Three syringes provide a full course of treatment.

Milk out the infected quarter. Clean teat thoroughly and wipe with cotton wool soaked in methylated spirits. Allow to dry. Insert the tip partly into the udder. Dip or spray teat with a recognised teat antiseptic.

WITHHOLDING PERIODS:It is an offence for users of this product to cause residues exceeding the relevant MRL in the New Zealand (Maximum Residues Limits of Agricultural Compounds) Food Standards.

MILK: When milking twice a day:

For 3, 4, 5, or 6 treatments given 24 hours apart: Milk intended for sale for human consumption must be discarded during treatment and for not less than 9 milkings or approximately 108 hours following the last treatment.

When milking once a day: For 3 treatments given 24 hours apart: Milk intended for sale for human consumption must be discarded during treatment and for not less than 5 once-a-day milkings or approximately 120 hours following the last treatment.

MEAT: Animals producing meat or offal for human consumption must not be sold for slaughter either during or within 10 days of cessation of the last treatment.

PenClox™ 1200 is indicated for the treatment of mastitis in lactating dairy cows, especially in cases caused by streptococci or penicillin-resistant staphylococci.

• Dual combination of 1gm Penicillin & 200mg Cloxacillin

• Above MIC90 of Streptococcus spp., Staph. aureus & CNS for duration of treatment

• Patented Formulation





www.virbac.co.nz

PenCloxTM 1200 High Potency Milking Cow is indicated for the treatment of mastitis in lactating dairy cows, especially in cases caused by Streptococci or penicillin-resistant Staphylococci.

• Dual combination of 1gm Pencillin & 200mg Cloxacillin• Above MIC90 of Streptococcus spp., Staph. aureus & CNS for duration

of treatment• Patented formulation• New Zealand trial work

31


Phenax® ClassicFor the vaccination of sheep and goats against contagious pustular dermatitis (scabby mouth or orf). Presented in a 150-dose applicator with easy-fl ow application needles and twist top.

Trusted, Reliable, Market Proven.

• New Zealand Strain

• New Zealand Manufactured

• Simple Eff ective Vaccine Applicator Included

INDICATIONS:For the vaccination of sheep and goats against contagious pustular dermatitis (scabby mouth or orf).

MODE OF ACTION:Virus antigen stimulates immunity to contagious pustular dermatitis (scabby mouth) in sheep and goats.

SPECIAL PRECAUTIONS:Care should be taken because Phenax® is a live virus vaccine that can be transmitted to and infect humans. Care should be taken to avoid contact with the vaccine, especially to cuts, scratches or abrasions. In the event of contact, wash the affected area with clean soapy water and treat with a disinfectant. In the event of infection, seek the advice of your local medical practitioner.

DESCRIPTION:

A live virus vaccine of contagious pustular dermatitis (scabby mouth or orf) virus. Presented in a 150-dose applicator with easy-flow application needles and twist top.

CONTRAINDICATIONS: Contains infectious orf virus so vaccination should not by carried out on properties that have no history of the disease.


MEAT AND MILK: Nil

DOSAGE:Deposit a droplet of vaccine on the inside of the thigh. Make two scratches about 25mm in length forming an “X” through the droplet. The skin must be broken, but do not scratch so heavily that blood washes the vaccine away. The blue-coloured vaccine should be visible along the scratches. A successful response to the vaccine will be indicated by a skin reaction (whitish thickened or raised area over the scratch mark with reddening of the surrounding peripheral tissue) that will be seen one week after administration. For full details refer to package insert.

Registered pursuant to the ACVM Act 1997 No. A6422. See www.foodsafety.govt.nz for registration conditions. Only available under Veterinary Authorisation.



www.virbac.co.nz

Phenax® Classic

Continued over page... 32

Phenax® ClassicUnscrew the cap and remove the tamper-proof seal using the tool at the end of the cap. Invert and tap the applicator to allow a droplet of vaccine to fall onto the vaccination site. Generally this is the inner thigh region of the animal. Make

two (2) scratches (Approx. 25mm) forming an “X” through the droplet. The skin must be broken, but do not scratch so heavily that blood washes the vaccine away. The blue coloured vaccine should be visible along the scratches.

Vaccinated animals can be returned to conventional pasture conditions. It is advisable to avoid grazing animals on pastures where heavy growth of thistle, gorse or other rough

fodder is available for up to 25 days following vaccination. Vaccinated animals seldom contract overt scabby mouth and re-vaccination is not necessary

Vaccination will induce the formation of a macropapullar lesion at the vaccination site. The lesion typically appears as a whitish thickened or raised area about the skin over the scratch mark, often up to 2-5mm across with accompanying reddening to the surrounding periphery approximately 5-8 days after vaccination. Examine a minimum of 20 animals to evaluate the vaccination process. Any animals that have not had “takes” of their vaccination should be revaccinated and examined after a further 8 days.

Phenax® Classic Scabby Mouth Vaccine is potent and is thoroughly tested before distribution.Failure to produce “takes” in vaccinated animals may be due to poor vaccination technique, pre-existing immunity in the vaccinated animals, or vaccine used outside the expiry date for the batch.

Occasionally the applicator may become blocked with sheep wool. To clear pull wire gently (preferably with pliers) until it stops and re-insert.

Note: Care is to be taken not to have contact with the vaccine.

Unscrew cap and remove tamper-proof seal with the

tool in the cap

Invert and tap the applicator to allow a droplet of vaccine to fall

onto the vaccination site

Mark thighs with two scratches in an X formation through

the droplet

Note: Vaccine must make contact with the scratches for the induction of a “take”

Directions for use

Post-vaccination care

Evaluation

Cleaning

Successful take Raised area of skin whitish in colour

Unsuccessful takeThin brown line of healing scratch

33


Revive and Diarrest

Diarrhoeic animals will die if they lose up to 15% of their body fl uid. Help your calves recover from scours in a matter of hours with Revive and Diarrest.

DIARREST: The only electrolytes proven treatments to provide earlier and sustained correction of the energy and fl uid replacement needs for rapid recovery from diarrhoea thanks to a balanced formulation of superior energy and electrolyte sources.

• Provides broad action for complex diarrhoeas

• Recovery period is shortened

• Can mix with milk or water without interfering with the clotting of milk (casein) proteins.

REVIVE POWDER:Supportive treatment for mild diarrhoea (scours) in calves, lambs & foals. To replace electrolytes, reverse dehydration, supplement energy needs and correct acidosis.

The only electrolyte proven treatments to provide earlier and sustained correction of the energy and fl uid replacement needs for rapid recovery from diarrhoea thanks to a balanced formulation of superior energy and electrolyte sources.

• Patented Ratio of superior energy sources dextrose and lactose combined with electrolytes

• Bicarbonate and bicarbonate precursors


REVIVE SYRUP:Supportive treatment for mild diarrhoea (scours) in calves, lambs & foals. To replace electrolytes, reverse dehydration, supplement energy needs and correct acidosis.

The only electrolyte proven treatments to provide earlier and sustained correction of the energy and fl uid replacement needs for rapid recovery from diarrhoea thanks to a balanced formulation of superior energy and electrolyte sources.

• Patented Ratio of superior energy sources dextrose and lactose combined with electrolytes

• Bicarbonate and bicarbonate precursors


DESCRIPTION:Revive Syrup: A straw-coloured viscous liquid containing the active ingredients per 250mL.

Revive Powder: An off-white powder containing the active ingredients per 2 litre dose.

Diarrest Powder: An off-white powder containing the active ingredients per 2 litre dose.

MODE OF ACTION: Revive: Formulated to replace electrolytes, reverse dehydration, supplement energy needs and correct acidosis.

Diarrest: Formulated to provide full maintenance energy requirements, replace electrolytes reverse dehydration and correct acidosis.

WITHHOLDING PERIODS: MEAT AND MILK: Nil.

No Antibiotic.

INDICATIONS:

Revive: The result is a supportive treatment for diarrhoea (scours) in calves, lambs and foals.

Diarrest: The result is a supportive treatment for diarrhoea (scours) in calves.

Registered pursuant to the ACVM Act 1997, Nos. A7259, A7296 & A7413. See www.foodsafety.govt.nz for registration conditions.



www.virbac.co.nz

DiarrestTM & Revive


Oral Replacement Therapies (ORT) – comparison

Provided by2 x 2L

Energy (1300-1500 kcal)

Osmolarity(<700mlOsm/L is acceptable)

Vytrate 324 332

Lectade Plus 456 302

Revive 780 430

Revive Syrup 805 400

Diarrest 1644 430

Serum sodium changes140

138

136

134

132

130

Conc

. (m

mol

/L)

Days of treatment

Diarrest ControlRevive

Day 3 Day 2Day 1Day 0Pre-infection

Revive and DiarrestTrialsStudy 1: Assessing carbohydrate digestibilityBased on the production of Hydrogen from residual carbohydrates by gut microflora. Hydrogen is mainly eliminated via dissolution in the blood, then expired across alveoli. By feeding a standard dose of carbohydrate and measuring breath hydrogen over several hours it is possible to estimate the efficiency of utilisation. This is a sensitive test, widely used in human studies.

Lactulose is undigestable and used as a benchmark for comparison.

Study 2: Assessing sugars for digestibility in calvesStudies at AHSC, Massey comparing monosaccharide, disaccharide, & combinations. The results demonstrate that the ratio of the disaccharide lactose and monosaccharide glucose are optimal in Revive and Diarrest for complete utilisation of the sugar content and is superior to a monosaccharide only ORT. Even a relatively small increase in the amount of lactose markedly increases breath hydrogen indicating incomplete digestion of carbohydrates.

Study 3: Induced diarrhoea in calvesThis was a project run for Virbac NZ at AHSC, Massey. Calves had diarrhoea due to infection with E. coli K99, plus rotavirus and a range of biochemical parameters were measured, including plasma volume, ECF, Na+, blood glucose, HCO3. Compared to a control electrolyte product Diarrest and Revive provided:1. Earlier, more sustained correction of hypoglycaemia2. Best serum sodium recovery3. Superior restoration of ECF4. Rapid correction of acidosis5. Best weight maintenance/gain

Breath hydrogen in calves following oral carbohydrates

60

50

40

30

20

10

01 2 3 4 5 6 7

Brea

th H

ydro

gen

(ppm

)

Time after ingestion (h)

150g Rice Flour

135g Lactulose

150g Maize Flour

135g Glucose

Breath hydrogen in calves following oral carbohydrates

20

15

10

5

0

-5

-10Vari

atio

n fr

om T

=0 (p

pm)

Hours following treatment

60g Glucose (eg Lectade Plus)

40g Glucose & 50g Lactose

40g Glucose & 70g Lactose

1.25g Lactose/kg bwt

1 2 3 4 5 6

35

SMARTShot B12 + Se


Shake well before and during use to ensure the product is fully re-suspended. Administer only with the SmartShot injector, by s/c or i/m injection into the anterior half of the neck. Sterilise all injection apparatus before use. Needles should be changed frequently and as necessary. Avoid simultaneous use of other selenium-containing products

LAMBS AT DOCKING: 0.5mL for lambs that are to be fattened for slaughter. 1mL for lambs that are to be kept as ewe replacements.

LAMBS AT WEANING: 2mL.

EWES: 5mL.

CALVES: 1mL/25kg l.w. .

PERSISTENT ACTIVITY: LAMBS FOR SLAUGHTER: Following injection of lambs with 0.5mL from 3 weeks of age (at docking time), vitamin B12 and selenium levels will be maintained at adequate concentrations for 3-4 months until time of slaughter.

LAMBS AS EWE REPLACEMENTS: Following injection of lambs with 1mL from 3 weeks of age (at docking time), vitamin B12 and selenium levels will be maintained at adequate concentrations for 180 days, and in some cases the effect may last for 200–240 days for vitamin B12 and 300 days for selenium. However, users are advised to consult their veterinarian before assuming adequacy beyond 180 days.

EWES: Following the pre-mating injection of ewes, vitamin B12 and selenium levels will be maintained at adequate concentrations for 180 days, and in some cases the effect may be for 200–240 days (especially for selenium). However, users are advised to consult their veterinarian before assuming adequacy beyond 180 days. Adequate levels will be maintained in the offspring until 1 month of age for vitamin B12 and from birth to weaning for selenium.

CALVES: Following injection of calves from 3 weeks of age, serum vitamin B12 levels will be maintained at concentrations ensuring adequacy for up to 3½ months and selenium levels for at least 10 months.

MODE OF ACTION:

The gradual dissolution of the encapsulating polymer produces a steady, prolonged release of vitamin B12, which is necessary for optimal energy and protein metabolism in ruminants. The extended release of selenium assists in maintaining the integrity of cell membranes, the functioning of the immune system and healthy thyroid activity.

INDICATION:

Long term prevention and treatment of cobalt (vitamin B12) and selenium deficiencies in sheep and cattle, especially when grazing cobalt and selenium deficient pastures. Cobalt

deficiency in soil or pasture leads to low vitamin B12 in body tissues. Vitamin B12 is an essential cofactor for energy and protein metabolism in ruminants and a deficiency may cause anorexia leading to ill thrift, starvation and poor growth, particularly in young animals. Selenium is an essential trace element that influences the responsiveness of the immune system and maintains the integrity of cell membranes through the action of the antioxidant selenoenzyme, glutathione peroxidase. A deficiency can cause white muscle disease (myopathy), limits the growth of young animals and reduces fertility in ewes and cows.

An oily suspension, containing 12mg/mL selenium as barium selenate and 3mg/mL hydroxocobalamin hydrochloride encapsulated in a lactide/glycolide co-polymer for extended release. Available in 500mL pillow packs.

• Flexible treatment options - tailor dose to suit length of effi cacy required in lambs

• Veterinary world-fi rst patented microencapsulation technology

• Long-acting Vitamin B12 & Selenium injection





www.virbac.co.nz

SMARTShot® B12 + Se


SMARTShot B12 + SeWITHHOLDING TIMES:

MILK: NIL.

MEAT: NIL.

CONTRAINDICATIONS:

Not to be administered to lambs or calves younger than 3 weeks of age.


Avoid simultaneous use of other selenium-containing products. Before use, veterinary advice should be sought to establish pasture cobalt and selenium levels, and blood and liver levels of vitamin B12 in the animals, to ensure that other causes of ill thrift are not overlooked. Veterinary advice should also be obtained on the selenium status of the animals and on the risks associated with other routine treatments such as dosing with anthelmintics that may contain selenium. Do not handle until all safety precautions have been read and understood. Avoid direct contact. If contact does occur, seek medical attention/advice. When handling, wear chemical-resistant gloves.

TOXICITY/OVERDOSE/ANTIDOTE:

Barium selenate is suspected of causing genetic defects in humans. It is ecotoxic in the aquatic and soil environments. This material is dangerous if swallowed, inhaled or absorbed through the skin.

HUMAN FIRST AID, SYMPTOMS OF POISONING:

Refer to the Material Safety Data Sheet included in each carton.

OTHER INFORMATION

Store upright in a cool place, preferably refrigerated. Do not freeze. Protect from light.


Registered to: AgResearch Ltd.





www.virbac.co.nz

37

SMARTShot® B12 Prime Lamb


Shake well before and during use to ensure the product is fully re-suspended. Administer only with the SMARTShot® injector, by s/c or i/m injection into the anterior half of the neck. Sterilise all injection apparatus before use. Needles should be changed frequently and as necessary.

LAMBS that are to be fattened for slaughter: 0.5mL administered at docking.

LAMBS that are to be kept as ewe replacements: 1mL administered at docking or weaning.

EWES: 5mL.

CALVES: 1mL /25kg l.w.

PERSISTENT ACTIVITY: LAMBS for slaughter: Following injection with 0.5mL from 3 weeks of age (docking time), vitamin B12 levels will be maintained at adequate concentrations for 3–4 months until time of slaughter.

LAMBS as ewe replacements: Following injection with 1mL from 3 weeks of age (at docking or weaning), vitamin B12 levels will be maintained at adequate concentrations for 180 days and in some cases the effect may last for 200–240 days. However, users are advised to consult their veterinarian before assuming adequacy beyond 180 days.

EWES: Following injection with 5mL pre-mating, vitamin B12

levels will be maintained at adequate concentrations for 180 days and in some cases the effect may last for 200–240 days. However, users are advised to consult their veterinarian before assuming adequacy beyond 180 days. Adequate vitamin B12 levels will be maintained in the offspring until 1 month of age.

CALVES: Following injection with 1mL/25kg l.w. from 3 weeks of age, serum vitamin B12 levels will be maintained at concentrations ensuring adequacy for up to 3½ months.



Registered to: AgResearch Ltd.


MODE OF ACTION:

The gradual dissolution of the encapsulating polymer produces a steady, prolonged release of vitamin B12, which is necessary for optimal energy and protein metabolism in ruminants.

INDICATION:

For long term prevention and treatment of cobalt (vitamin B12) deficiency in lambs, ewes and calves, especially when grazing cobalt-deficient pastures. Cobalt deficiency in soil or pasture leads to low vitamin B12 in body tissues. Vitamin B12 is an essential cofactor for energy and protein metabolism in ruminants and a deficiency may cause anorexia leading to ill thrift, starvation and poor growth, particularly in young animals.


MILK: NIL.

MEAT: NIL.

CONTRAINDICATIONS:

Not to be administered to lambs younger than 3 weeks of age.


Before use, veterinary advice should be sought to establish pasture cobalt levels and blood and liver levels of vitamin B12 in the animals, to ensure that other causes of ill thrift are not overlooked.

An oily suspension specifi cally formulated for treating lambs, but also suitable for ewes and calves, containing 3mg/mL hydroxocobalamin hydrochloride encapsulated in a lactide/glycolide co-polymer for extended release. Available in 500mL pillow packs.

• Flexible treatment options - tailor dose to suit length of effi cacy required in lambs

• Veterinary world-fi rst patented microencapsulation technology

• Long-acting Vitamin B12 injection





www.virbac.co.nz

SMARTShot® B12 Prime Lamb

38

Tetraguard® LA


By s/c or i/m injection at the rate of 20mg/kg b.w, ie. 1mL/10kg l.w. For doses over 10mL, it is desirable to split the total dose between several injection sites.


MILK: 168 hours (14 milkings).

MEAT: 28 days.

CONTRAINDICATIONS:

Do not use in horses, dogs or cats. Do not use in animals with a known history of allergic reactions to tetracyclines or with impaired liver function.

SIDE EFFECTS:

Transient reactions may occur at the injection site. Anaphylactic reactions have been reported rarely in calves following tetracycline injections. Prompt treatment with antihistamines is indicated.

OTHER INFORMATION:

Protect from direct sunlight. Store in a cool place.




MODE OF ACTION:

Oxytetracyclines are bacteriostatic compounds (bactericidal at high concentrations), which inhibit protein synthesis in the target organisms.

INDICATION:

Parenteral treatment of bacterial infections in cattle, sheep and pigs. Especially useful in the treatment of respiratory, arthritic, reproductive, enteric and inflammatory diseases.

An aqueous ready to use injectable solution containing 200mg/mL of oxytetracycline, as the long-acting magnesium complex. Presented in amber glass 100mL and 250mL multi-dose vials.

• Convenient 100mL & 250mL pack sizes

• One of only 2 registered tetracycline injections with s/c administration claim

• Made in New Zealand




www.virbac.co.nz

Tetraguard® LA

39





• Rain fast














50 2.5 2000

100 5 1000

150 7.5 666

200 10 500

250 12.5 400

300 15 333

350 17.5 285

400 20 250

450 22.5 222

500 25 200

550 27.5 181

600 30 166

650 32.5 153




TopLine

40

Tyloguard®


Administer by i/m injection in the anterior half of the neck. In cattle, the SLOW i/v route may be used.

CATTLE and CALVES: 5–10mg/kg b.w. (2.5–5mL/100kg) daily for no more than 5 days. If the i/v route is used initially, maintain therapeutic levels by administering an i/m dose 12 hours later. For difficult cases of mastitis, treatment may be combined with a course of the intramammary, Mastiguard Milking Cow. For details, see leaflet provided with the product.

PIGS: 5–10mg/kg b.w. (2.5–5mL/100kg) daily for no more than 3 days.

SHEEP and GOATS: 10mg/kg b.w. (2.5mL/50kg) daily for no more than 5 days.


MILK: Bovine milk 72 hours (6 milkings).

Sheep and goat milk 35 days.

3 x Tyloguard + 3 x Mastiguard - 72 hours (6 milkings) following the last treatment



MEAT: 21 days after last treatment.

SIDE EFFECTS:

As with any injectable, a reaction may occur in some animals, eg. pain and swelling at the injection site. On rare occasions, there may be oedema and protrusion of the rectal mucosa and erythema in pigs and cattle. However, these reactions resolve when treatment is discontinued.

OTHER INFORMATION:

Protect from direct sunlight. Store below 30°C.




MODE OF ACTION:

Tylosin is a member of the macrolide group of antibiotics. It is active against the most common mastitis pathogens isolated from cases of bovine mastitis in New Zealand. Due to the ‘pH trap’ phenomenon Tylosin will selectively accumulate in areas of low pH, as for example occurs in inflamed udder tissue.

INDICATION:

Treatment of bacterial and mycoplasmal infections caused by tylosin-sensitive organisms in cattle, sheep, pigs and goats, eg. mastitis, respiratory infections, footrot, metritis, dysentery, erysipelas, etc.

A sterile ready to use injectable solution containing 200mg/mL tylosin base. Manufactured in New Zealand. Available in 75mL and 200mL pillow packs.

• Dose-specifi c 75mL pack and larger 200mL available

• Tylosin base as active

• Registered by i/v route and milk withholding for combination therapy with Mastiguard® MC

• Convenient Plastic Pillow packs





www.virbac.co.nz

Tyloguard® RTU Injection

41

Tyloguard®


Administer by i/m injection in the anterior half of the neck. In cattle, the SLOW i/v route may be used.

CATTLE and CALVES: 5–10mg/kg b.w. (2.5–5mL/100kg) daily for no more than 5 days. If the i/v route is used initially, maintain therapeutic levels by administering an i/m dose 12 hours later. For difficult cases of mastitis, treatment may be combined with a course of the intramammary, Mastiguard Milking Cow. For details, see leaflet provided with the product.

PIGS: 5–10mg/kg b.w. (2.5–5mL/100kg) daily for no more than 3 days.

SHEEP and GOATS: 10mg/kg b.w. (2.5mL/50kg) daily for no more than 5 days.


MILK: Bovine milk 72 hours (6 milkings).

Sheep and goat milk 35 days.




MEAT: 21 days after last treatment.

SIDE EFFECTS:

As with any injectable, a reaction may occur in some animals, eg. pain and swelling at the injection site. On rare occasions, there may be oedema and protrusion of the rectal mucosa and erythema in pigs and cattle. However, these reactions resolve when treatment is discontinued.

OTHER INFORMATION:

Protect from direct sunlight. Store below 30°C.




MODE OF ACTION:

Tylosin is a member of the macrolide group of antibiotics. It is active against the most common mastitis pathogens isolated from cases of bovine mastitis in New Zealand. Due to the ‘pH trap’ phenomenon Tylosin will selectively accumulate in areas of low pH, as for example occurs in inflamed udder tissue.

INDICATION:

Treatment of bacterial and mycoplasmal infections caused by tylosin-sensitive organisms in cattle, sheep, pigs and goats, eg. mastitis, respiratory infections, footrot, metritis, dysentery, erysipelas, etc.

A sterile ready to use injectable solution containing 200mg/mL tylosin base. Manufactured in New Zealand. Available in 75mL and 200mL pillow packs.

• Dose-specifi c 75mL pack and larger 200mL available

• Tylosin base as active

• Registered by i/v route and milk withholding for combination therapy with Mastiguard® MC






www.virbac.co.nz

Vibrostrep®


By i/m or s/c injection. In animals producing food, injection must be in the anterior half of the neck.

COWS for BOVINE VIBRIOSIS (campylobacteriosis): Infuse 2–10mL into the uterus and inject 3–4mL/100kg b.w. by i/m or s/c injection, daily for 3 days.

BULLS for BOVINE VIBRIOSIS (campylobacteriosis): Infuse 2–10mL into the preputial cavity, massaging in, and give 3–4mL/100kg b.w. by i/m or s/c injection, daily for 3 days.

PIGS, SHEEP and CATTLE: For the treatment of vibriosis (campylobacteriosis), leptospirosis, actinobacillosis (woody tongue) and other infections caused by organisms susceptible to streptomycin and dihydrostreptomycin, inject 3–4mL/100kg b.w. once daily, for 3 days by i/m or s/c injection. Daily administration of 5,000,000 units of penicillin may improve the effectiveness of treatment. Lower doses may lead to a build-up of resistant bacteria. Higher doses may be used at the discretion of a veterinarian.


MILK: 72 hours (6 milkings).

MEAT: 30 days.

CONTRAINDICATIONS:

Not for use in bobby calves. Not to be used for the treatment of infections caused by organisms that are known to be resistant to dihydrostreptomycin or streptomycin. Not recommended for use in animals with renal dysfunction or in those already being treated with aminoglycoside (-mycins) antibiotics.

OTHER INFORMATION:

Store in original container, tightly closed, away from foodstuffs. Keep out of reach of children.




MODE OF ACTION:

Dihydrostreptomycin and streptomycin interfere with protein synthesis in susceptible strains of bacteria. The slight differences in structure between the two drugs allow some bacteria to be resistant to one drug but not the other.

INDICATION:

Treatment of vibriosis (campylobacteriosis), leptospirosis, actinobacillosis and infections caused by organisms susceptible to dihydrostreptomycin and streptomycin in pigs, sheep and cattle.

A sterile, aqueous high potency solution containing 500,000i.u. streptomycin/mL (250mg dihydrostreptomycin, as sulphate) and 250mg streptomycin, as sulphate. Manufactured in New Zealand and available in 100mL pillow packs.

• First-choice antibiotic for Woody Tongue & Vibriosis

• Made in New Zealand





www.virbac.co.nz

Vibrostrep®

42

Keen to chat?Want more information?

• Contact your Virbac Area Sales Manager

• Call us on 0800 VIRBAC (847 222)

• Visit us at www.virbac.co.nz

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