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REMA significa Restructuracion de memorias atemporales

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Changing the brain structure is possible. Substancial changes in the brain modify behaviour and psychological wellbeing. High statistics in the positive results Es posible cambiar la estructura cerebral . Cambios sustanciales logrados a traves de la aplicacion de la neurociencia. Aplicacion posible en casos de criminalidad. (criminología)

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Page 1: Scientific presentation of REMA in 17ma Conferencia International Multidisciplinaria  sobre Neuroscience  y Psiquiatria Biologica,     ESTRES y CONDUCTA

REMA

significa Restructuracion de memorias

atemporales

Page 2: Scientific presentation of REMA in 17ma Conferencia International Multidisciplinaria  sobre Neuroscience  y Psiquiatria Biologica,     ESTRES y CONDUCTA

REMA

means Restructuring Atemporal

Memories

From the acronymic in Spanish

Page 3: Scientific presentation of REMA in 17ma Conferencia International Multidisciplinaria  sobre Neuroscience  y Psiquiatria Biologica,     ESTRES y CONDUCTA

Developed in

REHUBA (Research on Human Behaviour Applied)

Miembros cientificos intervinientes en el articulo: Ulises Diego (Ph.D., Imperial College, UK) Thalia Fernandez (Ph.D., Departmento de neurobiologia cognitiva y

conductual,  UNAM, México) 

Director: Alicia Quaini (Neuroplasticidad, Terapia e investigacion. USA)

Page 4: Scientific presentation of REMA in 17ma Conferencia International Multidisciplinaria  sobre Neuroscience  y Psiquiatria Biologica,     ESTRES y CONDUCTA

Developed in

REHUBA (Research on Human Behaviour Applied)

Scientific Members: Ulises Diego (Ph.D., Imperial College, UK) Thalia Fernandez (Ph.D., Department of Behavioral and Cognitive

Neurobiology,  UNAM, México) 

Director: Alicia Quaini (Neuroplasticity, Therapy and Research, USA)

Page 5: Scientific presentation of REMA in 17ma Conferencia International Multidisciplinaria  sobre Neuroscience  y Psiquiatria Biologica,     ESTRES y CONDUCTA

Esta presentacion fue originariamente preparada para el

17ma Conferencia International Multidisciplinaria sobre Neuroscience y

Psiquiatria Biologica, Con el tema central de:

ESTRES y CONDUCTA Organizado por

•Centro de investigacion en fisiologia y bioquimica • Sociedad Internacional de estres y conducta• Sociedad rusa de biopsiquiatria• Sociedad ucraniana de psiquiatria biologica• Instituto de Medicina Experimental

San Petersburgo, Rusia, 2012

Page 6: Scientific presentation of REMA in 17ma Conferencia International Multidisciplinaria  sobre Neuroscience  y Psiquiatria Biologica,     ESTRES y CONDUCTA

This presentation was prepared for the

17th Multidisciplinary International Conference on Neuroscience and

Biological Psychiatry, STRESS and BEHAVIOR

Organized by•Centre for Physiology and Biochemical Research •International Stress and Behavior Society•The Russian Society for BioPsychiatry,•Ukrainian Society for Biological Psychiatry•Institute of Experimental Medicine

Page 7: Scientific presentation of REMA in 17ma Conferencia International Multidisciplinaria  sobre Neuroscience  y Psiquiatria Biologica,     ESTRES y CONDUCTA

Very Special Thanks

University of Moron, Buenos Aires, Argentina. Proffessor Domingo Liotta, Dean for the Faculty of Medicine, University of

Moron, Buenos Aires, Argentina, Professor of Anatomy. Superior Investigator Conicet Clinical Research Career. For his unconditional and unvaluable support.

Proffessor Jorge Affanni, MD, Senior Researcher at CONICET, director of the Institute of Neuroscience of the Faculty of Medicine, University of Morón and former head of the UBA (University of Buenos Aires). For his unconditional support, enthusiasm and direct cooperation with the work.

National University of Mexico, UNAM. Proffessor Thalia Fernandez, Director of Doctoral Thesis at the Department

of Behavioral and Cognitive Neurobiology, for her active participation in the study.

Friends of the UNITED NATIONS Dr. Noel Brown and Irving Sarnoff , President, Co-president and founders,

for their invitation to be part of the global work towards peace, which contributed to the development of this technique.

And Dr. Arya, who became Swami Veda Bharati, from the Himalayan Tradition, for sharing his knowledge and giving me the opportunity to serve.

Page 8: Scientific presentation of REMA in 17ma Conferencia International Multidisciplinaria  sobre Neuroscience  y Psiquiatria Biologica,     ESTRES y CONDUCTA

Purpose of the study:To show the modifications in a. Personality typesb. Severe Typesc. Clinical symptomsd. Severe Clinical symptoms

With the application of REMA

STUDY

Page 9: Scientific presentation of REMA in 17ma Conferencia International Multidisciplinaria  sobre Neuroscience  y Psiquiatria Biologica,     ESTRES y CONDUCTA

Proposito del estudio:Ver modificaciones posibles en:a. Tipos de personalidadb. Tipos severosc. Sintomas clinicos d. Sintomas clinicos severos

Con la aplicacion de REMA

ESTUDIO

Page 10: Scientific presentation of REMA in 17ma Conferencia International Multidisciplinaria  sobre Neuroscience  y Psiquiatria Biologica,     ESTRES y CONDUCTA

The Technique, brief explanation

REMA es una tecnica novedosa desarrollada por el equipo de REHUBA

Sus bases son localizar y desligar emociones de impacto negativo, de memorias de diferentes tipos guardadas en el sistema individual (cerebro, cuerpo)

Llamamos a esas memorias atemporales y el proceso consiste en modificar y aparentemente re-archivar esas memorias de manera que ya no afecten.

Las memorias en si se manitenen intactas como tales, pero disociadas de su contenido emocional negativo.

Page 11: Scientific presentation of REMA in 17ma Conferencia International Multidisciplinaria  sobre Neuroscience  y Psiquiatria Biologica,     ESTRES y CONDUCTA

Este estudio fue hecho en humanos.Los resultados obtenidos con el

Multiaxial Clinic Millon Inventory III (MCMI-III™) test.

Fechas del estudio: 2011-2012

ESTUDIO

Page 12: Scientific presentation of REMA in 17ma Conferencia International Multidisciplinaria  sobre Neuroscience  y Psiquiatria Biologica,     ESTRES y CONDUCTA

This study was done in humans.Results are based on

Multiaxial Clinic Millon Inventory III (MCMI-III™) test.

Study Dates: 2011-2012

STUDY

Page 13: Scientific presentation of REMA in 17ma Conferencia International Multidisciplinaria  sobre Neuroscience  y Psiquiatria Biologica,     ESTRES y CONDUCTA

Subjects’ profile

Participantes: fueron personas con un rango de normalidad, con tendencia a trastornos de personalidad mediano en un 60%, mediano a severo en un 25% y 15% con diagnostico claro de trastorno.

Edades entre 30 y 53, nivel de educacion similar, viviendo una vida normal con conflictos estandard.

La seleccion del grupo control y del grupo REMA fue aleatoria.

Page 14: Scientific presentation of REMA in 17ma Conferencia International Multidisciplinaria  sobre Neuroscience  y Psiquiatria Biologica,     ESTRES y CONDUCTA

Subjects’ profile

Participants were people in a range of normality , with personality disorder tendencies, mild in a 60%, mild to severe in a 25% and 15% with clear PD diagnosis.

Ages between 30 and 53, similar cultural and educational level, living normal life with average conflicts.

The selection for the control group Vs the REMA group was aleatory.

Page 15: Scientific presentation of REMA in 17ma Conferencia International Multidisciplinaria  sobre Neuroscience  y Psiquiatria Biologica,     ESTRES y CONDUCTA

22 participants

11 submitted to REMA procedures

11 in control group (waiting list)

STUDY

Page 16: Scientific presentation of REMA in 17ma Conferencia International Multidisciplinaria  sobre Neuroscience  y Psiquiatria Biologica,     ESTRES y CONDUCTA

22 participantes

a 11 se les aplico la tecnica REMA

11 fueron del Grupo Control (tipo lista de espera)

ESTUDIO

Page 17: Scientific presentation of REMA in 17ma Conferencia International Multidisciplinaria  sobre Neuroscience  y Psiquiatria Biologica,     ESTRES y CONDUCTA

TIME ADMINISTERED

Horas recibidas por cada participante: Between 5 and 10 para estos resultados.

Distribucion horaria: Sesiones de 2 horas promedio en dias consecutivos o alternados sin tardar mas de 72 horas entre sesion y sesion

Diferencia en tiempo entre primero y segundo test: 2 meses

Page 18: Scientific presentation of REMA in 17ma Conferencia International Multidisciplinaria  sobre Neuroscience  y Psiquiatria Biologica,     ESTRES y CONDUCTA

TIME ADMINISTERED

Hours dedicated to each participant: Between 5 and 15 hours for this results. (In some cases treatment continued to get complete results)

Hours distribution: average 2 hours sessions in consecutives or alternating days, but with no gaps superior to 3 days per process.

Time elapsed between first and second test: 2 months

Page 19: Scientific presentation of REMA in 17ma Conferencia International Multidisciplinaria  sobre Neuroscience  y Psiquiatria Biologica,     ESTRES y CONDUCTA

PERSONALITY TYPES Results

Global reduction in pathologies was observed in the “REMA GROUP” (pG<0.001)

No global significant changes were observed in control group

Page 20: Scientific presentation of REMA in 17ma Conferencia International Multidisciplinaria  sobre Neuroscience  y Psiquiatria Biologica,     ESTRES y CONDUCTA

SEVERE TYPES Results

Significant decrease in the Severe Types of the REMA GROUP was observed (p=0.01)

No significant changes were observedin control group

p=0.01 p=0.01 p=0.01

Schiz Bord Paran Schiz Bord Paran

Page 21: Scientific presentation of REMA in 17ma Conferencia International Multidisciplinaria  sobre Neuroscience  y Psiquiatria Biologica,     ESTRES y CONDUCTA

MILD CLINICAL SIMPTOMS Results

PDS

Global decrease in the “Mild clinical Types” was observed in the REMA GROUPNo significant changes were observed in control group

p=0.01 p=0.01 p<0.01p=0.02

PTS PTS Anx Som Dyst PTS Anx Som Dyst PTS

Page 22: Scientific presentation of REMA in 17ma Conferencia International Multidisciplinaria  sobre Neuroscience  y Psiquiatria Biologica,     ESTRES y CONDUCTA

SEVERE CLINICAL SIMPTOMS Results

p<0.001 p=0.01 p<0.01

Very significant global decrease of the “Severe clinical symptoms” was observed (p<0.001)

No significant changes were observed in control group

FTD M Dep Del D FTD M Dep Del D

Page 23: Scientific presentation of REMA in 17ma Conferencia International Multidisciplinaria  sobre Neuroscience  y Psiquiatria Biologica,     ESTRES y CONDUCTA

Global Results commented

Significant reduction of the four subgroups analyzed in the categories of: Avoidant Schyzotypal Dystimic

Depressive Borderline Post Trauma Stress

Dependant Paranoid Major Depression

Passive-aggressive Anxiety Delusional Disorder

Self-destructive Somatoform

Page 24: Scientific presentation of REMA in 17ma Conferencia International Multidisciplinaria  sobre Neuroscience  y Psiquiatria Biologica,     ESTRES y CONDUCTA

Global Results commented

as well as increasing in the score Compulsive when in a low to normal range, were observed in REMA Group and not in the Control Group.

Therefore that could be atributed to a treatment effect

Page 25: Scientific presentation of REMA in 17ma Conferencia International Multidisciplinaria  sobre Neuroscience  y Psiquiatria Biologica,     ESTRES y CONDUCTA

More on Results

Reduction in scores •Aggressive/Sadistic •Thought Disorders (FTD) was observed in both groups, though in different proportions, suggesting that the change in these two scores might be due to a placebo effect or uncontrolled variables in the experiment.

Page 26: Scientific presentation of REMA in 17ma Conferencia International Multidisciplinaria  sobre Neuroscience  y Psiquiatria Biologica,     ESTRES y CONDUCTA

INDIVIDUALRESULTS

EXAMPLES OF

Page 27: Scientific presentation of REMA in 17ma Conferencia International Multidisciplinaria  sobre Neuroscience  y Psiquiatria Biologica,     ESTRES y CONDUCTA

SUBJECT A Hours: 5

Page 28: Scientific presentation of REMA in 17ma Conferencia International Multidisciplinaria  sobre Neuroscience  y Psiquiatria Biologica,     ESTRES y CONDUCTA

SUBJECT A Hours: 5

Page 29: Scientific presentation of REMA in 17ma Conferencia International Multidisciplinaria  sobre Neuroscience  y Psiquiatria Biologica,     ESTRES y CONDUCTA

SUBJECT A Hours: 5

Page 30: Scientific presentation of REMA in 17ma Conferencia International Multidisciplinaria  sobre Neuroscience  y Psiquiatria Biologica,     ESTRES y CONDUCTA

SUBJECT A Hours: 5

Page 31: Scientific presentation of REMA in 17ma Conferencia International Multidisciplinaria  sobre Neuroscience  y Psiquiatria Biologica,     ESTRES y CONDUCTA

SUBJECT B Hours: 10

Page 32: Scientific presentation of REMA in 17ma Conferencia International Multidisciplinaria  sobre Neuroscience  y Psiquiatria Biologica,     ESTRES y CONDUCTA

SUBJECT B Hours: 10

Page 33: Scientific presentation of REMA in 17ma Conferencia International Multidisciplinaria  sobre Neuroscience  y Psiquiatria Biologica,     ESTRES y CONDUCTA

SUBJECT B Hours: 10

Page 34: Scientific presentation of REMA in 17ma Conferencia International Multidisciplinaria  sobre Neuroscience  y Psiquiatria Biologica,     ESTRES y CONDUCTA

SUBJECT C Hours: 10

Page 35: Scientific presentation of REMA in 17ma Conferencia International Multidisciplinaria  sobre Neuroscience  y Psiquiatria Biologica,     ESTRES y CONDUCTA

SUBJECT C Hours: 10

Page 36: Scientific presentation of REMA in 17ma Conferencia International Multidisciplinaria  sobre Neuroscience  y Psiquiatria Biologica,     ESTRES y CONDUCTA

SUBJECT C Hours: 10

Page 37: Scientific presentation of REMA in 17ma Conferencia International Multidisciplinaria  sobre Neuroscience  y Psiquiatria Biologica,     ESTRES y CONDUCTA

Main impact

Highest level of impact observed in. Anxiety . Somatoform. Depression

Page 38: Scientific presentation of REMA in 17ma Conferencia International Multidisciplinaria  sobre Neuroscience  y Psiquiatria Biologica,     ESTRES y CONDUCTA

Other unexpected collateral results

•Important remission in Psoriasis.

•Remission in Muscular Dystrophy (Genetically originated Degenerative disease). There was an unexpected stop in its evolution.

•Cell mutation and complete remission observed and reported by MD in Barcelona in a case of Keratosis Actinica.

Page 39: Scientific presentation of REMA in 17ma Conferencia International Multidisciplinaria  sobre Neuroscience  y Psiquiatria Biologica,     ESTRES y CONDUCTA

Controlled hours given at this moment:

665

to 104 patients

Hours given at this moment

Page 40: Scientific presentation of REMA in 17ma Conferencia International Multidisciplinaria  sobre Neuroscience  y Psiquiatria Biologica,     ESTRES y CONDUCTA

People trained in a first level of application of the REMA technique:

5(2 in USA and 3 in Spain)

Practitioners at this moment

Page 41: Scientific presentation of REMA in 17ma Conferencia International Multidisciplinaria  sobre Neuroscience  y Psiquiatria Biologica,     ESTRES y CONDUCTA

Closing Remarks

•Cases show stability over time.

•Memories stay and can be recalled but with no link to negative emotions.

Page 42: Scientific presentation of REMA in 17ma Conferencia International Multidisciplinaria  sobre Neuroscience  y Psiquiatria Biologica,     ESTRES y CONDUCTA

The obtained modifications of the brain seem to stay there to absorb all the future

information and experiences from a different perspective, from a more sane and

neutral point of view.

We are starting to register modifications produced during a year after therapy.

Closing remarks

Page 43: Scientific presentation of REMA in 17ma Conferencia International Multidisciplinaria  sobre Neuroscience  y Psiquiatria Biologica,     ESTRES y CONDUCTA

New Study starting in July

Los estudios realizados hasta este momento abren la puerta para la participacion interdisciplinaria.Apartir de Julio de este anio hemos trabajado con el Dr. Affanni en la Universidad de Moron, a los efectos de sentar las bases para el inicio de las actividades concretas de la Unidad de Vinculacion entre la Investigacion Clinica y la Investigacion Basica, creacion en esta facultad por inciativa del Dr. Domingo Liotta y cuya direccion esta a cargo del Dr. Jorge Mario Affanni. El proximo paso seria la firma de convenios con la delimitacion precisa de los objetivos de la investigacion.

Page 44: Scientific presentation of REMA in 17ma Conferencia International Multidisciplinaria  sobre Neuroscience  y Psiquiatria Biologica,     ESTRES y CONDUCTA

Razones especificas para la cooperacion

Los resultados de la observacion clinica sugieren cambios extraordinarios en el cerebro y esos cambios podrian ser explicados a nivel del sistema nervioso por la fisiologia.

Page 45: Scientific presentation of REMA in 17ma Conferencia International Multidisciplinaria  sobre Neuroscience  y Psiquiatria Biologica,     ESTRES y CONDUCTA

Razones especificas para la cooperacion

Como principio en REMA cortamos el vinculo entre la emovion perturbadora y la memoria, con los consecuentes cambios de conducta y precepcion.

Este modelo parece ser reproducible en animales cortando la comunicacion entre amigdala e hipocampo

Page 46: Scientific presentation of REMA in 17ma Conferencia International Multidisciplinaria  sobre Neuroscience  y Psiquiatria Biologica,     ESTRES y CONDUCTA

Razones especificas para la coparticipacion

A ambos nos interesa la accion inespecifica del sistema olfatorio involucrado en el funcionamiento del sistema limbico y por ende de relacion entre la amigdala (emocion) e hipocampo (memoria)

Page 47: Scientific presentation of REMA in 17ma Conferencia International Multidisciplinaria  sobre Neuroscience  y Psiquiatria Biologica,     ESTRES y CONDUCTA

Razones especificas para la coparticipacion

Por ambas partes vemos la vinculacion estrecha entre las acciones inespecificas del sistema olfatorio y el sueno que sirve para consolidar dichas modificaciones, tanto en la llamada fase de sueno lento como en la fase REM una de cuyas manifetaciones es el movimiento ocular.

Page 48: Scientific presentation of REMA in 17ma Conferencia International Multidisciplinaria  sobre Neuroscience  y Psiquiatria Biologica,     ESTRES y CONDUCTA

Razones especificas para la coparticipacion

El grupo del Dr. Affanni descubre que las alteraciones del sistema olfatorio y por ende del sistema limbico producen una clase de modiciaciones que solamente se ven durante el sueno. (Affanni and Garcia Sanmartino,1984)

Page 49: Scientific presentation of REMA in 17ma Conferencia International Multidisciplinaria  sobre Neuroscience  y Psiquiatria Biologica,     ESTRES y CONDUCTA

Otros proyectos posibles de coparticipacion

Estudio de las posibilidades de aliviar dolencias especificas y por lo tanto tomar pacientes con esa dolencia, aplicar REMA, y observar desarrollo de resultados. Ej.: pacientes con síndrome de colon Irritable, arritmia, alta presión arterial, psoriasis.

Page 50: Scientific presentation of REMA in 17ma Conferencia International Multidisciplinaria  sobre Neuroscience  y Psiquiatria Biologica,     ESTRES y CONDUCTA

Otros proyectos posibles de coparticipacion

Aplicación del programa ya esbozado en cárceles juveniles, para recuperación del delito e inserción social. Un programa que implicaría a toda la comunidad a la que pertenece el que ha delinquido, estableciendo la posibilidad de prevención, no sólo de reinserción. Implica entrenamiento y aplicación de REMA en las cárceles.

Page 51: Scientific presentation of REMA in 17ma Conferencia International Multidisciplinaria  sobre Neuroscience  y Psiquiatria Biologica,     ESTRES y CONDUCTA

Otros proyectos posibles de coparticipacion

Un proyecto de ley: A cargo de los Doctores Marcos Rosquin y Nicolás Ramallo, implicando prevención del desarrollo de conductas delictivas, atenuación ce acciones individuales y amparo psicológico para victimas y familias.

Page 52: Scientific presentation of REMA in 17ma Conferencia International Multidisciplinaria  sobre Neuroscience  y Psiquiatria Biologica,     ESTRES y CONDUCTA

Otros proyectos posibles de coparticipacion

Dentro del marco investigativo de la Universidad de Moron habria enfasis en:

La actividad onírica como consolidación de procesos curativos.

La influencia de las funciones no especificas del sistema olfatorio en las modificaciones cerebrales.

Page 53: Scientific presentation of REMA in 17ma Conferencia International Multidisciplinaria  sobre Neuroscience  y Psiquiatria Biologica,     ESTRES y CONDUCTA

Reestructuring Atemporal Memories

REMAwww.REMA.org.es