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SDMS and LIMS Integration
Anders Janesten, Ralf Schröder
©2011 Waters Corporation 1
Quality Lab WorkflowQ y
Analytical Data Sampling
Report
Report Review &EvaluationGeneration Creation Sign Off
Report CofA
Analytical Data Generation
Sampling Report Creation
Review &Sign Off
Evaluation
Report
Certificate of Analysis
Analytical Data Generation
Sampling
Report
Report Creation
Review &Sign Off
Evaluation
©2011 Waters Corporation 2
Generation Creation Sign Off
The Integration Challengeg g
Data SourcesData Sources
©2011 Waters Corporation 3
Data ConsumersData Consumers
Data Export/Re-usep /
Data SourcesData Sources
Waters NuGenesis SDMSWaters NuGenesis SDMS
©2011 Waters Corporation 4
Data ConsumersData Consumers
How to Create CoAs?
Waters NuGenesis SDMS
©2011 Waters Corporation 5
Data Transfer LIMS
Waters NuGenesis SDMSInstruments
Worklist
Batch ID
Sample ID
- Batch ID
- Sample ID
- Worklist
- Batch ID
- Sample ID
- ReportsWorklist- Worklist - Reports
- Files
- …- Results
©2011 Waters Corporation 6Print Data Raw Data
Extraction Template
SDMS2LIMS
©2011 Waters Corporation 7
Why Connecting Instruments to LIMSy g
Save timeSave time
Avoid errors
Increase compliance
Concentrate on exceptions
Simplify documentation
=> Control the process
©2011 Waters Corporation 8
Which Instruments Should be Connected?
All instruments?All instruments?
All instruments the LIMS knows?
Chromatographic instruments? (80% of the data)
Balances? (weights for chromatography)
Non chromatographic instruments?
=> Evaluation of effort and benefit
©2011 Waters Corporation 9
How Shall Instruments be Linked?
Each one individually (spaghetti connection)Each one individually (spaghetti connection)
To a central point and then to LIMS (platform)
Flexibility
Implementation costs
License costsLicense costs
Expertise
Tracability
=> What can the Waters solution do?
©2011 Waters Corporation 10
Phase 1:Phase 1:
LIMS to InstrumentLIMS to Instrument
©2011 Waters Corporation 11
CDS Solution
LIMS
Web Service
InterfaceInterface
Request Data
12
Return Data
1
COM Interface
©2011 Waters Corporation 12
Empower
LIMS to CDS
©2011 Waters Corporation 13
LIMS to CDS
©2011 Waters Corporation 14
LIMS to CDS
©2011 Waters Corporation 15
Transferred to Empowerp
©2011 Waters Corporation 16
Non-CDS Instruments Solution
LIMS
Web Service
Interface
1
Printed work listfor manual entry
©2011 Waters Corporation 17Non-CDS Instrument
Phase 2:Phase 2:
Instrument to SDMSInstrument to SDMS
©2011 Waters Corporation 18
CDS Solution
LIMS
Web Service
InterfaceInterface
COM Interface
.NET Interface
©2011 Waters Corporation 19
SDMS SystemEmpower
Print Report3 4
Printing to SDMSg
©2011 Waters Corporation 20
Complex Instruments Solutionp
LIMS
Web Service
Interface
.NET Interface
©2011 Waters Corporation 21
SDMS System
Print Report3 4
Non-CDS Instrument
Printing to SDMS
©2011 Waters Corporation 22
Phase 3:Phase 3:
SDMS to LIMSSDMS to LIMS
©2011 Waters Corporation 23
All Instrument Results
LIMS
Web Service
InterfaceInterface
COM
Return Data/Result
COM Interface 5
.NET Interface
Empower
©2011 Waters Corporation 24
SDMS SystemNon-CDS Instrument
What Format is Needed
©2011 Waters Corporation 25
LIMS Specific Outputp p
©2011 Waters Corporation 26
Within Seconds
©2011 Waters Corporation 27
All Instrument Results
LIMS
Web Service
InterfaceEasy Interface
COM
Robust
Easy
COM Interface
.NET Interface
Empower
©2011 Waters Corporation 28
SDMS SystemNon-CDS Instrument
Flexible
LIMS2VP + VP2LIMS
©2011 Waters Corporation 29
Two Major Types of Laboratoryj yp y
Discovery, R&D— Free-flow
— Geared towards new scientific discoveries ??— Seeks to protect intellectual property rights
??Process, QC— Follows standard protocols
— Geared towards routine testingg
— Often follows GxP such as EPA regulations
Test Test
©2011 Waters Corporation 30Maze obtained from pbs.org
Templatesp
TemplateDocumentp
Introduction
Introduction
Experiments