SMART Automation Presentation

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Agenda

1 Introduction Sakura Finetek

2 Workflow Management

3 SMART Automation

4 Customer & Patient Perspective

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Dedicated to Histopathology

We provide our customer in histopathology

laboratories worldwide with reliable, high

quality products and support, while

pursuing continuous improvement,

customer satisfaction, market leadership

and a positive employee work

environment.

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Sakura Core Values

Reliability

High Quality

Innovation

Customer Added Value

Continuous innovation Setting the standard

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19721871 1914 1979 1987 2004 2008

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Serving the histopathology world

Sakura Finetek USA., Inc.

Sakura Finetek Europe B.V.

Sakura Finetek Japan Co., Ltd.

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Grossing & trimming Identification Tissue Processing Tissue Embedding Microtomy

Staining Coverslipping Cryotomy Cytology Filing & Archiving

A complete product line

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Challenges in histopathology

Doing more with less

• Higher workload

• Turnaround time

• Shortage of skilled staff

• Cost pressure

• Safety requirements

• Increased quality requirements

• Competitive working environment

BottlenecksWaiting time

No standardisation

An inefficient lab

Multiple protocols

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Continue like this?

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Or, be SMART!

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A Rapid, Efficient & Consistent Quality Lab

Removing Bottlenecks &

Reducing waiting time and errors

Increase Same Day Diagnosis

Efficiency and Quality

Standardisation

Create a continuous workflow

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Remove bottlenecks and waiting time: Increase same day diagnosis

10 - 12 hours

Fixation

Grossing

WaitingProcessi

ng

Embedding

Microtomy

Staining

Coverslipping

Diagnosis

Conventional Process

SMART Automation Process

Every 15 min

Waiting/ Batching 1x per day

1 hour

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Average processing turnaround times:Superior performance Xpress ® x Series

Continuous Processing

Multi-batch processing

Overnight processing

1,5 hours

8 hours

20 hours

* Average processing turnaround times include waiting time (Source: SMART Analysis Tool)

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Same Day Results: Superior performance

Xpress® x Series

0%

10%

20%

30%

40%

50%

60%

70%

80%

90%

100%

Same day 2 days 3 days >3 days

80% same day results after using Xpress 1

1.) Rapid response, Molecular Friendly Surgical Pathology, Morales et al, Journal of American College of Surgeons, Vol. 207, September 2008

Xpress

Before-Xpress

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Creating a Continuous Efficient Workflow

Monday

Tuesday

Grossing

Processing / Xpress

Embedding / AutoTEC

Microtomy

Staining

Delivering / Microscopy

17:00

11:00

13:30

14:00

14:30

15:00

11:30

07:00

08:00

08:30

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Increasing efficiency & productivity: Batch process vs Continuous process

Batch process Continuous process

6 7 8 9 10 11 12 13 14 15 16 170

1.6

3.2

4.8

6.4

8.0

Occ

upan

cy (n

umbe

r)

Time

6 7 8 9 10 11 12 13 14 15 16 170

1.6

3.2

4.8

6.4

8.0

Occ

upan

cy (n

umbe

r)

Time

Occupancy of shift Conventional Technicians (per 60 min) Occupancy of shift Automation Technicians (per 60 min)

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SMART Automation Powered by Sakura

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Tissue-Tek® AutoWrite® Cassette & Slide Printers

Efficiency

• Continuous printing supporting a LEAN workflow

• Ease of use with stacked cassettes

• Full flexibility of all tissue carriers

Speed

• Rapid printing, up to 900 cassettes/ 800 slides per hour

• Convenient & rapid loading and unloading

Quality

• High quality 1D, 2D bar coding, graphics for easy and

reliable identification

• Compliant with SIX Sigma principles

• Connectable to LIMS & stand alone computer

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Accu-Edge®

Grossing Tool System

Quality

• Standardization of grossing leading to consistent

quality 

• Successful LEAN and SIX Sigma implementation  

• Quality Management demands standardization

• In-place Quality Management is required for laboratory

accreditation

Efficiency & speed

• Error reduction

• Less delays later in the process

• Overall process improvement

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SMART Automation Powered by Sakura

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Tissue-Tek ® Xpress® x Series

Efficiency

• Continuous efficient workflow/ Loading every 20 minutes:

• Workload leveling & Increased productivity

• Reduced levels of stress: Fewer human errors and rework Reduced cost

• Reagent volume reduction of more than 80%

Speed

• Standardized 1-hour processing/ Loading every 20 minutes

• Throughput of 120 cassettes/ to 960 cassettes in an 8-hour shift

• Unmatched same day diagnoses for all tissue types

• Reduced patient waiting time

Quality

• Excellent morphology and sharp nuclear details due to gentle microwave technology

• Standardized reproducible results: QC ready to use reagent kits

• Future ready: All results on one block including molecular studies

• Formalin- and xylene  free processing

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Tissue-Tek ® Xpress® x Series

Tissue-Tek® Xpress® x120

• Throughput of 120 cassettes per hour yielding to

a continuous throughput of up to 960 cassettes

in an 8-hour shift

• Load up to 40 cassettes every 15 minutes

Tissue-Tek® Xpress® x50

• Throughput of 50 cassettes per hour yielding to a

continuous throughput of up to 400 cassettes in

an 8-hour shift

• Load up to 40 cassettes every 40 minutes

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How does it work?

SMART Automation and Intelligent Design

• Unique retort design with novel microwave technology and advanced robotics

• Reduced reagent carryover

• Intuitive menu screens and reporting tool

• Compatible with the AutoTEC® and Paraform®

15 min

MW Agitation

AcetoneIsopropanol

Others 1-40

Cassettes

15 min

MW agitation

AcetoneIsopropanol

Others

15 min

Heat Vacuum

Paraffin

15 min

Heat Vacuum

Paraffin

How does it work?

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How does it work?

Complete Tissue Processing with only 2 reagents

• Low power microwave and reliable vacuum technology

• Circular microwave patterns

• Eliminate hot and cold spots

• Continuous throughput

• All specimens processed in the same program

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How does it work?

Novel System of Reagents for Distinct Detail

• Includes an exclusive paraffin formulation

• Preserves DNA, RNA, and proteins

• Eliminates the use of formalin and Xylene, minimizing waste management costs

• Virtually eliminates chemical exposure due to closed system

• Features easy-to-use processing reagent sets

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SMART Automation Powered by Sakura

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Tissue-Tek® AutoTEC® & Paraform®

Efficiency

• Fully automated embedding

• A continuous efficient workflow

• Free up capacity for more value adding work

Speed

• Continuous loading and unloading

• 120 cassettes per hour/ Loading every 15 minutes

• Perfect fit with Tissue-Tek® Xpress® x Series®

• Same throughput: 120 cassettes per hour

Quality

• Eliminating orientation mistakes, mix up and tissue loss

• Usage of one magazine, identical paraffin wax

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Tissue-Tek® AutoTEC® & Paraform®

Twelve Paraform® outer frame colors Six Paraform® inner cassettes types

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Tissue-Tek® AutoTEC® & Paraform®

Six Paraform® inner cassettes types

• Paraform® Standard Cassette

• Paraform® Biopsy Cassette

• Paraform® Orientation Cassette

• Paraform® 13*13 Biopsy Cassette

• Paraform® Core Biopsy Cassette

• Paraform® Shaved Biopsy Cassette

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Tissue-Tek® AutoTEC® & Paraform®

Principles

• Create a gentle workflow

• Create a higher productivity.– 120 blocks an hour are embedded

• Blocks will have a consistent quality

• Orientation is preserved by the special design of the Paraform® Cassettes

• Paraform Cassettes are compatible with all existing methods, like printing, processing and microtomy

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Operation of the Paraform® Cassette

1

2

3

4

Place the inner cassette in the outer frame on a flat surface

Position the cassette underneath the 4 tabs

Place the tissue sample in the center of the cassette

Close the lid

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Operation of the AutoTEC®

1

2

3

4

Cassettes are placed in magazine

Magazines are loaded

Each cassette is picked from magazine one by oneCassette type is identified

Cassettes are placed in pre-heated basemolds

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Operation of the AutoTEC®

1

2

3

4

Stager pushes down the cassette through the frameA precise amount of paraffin is dispensed

Basemold cools to form a solid blockBlock is removed from basemold and presented to sensors

Paraffin block is placed in one of the output doors

Consistent quality blocks ready for microtomy

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SMART Automation Powered by Sakura

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Tissue-Tek® Prisma® & Film®

Efficiency

• True walk-away staining and coverslipping

• Automated transfer from stainer to coverslipper

• A continuous efficient workflow

• Unmatched capacity, up to 11 runs of 60 slides simultaneously

Speed

• Unmatched speed, 660 slides per hour

• Full flexibility in staining protocols and batch size with reagent

reservoirs of 160 mL, 260 mL and 680 mL

• Multiple programs at the same time (routine and specials)

Quality

• Long lasting protection with adhesive backed polymer film

• Air bubble detector guarantees bubble free coverslipping

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SMART Automation Client Perspective

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Hillerød hospital: Not only figures but real life results

We are now delivering a better service to more patients

Hanne Bjørn, Senior Chief Biomedical Laboratory Scientist, Hillerød Hospital, Denmark

The workflow is steady and there are no batches to face each morning, staff are no longer so stressed.

The increased automation, as well as other innovations resulting from LEAN, have lead to a greatly improved workflow and processing time, and reduced standby time.

Our improvements have had a knock-on effect on the cytology lab personnel who have also increased output and become more patient focused.

Source: Clinical Lab Magazine

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Maastricht University Medical Centre:Faster Diagnosis of Cancer

Now, diagnoses are made within two hours. Continuously.

Professor Axel zur Hausen, Chair of thePathology Department at Maastricht University Medical Centre.

Malignant tumours can be diagnosed within a few hours without any concessions to quality.

New cassettes can be loaded every fifteen minutes on the Xpress without unnecessary waiting.

It is an improvement that we no longer have big stacks of specimen to process. In addition, it decreases the chance of making mistakes

“A quick and reliable diagnosis implies that treatment can be started sooner.

Source: Clinical Lab Magazine

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SMART Automation Patient Perspective

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Be SMART

A continuous efficient workflow

Unmatched same day results

A consistent high quality

Improved patient care