solubilization physical pharmacy solubilization by abdul-wahhab khedr demonstrator of pharmaceutics...
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Physical Pharmacy
SOLUBILIZATIONSOLUBILIZATIONBy
Abdul-Wahhab KhedrDemonstrator of Pharmaceutics & Industrial
Pharmacy
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Definition:Definition:
• SolubilizationSolubilization is the process of bringing into solution substances which are insoluble or sparingly soluble in water.
• Methods of Solubilization:1) The use of mixed solvents (blending and Co-solvency).2) The use of surface active agents (Micelle formation).3) The use of hydrotropic salts e.g. iodine and potassium
iodide.4) Complex formation e.g. caffeine and barbiturate.
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Determination of Solubility of Benzoic acidDetermination of Solubility of Benzoic acid
• Procedure:Procedure:1. In a glass bottle, add 0.5 gm benzoic acid & 20 ml
distilled water.2. Shake for 10 min and set aside for another 10 min.3. Filter the contents of the bottle, take 10 ml of the
filterate and titrate with 0.1 N NaOH using Ph.Ph. as indicator (3-5 dps).
4. The End Point is determined by the appearance of the first permanent faint pink colour.
5. Repeat the above steps using surfactant solutions (1%, 3%, 5%, 7%) instead of distilled water and determine the end points.
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E.P = Volume of titrant used
0.5 gm benzoic acid
20 ml dist. Water or sample soln
Shake for 10 minSet aside for 10 min
10 ml of filterate
3 dps Ph.Ph
0.1 N NaOH
ProcedureProcedure
Filter
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Calculation of SolubilityCalculation of Solubility
)/(10
1000.lub lg
FPEilitySo
Factor (F): is the amount of benzoic acid (in grams) neutralized by 1 ml of titrant (0.1 N NaOH).
Calculation of Factor (F):Calculation of Factor (F):
+ NaOH + H2O
1 mole benzoic acid ≡ 1 mole NaOH 122 gm ≡ 1000 ml 1 M NaOH 122 gm ≡ 1000 ml 1 N NaOH 122 /10 ≡ 1000 ml 0.1 N NaOH F ≡ 1 ml 0.1 N NaOH
0122.0100010
122
F
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Calculation of SolubilityCalculation of Solubility
)/(10
10000122.0.lub lg
PEilitySo
Results:Results:
Surfactant ConcnE.PSolubility (g/l)
1%
3%
5%
7%
Then draw the relationship between surfactant concn (on x-axis) and solubility (on y-axis).
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