Spice

• TRPA1/ANKTM1– Responds to cold temperatures, pungent natural

compounds, particularly capsaicin, and environmental irritants

– 3 cysteine residues which affect function• C415S, C422S, C622S

C, C, C

C, C, C

C, C, C

C, C, C

C, C, C

C, C, C

C, C, C

C, C, C

C, C, C

C, C, C

C, C, C

C, S, C

T, A, NC, S, C

C622S – BlackC422S – RedC415S – Green