standardized extract of syzygium cumini - naturalremedies cumini.pdfsyzygium cumini [ jamun ] oral...
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Specially developed to maintain
healthy blood sugar levels*
Standardized Extract of
Syzygium cuminiSyzygium cumini
What is Syzygium cumini?
Syzygium cumini (L.) Skeels (myrtaceae)
commonly known as “jamun” is widely used in
Ayurveda and other Indian folk medicines for the
treatment of diabetes mellitus.
Syzygium cumini seed extract
A natural way to maintain healthy
blood sugar levels
Traditional evidence
Clinical evidence
Pre-clinical evidence
Additional benefits of Syzygium cumini seed
extract in diabetes
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The seeds of Syzygium cumini are used by the
Ayurvedic physicians (and also in Indian folklore) 3in the management of diabetes mellitus
Seed powder Syzygium cumini has significantly 4-5reduced both fasting and postprandial blood sugar.
Several preclinical studies indicate beneficial
effects of seed extract of Syzygium cumini in 6-11controlling blood sugar levels.
Syzygium cumini seed extract stimulates insulin
secretion in isolated islets of langerhans from normal
as well as from diabetic animals and also inhibited 12insulinase activity from liver and kidney.
13-14Exhibits hypolipidemic effect in diabetic rats.
15Reduces tissue damage in diabetic rat brain.
Prevents the cataract development in diabetic 16rats.
Attenuates the progression of renal damage in 17diabetic mice.
Jamun
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Diabetes mellitus (high blood sugar levels), is
one of the oldest metabolic disorders known to
mankind.
All the renowned classic texts of Ayurveda like
Charaka Samhita (1000 B.C.), Sushruta Samhita
(600 B.C.) and subsequent works refer to this
disorder under the term Madhumeha (meaning
sugar in the urine).
Ayurvedic physic ians have treated
Madhumeha for thousands of years using a
combination of regulated lifestyle and herbal
drugs.
In recent years, scientists in their search for
alternative medicine to manage healthy blood
sugar levels have performed detailed
investigations on several herbs used traditionally
in Ayurveda.
2Diabetes mellitus and Ayurveda
Global Prevalence of Diabetes
The total number of people with diabetes is projected to rise from 171 million in 2000 to 366
1million in 2030.
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Syzygium cumini[ Jamun ]
Oral administration of Syzygium cumini seed extract
(SCE-100 mg/kg) caused a significant decrease in the
blood glucose level in diabetic rats. The effect was 15better than glibenclamide (600 µg/kg).
Safety
Regulatory status
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There have been no adverse side effects
associated with consumption of Syzygium cumini
The animal studies do not seem to indicate any
major adverse effects associated with the use of
Syzygium cumini seed extract.
Moreover, Syzygium cumini has a long history of
use in India as food and also as medicine in
traditional Indian systems of medicine.
Syzygium cumini is official in Ayurvedic
Pharmacopoeia of India. It is also listed in, German
Commission E monograph, MHRA-UK, Herbs of
Commerce- American Herbal Products Association
(AHPA).
Why Syzygium cumini seed extract from
Natural Remedies?
Availability
Dose
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Chemical standardization based on content of
ellagic acid and polyphenols.
Manufactured in a GMP and ISO 9001 - 2000
certified manufacturing facility.
The Product is Kosher and Halal Certified.
Syzygium cumini seed extract standardized to >2%
w/w ellagic acid and >20% w/w polyphenols.
Standardized Syzygium cumini seed extract can be
custom formulated.
1500 - 3000 mg/day/adult in divided doses
Standardized Syzygium cumini seed extract can be
incorporated in nutraceutical formulations intended
to maintain healthy blood sugar levels.
Plot No. 5B, Veerasandra Industrial Area, 19th Km Stone, Hosur Road, Electronic City Post,Bangalore - 560 100. INDIA , Ph : +91 80 4020 9999 / 98 / 97 / 96, Fax : +91 80 4020 9817Email: [email protected]
*Disclaimer : “These statements have not been evaluated by the Food and Drug Administration or any other regulatory body. This product is not intended to diagnose, treat, cure or prevent any disease”.
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Normal DiabeticControl
Diabetic + SCE Diabetic +glibenclamide
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References
1. Sarah W et al., Diabetes Care, 2004: 27: pp 1047 - 1053.
2. Charaka Samhita Vol II. Chikitsasthana. P.V. Sharma (1983),Chaukhamba Orientalia, Varanasi (India), pp. 118.
3. P. Stanely et al., J of Ethanopharmacol. 2004: 91: pp 209-213.
4. Sepaha GL and Bose SN. J Indian Med Assoc. 1956: 27: pp 388.
5. Srivastava Y et al., Asian Med J. 1983: 26 (7): pp 489.
6. Prince PS et al., J Ethnopharmacol. 1998 : 61(1) pp 1-7.
7. Vikrant V et al., J Ethnopharmacol. 2001 : 76(2) pp 139-143.
8. Grover JK et al., J Ethnopharmacol. 2000 : 73(3) pp 461-470.
9. Kar A et al., J Ethnopharmacol. 2003 : 84(1) pp 105-108.
10. Ravi K et al., J Med Food. 2004: 7(2):pp 187-191.
11. Ravi K et al., Biol Trace Elem Res. 2004: 99(1-3):pp 145-155.
12. Achrekar S et al., In Vivo. 1991: 5 (2): pp 143- 147.
13. Ravi et al., Food Chem Toxicol. 2005: 43(9): pp 1433-1439.
14. Sharma SB et al., J Ethnopharmacol. 2003 : 85(2-3) pp 201-206.
15. Stanely P et al., J Ethnopharmacol. 2003 : 84(2-3) pp 205-209.
16. Rathi SS et al., Phytother Res. 2002 : 16(8) : pp 774-777.
17. Grover JK et al., J Ethnopharmacol. 2001 : 46(3) pp 233-238.
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