state of the art standard of care for resectable nsclc ... · tnm classification for lung cancer...
TRANSCRIPT
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state‐of‐the‐art
standard of care for resectable NSCLC
surgical approach for resectable NSCLC
Dominique H. Grunenwald, MD, PhD
Professor Emeritus in Thoracic and Cardiovascular surgery
Pierre & Marie Curie University. Paris. France
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surgical approach for resectable nsclc
•which patient ?
-which resection ?
-which technique ?
-which surgeon ?
standard of care
guidelines
recommendations
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what do we expect from the surgery?
• the best local control
• i.e. a complete therapeutic response
• i.e. a chance of cure
• provided it could remain a harmless procedure
• a better survival and quality of life than
– no treatment
− other treatments
– no surgery in the context of multimodal therapy
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surgery = extirpation
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questions before considering surgery
depends on
operable patient? clinical performance
resectable tumour? TNM staging
type of resection? local invasion
which approach? tumour size and location
therapeutic pathway? state of the art
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definitions
• an "operable" patient has an acceptable risk of
death or morbidity
• a "resectable" tumour can be completely excised by
surgery with clear pathological margins
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does the patient have the functional
pulmonary reserve to tolerate the
proposed resection to maintain a
reasonable quality of life?
surgical resection offers little benefit if
the patient suffers postoperative
pulmonary insufficiency … or death
risks from surgery increase with age and comorbidities
because
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assessment by a multidisciplinary team (MDT)
thoracic surgery
pulmonology
oncology
imaging
nuclear medicine
pathology
consideration of the patient’s general condition
comorbidity
cardiac condition
lung condition
diagnostic and therapeutic indications
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Tripartite risk assessment (SCTS-BTS)
Eric Lim et al. Thorax 2010;65:iii1-iii27Copyright © BMJ Publishing Group Ltd & British Thoracic Society. All rights reserved.
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assessment by a multidisciplinary team (MDT)
the thoracic surgeon
pulmonology
oncology
imaging
nuclear medicine
pathology
consideration of the patient’s general condition
comorbidity
lung condition
cardiac condition
diagnostic and therapeutic indications
and acceptance
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definitions
• an "operable" patient has an acceptable risk of death or
morbidity
• a "resectable" tumour can be completely excised by
surgery with clear pathological margins
"early stage"
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what is early stage lung cancer?
this refers to cancers that are caught early enough that
they have the potential to be cured with surgery
Goldstraw P, et al. J Thorac oncol 2007;2:706-14
the TNM stage influences
survival after surgery
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TNM Classification for Lung Cancer (8th Edition)
T Classification: importance of tumor size highlighted
T1 T1a (≤1 cm), T1b (>1 to ≤2 cm), and T1c (>2 to ≤3 cm)
T2 T2a (>3 to ≤4 cm) and T2b (>4 to ≤5 cm)
T3 (>5 to ≤ 7cm)
T4 > 7 cm (prev. T3)
T2 involvement of main bronchus regardless of distance from carina (prev. T2/3)
T2 partial and total atelectasis/pneumonitis (prev. T2/3)
T4 diaphragm invasion (prev. T3)
deletion of mediastinal pleural invasion as a T descriptor
N Staging unchanged, new descriptors proposed for prospective testing and validation
p N1 single (pN1a) and multiple (pN1b) nodal station involvement
pN2 pN2a1 (single pN2 nodal station involvement without pN1 disease, “skip
metastasis”
pN2a2 with single station pN2 and pN1 involvement
pN2b with involvement of multiple pN2 nodal stations
M Staging
M1a unchanged
M1b single metastasis in a single organ
M1c multiple metastases
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stage groupings (8th edition)
Stage IA N0 and ≤ 3 cm
IA1, IA2, IA3 (a category for each cm in size)
Stage IB N0 and >3 to ≤ 4 cm
Stage IIA N0 and >4 to ≤ 5cm
Stage IIB N0 and >5 to ≤ 7 cm
or N1 and smaller tumors
Stage IIIA N0 and > 7cm or others T4
N1 and T3-T4
N2 and T1a-T2b
Stage IIIB N2 and T3-4
N3 and T1a-T2b
Stage IIIC N3 and T3-T4
Stage IVA Any T Any N with M1a and M1b
Stage IVB > 1 extrathoracic metastasis (M1C)
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stage IA : IA 1 T1a N0 M0 (≤1 cm)
very early IA2 T1b N0 M0 (>1 to ≤ 2cm)
IA3 T1c N0 M0 (>2 to ≤3cm)
stage IB : T2a N0 M0 (>3 to ≤ 4cm)
stage IIA : T2b N0 M0 (>4 to ≤ 5 cm)
stage IIB : T3 N0 M0 (>5 to ≤ 7cm)
early T1a-c N1 M0
T2a-b N1 M0
stage IIIA: T4 N0 M0
locally advanced T3-4 N1 M0
T1a-2b N2 M0
stage IIIB T3-4 N2 M0
locally advanced T1a-T2b N3 M0
stage IVA-B : Any T, any N, M1a-b-c
surgery
no
surgery
early stage lung cancer in the TNM 8th edition
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questions
depends on
operable patient? clinical performance YES
resectable tumour? TNM staging YES
type of resection? local invasion
which approach? tumour size and location
therapeutic pathway? state of the art
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type of resection depends on tumor size
and/or location (T factor)wedge resection
segmentectomy
lobectomy
pneumonectomy
along with systematic en-bloc dissection of mediastinal lymph node stations!
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type of resection depends on local invasion
(T factor)
lobectomy
+ extended resection
extended
pneumonectomy
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bilobectomy
(right side)
indication
parenchyma
bronchus
LSD
LMLID
LIG
LSG
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stage IA : IA 1 T1a N0 M0 (≤1 cm)
very early IA2 T1b N0 M0 (>1 to ≤ 2cm)
IA3 T1c N0 M0 (>2 to ≤3cm)
stage IB : T2a N0 M0 (>3 to ≤ 4cm)
stage IIA : T2b N0 M0 (>4 to ≤ 5 cm)
stage IIB : T3 N0 M0 (>5 to ≤ 7cm)
early T1a-c N1 M0
T2a-b N1 M0
stage IIIA: T4 N0 M0
locally advanced T3-4 N1 M0
T1a-2b N2 M0
stage IIIB T3-4 N2 M0
locally advanced T1a-T2b N3 M0
stage IVA-B : Any T, any N, M1a-b-c
surgery
no
surgery
which resection for stage I tumours ?
potential to be cured with surgery… alone
Ginsberg RJ and Rubinstein LV 1995
the gold standard in stage I
is an anatomic lobar resection
(Lung Cancer Study Group)
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remains an area of evolution
several situations where sublobar resection should be
reasonably considered as primary treatment for early-stage nsclc
patients with limited pulmonary reserve
poor physical conditions
multiple primary nsclcs
butthe extent of parenchymal resection
Asamura H. and Donington J. J Thorac Oncol 2017;12:1188-9
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1995 LCSG consensus : lobectomy = gold-standard (stage I nsclc)
enhancements in imaging technology
screening programs
minimally invasive surgical resection
reduced perioperative morbidity and mortality
equivalent oncologic effectiveness to open surgery
challenging lobectomy as a standard for small tumors
Blasberg JD, et al. J Thorac Oncol 2010;5:1583-93
sublobar resection: a movement from the
Lung Cancer Study Group
larger cohorts of
localized early-stage
disease
an evolving paradigm?
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sublobar resection ?
wedge resection
anatomical segmentectomy
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(Surveillance, Epidemiology, and End Results registry)
2,090 patients
limited resect. (segment. or wr) 688 (33%)
no difference in outcomes among patients treated with
lobectomy vs limited resection
overall survival
HR : 1.12 (95% CI: 0.93-1.35)
lung cancer-specific survival
HR: 1.24 (95% CI: 0.95-1.61)
Kates M, et al. Chest 2010
survival following lobectomy and limited resection
for the treatment of stage I nsclc <= 1cm in size: a
review of SEER data
in favor
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sublobar resection is equivalent to lobectomy for
clinical stage 1A lung cancer in solid nodules
(International Early Lung Cancer Action Program)
nsclc with a diameter of 30 mm or less (stage 1) n=347
10-yr survival sublobar res. (n=53) 85%
lobectomy (n=294) 86% P = .86
cancers 20 mm or less in diameter P = .45
equivalent survival for patients with clinical stage IA
nsclc in the context of computed tomography screening
for lung cancer
Altorki NK, et al. J Thorac Cardiovasc Surg 2014;147:754-62 (I-ELCAP)
in favor
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16 papers / 116 (1 meta analysis, 1 RCT)
represented the best evidence to answer the clinical question.
there is evidence that wedge resections, compared to
segmentectomies and lobectomies, lead to lower survival and
higher recurrence rates
lobectomy is still recommended for younger patients with
adequate cardiopulmonary function. against
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CALGB 140503
JCOG0802/WJOG4607L
expected results of clinical trials
will see !
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questions
depends on
operable patient? clinical performance YES
resectable tumour? TNM staging YES
type of resection? local invasion DECIDED
which approach? tumour size and location
therapeutic pathway? state of the art
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approach depends on tumor size and location…
• open thoracotomy
• vats
• uniportal vats
• robotic
• others (transmanubrial, …)
… and $$$ as well
Grunenwald D, et al. Ann Thorac Surg 1997;63:563-6
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video-assisted thoracic surgery (VATS) has become a common
surgical technique
VATS generally means operating by using thoracoscopy with a
minimal number of small incisions and without rib spreading
assumption that it has an oncologic outcome equivalent to that of
open thoracotomy but is a less invasive method
scientifically supported comparisons between VATS and open
thoracotomy with randomized controlled trials have been
scarcely reportedAsamura H. and Donington J. J Thorac Oncol 2017;12:1188-9
minimally invasive lobectomy
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video-assisted thoracic surgery (VATS) has become a common
surgical technique
VATS generally means operating by using thoracoscopy with a
minimal number of small incisions and without rib spreading
assumption that it has an oncologic outcome equivalent to that of
open thoracotomy but is a less invasive method
scientifically supported comparisons between VATS and open
thoracotomy with randomized controlled trials have been
scarcely reportedAsamura H. and Donington J. J Thorac Oncol 2017;12:1188-9
minimally invasive lobectomy
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open or mis* ?
safety?
* mini-invasive surgery
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intraoperative vascular risks
Watanabe A : 21 pulmonary artery injuries / 185 vats (11%) *
Tatsumi A : 1 death from intraoperative bleeding / 118 vats **
*Watanabe A. et al. Kyobu Geka 2003;56:943-8
**Tatsumi A. et al. Jpn Journal Thorac Cardiovasc Surg 2003;51:646-50**
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Gopaldas RR, et al. Ann Thorac Surg 2010;89:1563-70
video-assisted thoracoscopic versus open thoracotomy
lobectomy in a cohort of 13,619 patients
Nationwide Inpatient Sample database
lobectomy thoracotomy (n = 12,860)
vats (n = 759)
vats = higher incidence of intraoperative complications
(p = 0.04)
minimal incision = delay in control of bleeding
vats worse?
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open thoracotomy 24,811 (95.1%)
VATS 1,278 (4.9%)
end points vats
30-day postop. death ns
atelectasis and pneumopathy reduced
other postoperative complications ns
hospital length of stay decreased from 2.4 days
os and dfs not influenced
Pagès PB, et al. et al. Ann Thorac Surg 2016;101:1370-8
propensity score analysis comparing videothoracoscopic
lobectomy with thoracotomy: a french nationwide
study
vats equivalent ?
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propensty matched groups n=2721
lobectomy thoracotomy vats p
no. % no. %
patients 2721 2721
total complications 792 29 863 32 0.0357
major CP complic. 316 16 435 20 0.0094
atelectasis (bronchosc.) 65 2.4 150 5.5 <0.0001
initial ventilation < 48h 18 0.7 38 1.4 0.0075
wound infection 6 0.2 17 0.6 0.0218
in-hosp. mortality 27 1 50 1.9 0.0201
postop. hospital stay (days) 7.8 9.8 0.0003
VATS is associated with a lower incidence of complications compared with
thoracotomy.Falcoz PE, et al. Eur J Cardiothorac Surg 2016;492:602-9
video-assisted thoracoscopic surgery versus open
lobectomy for primary nsclc: a propensity-matched
analysis of outcome from the ESTS database
(28771 patients)
vats better ?
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open lobectomy 3058 patients (58.6%)
thoracoscopic lobectomy 2164 (41.4%)propensity matching produced 1848 patients in each group
5-year OS rates for open lobectomy 65.5%
for thoracoscopic lobectomy 68.7% ns
similar long-term survival in the setting of lung cancer
thoracoscopic lobectomy is an acceptable surgical treatment of
lung cancer
Wang BY, et al. J Thorac Oncol 2016;11:1326-34
thoracoscopic lobectomy produces long-term survival
similar to that with open lobectomy in cases of nsclc:
a propensity-matched analysis using a population-based
cancer registry (5222 patients)
vats equivalent ?
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a national study of nodal upstaging after thoracoscopic
versus open lobectomy for clinical stage I lung cancer
(nodal upstaging occurs when unsuspected lymph node metastases are
found during the final evaluation of surgical specimens)
Danish Lung Cancer Registry
1,513 pts VATS 717 (47%)
thoracotomy 796 (53%)
nodal upstaging 281 pts (18.6%)
thoracotomy higher N1 upstaging (13.1% vs 8.1%; p<0.001)
N2 upstaging (11.5% vs 3.8%; p<0.001)
no difference in OS between VATS and thoracotomy
(hazard ratio, 0.98; 95% confidence interval, 0.80 to 1.22, p=0.88).
Licht PB, et al. Ann Thorac Surg 2013;96:943-9
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a national study of nodal upstaging after thoracoscopic
versus open lobectomy for clinical stage I lung cancer
(nodal upstaging occurs when unsuspected lymph node metastases are
found during the final evaluation of surgical specimens)
Danish Lung Cancer Registry
1,513 pts VATS 717 (47%)
thoracotomy 796 (53%)
nodal upstaging 281 pts (18.6%)
thoracotomy higher N1 upstaging (13.1% vs 8.1%; p<0.001)
N2 upstaging (11.5% vs 3.8%; p<0.001)
no difference in OS between VATS and thoracotomy
(hazard ratio, 0.98; 95% confidence interval, 0.80 to 1.22, p=0.88).
Licht PB, et al. Ann Thorac Surg 2013;96:943-9
vats worse?
vats equivalent ?
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retrospective review
c-stage 1a p-stage 1a p
thoracotomy 1964 36,4% 30.5% 0.0002
vats 500 47,4% 38% 0.0002
thoracotomy VATS p
overall nodal upstaging (%) 9.9 4.8 0.0002
increased survival was found with VATS 0.0042
selection bias may play a role
the improved quality of life measures associated with VATS may
explain survival improvement despite lower surgical upstaging
Martin JT, et al. Ann Thorac Surg 2016;101:238-44
nodal upstaging during lung cancer resection is
associated with surgical approach!
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retrospective review
c-stage 1a p-stage 1a p
thoracotomy 1964 36,4% 30.5% 0.0002
vats 500 47,4% 38% 0.0002
thoracotomy VATS p
overall nodal upstaging (%) 9.9 4.8 0.0002
increased survival was found with VATS 0.0042
selection bias may play a role
the improved quality of life measures associated with VATS may
explain survival improvement despite lower surgical upstaging
Martin JT, et al. Ann Thorac Surg 2016;101:238-44
nodal upstaging during lung cancer resection is
associated with surgical approach!
vats worse?
vats better ?
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nodal upstaging more frequent in the open group (12.8% vs.
10.3%; p < 0.001)propensity score matching : 4437 patients in each group
upstaging remained more common for open approaches
however, in academic/research facility, the difference in nodal
upstaging no longer significant (12.2% vs. 10.5%, p = 0.08)
Medbery RL, et al. J Thorac Oncol 2016;11:222-33
nodal upstaging is more common with thoracotomy
than with vats during lobectomy for early-stage
lung cancer: an analysis from the national cancer
data base (16,983 patients)
vats worse?
vats equivalent ?
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large national or regional databases
VATS lower incidence of postoperative complications
shorter length of hospital stay by 1 to 2 days
some reports
higher incidence of nodal upstaging observed in open
possibility of insufficient nodal evaluation in VATS
these conclusions were derived from retrospective studies
therefore, harbor hidden biases that may affect the outcome
further randomized studies required to demonstrate the
prognostic equivalence and any differences in QOL or
postoperative complications
. Asamura H. and Donington J. J Thorac Oncol 2017;12:1188-9
to conclude on vats lobectomy
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retrospectively reported to be equivalent to VATS in all measures
of quality for treatment of lung cancer
no randomized trials have reported the comparative data between
RATS and VATS/thoracotomy for lung cancer
robot-assisted thoracic surgery (RATS)
Asamura H. and Donington J. J Thorac Oncol 2017;12:1188-9
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open versus minim. invasive surgery (MIS [VATS and robotic])
propensity score matching: 9,390 patients in each group
MIS have increased 30-day readmission rates p < 0.01
shorter median hospital length of stay p < 0.01
improved 2-yr survival p = 0.04
nodal upstaging ns
30-day mortality ns
Yang CF, et al. Ann Thorac Surg 2016;101:1037-42
VATS versus robotic lobectomy for clinical T1-2, N0 nsclcpropensity score matching : 1,938 patients in each group
no difference with regard to nodal upstaging, 30-day mortality,
and 2-year survival
use and outcomes of minimally invasive lobectomy
for stage I nsclc in the national cancer data base
(30,040 patients)
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clinical stage I or stage II nsclc
1,220 robotic lobectomies
12,378 VATS procedures
robotic lobectomy more comorbidities
longer operative times
robotic and vats equivalent complications
hospital stay
30-day mortality
nodal upstaging
Louie BE, et al. Ann Thorac Surg 2016; Sep;102(3):917-24
comparison of video-assisted thoracoscopic surgery
and robotic approaches for clinical stage I and stage
II nsclc using the sts database
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uniportal vats
Gonzales-Rivas D. WCLC 2016
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the future : uniportal robotic platform
Intuitive Sugical da Vinci Sp Single Port Robotic Surgical system
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stage IA : IA 1 T1a N0 M0 (≤1 cm)
early IA2 T1b N0 M0 (>1 to ≤ 2cm)
IA3 T1c N0 M0 (>2 to ≤3cm)
stage IB : T2a N0 M0 (>3 to ≤ 4cm)
stage IIA : T2b N0 M0 (>4 to ≤ 5 cm)
stage IIB : T3 N0 M0 (>5 to ≤ 7cm)
early T1a-c N1 M0
T2a-b N1 M0
stage IIIA: T4 N0 M0
locally advanced T3-4 N1 M0
T1a-2b N2 M0
stage IIIB T3-4 N2 M0
locally advanced T1a-T2b N3 M0
stage IVA-B : Any T, any N, M1a-b-c
surgery
no
surgery
surgical resection of lung cancer - standard of care
stage I & II tumours- surgery
- open , vats
- lobar or sublobar?
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stage IA : IA 1 T1a N0 M0 (≤1 cm)
early IA2 T1b N0 M0 (>1 to ≤ 2cm)
IA3 T1c N0 M0 (>2 to ≤3cm)
stage IB : T2a N0 M0 (>3 to ≤ 4cm)
stage IIA : T2b N0 M0 (>4 to ≤ 5 cm)
stage IIB : T3 N0 M0 (>5 to ≤ 7cm)
early T1a-c N1 M0
T2a-b N1 M0
stage IIIA: T4 N0 M0
locally advanced T3-4 N1 M0
T1a-2b N2 M0
stage IIIB T3-4 N2 M0
locally advanced T1a-T2b N3 M0
stage IVA-B : Any T, any N, M1a-b-c
no
surgery
surgical resection of lung cancer - standard of care
stage I & II tumours- surgery
- open or vats
- lobar or sublobar?
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stage IA : IA 1 T1a N0 M0 (≤1 cm)
early IA2 T1b N0 M0 (>1 to ≤ 2cm)
IA3 T1c N0 M0 (>2 to ≤3cm)
stage IB : T2a N0 M0 (>3 to ≤ 4cm)
stage IIA : T2b N0 M0 (>4 to ≤ 5 cm)
stage IIB : T3 N0 M0 (>5 to ≤ 7cm)
early T1a-c N1 M0
T2a-b N1 M0
stage IIIA: T4 N0 M0
locally advanced T3-4 N1 M0
T1a-2b N2 M0
stage IIIB T3-4 N2 M0
locally advanced T1a-T2b N3 M0
stage IVA-B : Any T, any N, M1a-b-c
no
surgery
surgical resection of lung cancer - standard of care
stage I & II tumours- surgery
- open or vats
- lobar or sublobar?
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stage IA : IA 1 T1a N0 M0 (≤1 cm)
early IA2 T1b N0 M0 (>1 to ≤ 2cm)
IA3 T1c N0 M0 (>2 to ≤3cm)
stage IB : T2a N0 M0 (>3 to ≤ 4cm)
stage IIA : T2b N0 M0 (>4 to ≤ 5 cm)
stage IIB : T3 N0 M0 (>5 to ≤ 7cm)
early T1a-c N1 M0
T2a-b N1 M0
stage IIIA: T4 N0 M0
locally advanced T3-4 N1 M0
T1a-2b N2 M0
stage IIIB T3-4 N2 M0
locally advanced T1a-T2b N3 M0
stage IVA-B : Any T, any N, M1a-b-c
surgery
no
surgery
state of the art ? – controversial situations
stage III-N2
surgery or not ?
upfront surgery or induction ?
risks ?
locally advanced –T3/4
surgery ?
is there a role for surgery in locally advanced nsclc ?
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what we know from evidence based
medicine in N2 disease
• dramatic benefit with induction chemotherapy compared
to surgery alone in two small-scale studies [Roth, Rosell,
1994]
• no benefit in large european randomized study in stage
IIIA category [Depierre, 2002]
• stage IIIA benefits from adjuvant chemotherapy
following "complete resection" [Arriagada, 2004;
Douillard, 2006]
• nothing on radiotherapy (Lung-ART still ongoing)
• nothing on surgery
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N2 disease – paradigms and opinions
• mediastinal downstaging from induction is the most
powerful positive prognostic factor for survival after
surgery [Betticher, 2003; Albain, 2009]
• rt should be considered the preferred locoregional
treatment for pts with stage IIIA-N2 nsclc responders to
induction ct [Van Meerbeck, 2007]
• good candidates for surgery may still be appropriately
managed by using resection rather than radiation
[Vansteenkiste, 2007]
• the role of surgery is not clearly defined [Roy and
Donington, 2007]
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N2 disease – paradigms and opinions
• mediastinal downstaging from induction is the most
powerful positive prognostic factor for survival after
surgery [Betticher, 2003; Albain, 2009]
• rt should be considered the preferred locoregional
treatment for pts with stage IIIA-N2 nsclc responders to
induction ct [Van Meerbeck, 2007]
• good candidates for surgery may still be appropriately
managed by using resection rather than radiation
[Vansteenkiste, 2007]
• the role of surgery is not clearly defined [Roy and
Donington, 2007]
no standard of care
case by case discussion
in a tumor board
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locally advanced T3-4
superior sulcus tumor
locally advanced nsclc are not "surgical", an evolving paradigm?
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en bloc vertebrectomy / intralesional approach
upfront surgery / induction rt-ct
pers. MDA Toronto
yr 2006 2009 2013
induction none, ct none ct-rt
surg. technique en bloc intralesional en bloc
pts 34 31 48
partial vert. 28 16 38
total vertebr. 6 15 10
R0 res. (%) 88 56 88
mortality (%) 3 5 6
5-yr surv. (%) 24 27 61
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1. evidence suggests that
triple modality therapy with
complete resection of
Pancoast tumors with
involvement of the spine
offers an advantage over
other therapeutic modalities
2. given the negative
prognostical influence of
N2 nodal status , those
patients must be precluded
from surgery
3. highly selected centers and
surgical teams
state of the art
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what about the surgical quality ?
lymph node dissection as an example
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resection without evidence of pathologic nodal involvement
lobectomy 83.9 %
sublobar resection 12.7 %
pneumonectomy 2.8 %
the number of LNs removed correlated with increasing tumor
size and extent of resection
the number of LNs removed correlated with improved survival
removal of <10 LNs was associated with a 12 % increased
risk of death (p < 0.001)
Samavoa AX, et al. Ann Surg Oncol 2016;23(Suppl 5):1005-11
rationale for a minimum number of lymph nodes
removed with nsclc resection: correlating the
number of nodes removed with survival in 98,970
patients
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importance of surgical quality measures (QMs) in nsclc was
highlighted in 2016
National Cancer Database
stage I (1) anatomic resection
(2) operation within 8 weeks of diagnosis
(3) R0 resection
(4) more than 10 lymph nodes sampled
99% of resections met at least one QM
only 22% satisfied all four
median OS no QMs 31 months
4 QMs 89 months
compliance with basic QMs was associated with improved OS
Surgical Quality
Asamura H. and Donington J. J Thorac Oncol 2017;12:1188-9
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quality measures (no.) 1 2 3 4
% of patients 99.7 94.9 68.6 22.5
more likely to meet all four measures
income of at least $38,000/year
insurance type (private insurance vs. Medicare)
centers with at least 38 cases/year
academic institutions
clinical stage IB patients
national adherence to quality measures is suboptimal
guideline compliance is strongly associated with survival
efforts should be instituted by national societies to improve adherence.
Samson P, et al. Ann Thorac Surg 2017;103:303-11
quality measures in clinical stage I nsclc : improved
performance is associated with improved survival(133,366 patients)
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adherence to four QMs
(1) neoadjuvant therapy
(2) lobectomy or more extensive procedure
(3) R0 resection
(4) >10 lymph nodes sampled
only 12.8% of stage IIIA resections satisfied all QMs
median OS no QMs 12 months
4 QMs 43.5 months
compliance with QMs remained a strong independent
predictor of survival
Asamura H. and Donington J. J Thorac Oncol 2017;12:1188-9
surgical quality in clinical stage IIIA
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recommendations
• ESMO
Postmus PE, et al. Ann Oncol 2017;28(Suppl.4)
• BTS-SCTS
Lim E, et al. Thorax 2010;65:iii1-iii27
• ACCP
Howington JA, et al. Chest 2013;143(5_suppl):e278S-e313S
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Suggested algorithm for locoregional lymph node staging
ESMO Clinical Practice guidelines. Postmus PE, et al. Ann Oncol 2017;28(Suppl.4)
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treatment of early stages (stages I and II) - surgery
ESMO Clinical Practice guidelines. Postmus PE, et al. Ann Oncol 2017;28(Suppl.4)
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ESMO Clinical Practice guidelines. Postmus PE, et al. Ann Oncol 2017;28(Suppl.4)
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take home messages
1. the therapeutic decision starts in a multidisciplinary tumor
board including a thoracic surgeon
2. detailed TNM staging according to the 8th edition
determines the choice of treatment
3. surgery should be offered to all patients with stage I and II
4. anatomical resection is preferred
5. lymph node dissection should conform to standard
specifications
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take home messages (cont'd)
6. surgical approach should be appropriate to the expertise of
the surgeon
7. pneumonectomy should be avoided where possible
8. patients with limited pulmonary reserve can be considered
for sublobar resection as an acceptable alternative to
lobectomy
9. compliance with surgical quality measures is associated with
improved survival
10. cancer surgery must be performed by board-certified
thoracic surgeons