Stem Cell Stem Cell TreatmentsTreatments

What is available What is available today?today?

Agenda

• What is a stem cell?• Types of stem cells• How does the body naturally

heal?• What is Stem cell Therapy?• Risks and secondary effects• Myths of stem cells• Current therapies

A A cellcell is the basic functional is the basic functional structure of the human structure of the human bodybody

Tissue is formed by more cells

Organs are formed by more tissues

Sistems are formed by more organs

A body is formed by many systems.

• A mature cell has specific functions depending on the organ where it belongs.

• A mature cell has a limited number of replications.

Mature Cells

What is a Stem Cell?

• Is capable of reproducing itself many times: Produce a cell that has identical properties as the original.

• Is capable of differentiation into another kind of cell. (transformation to another type of tissue).

• Homing capability.

A special type of cell, referred to as a “master cell”.

How does the body naturally heal?

• When in balance, there is a life cycle.– Stem cell is born, travels to the tissue to be worked on,

differentiates into that type of tissue (becomes tissue cell), when a cell of that tissue dies and is discarded, the new cell replaces it.

– We have continuous production of stem cells.

• Out of balance, accelerated damaged cells.– Could be many reasons.– Body does not release enough stem cells to repair damage.– Chronic disease.

• EmbryonicThey are located inside the blastocyte or embryos up

to 8 weeks of fertilization.

• Adult stem cells. They are located all over a formed body with higher

concentration on:– Cord blood and placenta– Fat– Bone Marrow

Types of stem cells by Types of stem cells by sourcesource

• Totipotent– Could grow and form a complete new

organism• Pluripotent

– Could form any other kind of cell• Multipotent

– Could diferentiate only on a cell of its line.• Unipotent

– Only can form one type of cell

Types of stem Types of stem cellscells

by potentialby potential

Why embryonic stem cells Why embryonic stem cells are controversial?are controversial?

Pros:• They are Highly prolific- Very easy to duplicate• They are Pluripotent - Can be differentiated into

all kind of tissue

Cons:• Has to come from a blastocyte - Embryo• They are Pluripotent- could differentiate into

unwanted kind of tissue on unwanted locations.• They are Highly prolific- risk of growing

theratomas• Gene information is also transferred to recipient.• Legal issues

Culture and differentiation from Culture and differentiation from embryonic stem cellembryonic stem cell

Adult stem cellsAdult stem cells Pros:• They are Highly prolific- but not

unlimited• They are Pluripotent or

multipotent• Primitive undifferentiated cells• Easier access

Cons:• Limited on proliferation• Limited in quantity on some areas

Bone Marrow Stem Cell

What is Stem Cell What is Stem Cell Therapy?Therapy?

Stem cell therapy = use of stem cells to treat medical conditions.

Difference between Infusion and Transplant Infusion: adding to your body. Reinforces your

current tissues and systems (immunologic, neurologic and metabolic)

Transplant: replacing an organ. Usually involves an organ transportation and storage, and an aggressive patient preparation.

• Autologous- own tissue. Same donor and recipient.

• Homologous / Allogenic- Tissues from the same species

• Heterologous – Tissue from other species

Types of Types of TransplantTransplant

Risks and secondary effects Risks and secondary effects of Stem cell therapy of Stem cell therapy

infusioninfusionAutologous

– Risk: Infection– Secondary effects: head ache, bruise skin.

Allogenic– Genetic Disease transmission– Low viability if not stored/processed properly– Tissue rejection– Secondary Effects: same as above and variable

with the complications.

CAUTION: the more different the tissue is, the more aggressive the risks are. (example: animal stem cells)

Myths of stem Myths of stem cellscells

• In the near future Stem cells will cure all and everyone!

• Stem cells cause theratomas.• Stem cells from your own body cannot treat your

own illness.• All Stem cells are illegal.• Stem cells therapies are super expensive, 50K+.• Stem cells from Shark cartilage are much better.• Stem cells from Placenta or Fat have 10x the

number of cells compared to bone marrow or umbilical cord.

Conditions with the best Conditions with the best results:results:

• IMMUNOLOGICAL DISEASESRheumatoid Arthritis Systemic LupusFibromyalgia Psoriatic ArthritisSjögren Syndrome Asthma

• METABOLIC DISEASESDiabetes Mellitus Renal InsufficiencyCardiac Insufficiency Hepatic Insufficiency

• NEURODEGENERATIVE DISEASESMultiple Sclerosis Alzheimer's

diseaseParkinson's disease

Conditions with the best Conditions with the best results:results:

• OPHTHALMIC DISEASESMaculopathy Diabetic RetinopathyOptic Nerve Atrophy Central Retinal Vascular

Occlusion

• Other:Pediatric: Muscular dystrophia Healthy Aging (Anti-

aging)Immunologic Esthetics: Face lift, Hair growth Neurologic (Autism, Cerebral Palsy)

TrendsTrends• Bone Marrow Stem Cell Therapy

– Been here for a few years and continues to grow.

• Cord Blood Stem Cell Therapy– Still Being studied. – Not so regulated– Consequences because of being allogenic.

• Fat tissue Stem Cell Therapy– Growing interest (easy to provide in a Dr’s office)– Specially for Esthetics

• Embryonic Stem Cell Therapy– Is going to take even longer to be useful.

The ProcedureThe ProcedureCase Study:Consultation, Blood work, Specialist assessment (if

needed).

Patient PreparationProcedure:

Aspiration of Bone marrow with local anesthesiaCell preparation, Dilution, Cell concentrationInfusion by IV and/or CatheterDirect injection to organs, Lumbar, joints, retro bulbar,

thyroid, subcutaneous, injuries, etc.

Recovery/Observation after procedureUsually, 3 day and 2 nights trip, but could be done in 1 day.

Patient steps for treatment

1. Study patient’s condition (Questionnaire, X-Ray, MRI, blood work, reports…)

2. Medical team determines best therapy for specific case

3. Coordination and Scheduling (date of procedure, transportation, accommodation, meals, etc.)

4. Patient travel and logistics support.5. PROCEDURE6. Follow up (1 day, 7, 30, 60 and 90

days)

ProgenCell performs safe Stem cell ProgenCell performs safe Stem cell therapies therapies

with NO complications up to date!with NO complications up to date!

In other words, ProgenCell provides outpatient treatment to improve patient’s health conditions by

autoinfusion of stem cells obtained from bone marrow. 

Powerful, Practical and Cost Effective!Powerful, Practical and Cost Effective!

• More than 600 treatments• No complications - very safe• All cases have had improvement• 50% excellent results, only one case with bad

results because of other factors.

Factors influencing the outcomeFactors influencing the outcome• Bone marrow condition• Chronic Disease stage (advanced/early stage)• Multiple conditions present• Harmful habits

ProgenCell ResultsProgenCell Results

Medical Medical CommiteeCommitee

• Our medical staff are pioneers in stem cell therapies, with more than 10 years of experience.

• The Scientific and Ethic committees are formed by doctors with different specialties:

President of the Scientific Committee: Dr. Luis Romero President of the Committee of Scientists: Dr. Jorge Luis GaviñoInternal Medicine: Dr. Miguel Angel Matildes Orthopedics: Dr. Joaquín Garcia ZeevaertOphthalmology: Dra. Norma Niño SulkowskaCardiology: Dr. Héctor Soto EspinozaNeurology: Dr Hugo Navarrete

Facilities

ProgenCell is located just one block inside Mexico, at the US-MEXICO border.

ConclusionsConclusionsStem cell therapy is:

Effective for selected cases.

Is not for everyone and can’t cure all.

A new perspective in medicine.

Treatment with scientific base

Possible hope for current incurable diseases

Definitely a promising future!

Learn more about stem cell therapiesby contacting us!