straight from the horse’s mouth: mental health experts talk about ethics and evidence-based...
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Straight from the Horse’s Mouth: mental health experts talk about ethics
and evidence-based medicine
Straight from the Horse’s Mouth: mental health experts talk about ethics
and evidence-based medicine
Mona Gupta MD CM, FRCPC, MADeputy Chief of Psychiatry, Women’s College Hospital &
Lecturer, Department of Psychiatry, University of Toronto
JEMH annual conference
October 3, 2008
Mona Gupta MD CM, FRCPC, MADeputy Chief of Psychiatry, Women’s College Hospital &
Lecturer, Department of Psychiatry, University of Toronto
JEMH annual conference
October 3, 2008
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AcknowledgementsAcknowledgements
I would like to acknowledge, with gratitude:
1) the generous support of the people of Canada, through the Canadian Institutes of Health Research, which funded this research
2) my doctoral thesis committee: Ross Upshur (supervisor), Bill Harvey, Lynne Lohfeld, and Lawrie Reznek
3) Dr J Maher
I would like to acknowledge, with gratitude:
1) the generous support of the people of Canada, through the Canadian Institutes of Health Research, which funded this research
2) my doctoral thesis committee: Ross Upshur (supervisor), Bill Harvey, Lynne Lohfeld, and Lawrie Reznek
3) Dr J Maher
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ContextContext
‘Today, no therapeutic method will be fully accepted unless supported by randomized controlled trials. In other words, understanding disease and treating patients increasingly are dominated by an evidence-based approach.’
Paris (2000) CJP, Vol 45, p.34
‘…the only ethical practice in [child] psychiatry is one that uses the principles of evidence-based medicine.’
Szatmari (2003) EBMH, Vol 6, p.1
‘Today, no therapeutic method will be fully accepted unless supported by randomized controlled trials. In other words, understanding disease and treating patients increasingly are dominated by an evidence-based approach.’
Paris (2000) CJP, Vol 45, p.34
‘…the only ethical practice in [child] psychiatry is one that uses the principles of evidence-based medicine.’
Szatmari (2003) EBMH, Vol 6, p.1
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ContentsContents
I. Background
II. What does EBM say about ethics?
III. Methods
IV. Descriptive and Analytic Themes
V. Conclusions
I. Background
II. What does EBM say about ethics?
III. Methods
IV. Descriptive and Analytic Themes
V. Conclusions
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I. BackgroundI. Background
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PhD thesis project: The ethics of evidence-based psychiatry
PhD thesis project: The ethics of evidence-based psychiatry
Case study approach
Two types of data:
1) Documents: UG & EBM
2) Individual interviewsthree sources of interview data(three participant groups)
Case study approach
Two types of data:
1) Documents: UG & EBM
2) Individual interviewsthree sources of interview data(three participant groups)
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II. What does EBM say about ethics?
II. What does EBM say about ethics?
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Definition of EBMDefinition of EBM
The conscientious, explicit, and judicioususe of current best evidence in makingdecisions about the care of individual patients. The practice of evidence-basedmedicine requires integration ofindividual clinical expertise and patientpreferences with the best availableexternal clinical evidence fromsystematic research.
Users’ Guide, Guyatt and Rennie, 2002, 674
The conscientious, explicit, and judicioususe of current best evidence in makingdecisions about the care of individual patients. The practice of evidence-basedmedicine requires integration ofindividual clinical expertise and patientpreferences with the best availableexternal clinical evidence fromsystematic research.
Users’ Guide, Guyatt and Rennie, 2002, 674
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‘…evidence-based medicine requires the integration of the best research evidence with our clinical expertise and our patient’s unique values and circumstances.’
Straus et al, 2005,1
‘…evidence-based medicine requires the integration of the best research evidence with our clinical expertise and our patient’s unique values and circumstances.’
Straus et al, 2005,1
How to practice EBM
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Evidence Hierarchy Evidence Hierarchy
• N of 1 randomized controlled trial• Systematic review of randomized trials• Single randomized trial• Systematic review of observational studies
addressing patient-important outcomes• Single observational study addressing patient
important outcomes• Physiologic studies• Unsystematic clinical observations
Guyatt and Rennie, 2002, p.7
• N of 1 randomized controlled trial• Systematic review of randomized trials• Single randomized trial• Systematic review of observational studies
addressing patient-important outcomes• Single observational study addressing patient
important outcomes• Physiologic studies• Unsystematic clinical observations
Guyatt and Rennie, 2002, p.7
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Basic values of EBMBasic values of EBM
1. Health is good
2. We ought to pursue the most effective means of achieving health.
1. Health is good
2. We ought to pursue the most effective means of achieving health.
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Why should we practice EBM? Why should we practice EBM?
There is no scientific answer to this question. EBM’s/EBP’s scientific superiority and therefore, greater effectiveness in improving patients’ health are assumed to be true.
Valid (quantitative) data = evidence
Increased certainty about healthcare interventions
Improved health outcomes
There is no scientific answer to this question. EBM’s/EBP’s scientific superiority and therefore, greater effectiveness in improving patients’ health are assumed to be true.
Valid (quantitative) data = evidence
Increased certainty about healthcare interventions
Improved health outcomes
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Assumption of EBMAssumption of EBM
If we pursue EBM we arrive at the most effective means of achieving the best health outcomes.
If we pursue EBM we arrive at the most effective means of achieving the best health outcomes.
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The “Bottom Line” of EBMThe “Bottom Line” of EBMValues of EBM We ought to pursue the most effective means of achieving the best health outcomes.
+ Assumption of EBM If we pursue EBM we arrive at the most effective means of achieving the best health outcomes
---------------------------
= Ethical conclusion We SHOULD adopt EBM because it is the most effective means of achieving the best health outcomes.
Values of EBM We ought to pursue the most effective means of achieving the best health outcomes.
+ Assumption of EBM If we pursue EBM we arrive at the most effective means of achieving the best health outcomes
---------------------------
= Ethical conclusion We SHOULD adopt EBM because it is the most effective means of achieving the best health outcomes.
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There is one very specific reference to ethics in EBM…
There is one very specific reference to ethics in EBM…
‘Some would argue – taking an extreme of what can be called a deontological approach to distributive justice – that the clinician’s only responsibility should be to best meet the needs of the individual under her care. An alternate view – philosophically consequentialist or utilitarian – would contend that even in individual decision making, the clinician should take a broader social view. In this broader view, the effect on others of allocating resources to a particular patient’s care would bear on the decision.’ Our own belief is that while individual clinicians should attend primarily to the needs of the patients under their care, they should not neglect the resource implications of the advice they offer their patients. Neglect of resource issues in one patient, after all, may affect resource availability for other patients under their care.’
(O’Brien et al. 2002, 625-6)
‘Some would argue – taking an extreme of what can be called a deontological approach to distributive justice – that the clinician’s only responsibility should be to best meet the needs of the individual under her care. An alternate view – philosophically consequentialist or utilitarian – would contend that even in individual decision making, the clinician should take a broader social view. In this broader view, the effect on others of allocating resources to a particular patient’s care would bear on the decision.’ Our own belief is that while individual clinicians should attend primarily to the needs of the patients under their care, they should not neglect the resource implications of the advice they offer their patients. Neglect of resource issues in one patient, after all, may affect resource availability for other patients under their care.’
(O’Brien et al. 2002, 625-6)
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EBM is explicitly consequentialist in its ethical orientation:
EBM is explicitly consequentialist in its ethical orientation:
EBM
‘The clinical decision analysis should include all the treatment strategies and the full range of outcomes (both good and bad) that we think are important.’ p. 157
EBM
‘The clinical decision analysis should include all the treatment strategies and the full range of outcomes (both good and bad) that we think are important.’ p. 157
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EBM is also explicitly utilitarian in its ethical orientation
EBM is also explicitly utilitarian in its ethical orientation
UG‘…EBM can support the appropriate goals of gaining the greatest
health benefit from limited resources.’ p. 10
UG‘…clinicians need not only weigh the benefits and risks, but also
consider whether these benefits will be worth the health care resources consumed.’ p. 623
EBM‘We need to consider whether the intervention will provide a benefit
at an acceptable cost.’ p. 163
UG‘…EBM can support the appropriate goals of gaining the greatest
health benefit from limited resources.’ p. 10
UG‘…clinicians need not only weigh the benefits and risks, but also
consider whether these benefits will be worth the health care resources consumed.’ p. 623
EBM‘We need to consider whether the intervention will provide a benefit
at an acceptable cost.’ p. 163
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II. Methods for individual interviews
II. Methods for individual interviews
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Main PropositionsMain Propositions
1. Evidence-based medicine/psychiatry is perceived to be a more ethical form of practice that pre-EBM/EBP.
2. EBM/EBP is considered to be ethical because it results in increased benefit and/or decreased harm to patients.
1. Evidence-based medicine/psychiatry is perceived to be a more ethical form of practice that pre-EBM/EBP.
2. EBM/EBP is considered to be ethical because it results in increased benefit and/or decreased harm to patients.
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Data CollectionData Collection• 3 groups of participants:
1) EBM experts (9)2) EBMH experts (11)3) Scholars taking an ethical or philosophical approach to EBM (13)
• A word about proponents and critics…
• Interviews lasted, approx 45-60 minutes each• Each interview was audiorecorded, most to tapes, a
few directly to my computer.• All interviews were transcribed by an independent
transcriptionist, ‘scrubbed’ by me, anonymized.
• 3 groups of participants:1) EBM experts (9)2) EBMH experts (11)3) Scholars taking an ethical or philosophical approach to EBM (13)
• A word about proponents and critics…
• Interviews lasted, approx 45-60 minutes each• Each interview was audiorecorded, most to tapes, a
few directly to my computer.• All interviews were transcribed by an independent
transcriptionist, ‘scrubbed’ by me, anonymized.
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Interview GuideInterview GuideSECTION 1:
1. Can we begin by you telling me a bit about what your professional background is, and how you became involved with EBM?
2. What does the phrase ‘evidence-based medicine’ mean?
3. What are the qualities of an EBM/EBP practitioner?4. How does one become a practitioner of EBM/EBP?5. Is evidence-based psychiatry different from
evidence-based medicine? If so, how? If not, should it be?
SECTION 1:
1. Can we begin by you telling me a bit about what your professional background is, and how you became involved with EBM?
2. What does the phrase ‘evidence-based medicine’ mean?
3. What are the qualities of an EBM/EBP practitioner?4. How does one become a practitioner of EBM/EBP?5. Is evidence-based psychiatry different from
evidence-based medicine? If so, how? If not, should it be?
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Interview Guide cont’dInterview Guide cont’dSECTION 2:
6. What does the term, ‘ethics’ mean to you? probe: What does it mean to be an ethical practitioner/researcher/colleague etc?
7.a ) Does evidence-based practice promote or impede ethical practice?
b) Is this any different for psychiatric practice?8. Do you think EBM is value-neutral or value-laden? Please
elaborate.9. What has been the ethical impact of EBM/EBP, if any?
probes: practice, teaching, research, policy10. Are there ethical challenges for EBM/EBP? If so, what are
they?
SECTION 2:
6. What does the term, ‘ethics’ mean to you? probe: What does it mean to be an ethical practitioner/researcher/colleague etc?
7.a ) Does evidence-based practice promote or impede ethical practice?
b) Is this any different for psychiatric practice?8. Do you think EBM is value-neutral or value-laden? Please
elaborate.9. What has been the ethical impact of EBM/EBP, if any?
probes: practice, teaching, research, policy10. Are there ethical challenges for EBM/EBP? If so, what are
they?
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Data AnalysisData Analysis• Each transcript re-read, key themes noted, key quotes
highlighted
• Each transcript coded, using qualitative data management software package, HyperResearch
• Development of analytic and synthetic ideas (convergent, divergent and unique)
• Interim analysis - today I will present a mix of descriptive themes (answers to the questions) and analytic ideas (robust in terms of frequency and depth)
• Each transcript re-read, key themes noted, key quotes highlighted
• Each transcript coded, using qualitative data management software package, HyperResearch
• Development of analytic and synthetic ideas (convergent, divergent and unique)
• Interim analysis - today I will present a mix of descriptive themes (answers to the questions) and analytic ideas (robust in terms of frequency and depth)
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IV. Descriptive and Analytic Themes
IV. Descriptive and Analytic Themes
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What is EBM?What is EBM?• There was a lot of consistency in the formal
definition of EBM (hierarchy of evidence, patients’ values are essential to decision-making)
• Things became more confusing when there were opportunities to flesh it out, ie use examples they had given to figure out how EBM works in actual practice
• Quotes
• There was a lot of consistency in the formal definition of EBM (hierarchy of evidence, patients’ values are essential to decision-making)
• Things became more confusing when there were opportunities to flesh it out, ie use examples they had given to figure out how EBM works in actual practice
• Quotes
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1. Analytic theme:There is a major divide about what
EBM entails
1. Analytic theme:There is a major divide about what
EBM entails
• EBM is integration of evidence with patients’ values (esp. group 1)
vs
• EBM is about critical appraisal and bringing that knowledge to your clinical practice (esp. group 2)
• EBM is integration of evidence with patients’ values (esp. group 1)
vs
• EBM is about critical appraisal and bringing that knowledge to your clinical practice (esp. group 2)
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What is EBP?What is EBP?
• Principles of EBM are directly applied to mental health
• Whether they should be, varies
• Quotes
• Principles of EBM are directly applied to mental health
• Whether they should be, varies
• Quotes
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Who is an EBM practitioner?Who is an EBM practitioner?
• Someone with graduate-level training in methods
vs
• Someone who knows what the best pre-appraised sources are and looks up information there
• Someone with graduate-level training in methods
vs
• Someone who knows what the best pre-appraised sources are and looks up information there
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2. Analytic Theme:EBM promotes critical thinking
vs EBM impedes critical thinking
2. Analytic Theme:EBM promotes critical thinking
vs EBM impedes critical thinking
‘Critical thinking’ is an important concept that comes up for most participants.
EBM proponents (regardless of group) see EBM as encouraging a critical thinking
EBM critics (regardless of group) see EBM as discouraging critical thinking
‘Critical thinking’ is an important concept that comes up for most participants.
EBM proponents (regardless of group) see EBM as encouraging a critical thinking
EBM critics (regardless of group) see EBM as discouraging critical thinking
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EBM promotes ethical practiceEBM promotes ethical practice
1. EBM has the potential to tell us what is useless or harmful. This is particularly important in mental health.
• quotes
2. EBM helps us to be better practitioners by forcing us to recognize uncertainty
3. EBM helps us to deliver better care by promoting informed patient decision-making
1. EBM has the potential to tell us what is useless or harmful. This is particularly important in mental health.
• quotes
2. EBM helps us to be better practitioners by forcing us to recognize uncertainty
3. EBM helps us to deliver better care by promoting informed patient decision-making
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EBM impedes ethical practice: EBM impedes ethical practice:
1. EBM-sanctioned knowledge can be problematic in conceptual, ethical and practical ways e.g.industry influence on evidence creation
2. Larger issue: where is the user perspective?
3. Limits choice inappropriately
1. EBM-sanctioned knowledge can be problematic in conceptual, ethical and practical ways e.g.industry influence on evidence creation
2. Larger issue: where is the user perspective?
3. Limits choice inappropriately
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Unique ThemesUnique Themes
1. EBM has emerged in the context of the rise of certain social values
2. The demands of clinical practice may conflict with the principles of EBM• Acknowledging uncertainty vs the need to be
decisive
• Using treatments that do not have specific indications
• quotes
1. EBM has emerged in the context of the rise of certain social values
2. The demands of clinical practice may conflict with the principles of EBM• Acknowledging uncertainty vs the need to be
decisive
• Using treatments that do not have specific indications
• quotes
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V. ConclusionsV. Conclusions
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Next Steps with the dataNext Steps with the data
• ‘Clean’ the coding scheme• Continue to develop analytic and synthetic
ideas• Test the main propositions
My hunch - participants will NOT view EBM’s ethical principles as utilitarian, or even consequentialist, but as promoting both duties (particularly in the form of informed consent) and virtues (particularly honesty or transparency)
• ‘Clean’ the coding scheme• Continue to develop analytic and synthetic
ideas• Test the main propositions
My hunch - participants will NOT view EBM’s ethical principles as utilitarian, or even consequentialist, but as promoting both duties (particularly in the form of informed consent) and virtues (particularly honesty or transparency)
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A final word from mental health experts…
A final word from mental health experts…
Group 2 participants, whether proponents or critics, really see psychiatric practice as occurring within a values-saturated context. As a result, they focus more on the critical appraisal aspect of EBM and they worry less about ‘integration.’
Group 2 participants, whether proponents or critics, really see psychiatric practice as occurring within a values-saturated context. As a result, they focus more on the critical appraisal aspect of EBM and they worry less about ‘integration.’
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Thank you!Thank you!