strategies that work in early palliation of chronic disease · randomized to early integrated...
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STRATEGIES THAT WORK IN EARLY PALLIATION OF CHRONIC DISEASE
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■ Tara Lohmann MD FRCPC, Respirologist■ Jessica Simon MB ChB FRCPC, Palliative Care■ Michael Slawnych MD FRCPC, Cardiologist■ Chandra Thomas MSc MD FRCPC, Nephrologist
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Faculty/Presenter Disclosure
■ Faculty: Dr. Michael Slawnych
■ Relationships with financial sponsors: – Grants/Research Support: None– Speakers Bureau/Honoraria: Novartis: speaker fees for talk on palliative
cardiology– Consulting Fees: None– Patents: None– Other: Work for University of Calgary and Alberta Health Services
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Faculty/Presenter Disclosure
• Faculty: Tara Lohmann
• Relationships with financial sponsors:– Grants/Research Support: None– Speakers Bureau/Honoraria: None– Consulting Fees: None– Patents: None– Other: Work for University of Calgary and Alberta Health Services
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Faculty/Presenter Disclosure
• Faculty: Jessica Simon• Relationships with financial sponsors:
– Grants/Research Support: CIHR, Alberta Innovates, Canadian Frailty Network– Speakers Bureau/Honoraria: None– Consulting Fees: None– Patents: None– Other: Alberta Health Services (physician consultant ACP, GCD, AHS Calgary
Zone
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Faculty/Presenter Disclosure
• Faculty: Chandra Thomas
– Grants/Research Support: None– Speakers Bureau/Honoraria: None– Consulting Fees: None– Patents: None– Other: Work for University of Calgary and AHS
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Disclosure of Financial Support
• This program has NOT received financial support
• This program has NOT received in-kind support from
• Potential for conflict(s) of interest:– NONE
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Mitigating Potential Bias
- This talk will not include any discussion of drugs/therapies related Novartis.
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Workshop Objectives■ Employ strategies to overcome barriers in providing a
palliative care approach. ■ Recognize the impact of prognostic uncertainty in
delaying the provision of palliative care. ■ Apply a rational approach to deprescribing medications
and advanced interventions in persons with chronic disease in the last years of life.
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What is the palliative care that you do in your practice?
What are hoping to take away from today?
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I consult the palliative care service:
NeverRarelySometimesOftenAlways
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Why would/wouldn’t you consult the palliative care service?
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Some definitions- Palliative care- Palliative approach to care- Hospice care
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151 Patients with newly diagnosed with metastatic NSCL cancer randomized to early integrated palliative care (PC) vs standard oncologic treatment
PC group had better quality of life (FACT-L, HADS), fewer patients had depressive symptoms (16% vs 38%)
Fewer patients in the PC group had aggressive end-of-life care, yet median survival was longer (11.6 vs 8.9 months)
Temel JS et al. NEJM 2010; 363: 733-42
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What is a palliative approach to care?
Adapted from Temel et al., 2010; Boucher et al., 2018
Illness comprehension
and coping
Symptoms and functional
status
Advance Care Planning and
shared decision making
Coordination of care
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Barriers to palliative
care in non-cancer disease
Patient/Carer
factors
Physician & HCP
factors
Illnessfactors
Systemfactors
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Based on the definition of a palliative care approach, does this reframe your role in the palliative care of your patients?
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What is the evidence for a palliative approach to care in non-cancer?
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■ Improved breathlessness mastery (CRQ) in the intervention group vs. control
■ Pre-post analysis: intervention group had improved quality of life, dyspnea, mastery, POS at 6 weeks.
■ Survival benefit in the intervention group
Higginson et al. Lancet Respir Med 2014 (2): 979-987.
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INSPIRED COPD Outreach Program TM
■ Home-based COPD program designed to ease transitions from hospital to community
Rocker, G.M. & Verma, J. ‘INSPIRED’ COPD Outreach Program™: Doing the right things right. Clinical & Investigative Medicine 2014; 38(1): E311-E319.
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Why? Early conversations about patient values and goals linked to better serious illness care
• Increased goal-concordant care
• Improved quality of life / patient well-being
• Fewer hospitalizations
• More and earlier palliative/hospice care
• Better patient and family coping
Mack JCO 2010; Wright JAMA 2008; Chiarchiaro AATS 2015; Detering BMJ 2010; Zhang Annals 2009
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Heyland 2006 CMAJ
What matters most to seriously ill patients?
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Who has heard of the Serious Illness Conversation Care Program?
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A tool you can use: The Serious Illness Care Program
The Serious Illness Care Program improves the lives of people with serious illness by increasing meaningful conversations with their clinicians about their values and priorities
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https://www.youtube.com/watch?v=45b2QZxDd_o
Atul Gawande Video
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Tools
Education
Systems Change
Serious Illness Care Program Components
Measurement and Improvement (QI)
Reminder SystemConversation
using the Guide
Documentation template in EMR
Patient & Family ResourcesPatient Screening
Serious Illness Conversation Guide
Clinician ReferenceGuide
Patient preparation materials
Family Comm.Guide
Train Clinicians
2.5-hour clinician training sessions
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Why?
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What do checklists or guides do?
• Bridge gap between evidence and “real world”implementation
• Assure adherence to key processes• Achieve higher level of baseline performance• Ensure completion of necessary tasks during
complex, stressful situations
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Clinician Steps• Prompts
essential steps• Intentional sequence
Conversation Guide• Critical topics• Proven language
So what is the guide?
… embedded in a Process that includes cuing and documenting
Checklist + Language + Process
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Out-patient Process
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Nurse champion screens handover
report(>5days, >65yrs)
MDdecides if patient is appropriate or identifies other
patients
Nurse Champion flags 1-2 patients per meeting and raises these at handover
At Bullet Rounds Nurse Clinician identifies staff
member to set up family meeting
Staff member prepares patient and asks who else should be at the meeting (checks if
green sleeve in hospital) gives info letter
Pt agrees to meeting
Staff member sets up meeting (room/translator etc):1. Makes appt in SCM
2. Pages MD to confirm
Day of conversation: 1. Charge nurse cues MD
of meeting2. Pages MD if late/no
show
MD gets conversation materials and
handouts from designated location
MD has conversation
and gives handout materials to pt(± residents)
Bedside nurse follows up with pt
about conversation
MD:1. Documents on TR
and prints2. Shows TR to
patient
On Discharge:1.Bedside Nurse checks latest TR
and GCD in green sleeve2. Instructs pt on how to use green sleeve and sends it home with pt
Yes
Yes
NoMD informed
Unit clerk puts TR in Green sleeve
Pt confirms TRMD hands it to unit
clerk
Yes
No
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How to bridge the gap between what patients wantand what they get?
Ask patients about their values and prioritiesand write it down
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PAUSE
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Rationalizing medications and investigations
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You have had a serious illness care conversation with Dorothy
Illness Understanding: last year of life, deteriorating health
Goals: Remaining in her home as long as possible
Worries: Taking so many pills, not afraid to die, hopes to die in her sleep
Sources of strength: Her faith
Critical abilities: Eating and talking
Tradeoffs: Does not want “heroics” or prolonged hospital stays, would rather allow natural death at that time
Family: Is wondering about asking her homecare companion to be her agent
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Dorothy’s meds…TiotropiumSalbutamolBudesonide/FormoterolAcetaminophen SR 650mg tidMorphine IR 10 mg qid prnGabapentin 300 mg at bedtimeDocusate 100 mg po dailySenna 8.6-17.2mg as neededOmeprazole 30 mg bidGlargine insulin 25 units at bedtimeHumulin R 8-12 units bid qAM & qSupperLevothyroxine 88 mcg daily Amlodipine 10 mg dailyFurosemide 80 mg bidCarvedilol 25 mg bid
Ramipril 10 mg bidNitro patch 0.6 mg/h on during the dayAtorvastatin 20 mg daily at bedtimeAmiodarone 200 mg p.o. once dailyWarfarin 2mg alternating with 3mg dailyVitamin D3 2000 units dailyCalcium carbondate 1250mg tidDarbepoeitin 40 mcg sc every 2 weeksFerrous Fumuarate 300 mg bidEscitalopram 20 mg p.o. once dailyDuloxetine 60 mg p.o. once daily Zopiclone 7.5 mg daily at bedtimeTrazodone 400 mg p.o. once daily Melatonin 5 mg p.o. at bedtime
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Mild cognitive impairment
HFrEF, Prior MI, CABG, ICD, Afibon anticoagulation
CKD with an eGFR of 12ml/min
COPD
GERD
DM2 on insulin
Remote colon cancer treated surgically
Osteoarthritis, Chronic pain
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How Many Prescription Medications are Canadian Seniors Taking?
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https://www.ismp-canada.org/download/safetyBulletins/2018/ISMPCSB2018-03-Deprescribing.pdf
Canadian Institute for Health Information - 2014
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Morin et al. 2017
Polypharmacy Over the Course of the Last 12 Months of Life of Older People in Sweden, by Living Arrangement
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Dr. Pinel ordering the removal of chains from patients at the Paris Asylum for insane women (1795 Painting by Tony Robert-Fleury)
Dr. Philippe Pinel, French Physician and Psychiatrist (1745-1826)
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“It is an art of no little importance to administer medicines properly; but it is an art of much greater and more difficult acquisition to know when to suspend or altogether omit them.”
Pinel ordering the removal of chains from patients at the Paris Asylum for insane women (1795 Painting by Tony Robert-Fleury)
Dr. Philippe Pinel, French Physician and Psychiatrist (1745-1826)
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Appropriate polypharmacyMedications are prescribed according to best evidence and their use has been optimised
Problematic polypharmacyThe prescribing of multiple medications where the intended benefit of the medications are not realised.
https://www.nice.org.uk/advice/ktt16
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1. Identification– Patients with multi-morbidity* are identified by their GP
practice
2. Assessing Values, Priorities and Goals– Patients with an individualized management plan for multi-
morbidity are given opportunities to discuss their values, priorities and goals
3. Coordination of Care– Patients get an individualized management plan and know
who is responsible for coordinating their care
4. Reviewing Medicines and Other Treatments– discuss whether medicines and other treatments can be
stopped or changed
*more than 1 long-term health condition
Clinical Assessment and Management of Multimorbidity: NICE guideline
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Statins …
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• In both old (75–84 years) and very old (85+) people without diabetes, taking statins was not associated with a lower risk for CVD or all-cause mortality.
• Among those with diabetes, statin use was associated with lower CVD risk (hazard ratio, 0.76) and all-cause mortality (0.84) in the 75–84 age group; the protective effect was not apparent among the very old.
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Kutner et al. 2015
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• Eligibility included:• adults with an estimated life expectancy of between
1 month and 1 year • statin therapy for 3 months or more for primary or
secondary prevention of cardiovascular disease• recent deterioration in functional status • no recent active cardiovascular disease
• ~ 50% of the patients had a cancer diagnosis
• Participants were randomized to either discontinue or continue statin therapy and were monitored monthly for up to 1 year.
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Fitting it all together
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How do we navigate advanced technology in individuals with multimorbidity and prognostic uncertainty?
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Illness Trajectories
Lunney, Lynn, Hogan. J Am Geritric Soc, 2002
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What is dialysis?What can dialysis provide and not provide?What situations/conditions make providing dialysis challenging?Is dialysis technically feasible for this individual?Is dialysis in the best interest of this individual?Is dialysis consistent with this individual’s goals?
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Source: N Engl J Med 2009;361:1539-47.
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Source: N Engl J Med 2009;361:1539-47.
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https://secure.cihi.ca/free_products/2015_CORR_AnnualReport_ENweb.pdf
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Dorothy decides that dialysis is not consistent with her goals…
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Admitted with shortness of breath…
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Heated, Humidified High-flow oxygen (HHHFO): OptiflowTM
(Optiflow TM) Fisher & Paykel Healthcare
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What are your experiences with HHHFO?
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Heated, Humidified High-Flow Oxygen (OptiflowTM)
PROCan eat, communicate
Improved mucociliary clearance
Less nasal dryness vs conventional oxygen therapies (1)
May reduce dyspnea severity and respiratory distress (2,3,4)May reduce the need for mechanical ventilation (in pts accepting ICU)More comfortable than face mask (3)
CONMust be connected to wall oxygen source at all timesReports of dyspnea crises when weaningNot yet known if safe in hypercapnic respiratory failureFalse sense of clinical stability
Noisy device
Limited resource, cost
1. Cuquemelle et al. Respir Care 2012 2. Frat JP et al. NEJM 2015 3. Sotello et al. Am J Med Sci 2015 4. Epstein et al. J Pall Med 20177
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Severe hypoxemia + M1 GCDUnderlying causes have been investigated and being treated
Is HHHFO indicated?Can’t tolerate other high flow oxygen devices
Dyspnea refractory to non-pharmacologic and pharmacologic interventionsSecretions are difficult to expectorate
Are there contraindications?AECOPD with pH <7.35
Acute or chronic respiratory acidosisNasal pathology
YES NO
Continue treating with other high flow oxygen modalities to target SpO2
YES
NO
Discussion with patient & familyPros/cons of optiflowTreatments and expected outcomesPlan for if deterioration occurs despite maximum medical Rx and HHHFO
Consider other modalities:eg BIPAP for AECOPD with low pH
Initiate HHHFOMonitor and titrate therapy according to protocols
Improving clinical status? YES
Titrate HHFO to achieve treatment goals, discontinue if/when possible
NO
Optimize causes/comorbiditiesReassess treatment goals +/- GCD
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What about the ICD …
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1st Documented Successful Defibrillation of a Human (Dr. Claude Beck (1947)
From: The Birth of Defibrillation: A Slow March Towards Treating Sudden Death Stephen by M. Chihrin
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Bernard Lown, MD, Nobel Laureate
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“… the implanted defibrillator system represents an imperfect solution in search of a plausible and practical application … ”
“If the patient with such an implanted device is found dead, numerous questions will loom including the gnawing doubt that electrocution may have been a factor … ”
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Michel Mirowski, MD (from Kappenberger 2010)
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328,027 ICDs were implanted in 2009•222,407 new implants (133,262 in the USA – 60%)•105,620 generator upgrades
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Are ICDs effective?
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Stewart et al. 2010
Patient Expectations from ICDs to Prevent Death
Subjects were asked how many lives per 100 they would expect an ICD to save during the first 5 years after implantation
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Stewart et al. 2010
Patient Expectations from ICDs to Prevent Death
Subjects were asked how many lives per 100 they would expect an ICD to save during the first 5 years after implantation
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Stewart et al. 2010
Patient Expectations from ICDs to Prevent Death
Subjects were asked how many lives per 100 they would expect an ICD to save during the first 5 years after implantation
7.2%
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ICD deactivation was discussed and agreed upon
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Dorothy ultimately dies peacefully…
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Recap
Employ strategies to overcome barriers in providing a palliative care approach. Recognize the impact of prognostic uncertainty in delaying the provision of palliative care. Apply a rational approach to deprescribing medications and advanced interventions in persons with chronic disease in the last years of life.
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Questions