structure of v3-containing hiv-1 gp120 core huang, c. c., tang, m., zhang, m. y., majeed, s.,...

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Outline ●V3 region of gp120 protein plays a critical role in HIV entry to CD4 T-Cells ●V3 sequences are conserved and determine coreceptor used for viral entry ●Superimposing antibodies on V3 structure with core blocks coreceptor binding ●Accessibility of antibodies to V3 aids in immunodominance ●Studying the structure of V3 can aid in the understanding of the neutralization and progression of HIV virus

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