Journal of Inorganic Eioc~e~~st~y 96 @OO.?)

tudies on platinum(I1) complexes 8 a eis-PtL,Cl, where L stands

T”e University of Sydney, Australia iversity of Sydney, Australia

Philip Beale, Royal Prince @red Hospital NSW Australia

~~splati~ i,s a highly used and successful drug in cancer chemotherapy. However, it suffers from two major ~~~wba~k~ which are severe normal tissue toxicity and the frequent occurrence of initial and acquired resistance to t~e~t~e~~. The side- effects include neurotoxicity, nephrotoxicity, ototoxicity, nausea, vomiting and hair-loss. In an attempt to reduce toxicity and widen the spectrum of activity, thousands of cisplatin analogues have been prepared by varying e ~~at~~~ ofthe labile and non-labile ligands. However, it is found that all cisplatin analogues generally have similar s~~~t~~lrn of activity and develop similar resistance. Currently platinum compounds with markedly different structures are looked 8.t with the idea that these may have distinctly different types of interaction with DNA and hence different spectrum of~~t~vi~ eg ~~ana~arn~~e ~iati~urn complexes and compounds with multiple metal centres. It was suggested that the ~~trodM~t~o~ of bulky pl ligands could activate trams-geometry by reducing the reactivity of the compounds. redeem such ~o~~~~~~~d$ prepared. It has also been found that planaramineplatinum(I1) corn iexes with cis-geometry can also be antica

473. The aim of the present study is to prepare new cis-planaramineplatinum (II) ~orn~~~~e~ oftbe type cis- PtL,Cl, and cis-Pt ( LCl, [where L stands for 3-hydroxypyridine and 2,3-diaminepyrid~ne~, dete designed complexe inst a number of cancer cell-lines and quantify the nature ofinteraction wit are synthesized using modified Dhara method. Interaction with DNA is studied using eel-electrode visible s~e~tr~photomet~ and restriction enzyme digestion. Activity against a number of ~isplati~- resistant cancer ceil-lines is determined using MTT assay. All the three compo This poster will describe the results of the studies in terms of their structure a