sunday, february 19, 2012 -...
TRANSCRIPT
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SCIENTIFIC PROGRAM Sunday, February 19, 2012 First day of the workshop/open day at the Weizmann Institute of Science (WIS) – Rehovot 08:30 Bus departs from Tel-Aviv to the WIS campus (invited
speakers from overseas only) 09:30 Registration, exhibition and coffee 10:00 Welcome 10:05 Welcome address by: Haim Garty, Vice President of
the Weizmann Institute of Science
SESSION 1: PCD IN DEVELOPMENT & DISEASE
Chair: Adi Kimchi 10:15 STEM CELLS, APOPTOSIS AND TUMOR
SUPPRESSION Hermann Steller, HHMI/Rockefeller University, USA
10:50 MOLECULAR DISSECTION OF A PROGRAMMED
NECROSIS PATHWAY Xiaodong Wang, National Institute of Biological Sciences, China
11:25 ROLE OF AUTOPHAGY IN SUPPORTING CANCER
METABOLISM AND GROWTH Eileen White, Rutgers University, USA
12:00-13:00 Light lunch for registered participants
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Sunday, February 19, 2012
SESSION 2: MECHANISMS OF PCD
Chair: David Wallach 13:00 CUTTING BOTH WAYS: HOW CASPASES
PROMOTE AND PREVENT CELL DEATH Douglas Green, St. Jude Children's Research Hospital, USA
13:35 RELEASE OF FIND-ME SIGNALS DURING
APOPTOSIS Kodi Ravichandran, University of Virginia, USA
14:10 ARE CERTAIN BCL-2 PRO-SURVIVAL PROTEINS
ESSENTIAL FOR CANCER DEVELOPMENT OR MAINTENANCE? Jerry Adams, Walter and Eliza Hall Institute, Australia
14:45 AN UPSTREAM ROLE OF RIP1 KINASE IN
MEDIATING TNFα PRODUCTION Junying Yuan, Harvard Medical School, USA
15:20 Coffee Break 16:00 Bus departs from WIS to Ein-Gedi 18:00 Ein-Gedi: check-in
19:30 Dinner 20:30 Cocktail Reception
(“Baobab” lawn, nearby the hotel lobby)
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Monday, February 20, 2012 04:00-04:30 Coffee and Cake (Amihai Hall, adjacent to the lobby) 04:30-09:00 Masada at Sunrise (Dining room for breakfast is open until 09:45) SESSION 3: APOPTOSIS IN DEVELOPMENT I
Chairs: Kristin White & Andreas Bergmann 11:15 GENETIC ANALYSIS OF CHEMOTHERAPEUTIC
AGENT-INDUCED APOPTOSIS IN C. ELEGANS Michael Hengartner, University of Zurich, Switzerland 11:40 DEATH AND SURVIVAL IN THE C. ELEGANS
NERVOUS SYSTEM Barbara Conradt, LMU Biocenter, Germany 12:05 DROSOPHILA P53 ISOFORMS DIFFERENTIALLY
REGULATE APOPTOSIS AND COMPENSATORY PROLIFERATION
Bertrand Mollereau, Ecole Normale Supérieure of Lyon, France
12:30 THE ROLE OF APOPTOSIS/CELL COMPETITION
IN TUMOUR GROWTH IN DROSOPHILA Gines Morata, The Centro de Biología Molecular
Severo Ochoa, Spain 12:55 VASCULAR PATTERNING REGULATES
INTERDIGITAL CELL DEATH VIA A ROS-MEDIATED MECHANISM
Elazar Zelzer, Weizmann Institute of Science, Israel 13:20-14:30 Lunch
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Monday, February 20, 2012
SESSION 4: PCD SIGNALING, METABOLISM & DISEASE
Chairs: Kodi Ravichandran & Suzanne Cory 14:45 INVOLVEMENT OF P73, A P53-FAMILY MEMBER,
IN METABOLISM AND SENESCENCE Gerry Melino, University of Leicester, UK 15:10 HIPPO PATHWAY AND DNA DAMAGE RESPONSE Yosef Shaul, Weizmann Institute of Science, Israel 15:35 VDAC1-BASED PEPTIDES INTERACT WITH ANTI-
APOPTOTIC PROTEINS TO PREVENT THEIR PROTECTION AGAINST CELL DEATH
Varda Shoshan-Barmatz, Ben-Gurion University, Israel
16:00 IMMUNOGENIC CELL STRESS AND DEATH IN
ANTICANCER CHEMOTHERAPIES Guido Kroemer, Institut Gustave Roussy, France 16:25-17:00 Coffee Break
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Monday, February 20, 2012
SESSION 4 (cont’d)
Chairs: Kodi Ravichandran & Suzanne Cory 17:00 LINEAR UBIQUITIN IN CELL DEATH AND
IMMUNE SIGNALING Henning Walczak, Imperial College London, UK
17:25 CORRECTION OF AXON GUIDANCE ERRORS
RESULT IN NEURONAL CELL LOSS Oded Behar, The Hebrew University of Jerusalem,
Israel 17:50 CONTROL OF CASPASE-8 ACTIVATION BY
UBIQUITIN Avi Ashkenazi, Genentech, USA 18:15 DEATH-INDEPENDENT OUTCOMES OF FAS
RECEPTOR STIMULATION Sean Cullen, Trinity College Dublin, Ireland 18:30-19:45 Dinner 20:00-22:00 Poster session I
The “Best Poster” committee: Seamus Martin, Masayuki Miura, & Colin Duckett
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Tuesday, February 21, 2012
Session 5: The Mitochondrial Pathway
Chairs: Xiaodong Wang & Douglass Green 09:00 THE DYNAMICS OF BAX LOCALIZATION TO
MITOCHONDRIA Richard J. Youle, National Institutes of Health, USA
09:25 REGULATION OF CASPASE-DEPENDENT AND
INDEPENDENT CELL DEATH BY THE BCL-2 FAMILY Emily Cheng, Memorial Sloan-Kettering Cancer Center, USA
09:50 INTEGRATING MITOCHONDRIAL MORPHOLOGY
AND ULTRASTRUCTURE IN THE CONTROL OF APOPTOSIS: LESSONS FROM CELLULAR AND MOUSE MODELS Luca Scorrano, University of Geneva, Switzerland
10:15 NOVEL FUNCTIONS FOR ANCIENT BCL-2
FAMILY MEMBERS Jean-Claude Martinou, University of Geneva, Switzerland
10:40-11:10 Coffee Break
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Tuesday, February 21, 2012
Session 5 (cont’d)
Chairs: Xiaodong Wang & Douglass Green 11:10 INTERACTIONS WITH SUB-CELLULAR
MEMBRANES REGULATE BCL-2 FAMILY PROTEIN: PROTEIN INTERACTIONS WITH LIFE AND DEATH CONSEQUENCES David Andrews, McMaster University, Canada
11:35 REGULATION OF STRESS-INDUCED NUCLEAR
PROTEIN REDISTRIBUTION: A NOVEL FUNCTION AND ACTION OF BAX AND BAK Reuven Stein, Tel Aviv University, Israel
12:00 A NOVEL MITOCHONDRIAL PATHWAY THAT
REGULATES CELL FATE AND FUNCTION Atan Gross, Weizmann Institute of Science, Israel
12:25 DIFFERENTIAL CONTROL OF BAK TARGETING
AND BAK-MEDIATED CELL DEATH IN NORMAL LIVER AND LIVER TUMOR Gyorgy Hajnoczky, Thomas Jefferson University, USA
12:50 THE ATM-BID PATHWAY REGULATES
QUIESCENCE AND SURVIVAL OF HEMATOPOIETIC STEM CELLS Maria Maryanovich, Weizmann Institute of Science, Israel
13:05-14:30 Lunch 14:45-17:30 Ein-Gedi Springs and the Dead-Sea (departure 14:45 &
15:00) OR walking tour of the Botanical garden (14:30) 18:00-19:15 Dinner
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Tuesday, February 21, 2012
Session 6: Immunity, Signaling & Cell Clearance
Chairs: Eileen White & Gideon Berke 19:30 INTERACTIONS BETWEEN DYING CELLS AND
THE IMMUNE SYSTEM Seamus Martin, The Smurfit Institute, Trinity College, Ireland
19:55 MOLECULAR MECHANISMS OF PHAGOCYTIC
RECEPTOR ACTION IN APOPTOTIC CELL CLEARANCE Estee Kurant, Technion - Israel Institute of Technology, Israel
20:20 NEW LIVES GIVEN BY CELL DEATH:
MACROPHAGE DIFFERENTIATION FOLLOWING THEIR ENCOUNTER WITH APOPTOTIC LEUKOCYTES DURING THE RESOLUTION OF INFLAMMATION Amiram Ariel, University of Haifa, Israel
20:45-21:15 Coffee break 21:15 THE ‘APOPTOTIC’ CASPASES AS REGULATORS
OF INFLAMMATION: NEW LESSONS ABOUT CASPASE-8 FUNCTION David Wallach, Weizmann Institute of Science, Israel
21:40 THE E3 UBIQUITIN LIGASE SCF β-TrCP IS
ESSENTIAL FOR INTESTINAL BARRIER FUNCTION AND GUT HOMEOSTASIS
Yinon Ben-Neriah, The Hebrew University of Jerusalem, Israel
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Wednesday, February 22, 2012
Session 7: PCD & Inhibitor of Apoptosis (IAP) Proteins
Chairs: Hermann Steller & Guy Salvesen 09:00 IAP (INHIBITOR OF APOPTOSIS) PROTEINS AT
THE INTERFACE OF APOPTOSIS AND INTRACELLULAR SIGNALING Colin Duckett, University of Michigan Medical School, USA
09:25 IAP-ANTAGONIST REGULATION IN DROSOPHILA
Hyung Don Ryoo, New York University School of Medicine, USA
09:50 THE INHIBITOR OF APOPTOSIS PROTEIN LIVIN
PLAYS A DUAL ROLE IN TUMORIGENICITY AND MAY SERVE AS POTENTIAL TARGETS FOR CANCER THERAPY Dina Ben-Yehuda, The Hebrew University of Jerusalem, Israel
10:15 THE PRO-APOPTOTIC ARTS PROTEIN INITIATES
MITOCHONDRIAL APOPTOSIS UPSTREAM OF MOMP AND PROMOTES THE RELEASE OF CYTOCHROME C AND SMAC/DIABLO Sarit Larisch, University of Haifa, Israel
10:40 SEPT4/ARTS REGULATES STEM-CELL
DEPENDENT REGENERATION AND TUMOR FORMATION Yaron Fuchs, Rockefeller University, USA
10:55-11:25 Coffee break
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Wednesday, February 22, 2012
Session 8: Apoptosis in Development II
Chairs: Michael Hengartner & Gines Morata 11:25 PHYSIOLOGICAL FUNCTION OF CELL DEATH
DURING NEURAL DEVELOPMENT Masayuki Miura, University of Tokyo, Japan
11:50 THE NAB-BRK SIGNAL BIFURCATES AT JNK TO
INDEPENDENTLY INDUCE APOPTOSIS AND COMPENSATORY PROLIFERATION
Offer Gerlitz, The Hebrew University of Jerusalem, Israel
12:15 DISTINCT SPATIOTEMPORAL PATHWAYS
CONVERGE ON A UBIQUITIN LIGASE COMPLEX TO RESTRICT CASPASE ACTIVATION DURING SPERMATID TERMINAL DIFFERENTIATION IN DROSOPHILA Eli Arama, Weizmann Institute of Science, Israel
12:40 GENETIC CONTROL OF PROGRAMMED CELL
DEATH IN DROSOPHILA Andreas Bergmann, University of Massachusetts Medical School, USA
13:05-14:20 Lunch
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Wednesday, February 22, 2012
Session 9: PCD Without the Canonical Apoptotic Machinery
Chairs: Guido Kroemer & Yossi Shiloh 14:30 YEAST AS A CELL DEATH MODEL SYSTEM
IDENTIFIES NEW HUMAN DISEASE GENES J. Marie Hardwick, Johns Hopkins University, USA
14:55 “CHEMICAL ARMS RACE AT SEA”: THE ROLE
OF SPHINGOLIPIDS IN REGULATION OF PCD AND VIRAL REPLICATION CYCLES DURING HOST-VIRUS INTERACTIONS IN THE MARINE ENVIRONMENT Asaf Vardi, Weizmann Institute of Science, Israel
15:20 DEVELOPMENTAL CELL DEATH IN
DICTYOSTELIUM Pierre Golstein, Centre d’Immunologie de Marseille-Luminy, France
15:45-16:10 Coffee break
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Wednesday, February 22, 2012
Session 9 (cont’d)
Chairs: Guido Kroemer & Yossi Shiloh 16:10 TWO PROGRAMMED CELL DEATH SYSTEMS IN
ESCHERICHIA COLI: AN APOPTOTIC-LIKE DEATH IS INHIBITED BY THE MAZEF-MEDIATED DEATH PATHWAY Hanna Engelberg-Kulka, The Hebrew University of Jerusalem, Israel
16:35 DIE HARDER: FROM APOPTOSIS TO NECROSIS
IN YEAST Frank Madeo, University of Graz, Austria
17:00 PLANT BIOLOGY: IN THE WORLD FULL OF
DYING CELLS, CELL CORPSES AND ANCESTRAL CELL-DEATH REGULATORS Peter Bozhkov, Uppsala BioCentre, Sweden
17:20-18:45 Poster session II
The “Best Poster” committee: Seamus Martin, Masayuki Miura, & Colin Duckett
19:30 Gala Dinner at Metzoke Dragot
Departure from the hotel lobby
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Thursday, February 23, 2012
Session 10: Apoptosis in Development III
Chairs: Pascal Meier & Shai Shaham 09:00 STRESS, DEATH AND THE P53 REGULATORY
NETWORK John Abrams, University of Texas Southwestern Medical Center, USA
09:25 REGULATION OF NEURAL STEM CELL
APOPTOSIS IN DROSOPHILA Kristin White, MGH/Harvard Medical School, USA
09:50 CELL DEATH AND CORPSE CLEARANCE IN THE
DROSOPHILA OVARY Kim McCall, Boston University, USA
10:15 INDUCTION OF NON-CLASSICAL APOPTOSIS BY
THE ADENOVIRUS E4ORF4 PROTEIN Tamar Kleinberger, Technion - Israel Institute of Technology, Israel
10:30-11:00 Coffee break
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Thursday, February 23, 2012
Session 11: Caspases, Apoptosis & Cellular Remodeling
Chairs: Moshe Oren & Avi Ashkenazi 11:00 CASPASES, PARACASPASES, AND THE SPACE
BETWEEN DEATH AND SURVIVAL Guy Salvesen, Sanford-Burnham Medical Research Institute, USA
11:25 REGULATION OF CASPASE ACTIVATION Pascal Meier, The Institute of Cancer Research, UK
11:50 MECHANISMS OF OF NEURONAL ELIMINATION DURING DEVELOPMENT Avraham Yaron, Weizmann Institute of Science, Israel
12:15 DSARM/SARM1 GOVERNS A NOVEL INJURY-
INDUCED AXON DEATH PATHWAY Marc Freeman, University of Massachusetts Medical School/HHMI, USA
12:40 RESISTANCE TO APOPTOSIS IS REGULATED DURING DEVELOPMENT Arash Bashirullah, University of Wisconsin-Madison, USA
12:55-14:00 Lunch
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Thursday, February 23, 2012
Final session: Alternate Death Pathways
Chairs: Richard Youle & J. Marie Hardwick 14:15 SIGNALLING PATHWAYS CONTROLLING
AUTOPHAGY AND ITS CROSSTALK WITH APOPTOSIS Adi Kimchi, Weizmann Institute of Science, Israel
14:40 MEMBRANE PORE FORMATION AND PROGRAMMED NECROTIC CELL DEATH Zvi Fishelson, Tel Aviv University, Israel
15:05 A NEW C. ELEGANS CELL DEATH PROGRAM: IMPLICATIONS FOR NEURODEGENERATION AND CANCER Shai Shaham, Rockefeller University, USA
15:30 JUN PROTEINS ARE NOVEL REGULATORS OF AUTOPHAGY Eitan Shaulian, The Hebrew University of Jerusalem, Israel
15:55 AUTOPHAGY AND CELL DEATH: CONTEXT MATTERS Eric Baehrecke, University of Massachusetts Medical School, USA
16:20 THE ADAPTOR PROTEIN FADD PROTECTS EPIDERMAL KERATINOCYTES FROM NECROPTOSIS IN VIVO AND PREVENTS SKIN INFLAMMATION Marion Bonnet, University of Cologne, Germany
16:35-17:00 Coffee break
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Thursday, February 23, 2012
Keynotes
Chair: Gerry Melino 17:00 THE DARK SIDE OF P53: MUTANT P53 AND
CANCER Moshe Oren, Weizmann Institute of Science, Israel
17:30 THE DNA DAMAGE RESPONSE: SURVIVAL OR
DEMISE? Yosef Shiloh, Tel Aviv University, Israel
18:00 Closing remarks 18:15 Departure
Overnight at the Grand Court hotel in Jerusalem (pre-reserved only)
Friday, February 24, 2012 08:00 Half-day tour of Jerusalem ( pre-registered only)
Departure from the Grand-Court hotel Please present tour ticket Tour will end at 13:00 at the Grand-Court hotel
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LLIISSTT OOFF PPOOSSTTEERRSS
PCD in Development
P-1 Mtch2 during meiosis: molecular characterization, Andres Goldman, URUGUAY
P-2 To die or not to die, FAK is the question, Juan Pablo Macagno, SCOTLAND, UK
P-3 Global regulation of programmed cell death and survival in C. elegans, Nadin Memar, GERMANY
P-4 Apoptosis, cellular tension and morphogenesis, Magali Suzanne, FRANCE
P-5 Embryonic and induced stem cells express TRAIL receptors but are resistant to TRAIL induced apoptosis , Vladimir Vinarsky, CZECH REPUBLIC
PCD Signaling and Disease
P-6 A genetic screen to identify genes mediating ER stress induced retinal degeneration in Drosophila, Pedro Domingos, PORTUGAL
P-7 Monitoring protein-protein interactions within the cell death network, Yuval Gilad, ISRAEL
P-8 Mechanisms of cell death of resting human T cells induced by curcumin or etoposide, Zbigniew Korwek, POLAND
P-9 The protein expression pattern of VDAC1 and MAVS in human cancer and their potential usage as novel tumor biomarkers, Avia Lavon and Ilan Sela, ISRAEL
P-10 Expression and functions of T-plastin in cutaneous T cell lymphoma (CTCL), Laurence Michel, FRANCE
P-11 Regulation of non-apoptotic caspase activity by crinkled, an unconventional myosin, Mariam Orme, UK
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P-12 Induction of cell death by apoptotic cells, Ainhoa Perez-Garijo, USA
P-13 The antiapoptotic protein AAC-11 as a novel exploitable therapeutic target in human malignancies , Jean-Luc Poyet, FRANCE
P-14 Anti-apoptotic machinery protects botrytis from PCD-inducing plant metabolites and is essential for disease establishment, Neta Shlezinger, ISRAEL
P-15 The involvement of brain inflammation and TNFα in neuronal cell death in neuronopathic forms of Gaucher disease, Einat Vitner, ISRAEL
The Mitochondrial Pathway
P-16 Anion-transport inhibitors prevent VDAC1 oligomerization and apoptosis, Danya Ben Hail, ISRAEL
P-17 The role of MTCH2/MIMP in skeletal muscle, Liat Buzaglo, ISRAEL
P-18 IAP antagonist induced mitochondrial dynamics regulate XIAP degradation, Anshuman Kelkar, USA
P-19 The VDAC1 degradation pathway and stress-induced VDAC1 truncation: Characterization, mechanism and effect on apoptosis, Hadas Pahima, ISRAEL
P-20 A Physiological System for Selective Mitochondrial Destruction in Drosophila, Yoav Politi, ISRAEL
P-21 Mek/Erk phosphorylate Mfn1 switching its functions in mitochondrial morphology and apoptosis, Aswin Pyakurel, SWITZERLAND
P-22 Direct and indirect roles of the mitochondria in caspase activation during Drosophila spermatogenesis, Liat Ravid, ISRAEL
P-23 The autophagy protein Atg12 associates with anti-apoptotic Bcl-2 family members to promote mitochondrial apoptosis, Assaf Rubinstein, ISRAEL
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P-24 VDAC1-based peptides: Novel pro-apoptotic agents and a potential therapeutic drug for B-cell chronic lymphocytic leukemia, Anna Shteinfer, ISRAEL
P-25 Nanowire PALM of mitochondrial dynamics in cell life and death: a preliminary account, Kathy Ushakov, SWITZERLAND
P-26 The effect of VDAC1 silencing by siRNA on cancer cell growth, Lilia Vasilkovsky, ISRAEL
P-27 MTCH2/MIMP: A novel regulator of liver apoptosis and metabolism, Yehudit Zaltsman, ISRAEL
P-28 Cell Penetrating VDAC1-Based Peptides Can Induce Cell Death in Various Human Cancer Cell lines, Alexandra Zooravlov, ISRAEL
Caspases, Apoptosis and Cellular Remodeling
P-29 TNFα mediated hepatitis is inhibited due to Ceramide Synthase 2 deficiency, Muhammad Ali, ISRAEL
P-30 A caspase and E2F-1 dependent feed forward mechanism of Noxa induction favors activation of cell death by the Bcl-2/Bcl-xL inhibitor ABT-737, Frédérique Braun, FRANCE
P-31 Caspase levels and execution efficiencies determine the apoptotic potential of the cell, Anat Florentin, ISRAEL
P-32 DOR is a novel regulator of autophagy and apoptosis, Saska Ivanova, SPAIN
P-33 A caspase cascade of axon degeneration during development, David Simon, USA
Alternate Death Pathways
P-34 Streptolysins S-mediated cell necrosis switches on quorum sensing in Streptococci, Moshe Baruch, ISRAEL
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P-35 PKD is a novel VPS34-kinase that regulates ROS-induced autophagy downstream of DAPK, Avital Eisenberg-Lerner, ISRAEL
P-36 DAP1, a novel substrate of mTOR, negatively regulates autophagy, Itay Koren, ISRAEL
P-37 Study of non-classical low level cell death induced by adenovirus E4orf4 protein in Drosophila model system, Antonina Pechkovsky, ISRAEL
P-38 Autophagy plays a role in Ca2+-dependent retinal degeneration in Drosophila, Shirley Weiss, ISRAEL
P-39 The protease HtrA2/Omi and the lysosomal pathway mediate a nonapoptotic physiological cell death program in Drosophila, Keren Yacobi-Sharon, ISRAEL
PCD in Unicellular Organisms
P-40 Sensing environmental stress conditions and regulation of cell fate via redox signaling in diatoms, Shilo Rosenwasser, ISRAEL
P-41 The “double edged sword” role of reactive oxygen species in regulating susceptibility to viral infection Emiliania huxleyi, Uri Sheyn, ISRAEL
Immunity, Signaling and Cell Clearance
P-42 Novel roles for the chemokine receptor D6 in the regulation of the resolution of inflammation, Miran Aswad, ISRAEL
P-43 Role of lipids in apoptotic cells collection by microglia in developing brain, Oksana Breus, GERMANY
P-44 Novel roles for ARTS in neutrophil apoptosis and macrophage-mediated resolution of inflammation, Naama Maimon, ISRAEL
P-45 Molecular mechanisms in regulation of SIMU expression, Yael Sellman, ISRAEL