SUPERIOR PROTECTION RIGHT FROM THE START.

The costs of respiratory disease are astounding.

• Prevalence of 41% to 70% in U.S.7

• BRSV infection is

associated with high

morbidity (60% to 80%)8

• Fatality rates may

be as high as 20%8

$1BANNUAL COST

#1BEEF

#2DAIRY

It has been estimated that BRD costs the cattle industry $1 billion

annually from death, reduced feed efficiency and treatment costs.1

Respiratory disease remains the most economically devastating

condition in the beef industry2

• Approximately 75% of feedlot illnesses3,4,5

• 50% of feedlot deaths3,4,5

The second-most significant disease in dairy operations.6

• 22% of unweaned heifer deaths6 • 46% of weaned heifer deaths6

BRSV IBR PI3

• Immunosuppressive• May predispose cattle

to bacterial pneumonia9

• Easily spread• Causes severe upper

respiratory infections• Possible latent

infection

Safe for use in all types, ages and classes of cattle.

The safety of INFORCE™ 3 was demonstrated in three separate studies.

1. Field safety study15:

The safety of INFORCE 3 was evaluated in a cattle safety study, which was one of the largest

ever conducted by Zoetis. INFORCE 3 was administered intranasally to:

• 0- to 8-day-old calves • Pregnant cows in all three trimesters • Weaned calves • Total of 1,873 animals • High-stress stocker cattle • Three geographic locations

RESULTS — INFORCE 3: SAFE IN ALL TYPES, AGES AND CLASSES OF CATTLE

2. Intensive safety study in young calves16:

INFORCE 3 and a commercial 5-way intranasal vaccine were both administered intranasally:

• A 10X concentrated dose to 3- to 10-day-old colostrum-deprived calves • A dose of a commercial vaccine was administered parenterally to all animals 14 days

post-intranasal dose

RESULTS — INFORCE 3: SAFE IN YOUNG CALVES

3. High-risk stocker study17:

INFORCE 3 and a commercial 5-way intranasal vaccine were both administered intranasally to:

• High-risk stocker calves on arrival at a feedlot

• A dose of a commercial vaccine was administered parenterally to all calves 14 days

post-intranasal dose

RESULTS — INFORCE 3: SAFE IN HIGH-RISK STOCKER CATTLE

BRSV can be prevented.

INFORCE™ 3 is the first and only respiratory vaccine to be granted the “prevention of disease” indication, the highest label claim available for BRSV protection.

INFORCE 3 = NO DEATHS

All INFORCE 3 vaccinates survived

severe BRSV challenges, while almost

all unvaccinated controls died.10,11

20%

40%

60%

80%

100%

3- to 9-day-old calves*

(P 0.0001)

6- to 8-week-old calves*

(P 0.0001)

0%

–< –<

% M

orta

lity

100%90%

0% 0%

INFORCE 3 Control

INFORCE 3 = LESS LUNG DAMAGE

Fewer lung lesions due to BRSV

infections mean INFORCE 3 vaccinates

should be expected to require reduced

labor and treatment costs, and

improved productivity.9,10

20%

40%

60%

3- to 9-day-old calves*

(P=0.0006)

6- to 8-week-old calves*

(P<0.0001)

0%

% L

ung

Dam

age

57.6%

13.5%

43.8%

5.8%

INFORCE 3 Control

A strong defense against IBR and PI3 viruses.

INFORCE 3 Control

INFORCE 3 = LESS IBR DISEASE

Fewer sick calves mean less treatment

cost, reduced labor requirements

and decreased chance of secondary

bacterial infection.12,13

20%

40%

60%

80%

100%

3- to 9-day-old calves(P 0.0001)

6- to 8-week-old calves(P 0.0001)

0%

< <

% M

orbid

ity

100%100%

5.6% 5%

INFORCE 3 = LESS PI3 VIRUS SHEDDING

Compared with unvaccinated controls,

INFORCE 3 vaccinates shed 99.9% less

PI3 virus after challenge.14

99.9%LESS VIRUS SHED

Developed specifically for intranasal use.

• Helps stimulate local immunity• Triggers a rapid innate immune response• Helps provide protection where viruses attack first• Helps prime the immune system for a memory

response to subsequent disease challenges

1 Brodersen BA, Bovine respiratory syncytial virus. Vet Clin Food Anim 2010;26:323-333.2 NAHMS Beef Cow/Calf Health & Productivity Audit; Part III: Beef Cow/Calf Health Management, January 2008. Available at: http://www.aphis.usda. Accessed July 2010.3 Edwards AJ. Respiratory diseases of feedlot cattle in the USA. Bovine Practitioner 1996;30:5-7.4 Galyean ML, Perino LJ, Duff CG. Interaction of cattle health/immunity and nutrition. J Anim Sci 1999;77:1120-1134.5 Loneragan DH, Dargatz DA, Morley PS, et al. Trends in mortality rates among cattle in U.S. feedlots. J Amer Vet Med Assoc 2001;219:1122-1127.6 NAHMS Dairy 2007 Part I: Reference of Dairy Cattle Health and Management Practices in the United States, October 2007. Available at: http://www.aphis.usda. Accessed July 2010.7 Steven T, Grubbs ST, Kania SA, Potgieter LND. Prevalence of ovine and bovine respiratory syncytial virus infections in cattle determined with a synthetic peptide-based immunoassay. J Vet Diagn Invest 2001;13:128–132. 8 Valarcher JF, Geraldine Taylor G. Bovine respiratory syncytial virus infection Vet Res 2007;38:153-180. 9 Ellis JA. Bovine parainfluenza-3 virus, Vet Clin Food Anim, 2010 (In press).10 Data on file, Study Report No. 3131R-60-08-557, Zoetis Inc.11 Data on file, Study Report No. 3131R-60-09-669, Zoetis Inc.12 Data on file, Study Report No. 3131R-60-08-548, Zoetis Inc. 13 Data on file, Study Report No. 3131R-60-09-720, Zoetis Inc. 14 Data on file, Study Report No. 3131R-60-08-568, Zoetis Inc.15 Data on file, Study Report No. 3437R-60-09-716, Zoetis Inc.16 Data on file, Study Report No. 3131R-60-09-671, Zoetis Inc.17 Data on file, Study Report No. 3131W-60-09-672, Zoetis Inc.

All trademarks are the property of Zoetis Inc., its affiliates and/or its licensors. ©2013 Zoetis Inc. All rights reserved. INF13004

Get your cattle off to a stronger, healthier start with INFORCE 3. To learn more, contact your Zoetis representative, call 888-ZOETIS1

(888-963-8471) or visit zoetisUS.com.

Team up with your veterinarian to develop a complete vaccination protocol, starting with INFORCE™ 3.• INFORCE 3 helps give cattle a stronger start for greater productivity• Early protection can help reduce susceptibility to secondary bacterial infections• For dairy herds, use INFORCE 3 in baby calves, on arrival, at weaning,

before moving to group pens, or with cows and heifers prefreshening• INFORCE 3 is perfect for use in calves in beef herds at branding, preconditioning,

weaning, pre-shipment or on arrival in stocker or feedlots

A strong foundation for a complete vaccination protocol.

INFORCE 3 is available in four convenient dose sizes.