supplementary material for · ainstitute for advanced and applied chemical synthesis, jinan...
TRANSCRIPT
![Page 1: Supplementary Material for · aInstitute for Advanced and Applied Chemical Synthesis, Jinan University, Guangzhou, 510632, China and bResearch School of Chemistry, Institute of Advanced](https://reader035.vdocument.in/reader035/viewer/2022071516/6139155fa4cdb41a985b7a2a/html5/thumbnails/1.jpg)
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Supplementary Material for
The Synthesis, Structural Characterisation and Chemoselective Manipulation of Certain Functionalized Cyclic Sulfates Derived from Chiral, Non-Racemic and
Polysubstituted Bicyclo[2.2.2]octane-2,3-diols
Martin G. Banwell,a,* Antony L. Crisp,b BoRa Lee,b Ping Lan,a
Hannah Bollard,b Jas S. Ward,b and Anthony C. Willisb
aInstitute for Advanced and Applied Chemical Synthesis, Jinan University,
Guangzhou, 510632, China
and
bResearch School of Chemistry, Institute of Advanced Studies,
The Australian National University, Canberra, ACT 2601, Australia
CONTENTS Page
1. Plots Derived from the X-ray Analyses of Compounds 13, 16, 17, 18, 23, 25, 33, 40 and
42……………………………….………………………………………………………...S2
2. 1H and 13C{1H} NMR Spectra for Compounds 12 (1H NMR spectrum only), 13-18, 19,
20, (1H NMR spectrum only), 21/22 (mixture), 23-26, 28/29 (mixture), 30, 31/32
(mixture), 33, 34, 41, sulfite precursors to 42 (mixture) and 42 ………..…….……….S11
*Corresponding author. Email: [email protected]
10.1071/CH21140_ACAustralian Journal of Chemistry
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Figure S1: Plot arising from the single-crystal X-ray analysis of compound 13 – thermal ellipsoids at 50% probability (crystal grown by slow evaporation of a sample dissolved in
dichloromethane/hexane) (CCDC 2082646).
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Figure S2: Plot arising from the single-crystal X-ray analysis of compound 16 – thermal ellipsoids at 50% probability (crystal grown by slow evaporation of a sample dissolved in
dichloromethane/hexane) (CCDC 2082647).
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Figure S3: Plot arising from the single-crystal X-ray analysis of compound 17 – thermal ellipsoids at 50% probability (crystal grown by slow evaporation of a sample dissolved in
dichloromethane/hexane) (CCDC 2082648).
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Figure S4: Plot arising from the single-crystal X-ray analysis of compound 18 – thermal ellipsoids at 50% probability (crystal grown by slow evaporation of a sample dissolved in
dichloromethane/hexane) (CCDC 2082649).
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Figure S5: Plot arising from the single-crystal X-ray analysis of compound 23 – thermal ellipsoids at 50% probability (crystal grown by slow evaporation of a sample dissolved in
dichloromethane/ethyl acetate) (CCDC 2082650).
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Figure S6: Plot arising from the single-crystal X-ray analysis of compound 25 – thermal ellipsoids at 50% probability (crystal grown by slow evaporation of a sample dissolved in
dichloromethane/hexane/ethyl acetate/chloroform) (CCDC 2082651).
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Figure S7: Plot arising from the single-crystal X-ray analysis of compound 33 – thermal ellipsoids at 50% probability (crystal grown by slow evaporation of a sample dissolved in
dichloromethane/hexane/ethyl acetate) (CCDC 2082652).
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Figure S8: Plot arising from the single-crystal X-ray analysis of compound 40 – thermal
ellipsoids at 30% probability (crystal grown by slow evaporation of a sample dissolved in hexane/ethyl acetate) (CCDC 2082653).
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Figure S9: Plot arising from the single-crystal X-ray analysis of compound 42 – thermal ellipsoids at 50% probability (crystal grown by slow evaporation of a sample dissolved in
dichloromethane/ hexane) (CCDC 2082654).
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S11
0.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.59.0
f1 (ppm)
OO
O
400 MHz 1H NMR spectrum
of compound 12 (recorded in CDCl3)
CHCl3
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S12
0.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.59.0f1 (ppm)
OO
O
400 MHz 1H NMR spectrum
of compound 13 (recorded in CDCl3)
CHCl3
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S13
0102030405060708090100110120130140150160170180190200f1 (ppm)
19.0
22.5
25.2
25.7
36.7
39.0
41.1
42.2
49.2
77.4
79.1
83.4
109.4
130.2
135.9
OO
O
100 MHz 13C NMR spectrum
of compound 13 (recorded in CDCl3)
CDCl3
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S14
-0.50.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.0f1 (ppm)
400 MHz 1H NMR spectrum
of compound 14 (recorded in CDCl3)
OHOH
O
CHCl3
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S15
-100102030405060708090100110120130140150160170180190200210220230f1 (ppm)
18.5
25.4
36.8
39.6
43.3
43.7
53.4
70.7
74.3
131.1
136.9
220.1
125 MHz 13C NMR spectrum
of compound 14 (recorded in CDCl3)
OHOH
O
CDCl3
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S16
-0.50.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.59.0
f1 (ppm)
OHOH
MeO
400 MHz 1H NMR spectrum of compound 15
(recorded in CDCl3)
CHCl3
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S17
-100102030405060708090100110120130140150160170180190200210f1 (ppm)
14.4
21.1
21.8
26.5
31.6
34.7
35.3
37.9
48.8
56.7
70.3
74.0
85.4
OHOH
MeO
100 MHz 13C NMR spectrum
of compound 15 (recorded in CDCl3)
CDCl3
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S18
0.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.59.09.510.0
f1 (ppm)
OO
MeO
S O
:
400 MHz 1H NMR spectrum
of compound 16 (recorded in CDCl3)
CHCl3
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S19
0102030405060708090100110120130140150160170180190200210f1 (ppm)
14.0
20.4
21.7
26.1
31.5
32.1
34.6
37.9
47.1
56.8
81.6
84.6
86.2
OO
MeO
S O
:
100 MHz 13C NMR spectrum
of compound 16 (recorded in CDCl3)
CDCl3
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S20
0.0.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.59.0
f1 (ppm)
OO
MeO
S:O
400 MHz 1H NMR spectrum
of compound 17 (recorded in CDCl3)
CHCl3
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S21
-100102030405060708090100110120130140150160170180190200210f1 (ppm)
14.0
20.5
22.0
26.3
32.3
32.5
34.9
38.1
46.6
56.9
84.9
86.5
90.9
OO
MeO
S:O
100 MHz 13C NMR spectrum
of compound 17 (recorded in CDCl3)
CDCl3
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S22
0.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.59.0f1 (ppm)
OO
MeO
SO
O
400 MHz 1H NMR spectrum
of compound 18 (recorded in CDCl3)
CHCl3
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S23
-100102030405060708090100110120130140150160170180190200210f1 (ppm)
13.8
20.1
21.3
26.3
31.1
31.3
34.6
36.4
46.2
56.7
81.3
84.7
85.4
OO
MeO
SO
O
100 MHz 13C NMR spectrum
of compound 18 (recorded in CDCl3)
CDCl3
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S24
-0.50.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.59.0f1 (ppm)
OO
SO
O
400 MHz 1H NMR spectrum
of compound 19
(recorded in CDCl3)
CHCl3
H2O
Grease
silicone
grease
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S25
-2.0-1.5-1.0-0.50.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.59.09.5f1 (ppm)
400 MHz 1H NMR spectrum
of compound 20 (recorded in CDCl3)
OHOH
O
CHCl3
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S26
-20-100102030405060708090100110120130140150160170180190200210220f1 (ppm)
14.5
21.0
21.7
23.8
35.5
36.5
36.8
39.6
51.2
68.6
72.1
221.2
100 MHz 13C NMR spectrum
of compound 20 (recorded in CDCl3)
OHOH
O
CDCl3
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S27
-1.0-0.50.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.59.09.510.0f1 (ppm)
400 MHz 1H NMR spectrum
of compounds 21 and 22 (1:2 dr) (recorded in CDCl3)
OO
22
S O
+
21
:
O
OO
S:O
O
CHCl3
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S28
-20-100102030405060708090100110120130140150160170180190200210220230240f1 (ppm)
14.0
14.2
21.0
21.2
21.3
21.8
23.5
23.7
33.4
34.4
35.1
35.3
35.6
36.0
39.7
49.7
49.8
79.7
84.0
84.9
89.0
218.7
219.1
100 MHz 13C NMR spectrum
of compounds 21 and 22 (1:2 dr)
(recorded in CDCl3)
OO
22
S O
+
21
:
O
OO
S:O
O
CDCl3
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S29
0.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.59.0f1 (ppm)
OO
SO
O
O
400 MHz 1H NMR spectrum
of compound 23 (recorded in CDCl3)
CHCl3
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S30
-100102030405060708090100110120130140150160170180190200210220230f1 (ppm)
13.8
20.7
20.9
23.4
32.9
33.8
35.4
39.1
48.6
79.4
83.3
217.7
OO
SO
O
O
100 MHz 13C NMR spectrum
of compound 23 (recorded in CDCl3)
CDCl3
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S31
-1.0-0.50.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.59.09.510.0f1 (ppm)
CHCl3
silicone
grease
OO
HO
SO
O
400 MHz 1H NMR spectrum
of compound 24 (recorded in CDCl3)
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S32
-100102030405060708090100110120130140150160170180190200210220f1 (ppm)
12.9
19.9
21.5
25.7
31.7
33.9
35.8
36.1
49.8
74.5
80.7
84.5
OO
HO
SO
O
100 MHz 13C NMR spectrum
of compound 24 (recorded in CDCl3)
CDCl3
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S33
-1.0-0.50.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.59.09.510.0f1 (ppm)
OO
HO
SO
O
400 MHz 1H NMR spectrum
of compound 25 (recorded in CDCl3)
CHCl3
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S34
-100102030405060708090100110120130140150160170180190200210f1 (ppm)
13.9
20.3
21.6
26.3
31.1
34.6
36.5
37.8
46.6
75.5
81.2
85.3
OO
HO
SO
O
100 MHz 13C NMR spectrum
of compound 25 (recorded in CDCl3)
CDCl3
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S35
-1.0-0.50.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.59.09.510.0f1 (ppm)
OO
O
SO
O
S
SMe
400 MHz 1H NMR spectrum
of compound 26 (recorded in CDCl3)
CHCl3
H2O
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S36
-100102030405060708090100110120130140150160170180190200210220230f1 (ppm)
13.8
19.5
20.4
21.4
26.7
30.9
34.1
34.5
36.5
46.4
80.7
84.8
86.5
215.4
OO
O
SO
O
S
SMe
100 MHz 13C NMR spectrum
of compound 26 (recorded in CDCl3)
CDCl3
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S37
-1.0-0.50.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.59.09.510.0f1 (ppm)
28
O
OO S
O
:
29
O
OO S:
+
O
400 MHz 1H NMR spectrum
of compounds 28 and 29 (1:1 dr)
(recorded in CDCl3)
CHCl3
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S38
-100102030405060708090100110120130140150160170180190200210220230f1 (ppm)
19.2
19.3
24.4
24.6
32.1
33.7
38.9
39.0
40.1
40.6
40.6
41.8
42.3
49.2
49.9
80.8
84.9
85.1
90.0
131.5
131.8
138.4
138.6
220.1
220.3
28
O
OO S
O
:
29
O
OO S:
+
O
75 MHz 13C NMR spectrum
of compounds 28 and 29 (1:1 dr)
(recorded in CDCl3)
CDCl3
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S39
-0.50.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.59.09.5f1 (ppm)
O
OHOH
400 MHz 1H NMR spectrum
of compound 30 (recorded in CDCl3)
CHCl3
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S40
-100102030405060708090100110120130140150160170180190200210220230240f1 (ppm)
18.9
22.0
23.5
26.5
30.4
37.0
38.0
39.2
46.9
69.2
74.2
223.9
O
OHOH
100 MHz 13C NMR spectrum
of compound 30 (recorded in CDCl3)
CDCl3
![Page 41: Supplementary Material for · aInstitute for Advanced and Applied Chemical Synthesis, Jinan University, Guangzhou, 510632, China and bResearch School of Chemistry, Institute of Advanced](https://reader035.vdocument.in/reader035/viewer/2022071516/6139155fa4cdb41a985b7a2a/html5/thumbnails/41.jpg)
S41
-0.50.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.59.09.510.0f1 (ppm)
CHCl3
32
O
OO S
O
:
31
O
OO S:
+
O
400 MHz 1H NMR spectrum
of compounds 31 and 32 (1:1 dr) (recorded in CDCl3)
![Page 42: Supplementary Material for · aInstitute for Advanced and Applied Chemical Synthesis, Jinan University, Guangzhou, 510632, China and bResearch School of Chemistry, Institute of Advanced](https://reader035.vdocument.in/reader035/viewer/2022071516/6139155fa4cdb41a985b7a2a/html5/thumbnails/42.jpg)
S42
-100102030405060708090100110120130140150160170180190200210220230240250f1 (ppm)
17.3
17.6
21.7
21.8
22.8
22.9
25.5
25.7
29.7
30.2
34.0
34.1
35.7
36.1
38.8
39.1
46.0
46.2
80.7
84.8
85.5
90.2
220.9
221.1
32
O
OO S
O
:
31
O
OO S:
+
O
100 MHz 13C NMR spectrum
of compounds 31 and 32 (1:1 dr)
(recorded in CDCl3)
CDCl3
![Page 43: Supplementary Material for · aInstitute for Advanced and Applied Chemical Synthesis, Jinan University, Guangzhou, 510632, China and bResearch School of Chemistry, Institute of Advanced](https://reader035.vdocument.in/reader035/viewer/2022071516/6139155fa4cdb41a985b7a2a/html5/thumbnails/43.jpg)
S43
-0.50.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.59.09.510.0f1 (ppm)
OO S
O
O
O
400 MHz 1H NMR spectrum
of compound 33 (recorded in CDCl3)
CHCl3
![Page 44: Supplementary Material for · aInstitute for Advanced and Applied Chemical Synthesis, Jinan University, Guangzhou, 510632, China and bResearch School of Chemistry, Institute of Advanced](https://reader035.vdocument.in/reader035/viewer/2022071516/6139155fa4cdb41a985b7a2a/html5/thumbnails/44.jpg)
S44
-40-30-20-100102030405060708090100110120130140150160170180190200210220230240f1 (ppm)
16.9
21.4
22.6
24.9
29.5
33.5
35.3
38.6
45.6
81.0
85.0
219.6
OO S
O
O
O
100 MHz 13C NMR spectrum
of compound 33 (recorded in CDCl3)
CDCl3
![Page 45: Supplementary Material for · aInstitute for Advanced and Applied Chemical Synthesis, Jinan University, Guangzhou, 510632, China and bResearch School of Chemistry, Institute of Advanced](https://reader035.vdocument.in/reader035/viewer/2022071516/6139155fa4cdb41a985b7a2a/html5/thumbnails/45.jpg)
S45
-1.0-0.50.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.59.0f1 (ppm)
OO S
O
O
OHH
400 MHz 1H NMR spectrum
of compound 34 (recorded in CDCl3)
CHCl3
![Page 46: Supplementary Material for · aInstitute for Advanced and Applied Chemical Synthesis, Jinan University, Guangzhou, 510632, China and bResearch School of Chemistry, Institute of Advanced](https://reader035.vdocument.in/reader035/viewer/2022071516/6139155fa4cdb41a985b7a2a/html5/thumbnails/46.jpg)
S46
-100102030405060708090100110120130140150160170180190200210220230f1 (ppm)
16.7
22.4
25.8
26.0
32.1
32.2
34.8
37.3
41.6
75.9
82.6
86.2
OO S
O
O
OHH
100 MHz 13C NMR spectrum
of compound 34 (recorded in CDCl3)
CDCl3
![Page 47: Supplementary Material for · aInstitute for Advanced and Applied Chemical Synthesis, Jinan University, Guangzhou, 510632, China and bResearch School of Chemistry, Institute of Advanced](https://reader035.vdocument.in/reader035/viewer/2022071516/6139155fa4cdb41a985b7a2a/html5/thumbnails/47.jpg)
S47
0.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.59.0
f1 (ppm)
400 MHz 1H NMR spectrum
of compound 41 (3.6:1 dr) (recorded in CDCl3)
CHCl3
OHOH
![Page 48: Supplementary Material for · aInstitute for Advanced and Applied Chemical Synthesis, Jinan University, Guangzhou, 510632, China and bResearch School of Chemistry, Institute of Advanced](https://reader035.vdocument.in/reader035/viewer/2022071516/6139155fa4cdb41a985b7a2a/html5/thumbnails/48.jpg)
S48
-100102030405060708090100110120130140150160170180190200
f1 (ppm)
19.1
23.0
23.8
26.9
33.0
33.8
34.4
37.0
38.6
45.1
46.9
73.0
75.6
OHOH
100 MHz 13C NMR spectrum
of compound 41 (3.6:1 dr) (recorded in CDCl3)
CDCl3
![Page 49: Supplementary Material for · aInstitute for Advanced and Applied Chemical Synthesis, Jinan University, Guangzhou, 510632, China and bResearch School of Chemistry, Institute of Advanced](https://reader035.vdocument.in/reader035/viewer/2022071516/6139155fa4cdb41a985b7a2a/html5/thumbnails/49.jpg)
S49
-1.0-0.50.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.59.0
f1 (ppm)
CHCl3
OOSO
400 MHz 1H NMR spectrum
of the sulfite precursors to compound 42 (mixture of 4 diastereomers) (recorded in CDCl3)
![Page 50: Supplementary Material for · aInstitute for Advanced and Applied Chemical Synthesis, Jinan University, Guangzhou, 510632, China and bResearch School of Chemistry, Institute of Advanced](https://reader035.vdocument.in/reader035/viewer/2022071516/6139155fa4cdb41a985b7a2a/html5/thumbnails/50.jpg)
S50
-100102030405060708090100110120130140150160170180190200f1 (ppm)
19.1
19.3
21.8
22.0
23.6
23.9
26.4
27.1
32.6
32.8
33.2
33.2
34.9
35.3
38.3
38.6
42.1
42.3
43.4
44.2
47.8
48.0
85.6
86.0
90.3
90.9
OOSO
100 MHz 13C NMR spectrum
of the sulfite precursors to compound 42 (mixture of 4 diastereomers) (recorded in CDCl3)
CDCl3
![Page 51: Supplementary Material for · aInstitute for Advanced and Applied Chemical Synthesis, Jinan University, Guangzhou, 510632, China and bResearch School of Chemistry, Institute of Advanced](https://reader035.vdocument.in/reader035/viewer/2022071516/6139155fa4cdb41a985b7a2a/html5/thumbnails/51.jpg)
S51
-1.0-0.50.00.51.01.52.02.53.03.54.04.55.05.56.06.57.07.58.08.59.0
f1 (ppm)
OOSO
O
400 MHz 1H NMR spectrum
of compound 42 (4:1 dr) (recorded in CDCl3)
CHCl3
![Page 52: Supplementary Material for · aInstitute for Advanced and Applied Chemical Synthesis, Jinan University, Guangzhou, 510632, China and bResearch School of Chemistry, Institute of Advanced](https://reader035.vdocument.in/reader035/viewer/2022071516/6139155fa4cdb41a985b7a2a/html5/thumbnails/52.jpg)
S52
-100102030405060708090100110120130140150160170180190200f1 (ppm)
18.8
21.9
23.2
26.1
32.7
33.0
34.0
35.2
38.5
43.0
46.5
85.8
86.1
OOSO
O
100 MHz 13C NMR spectrum
of compound 42 (4:1 dr) (recorded in CDCl3)
CDCl3