Supporting InformationHancock et al. 10.1073/pnas.0914625107

Fig. S1. Map showing the geographic origin of each population relative to the ecoregion domains.

Fig. S2. Maps showing subsistence variables for each population. Points outlined in black are populations that were genotyped by our group.

Hancock et al. www.pnas.org/cgi/content/short/0914625107 1 of 4

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Fig. S3. Transformed allele frequency plotted against population for two main dietary component variables: (A) cereals, and (B) fats, meat, and milk. SNPswere polarized based on the relative difference between the two categories in the first region where both were present; then, transformed allele frequencieswere computed by subtracting the mean allele frequency across populations. SNPs with ranks less than 10−4 are included in the plots. Vertical lines separatepopulations into seven major geographic regions (sub-Saharan Africa, Middle East, Europe, West Asia, East Asia, Oceania, or the Americas). Red denotespopulations that are members of the category being tested, and all other populations are blue. Lines are drawn through the mean for the set of populations ina given region that are part of the category of interest, and gray shading denotes the central 50% interval.

Hancock et al. www.pnas.org/cgi/content/short/0914625107 2 of 4

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Fig. S4. Transformed allele frequency plotted against population for three subsistence variables: (A) agriculture, (B) horticulture, and (C) pastoralism. SNPswere polarized based on the relative difference between the two categories in the first region where both were present; then, transformed allele frequencieswere computed by subtracting the mean allele frequency across populations. SNPs with ranks less than 10−4 are included in the plots. Vertical lines separatepopulations into seven major geographic regions (sub-Saharan Africa, Middle East, Europe, West Asia, East Asia, Oceania, or the Americas). Red denotespopulations that are members of the category being tested, and all other populations are blue. Lines are drawn through the mean for the set of populations ina given region that are part of the category of interest, and gray shading denotes the central 50% interval.

Hancock et al. www.pnas.org/cgi/content/short/0914625107 3 of 4

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Fig. S5. Transformed allele frequencies plotted against population for the SNPs with the strongest signals for two ecoregion domains: (A) humid temperate,and (B) humid tropical ecoregion domains. SNPs were polarized based on the relative difference between the two categories in the first region where bothwere present; then, transformed allele frequencies were computed by subtracting the mean allele frequency across populations. SNPs with ranks less than 10−4

are included in the plots. Vertical lines separate populations into seven major geographical regions (sub-Saharan Africa, Middle East, Europe, West Asia, EastAsia, Oceania, or the Americas). Red denotes populations that are members of the category being tested, and all other populations are blue. Lines are drawnthrough the mean for the set of populations in a given region that are part of the category of interest, and gray shading denotes the central 50% interval.

Hancock et al. www.pnas.org/cgi/content/short/0914625107 4 of 4