surgical approaches to pulmonary metastases...pulmonary metastasectomy the problem martini n, huvos...
TRANSCRIPT
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Surgical Approaches to Pulmonary Metastases
Raja M Flores MD Professor and Chief
Thoracic Surgery Mount Sinai School of Medicine
New York, New York
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History of Lung Metastasectomy
• 1882 Weinlechner +CW
• 1926 Divis Procedure for mets
• 1933 Barney & Churchill 1st lobectomy
• 1940 Alexander & Haight Bil Lobectomy
• 1979 McCormack et al MSKCC exp
• 1997 Pastorino 5206 IRLM
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Marcove RC, Mike V, Hajek JV et al. Osteogenic sarcoma under the age of 21: a review of 145 operative cases after amputation J Bone Joint Surg 1970;52A:411421 • 83% developed pulmonary metastases within two years and ALL DEAD within next two years
Pulmonary Metastasectomy
The Problem
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Martini N, Huvos AG, Mike V. et al. Multiple pulmonary resections in the treatment of
of osteogenic sarcoma. Ann Thorac Surg 1971;12:271-280
29 consecutive patients underwent thoracotomy
22 completely resected and re-resected
32% five year survival 18% twenty year survival
Pulmonary Metastasectomy
The Solution
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The role of metastectomy is dependent on the biology of the
tumor
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• Newer chemotherapeutic agents • Effective on micrometastatic disease • Unable to eradicate gross disease • Adjuvant or salvage surgery
• Also when chemotherapy is completely
ineffective
Pulmonary Metastasectomy Modern Evolution
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Pulmonary Metastasis
Survival after Resection Author Year # Patients Survival Mountain 1984 443 35 Eckersberger 1988 122 38 / 28 Venn 1989 118 35 / 51 Forquier 1997 50 44* Robert 1999 276 48 Pastorino 1997 5206 36 Piltz 2002 105 40*
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Criteria for Resection
1. Presence of lung nodules or changes consistent with metastases
2. Primary tumor controlled
3. Complete resection probable
4. Sufficient lung reserve after resection
5. No extrathoracic metastases
6. Alternative treatment not effective
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Rationale for metastectomy in various primary tumors
Primary Site Goal When to resect
Sarcoma Permanent cure When possible
Germ cell Teratoma Systematic
Colon Cure + Liver Selective
Kidney Occasional cure Highly selective
Melanoma New primary,cure Single lesion
Breast New primary, ER/PR Single lesion
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Any solitary metastasis must consider the possibility of a
new primary lung cancer
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VATS
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VATS Wedge resection A non-anatomic resection of
lung parenchyma
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Wedge Disadvantage
• The lung is a 3-dimensional structure • A wedge converts it into a 2-dimensional
structure • Therefore, greater loss of normal lung
parenchyma
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Precision Cautery
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Pastorino et al.
Long-term results of lung metastasectomy: Prognostic analyses based on 5206 cases.
The InternationalRegistry of Lung Metastases.
J Thorac Cardiovasc Surg1997;113:37-49
Pulmonary Metastasectomy
Results of Metastasectomy
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Long term survival by tumor Primary # 5-year % 10 year % Colorectal 653 35% 22% Breast 411 37% 21% Kidney 402 41% 24% Sarcoma 1917 31% 26% Melanoma 282 21% 14% Germ cell 318 68% 63%
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The International Registry of Lung Metastasis
TYPE OF RESECTION %
Wedge resection 67
Segmentectomy 9
Lobectomy/ Bilobectomy 21
Pneumonectomy 3
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The International Registry of Lung Metastasis
PROCEDURE %
Unilateral Thoracotomy 58
Bilateral Thoracotomy 11
Sternotomy 27
Thoracoscopy 2
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The International Registry of Lung Metastasis
Group Resectable Risk Factor DFI # Mets.
I Yes None >36 mo. Single
II Yes One <36 mo. Or Multiple
III Yes Two <36 mo. & Multiple
IV Unresectable
Prognostic Grouping
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We know the numerator but NOT the denominator
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The International Registry of Lung Metastasis
Overall Actuarial Survival Complete vs Incomplete Resection
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The International Registry of Lung Metastasis
Survival according to Number of Metastasis
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The International Registry of Lung Metastasis
Survival according to Histology
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The International Registry of Lung Metastasis
Survival According to Disease Free Interval
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The International Registry of Lung Metastasis
Survival based on Prognostic Groups
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Oligometastasis : Colorectal
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Pulmonary Metastasis from Colorectal Cancer
Overall Survival Pfannschmidt J. et al J Th CV Surg 2003;126:732-739
N = 167 5 yr. survival = 32.4% Med. Survival 40.2 mo
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Pulmonary Metastasis from Colorectal Cancer
Survival based on # of Metastasis Pfannschmidt J. et al J Th CV Surg 2003;126:732-739
One Met
Multiple Mets
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Pulmonary Metastasis from Colorectal Cancer
Survival based on Lymph Node Status and Pre-operativ CEA level
Pfannschmidt J. et al J Th CV Surg 2003;126:732-739
CEA >5 ng/mL
CEA 5 ng/mL or <
Lymph nodes (-)
Hilar LNs (+) Med LNs
(+)
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Pulmonary Metastasectomy Resection of lung/liver metastases
• 81 patients • Median follow-up of 3.7 years • 43% DOD • 26% AWD • 31% NED * 30% actual 5-year survivors
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Metastatic Melanoma to Lung
Survival after Surgical vs. Non-surgical Treatment
Tefra et al: JTCVS 1995;110:119-129
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Pulmonary Metastases Soft Tissue Sarcoma
23% of patients in the MSKCC prospective database from 1983-1997 developed or presented with pulmonary metastases.
3149
Billingsley, et al. Ann Surg 229:602-612
719
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Pulmonary Metastases Soft Tissue Sarcoma
MSKCC prospective sarcoma database from
January 1983 – February 1997.
3149 adult patients with soft tissue sarcoma.
719 patients with lung metastasis.
248 patients underwent pulmonary resection.
86 patients underwent pulmonary re-resection.
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Pulmonary Metastasis
Soft Tissue Sarcomas Disease-specific Survival
Overall By Treatment
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Time (months)
120967248240
Propo
rtion S
urvivi
ng1.0
.8
.6
.4
.2
0.0
Survival following re-resection
n=86
median survival: 43 mo
5 year survival: 36%
median follow-up: 35 months
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Conclusions
• Metastectomy can be performed on all tumors with favorable biology
• Selected patients • Disease free interval • Complete resection • Good pulmonary function • Number of lesions
• Indications evolving as chemotherapy evolves • NOT FOR ALL PATIENTS