“TARGETED EPIGENETIC THERAPIES: THE NEXT FRONTIER?” AND “ADN

TECHNOLOGY AND EVOLUTION OF THE CENTRAL DOGMA”

Juliana Caro Palacio

Medicine Student

Molecular Biology

III Semester

UPB

FOLDING

FOLDING

DNA

RNA

PROTEIN

PHENOTYPE

Expression

Transcription

Translation

Replication

INTRODUCTION

TARGETED EPIGENETIC THERAPIES: THE NEXT

FRONTIER? (JANUARY 2014)

NEW #1

TARGETED EPIGENETIC THERAPIES: THE NEXT FRONTIER? (JANUARY 2014)

Epigenetic therapies

•Clinical success•Improve patient outcomes

Epigenome•System that alters the structure of DNA•Regulating gene activity without changing

the nucleotide sequence.

Epigenetic effectors

•Enzymes EZH2 and UTX•Regulate multiple transcription factors

TARGETED EPIGENETIC THERAPIES: THE NEXT FRONTIER? (JANUARY 2014)

Epigenetic

Progression and tumor formation

Therapies targeted at specific epigenetic regulators

TARGETED EPIGENETIC THERAPIES: THE NEXT FRONTIER? (JANUARY 2014)

Gen ARID1A

Epigenetic regulatory

Associated with approximately

half of the ovarian clear-cell cancers

tested

Tumor suppressor

I think today is very necessary implement epigenetics, due to

large number of abnormalities

discovered and the variety of cancers

where this technique may be useful for

better approaches, diagnoses and

therapies.

PERSONAL OBSERATION

ADN TECHNOLOGY AND EVOLUTION OF THE CENTRAL DOGMA (JANUARY 2014)

NEW #2

ADN TECHNOLOGY AND EVOLUTION OF THE CENTRAL DOGMA (JANUARY 2014)

Central Dogma

• Artificial evolution

DNA sequences captured digitally

• Reconstruction of genomic

In silico models

• Predict and influence the phenotype

ADN TECHNOLOGY AND EVOLUTION OF THE CENTRAL DOGMA (JANUARY 2014)

Extension of the Central

Dogma

Reintroduction of megafauna

Synthetic biology

Release of extinct pathogens

Biodiversity preservation

ADN TECHNOLOGY AND EVOLUTION OF THE CENTRAL DOGMA (JANUARY 2014)

Evolution of the Central

Dogma

Recording and storage of

DNA sequence data obtained by sequencing

Use of information for de

novo chemical synthesis of DNA

Expression of synthetic DNA

through to RNA transcription and

protein translation

Replication and dissemination of data by file sharing across

the internet

I think these scientific advances are very important for the evolution of molecular biology if

used with therapeutic actions, because they facilitate access to information and help control

many diseases and abnormalities presented during development.

PERSONAL OBSERATION

MEDICAL UTILITY

Allow quick access at any time and place at libraries genes, obtaining detailed information on mutations,

expression and development of genes, looking for

improvement and reconstruction of the

genome

MEDICAL UTILITY

Apply the epigenetic in order to prevent the expression of more than one gene at time,

through manipulation of chromosomes and the transcription machinery, thereby reducing mutations, diseases and clinical morbidity.

MEDICAL UTILITY

Facilitate the creation of synthetic genetic material for the correction and

construction of new biochemical pathways, thereby improving the

quality of life, therapies and treatments.

MEDICAL UTILITY

Martínez Sánchez, Lina María. Biología Molecular. 7 Edición. Medellín. UPB. Facultad de Medicina 2012. Pp 74-77

“Targeted Epigenetic Therapies: The Next Frontier?”. Pub-Med. (online magazine). January 2014. Avaliable at: http://jnci.oxfordjournals.org/content/102/24/1824.long

“DNA technology and evolution of the Central Dogma”. ScienceDirect. (online magazine). January 2014. Avaliable at: http://www.sciencedirect.com.consultaremota.upb.edu.co/science/article/pii/S0169534713002498

BIBLIOGRAPHY

THANKS !!

“Isn't he strongest species that survives, nor the most intelligent, but the one that responds to change”. Charles Darwin