the army’s university affiliated research center the utexas uarc chem-bio program objectives dr....
Post on 19-Dec-2015
215 views
TRANSCRIPT
![Page 1: The Army’s University Affiliated Research Center The UTEXAS UARC Chem-Bio Program Objectives Dr. Steve Kornguth, Director Biological and Chemical Countermeasures](https://reader036.vdocument.in/reader036/viewer/2022062714/56649d355503460f94a0cc06/html5/thumbnails/1.jpg)
The Army’s University Affiliated Research Center
The UTEXAS UARCChem-Bio Program Objectives
Dr. Steve Kornguth, Director Biological and Chemical Countermeasures
![Page 2: The Army’s University Affiliated Research Center The UTEXAS UARC Chem-Bio Program Objectives Dr. Steve Kornguth, Director Biological and Chemical Countermeasures](https://reader036.vdocument.in/reader036/viewer/2022062714/56649d355503460f94a0cc06/html5/thumbnails/2.jpg)
UARC Chem-Bio Program
![Page 3: The Army’s University Affiliated Research Center The UTEXAS UARC Chem-Bio Program Objectives Dr. Steve Kornguth, Director Biological and Chemical Countermeasures](https://reader036.vdocument.in/reader036/viewer/2022062714/56649d355503460f94a0cc06/html5/thumbnails/3.jpg)
UARC Chem-Bio Program
Objectives
To minimize by 2015 the operational and combat capability constraints posed by Chem-Bio threat.
![Page 4: The Army’s University Affiliated Research Center The UTEXAS UARC Chem-Bio Program Objectives Dr. Steve Kornguth, Director Biological and Chemical Countermeasures](https://reader036.vdocument.in/reader036/viewer/2022062714/56649d355503460f94a0cc06/html5/thumbnails/4.jpg)
Components of Consortium
• The University of Texas System
Austin, Dallas, Galveston, San Antonio– Texas Department of Health, First Responders– Texas National Guard, 6th Civil Support Team– Institute for Defense Analyses– Central Texas FBI
![Page 5: The Army’s University Affiliated Research Center The UTEXAS UARC Chem-Bio Program Objectives Dr. Steve Kornguth, Director Biological and Chemical Countermeasures](https://reader036.vdocument.in/reader036/viewer/2022062714/56649d355503460f94a0cc06/html5/thumbnails/5.jpg)
Research to Operations
• Sensors and Situation Awareness
• Medical Countermeasures
• Communication
• Transition through OEM, 6th CST, NG
• Archival Data Set and Disease Surveillance
• Interface with INTEL- FBI
![Page 6: The Army’s University Affiliated Research Center The UTEXAS UARC Chem-Bio Program Objectives Dr. Steve Kornguth, Director Biological and Chemical Countermeasures](https://reader036.vdocument.in/reader036/viewer/2022062714/56649d355503460f94a0cc06/html5/thumbnails/6.jpg)
Research Areas
• Scientific validation of B/C incident– situation awareness systems-sensors, signatures
• Medical countermeasures– Biosurveillance-archival data, HAN– Vaccine, pharmaceuticals, transport
• Communications– Security,medical, public; mobilize resources– Intelligent software agents
![Page 7: The Army’s University Affiliated Research Center The UTEXAS UARC Chem-Bio Program Objectives Dr. Steve Kornguth, Director Biological and Chemical Countermeasures](https://reader036.vdocument.in/reader036/viewer/2022062714/56649d355503460f94a0cc06/html5/thumbnails/7.jpg)
Sensor Element-Binders
• High affinity antibodies-Kd less than 10-12
• Aptamers
• cDNA probes
![Page 8: The Army’s University Affiliated Research Center The UTEXAS UARC Chem-Bio Program Objectives Dr. Steve Kornguth, Director Biological and Chemical Countermeasures](https://reader036.vdocument.in/reader036/viewer/2022062714/56649d355503460f94a0cc06/html5/thumbnails/8.jpg)
Sensor Platforms
• Multi-array system – Stephen Johnston
• Chip detection- James Chambers
• Redox Detector- Adam Heller and Gal
• “Electronic Tongue”- Anslyn and Neikirk
![Page 9: The Army’s University Affiliated Research Center The UTEXAS UARC Chem-Bio Program Objectives Dr. Steve Kornguth, Director Biological and Chemical Countermeasures](https://reader036.vdocument.in/reader036/viewer/2022062714/56649d355503460f94a0cc06/html5/thumbnails/9.jpg)
Virulence Factors
• Gene encoding binding to target cells – LEE is an attachment gene
• Heme transport gene– Aerobactin is iron transport gene– pColV is plasmid with Aerobactin gene
![Page 10: The Army’s University Affiliated Research Center The UTEXAS UARC Chem-Bio Program Objectives Dr. Steve Kornguth, Director Biological and Chemical Countermeasures](https://reader036.vdocument.in/reader036/viewer/2022062714/56649d355503460f94a0cc06/html5/thumbnails/10.jpg)
Information Processing
• Software agent for belief maintenance
• Software agent for resource allocation
![Page 11: The Army’s University Affiliated Research Center The UTEXAS UARC Chem-Bio Program Objectives Dr. Steve Kornguth, Director Biological and Chemical Countermeasures](https://reader036.vdocument.in/reader036/viewer/2022062714/56649d355503460f94a0cc06/html5/thumbnails/11.jpg)
Field Work
• TDH Archival data and HAN
• 6th CST integration with OEM through IAT
• Integrate with Texas National Guard through General Daniel James III
• Integrate with Metropolitan Medical Response System (HHS)
• University linkage through IAT
![Page 12: The Army’s University Affiliated Research Center The UTEXAS UARC Chem-Bio Program Objectives Dr. Steve Kornguth, Director Biological and Chemical Countermeasures](https://reader036.vdocument.in/reader036/viewer/2022062714/56649d355503460f94a0cc06/html5/thumbnails/12.jpg)
Persons Funded• Sensors- G. Georgiou, B. Iverson, E .Anslyn, A. Ellington, S. Payne, J. Chambers, A. Heller• Antivirals- R. Shope, D .Gorenstein,
S. Johnston • Public Health, Training and 1st Responders-
S. Barber, S. Collier, D. Perotta, D. Eaton, J. Davis • DoD Transition- G. Boezer, J. Grote
![Page 13: The Army’s University Affiliated Research Center The UTEXAS UARC Chem-Bio Program Objectives Dr. Steve Kornguth, Director Biological and Chemical Countermeasures](https://reader036.vdocument.in/reader036/viewer/2022062714/56649d355503460f94a0cc06/html5/thumbnails/13.jpg)
Technology Demonstration
Identified Underground Facility at Ft. Hood, 3rd Corps- 72,000 sq ft footprint.
Scenario should utilize sensor, communications, medical response elements-demonstrate teaming
![Page 14: The Army’s University Affiliated Research Center The UTEXAS UARC Chem-Bio Program Objectives Dr. Steve Kornguth, Director Biological and Chemical Countermeasures](https://reader036.vdocument.in/reader036/viewer/2022062714/56649d355503460f94a0cc06/html5/thumbnails/14.jpg)
Vulnerabilities
• Focus on early alert as well as consequence management– Intel– Biosurveillance:Archival and Emergent
• Resource Allocation- locally, regionally– Succession Issues– Limits on antibiotic for families– Doctrine
![Page 15: The Army’s University Affiliated Research Center The UTEXAS UARC Chem-Bio Program Objectives Dr. Steve Kornguth, Director Biological and Chemical Countermeasures](https://reader036.vdocument.in/reader036/viewer/2022062714/56649d355503460f94a0cc06/html5/thumbnails/15.jpg)
Vulnerabilities
• Different needs in different states: urban, livestock, plant
• Overarching Integrated Strategy: e.g Medical, Security, Evidence Retention Agencies
![Page 16: The Army’s University Affiliated Research Center The UTEXAS UARC Chem-Bio Program Objectives Dr. Steve Kornguth, Director Biological and Chemical Countermeasures](https://reader036.vdocument.in/reader036/viewer/2022062714/56649d355503460f94a0cc06/html5/thumbnails/16.jpg)
SUCCESSES in FY 2000 I
• Generated high affinity Ab’s-anthracis toxin• Designed aptamer based MEMS chip• Developed anti-ricin aptamers for detector
elements• Detect 108 copies/microliter of 70 base
DNA in 20 min; S/N ratio 7 • Characterize heme transport gene in
pathogenicity island
![Page 17: The Army’s University Affiliated Research Center The UTEXAS UARC Chem-Bio Program Objectives Dr. Steve Kornguth, Director Biological and Chemical Countermeasures](https://reader036.vdocument.in/reader036/viewer/2022062714/56649d355503460f94a0cc06/html5/thumbnails/17.jpg)
Successes in FY 2000 II
• Demonstrated new vaccine against multiple pathogens
• Identified potential signatures for early alert disease outbreak
• Developed compounds with potential protective properties against Pichinde virus
![Page 18: The Army’s University Affiliated Research Center The UTEXAS UARC Chem-Bio Program Objectives Dr. Steve Kornguth, Director Biological and Chemical Countermeasures](https://reader036.vdocument.in/reader036/viewer/2022062714/56649d355503460f94a0cc06/html5/thumbnails/18.jpg)
Successes in FY 2000 III
• Defined B/C Incident constituencies and their unique communications requirements
• Identified “signature” flags in health system for early warning of B/C event
• Identified ER facility and faculty at Hermann Hospital, Houston, with leading edge electronic data entry for surveillance